Conserved Protein Domain Family
Glyco_hydro_79n
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pfam03662: Glyco_hydro_79n 
Glycosyl hydrolase family 79, N-terminal domain
Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.
Links
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Statistics
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PSSM-Id: 427433
Aligned: 31 rows
Threshold Bit Score: -1
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEF50783      30 VVQVTVRGLTSRASTDENFICATLDWWPDTKCDYGQCPWGQAGILNLDLENKILANAIKAFDPLRIRIGGSLQDQLVYQV 109 castor bean
XP_006345162  24 EIVLTIDASTKVAWTDANYICATIDWWPKEKCNYKQCPWGSASIINLDLTHPYLENAIRAFKGLRLRLGGSLQDQVIYGV 103 potato
XP_006354766  23 DTEFLIDGTVKIAETDDNYVCATLDWWPKEKCNYNECPWGSASLINLDLSHPFLANSIQAFNHLRLRLGGSLQNRIIYDV 102 potato
KRH56864      24 HGSILVDGIQAIAETDDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEV 103 soybean
XP_010663310  24 DAIIKVDGATTVAETDANFICATLDWWPHDKCNYNHCPWGYSSVINMDLSHPLFAKAIEAFKHLRIRIGGSLQDQVLYDI 103 wine grape
Q8L608        26 RTTLVIDGSRRIAETDENFICATLDWWPPEKCNYDQCPWGYASLINLNLASPLLAKAIQAFRTLRIRIGGSLQDQVIYDV 105 thale cress
Q9FF10        29 RASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDV 108 thale cress
XP_006374165  24 RATISIDGTIAVAVIDDNFICATLDWWPHDKCNYNQCPWSYSSVTNLDLSHPLLAKAIQAFRNLRIRIGGSLQDQVLYDV 103 black cottonwood
XP_006837042  23 EVLVKVKSVNTIAHTDDNFVCATLDWWPSDKCNYGECPWIEAGILNLDLENPNLGKAIKAFNPLRVRVGGSLQDQVVYHV 102 Amborella trich...
1_pfamImport   1 -VNVSVQADYVVARTDGNFICATVDWWPPEKCDFGDCSWGNTSIKNLDLSNKILRNAITAFGTMRVRLGGTLQDQVKY-- 77 
XP_006345162  24 EIVLTIDASTKVAWTDANYICATIDWWPKEKCNYKQCPWGSASIINLDLTHPYLENAIRAFKGLRLRLGGSLQDQVIYGV 103 potato
XP_006354766  23 DTEFLIDGTVKIAETDDNYVCATLDWWPKEKCNYNECPWGSASLINLDLSHPFLANSIQAFNHLRLRLGGSLQNRIIYDV 102 potato
KRH56864      24 HGSILVDGIQAIAETDDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEV 103 soybean
XP_010663310  24 DAIIKVDGATTVAETDANFICATLDWWPHDKCNYNHCPWGYSSVINMDLSHPLFAKAIEAFKHLRIRIGGSLQDQVLYDI 103 wine grape
Q8L608        26 RTTLVIDGSRRIAETDENFICATLDWWPPEKCNYDQCPWGYASLINLNLASPLLAKAIQAFRTLRIRIGGSLQDQVIYDV 105 thale cress
Q9FF10        29 RASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDV 108 thale cress
XP_006374165  24 RATISIDGTIAVAVIDDNFICATLDWWPHDKCNYNQCPWSYSSVTNLDLSHPLLAKAIQAFRNLRIRIGGSLQDQVLYDV 103 black cottonwood
XP_006837042  23 EVLVKVKSVNTIAHTDDNFVCATLDWWPSDKCNYGECPWIEAGILNLDLENPNLGKAIKAFNPLRVRVGGSLQDQVVYHV 102 Amborella trich...
