5Y58,5Y58,6ERF,6ERF


Conserved Protein Domain Family
Ku_N

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pfam03731: Ku_N 
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Ku70/Ku80 N-terminal alpha/beta domain
The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold.
Statistics
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PSSM-Id: 397685
View PSSM: pfam03731
Aligned: 13 rows
Threshold Bit Score: 157.893
Threshold Setting Gi: 1321391394
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y58_C         4 GILFCIELSETMFKESSDLEYkspl----leiLESLDELMSQLVITRPG-TAIGCYFYYCNREDA----KEGIYELFP-- 72  Saccharomyces c...
5Y58_B         4 STTFIVDVSPSMMKNNNVSKS-----------MAYLEYTLLNKSKKSRKtDWISCYLANCPVSEN----SQEIPNVFQ-- 66  Saccharomyces c...
Q9I7M8         7 CLIIVLDVRTCAAEEVKLKSA------------KCVAEILKDKIVCDRK-DYVSFVLVGCDTDEIkt-eDASHPNVLP-- 70  fruit fly
XP_002942054   8 AVVLCMDVGLAMSHSNQGEESpfe------qaKKVMMLFLQRQVFAESK-DEIAVVLFGTDTTDNalarGDQYENISV-- 78  tropical clawed...
P27641         9 AVVLCVDVGVAMGNSFPGEESpie------qaKKVMTMFVQRQVFSESK-DEIALVLYGTDGTDNalagKDQYQNITV-- 79  house mouse
6ERF_F        26 AVVLCMDVGFTMSNSIPGIESpfe------qaKKVITMFVQRQVFAENK-DEIALVLFGTDGTDNplsgGDQYQNITV-- 96  human
O94395        19 AILFVIEVSPSMLDPVDEFTPssl-----qmaLICAYQLAAQRVITNPS-DIMGVLLYGTESS------TGRFANQMM-- 84  Schizosaccharom...
Q9FQ08        30 FVVYLIDASPKMFCSTCPSEEedkqeshfhiaVSCIAQSLKAHIINRSN-DEIAICFFNTREKKN----LQDLNGVYV-- 102 thale cress
6ERF_A        37 SLIFLVDASKAMFESQSEDELtpf-----dmsIQCIQSVYISKIISSDR-DLLAVVFYGTEKDKN----SVNFKNIYV-- 104 human
O93257        58 SLIFLVDASKAMFEPYENEEAatpf----dmtMQCIRNVYTSKIISSDK-DLLSVVFYGMENNKN----SADFKHIYV-- 126 chicken
Q9U2D2        20 YTFFIIDGNPAMFETSKAGEPpef-----klaLKLILDEIVRVCCSRSLnNHIGVIVTSTKNSE-----TEGLENSTL-- 87  Caenorhabditis ...
Q23976        33 AILFVVDANLQTAGVERLLEA-----------LNIIRTAFISGLLVNDK-DLIGLIFANTKHSPPpl-eASALDNIVMpd 99  fruit fly
KAE8611069    36 SLIFLIDASKPMFESTGDELTpfd------ltLQCIRSVYASKIISSDH-DLLSVVFFGTRESNN----CDPFKHLCV-- 102 tropical clawed...
5Y58_C        73 -------LR-----DINATFMKKLNDLLEDLSSgrislydyfmFQQTGSEKQVRLSVLFTFMLdtfLEEipGQKQLSNKR 140 Saccharomyces c...
5Y58_B        67 -------IQsflapVTTTATIGFIKRLKQYCDQ----------HSHDSSNEGLQSMIQCLLVVsldIKQqfQARKILKQI 129 Saccharomyces c...
Q9I7M8        71 -------FG-----EPRLCSWQLLLEFFQFVNK------------TACEDGEWLNGLQAALE----LQNvaTTLRVARRR 122 fruit fly
XP_002942054  79 -------HR-----HLMLPDFDLLEQIQNVVEP-------------GSTQADFLDALIVSMDL---LQKetLGKKYERLH 130 tropical clawed...
P27641        80 -------CR-----HLMLPDFDLLEDIGNKIQP-------------SSQQADFLDALIVCMDL---IQRetIGKKFGKKH 131 house mouse
6ERF_F        97 -------HR-----HLMLPDFDLLEDIESKIQP-------------GSQQADFLDALIVSMDV---IQHetIGKKFEKRH 148 human
O94395        85 -------LL-----DIDPPDAERIKSLQSFEKDfqfs---kekFKPCSCQVSLSSVLYHCSVI---FT---TKAENFEKR 143 Schizosaccharom...
Q9FQ08       103 -------FNvperdSIDRPTARLIKEFDLIEESfdkeigsqtgIVSDSRENSLYSALWVAQAL---LRK--GSLKTADKR 170 thale cress
6ERF_A       105 -------LQ-----ELDNPGAKRILELDQFKGQqgqk--rfqdMMGHGSDYSLSEVLWVCANL---FSD--VQFKMSHKR 165 human
O93257       127 -------LQ-----ELDNPGAKRILELDQYRGDegrv--lfreTFGHNADYSLGEALWACSNL---FSD--VRVRLSHKR 187 chicken
Q9U2D2        88 -------LV-----PMGVLGQEEVNKIKEIAEEenlls-avnnYGGDHHKSDLSNVLNYCKRV---FA---SCSNTRHQS 148 Caenorhabditis ...
