3OII,3BBE,3O7B


Conserved Protein Domain Family
EMG1

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pfam03587: EMG1 
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EMG1/NEP1 methyltransferase
Members of this family are essential for 40S ribosomal biogenesis. The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases.
Statistics
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Aligned: 138 rows
Threshold Bit Score: 124.933
Threshold Setting Gi: 121902836
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3OII_A            44 VVLAMASLETHKISsng-----------pggDKYVLLNCDDH----------------------QGL--LKK---MGRDI 85  baker's yeast
Q57977             5 IILAKSALELIPEEiknki-------rksrvYKYDILDSNYH----------------------YKAm--EK---LKDKE 50  Methanocald...
Q9HJ48             4 LVIADAELETIPEEmqadpairrfakkrnkrVDRMILDSNYM----------------------HTSidRYF---PNESK 58  Thermoplasm...
EQB72294           5 VVI-DAELETVPDImkddysiriqakkrgklASKMLLDSNFM----------------------HSAieRYF---PGESN 58  Thermoplasm...
Q6L170             4 IVIGDAELETIPDEmrndpvlrrmanknkkdINYMLLDSNYM----------------------HSIieRYY---PGKSN 58  Picrophilus...
CBRAS:FFONT_1267  25 V---ESSLEPLPKElvnskkavilsrrfniePKYLILDKSLF----------------------YEEm--KV---LKEKE 74  Fervidicocc...
EAY07816          19 ltfiidgvKLYPHs----------------kYPRPLLVTDEE---------------------------------EFESQ 49  Trichomonas...
Q8I5G2           208 IVLLFSPLALTSIkn---------------kQKTCIINADDHmnmfmnklenlenaikfekkekEKRklEQIiqsVKNKL 272 Plasmodium ...
Q4XF39           184 fFLVFSPLAITSIk-----------------NKSSVINADEHmdflekklesldeliditrnyrERQnlQQTrdnIKNKL 246 Plasmodium ...
3BBE_A             5 IILAKSALELIPEEiknki-------rksrvYKYDILDSNYH----------------------YKA--MEK---LKDKE 50  Methanocald...
3OII_A            86 SEARPDIT----HQCLLTLLDSPINKAGKLQVYIQTSRGILIEVNPTVRIPRTFKRFSGLMVQLLHKLSIRSVNsEE-KL 160 baker's yeast
Q57977            51 MRGRPDII----HISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLKGER-------N-HL 118 Methanocald...
Q9HJ48            59 RRGRPDII----YLLLEMTQESILNHKNQLRTYVHTRNNQVIRISPITRMPKSYNRFIGLFEDLFEKRIITNNG-KE--L 131 Thermoplasm...
EQB72294          59 RRGRPDII----FHLLMTSLESILNKKSGLRVIIHTRNNQIIEINPSIRLPKSYNRFVGLMEDLFDKRAIGPQS-ET--L 131 Thermoplasm...
Q6L170            59 RFGRPDII----YIFLEVALESILNKSGNLRIFIHTKRNKVIEINPEVRLPKSYNRFQGLIEDLFRKNRIVYNG-NT--L 131 Picrophilus...
CBRAS:FFONT_1267  75 KRGRPDII----HQFLLATQYSYLNLKGKLKVFIHTINNDIIEVNPITRIPKNYFQFVSLIQNLYKYKKVPRSG-EA--L 147 Fervidicocc...
EAY07816          50 KITKKDIIteqlYHVLYFLQNTALNLSGQQRVLLRTEDKQVIFVDPRLKVPDVFDDYLAMLHLLMEDRRVCSVE-KGsEI 128 Trichomonas...
Q8I5G2           273 ENIRLDIL----FFTLLSLRDSILNKKGKLQIYIYTVNGSFIFVSPLFRVPRNFTLFKKVMLNLLKRGVVYDDQ-KN-VL 346 Plasmodium ...
Q4XF39           247 DNIRLDIL----FFTLLSLRDSIINKKKQIQIYIHTINGLLIYVSPIFRVPRNFFIFKKVMLSLMKNNIVTDEN-KN-TL 320 Plasmodium ...
3BBE_A            51 MRGRPDII----HISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLK------GE-RN-HL 118 Methanocald...
3OII_A           161 LKVIK-NPITDHLPT--KCRKVT-LSFDA-PVIRVqdyiekldddesicVFVGAMARGKdnF---AD----Eyv------ 222 baker's yeast
Q57977           119 IKMEE-KTLEDLLNEinAKKIAI-MTKTGklthpkl-------lkeydtFIIGGFPYGK--L---KI----Nkekvf--- 177 Methanocald...
Q9HJ48           132 LSMEE-SSLGDLINSirRDRTIL-LHPKGemrkpsef-----isnanilIVIGGFSEGD--F---IS----Dtsf----- 190 Thermoplasm...
EQB72294         132 MKVTD-GNWKDALNMt-EGNQIL-LSPRGipgkiadv----fhgagdqsVIIGGFSQGD--F---IS----Dvys----- 190 Thermoplasm...
Q6L170           132 LDMYD-MDLLSLLSR--FNNVIV-LSPHGeknrlnn------iisddvcFLIGGFSEGD--Y---IT----Dvyk----- 187 Picrophilus...
CBRAS:FFONT_1267 148 LILRKnVKLSEYLKEknIEKPIL-LHEKAekveynele---kfyfppcsFLIGGFPHGD--F---SK----Dtkmv---- 210 Fervidicocc...
EAY07816         129 MKFVK-SDLTHSIPT--GAKRIA-AYLSKtdsvtspde---flkaeptaVYIHL-----------------Dptvqsyde 184 Trichomonas...
Q8I5G2           347 LKIIF-NDITSYVED---AVCIA-ISNKGfptdvkkltdkikqtknnyfFFISLSNSHD--V---TKfmdiIkkektktf 416 Plasmodium ...
Q4XF39           321 LKILP-NPVKYYVGS---STCVW-ISNDGfptdakkfadklkvsngkysFFLSLSNSYN--L---TYfmekTknrneeni 390 Plasmodium ...
3BBE_A           119 IKMEE-KTLEDLLNEi-NAKKIAiMTKTGkLTHPKllke-------ydtFIIGGFPYGK--LkinKE----Kvfg----- 178 Methanocald...
3OII_A           223 --deKVGLS-NYPLSASVACSKFCHGAE 247 baker's yeast
Q57977           178 gdikEISIY-NKGLMAWTVCGIICYSLs 204 Methanocaldococcus jannaschii DSM 2661
Q9HJ48           191 -ineRYAIF-DQELTIWSVANEMVANYE 216 Thermoplasma acidophilum DSM 1728
EQB72294         191 -lgsGISIY-PGELSIWSVAMECICQYE 216 Thermoplasmatales archaeon A-plasma
Q6L170           188 -kykSYSIF-NEELTIWSVGMEVITEYE 213 Picrophilus torridus
CBRAS:FFONT_1267 211 -awrSISLKkDFIMDAWMVADRIICHLE 237 Fervidicoccus fontis Kam940
EAY07816         185 vllgKYCVS-NDILSAVTLASRILHSME 211 Trichomonas vaginalis G3
Q8I5G2           417 sydyLVRLS-DLQLSAVALTSKL-THFL 442 Plasmodium falciparum 3D7
Q4XF39           391 hfnyHIKLS-DFKLSPVTICSKL-SHFL 416 Plasmodium chabaudi
3BBE_A           179 -dikEISIY-NKGLMAWTVCGIICYSLs 204 Methanocaldococcus jannaschii
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