1_pfamImport   1 -VNVSVQADYVVARTDGNFICATVDWWPPEKCDFGDCSWGNTSIKNLDLSNKILRNAITAFGTMRVRLGGTLQDQVKY-- 77 

EEF50783     110 GNYIKKFPHFKRRdgDDYLFGFTRGSLPMDRWDQINALFNQTGVKLTFGLNALIGKQKskdDGSILWVGDWDPQNARDFM 189 castor bean
XP_006345162 104 GNLKSPCSSFTQQ--KDGLFGFSRGCLPMQRWDELNNLFKKTGALVTFGLNALYGRQP---TNRHAWVGNWDSSNALDFI 178 potato
XP_006354766 103 GNLESPCHPFTKQ--GDELFGFSNGCLHMDRWDELNSFFNKTGALVTFGLNALRGRQR---TSKRVWEGNWDSSNAHDFI 177 potato
KRH56864     104 GSLKSPCHPFQKM--KGGLFGFSKGCLQMKRWDELNHFFDETGALVTFGLNALHGRHQ---ISHTVWGGDWDPSNAKDFI 178 soybean
XP_010663310 104 GSLRSPCHPFRKM--NDGLFGFSKGCLRMSRWDELNRLFSQTGVILTFGLNALYGRYQ---IRKGAWAGVWDSSNTQNFI 178 wine grape
Q8L608       106 GDLKTPCTQFKKT--DDGLFGFSEGCLYMKRWDEVNHFFNATGAIVTFGLNALHGRNK---LNGTAWGGDWDHTNTQDFM 180 thale cress
Q9FF10       109 GNLKTPCRPFQKM--NSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHK---LRGKAWGGAWDHINTQDFL 183 thale cress
XP_006374165 104 ESLKAPCHPFRKM--KGGLFGFSKGCLHMNRWDELNHLFSRTGAIVTFGLNALYGRHQ---IRKGVWGGAWDSSNACDFM 178 black cottonwood
XP_006837042 103 G-KVKKCPHFKIK--GDGLFGFSKGCLPMDRWNALHHLLSDNGALVTFGLNALYGRQQh--PNKTEWTGPWDSSNARDFI 177 Amborella trich...
1_pfamImport  78 --TSKPCHEFKAAd-GDSNYEFIDGCISLNRWDKIHEFFNTTGAFITFGINALHGRVK---GHDGVYTGPWDPENARFFI 151
XP_006345162 104 GNLKSPCSSFTQQ--KDGLFGFSRGCLPMQRWDELNNLFKKTGALVTFGLNALYGRQP---TNRHAWVGNWDSSNALDFI 178 potato
XP_006354766 103 GNLESPCHPFTKQ--GDELFGFSNGCLHMDRWDELNSFFNKTGALVTFGLNALRGRQR---TSKRVWEGNWDSSNAHDFI 177 potato
KRH56864     104 GSLKSPCHPFQKM--KGGLFGFSKGCLQMKRWDELNHFFDETGALVTFGLNALHGRHQ---ISHTVWGGDWDPSNAKDFI 178 soybean
XP_010663310 104 GSLRSPCHPFRKM--NDGLFGFSKGCLRMSRWDELNRLFSQTGVILTFGLNALYGRYQ---IRKGAWAGVWDSSNTQNFI 178 wine grape
Q8L608       106 GDLKTPCTQFKKT--DDGLFGFSEGCLYMKRWDEVNHFFNATGAIVTFGLNALHGRNK---LNGTAWGGDWDHTNTQDFM 180 thale cress
Q9FF10       109 GNLKTPCRPFQKM--NSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHK---LRGKAWGGAWDHINTQDFL 183 thale cress
XP_006374165 104 ESLKAPCHPFRKM--KGGLFGFSKGCLHMNRWDELNHLFSRTGAIVTFGLNALYGRHQ---IRKGVWGGAWDSSNACDFM 178 black cottonwood
XP_006837042 103 G-KVKKCPHFKIK--GDGLFGFSKGCLPMDRWNALHHLLSDNGALVTFGLNALYGRQQh--PNKTEWTGPWDSSNARDFI 177 Amborella trich...