Q23976       100 ncavflpLR-----QLTKPIVEHYLEFMGGVETqfad---vygLAEPDGRGRFDLMIRLCIEM---LEK--CGKKLNNAK 166 fruit fly
KAE8611069   103 -------LH-----DLDTPGAKRILDLDKYKEEkgra--lfrdTIGCGGDFSLGEALWLCSNL---FSN--VKVKMSHKR 163 tropical clawed...
5Y58_C       141 VFLFTDIDKPQE------AQDIDERARLRRL------------------TIDLFDNKVNFA--TFFI----GYADKPFDN 190 Saccharomyces c...
5Y58_B       130 VVFTDNLDDLDI------TDEEIDLLTEELStrii----------lidcGKDTQEERKKSN--WLKLveaiPNSRIYNMN 191 Saccharomyces c...
Q9I7M8       123 ILLLFDFNDFPQ------DYEKFNEITDELL------------------GENIELIVGTHN--IAYI----DNAITSQPQ 172 fruit fly
XP_002942054 131 IAVFSDLSSPF-------SVDQLEVIIANLKkagislqfflpfpveeeeAGDSSNNRGD-----SG-----SSDRGRGPG 193 tropical clawed...
P27641       132 IEVFTDLSSPF-------SQDQLDVIICNLKksgislqf---flpfpidKNGEPGERGDLDsgLDHL-------KPSFPQ 194 house mouse
6ERF_F       149 IEIFTDLSSRF-------SKSQLDIIIHSLKkcdislqf---flpfslgKEDGSGDRGD-G--PFRL----GGHGPSFPL 211 human
O94395       144 LFLITDNDHPAW------DATERDIILQR--------------------AKDLRDLDIQVH--PVFLd---PPTHSFRIN 192 Schizosaccharom...
Q9FQ08       171 MFLFTNEDDPFGsmrisvKEDMTRTTLQR--------------------AKDAQDLGISIE--LLPLs---QPDKQFNIT 225 thale cress
6ERF_A       166 IMLFTNEDNPHGn-----DSAKASRARTK--------------------AGDLRDTGIFLD--LMHL----KKPGGFDIS 214 human
O93257       188 IMLFTNEDNPHAn-----DSAKAKLARTR--------------------AGDLRDTGIILD--LMHL----KKPGGFDIS 236 chicken
Q9U2D2       149 VIYLTNNRNPFE------RDDFLESSHFKRTkaav----------tkiiGEGHRKTLGEFS--VIML-----------PE 199 Caenorhabditis ...
Q23976       167 IAYVTDVREPHPs-----NSNHFQAALQK--------------------ASDLEGKEFEFH--VIPM------VDDFDYE 213 fruit fly
KAE8611069   164 IMLFTNEDNPHAn-----DQAKAKQARAK--------------------AEDLREMGIFLD--LMHL----EKPEGFDIS 212 tropical clawed...
5Y58_C       191 EFYSDILQLGSHTNENTGLDSefdgpstkpiDAKYIKSRILRKKEVKRIM 240 Saccharomyces cerevisiae S288C
5Y58_B       192 ELLVEITSPATSVVKPVRVFS----------GELRLGADILSTQTSNPSG 231 Saccharomyces cerevisiae S288C
Q9I7M8       173 AIFNFSRKCGPDELNNQKYALs---------LVPRCNATLCSFKEALHTV 213 fruit fly
XP_002942054 194 KGLSDQQKEGIEMVRKIMFSLdgedglsevfTFRESLERLSIFKKIERRP 243 tropical clawed frog
P27641       195 KGLTEQQKEGIRMVTRVMLSLegedgldeiySFSESLRQLCVFKKIERRS 244 house mouse
6ERF_F       212 KGITEQQKEGLEIVKMVMISLegedgldeiySFSESLRKLCVFKKIERHS 261 human
O94395       193 IFYSDFLYIVYGRQDVSNLVNrg------qaQLQHMLNMITALQKPKRAH 236 Schizosaccharomyces pombe 972h-
Q9FQ08       226 LFYKDLIGLNSDELTEFMPSVg--------qKLEDMKDQLKKRVLAKRIA 267 thale cress
6ERF_A       215 LFYRDIISIAEDEDLRVHFEEs--------sKLEDLLRKVRAKETRKRAL 256 human
O93257       237 LFYRDIINVAEDEDLGIQPDEs--------gKLEHLMKKVRAKETRKRAL 278 chicken
Q9U2D2       200 DGYKPQDKDEKRKEPWYDLDTev------fsTECDAAARIRQKITAQRSH 243 Caenorhabditis elegans
Q23976       214 PFYKEFITLSRAIELDAFQVPda-------qMLREILSDRKLKQDFLRRC 256 fruit fly
KAE8611069   213 LFYRDIVNTAEDQDLGVQFKAs--------eKLDDLLKKVRAKEAKKRAl 254 tropical clawed frog
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