1_pfamImport  78 --TSKPCHEFKAAd-GDSNYEFIDGCISLNRWDKIHEFFNTTGAFITFGINALHGRVK---GHDGVYTGPWDPENARFFI 151

EEF50783     190 KYTISKGYHIDSYELG-NELCGSGVSAR--LDAVEYGNDVIALRKLVNELYPDP-NSRPAVLGPAGFYDQQWFNTFLMTV 265 castor bean
XP_006345162 179 KYTVAKGYQINSWEFG-NELSGSGIGAS--VDAAQYGKDVIQLHNLLNQVYQNT-PVRPLLLAPGGFYDPGWFGKLLQVS 254 potato
XP_006354766 178 YYTVSKGYQIHSWEFG-NELSGKGIGAK--VDAEQYGEDVIHLNNLIDQLYKHF-QPRPLLLAPGGFYDKEWFETFLEVS 253 potato
KRH56864     179 NYTISKGYKIDSWEFG-NELSGKGIGAR--VGAAQYGKDLIKLKEILRTLYKNS-TFKPSLVAPGGFYNKEWFDKLLQVT 254 soybean
XP_010663310 179 KYTISKGYQIDSWEFG-NELSGSGVGAS--VNAEQYGKDLINLKAIINKLYNNS-NVKPLLVAPGGFYEQDWYAKLLQVS 254 wine grape
Q8L608       181 NYTVSKGYAIDSWEFG-NELSGSGIWAS--VSVELYGKDLIVLKNVIKNVYKNS-RTKPLVVAPGGFFEEQWYSELLRLS 256 thale cress
Q9FF10       184 NYTVSKGYVIDSWEFG-NELSGSGVGAS--VSAELYGKDLIVLKDVINKVYKNSwLHKPILVAPGGFYEQQWYTKLLEIS 260 thale cress
XP_006374165 179 NYTVLKGYKIDSWEYG-NELSGSGVSAS--VSAELYGKDLIKLKDVVNNLYKNS-DLKPSLVAPGGFFDKQWYAKLLQVT 254 black cottonwood
XP_006837042 178 NYTISNAQKIDSWEFG-NELSGSGIAAS--VNPTQYGQDLIDLKKVVTELYNSSsMPQPKILAPGGFFDRDWFIKLLESS 254 Amborella trich...
1_pfamImport 152 RHIVQNKQYVDSWEFGsNELCGNGGKSNflVDGNQYGLDLIAFKAMLIDEYAKF-GGPPKVAAPGGFYVEDWYKNMLSTS 230
XP_006345162 179 KYTVAKGYQINSWEFG-NELSGSGIGAS--VDAAQYGKDVIQLHNLLNQVYQNT-PVRPLLLAPGGFYDPGWFGKLLQVS 254 potato
XP_006354766 178 YYTVSKGYQIHSWEFG-NELSGKGIGAK--VDAEQYGEDVIHLNNLIDQLYKHF-QPRPLLLAPGGFYDKEWFETFLEVS 253 potato
KRH56864     179 NYTISKGYKIDSWEFG-NELSGKGIGAR--VGAAQYGKDLIKLKEILRTLYKNS-TFKPSLVAPGGFYNKEWFDKLLQVT 254 soybean
XP_010663310 179 KYTISKGYQIDSWEFG-NELSGSGVGAS--VNAEQYGKDLINLKAIINKLYNNS-NVKPLLVAPGGFYEQDWYAKLLQVS 254 wine grape
Q8L608       181 NYTVSKGYAIDSWEFG-NELSGSGIWAS--VSVELYGKDLIVLKNVIKNVYKNS-RTKPLVVAPGGFFEEQWYSELLRLS 256 thale cress
Q9FF10       184 NYTVSKGYVIDSWEFG-NELSGSGVGAS--VSAELYGKDLIVLKDVINKVYKNSwLHKPILVAPGGFYEQQWYTKLLEIS 260 thale cress
XP_006374165 179 NYTVLKGYKIDSWEYG-NELSGSGVSAS--VSAELYGKDLIKLKDVVNNLYKNS-DLKPSLVAPGGFFDKQWYAKLLQVT 254 black cottonwood
XP_006837042 178 NYTISNAQKIDSWEFG-NELSGSGIAAS--VNPTQYGQDLIDLKKVVTELYNSSsMPQPKILAPGGFFDRDWFIKLLESS 254 Amborella trich...
1_pfamImport 152 RHIVQNKQYVDSWEFGsNELCGNGGKSNflVDGNQYGLDLIAFKAMLIDEYAKF-GGPPKVAAPGGFYVEDWYKNMLSTS 230

EEF50783     266 GPNVVDGVTHHIYNLGAGVDKALINKIQDPYFLDQIAQTFKDVSDSVRQFGPWSGPWVGESGGAYNSGGKDVSHTFANGF 345 castor bean
XP_006345162 255 GRGTVNVLTHHIYNLGPGSDSKLVDKILNPEYLSRTEGTFSSLTQTILRNGPWASAWVGESGGAFNSGGPDVSNAFVDSF 334 potato
XP_006354766 254 GPGTVDALTHHIYNLGPGSDLNLVNKILNPLHLNKIADTFSNLIQTIEINGPWTSAWVGESGGAFNNGGPNVSNTFVNSF 333 potato
KRH56864     255 GPGIVNVLTHHVYNLGPGSDEHLDRKILDPECLSKVESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSVSNTFVNSF 334 soybean
XP_010663310 255 GSSTVNVVTHHIYNLGAGVDPNLVSKILNPHYLSRVEETFKSLDKTLQTWGPWASAWVGESGGAYNSGGHLVSNTFVNSF 334 wine grape
Q8L608       257 GPGVLDVLTHHIYNLGPGNDPKLVNKILDPNYLSGISELFANVNQTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSF 336 thale cress
Q9FF10       261 GPSVVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSF 340 thale cress
XP_006374165 255 GSGIVNFVTHHIYNLGAGMDPNLVNKILDPHYLSKVSETFSNLSQTIQQNGPWASAWVGESGGAYNSGGRHVSDTFVNSF 334 black cottonwood
XP_006837042 255 GSGVVDVLTHHIYNLGAGNDPIVPNRMVDPFYLSEIAETYKSIQLTIQDFGPWSAAWVGEAGGAYNSGGPNVSNAFIDSF 334 Amborella trich...
1_pfamImport 231 GYGVVDIVTHHVYNLGSGGDGNLVDKVTDPKVLDNIVPTYNEVVGTIKSAGPWSSAWVGESGGAHSSGGKGLSNTFANSF 310
XP_006345162 255 GRGTVNVLTHHIYNLGPGSDSKLVDKILNPEYLSRTEGTFSSLTQTILRNGPWASAWVGESGGAFNSGGPDVSNAFVDSF 334 potato
XP_006354766 254 GPGTVDALTHHIYNLGPGSDLNLVNKILNPLHLNKIADTFSNLIQTIEINGPWTSAWVGESGGAFNNGGPNVSNTFVNSF 333 potato
KRH56864     255 GPGIVNVLTHHVYNLGPGSDEHLDRKILDPECLSKVESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSVSNTFVNSF 334 soybean
XP_010663310 255 GSSTVNVVTHHIYNLGAGVDPNLVSKILNPHYLSRVEETFKSLDKTLQTWGPWASAWVGESGGAYNSGGHLVSNTFVNSF 334 wine grape
Q8L608       257 GPGVLDVLTHHIYNLGPGNDPKLVNKILDPNYLSGISELFANVNQTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSF 336 thale cress
Q9FF10       261 GPSVVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSF 340 thale cress
XP_006374165 255 GSGIVNFVTHHIYNLGAGMDPNLVNKILDPHYLSKVSETFSNLSQTIQQNGPWASAWVGESGGAYNSGGRHVSDTFVNSF 334 black cottonwood
XP_006837042 255 GSGVVDVLTHHIYNLGAGNDPIVPNRMVDPFYLSEIAETYKSIQLTIQDFGPWSAAWVGEAGGAYNSGGPNVSNAFIDSF 334 Amborella trich...
1_pfamImport 231 GYGVVDIVTHHVYNLGSGGDGNLVDKVTDPKVLDNIVPTYNEVVGTIKSAGPWSSAWVGESGGAHSSGGKGLSNTFANSF 310

EEF50783     346 WYLDQLG 352 castor bean
XP_006345162 335 WYLDQLG 341 potato
XP_006354766 334 WYLDQLG 340 potato
KRH56864     335 WYLDQLG 341 soybean
XP_010663310 335 WYLDQLG 341 wine grape
Q8L608       337 WYLDQLG 343 thale cress
Q9FF10       341 WYLDQLG 347 thale cress
XP_006374165 335 WYLDQLG 341 black cottonwood
XP_006837042 335 WYLDQLG 341 Amborella trichopoda
1_pfamImport 311 WYLDQLG 317
XP_006345162 335 WYLDQLG 341 potato
XP_006354766 334 WYLDQLG 340 potato
KRH56864     335 WYLDQLG 341 soybean
XP_010663310 335 WYLDQLG 341 wine grape
Q8L608       337 WYLDQLG 343 thale cress
Q9FF10       341 WYLDQLG 347 thale cress
XP_006374165 335 WYLDQLG 341 black cottonwood
XP_006837042 335 WYLDQLG 341 Amborella trichopoda
1_pfamImport 311 WYLDQLG 317
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