3BBE,3O7B


Conserved Protein Domain Family
EMG1

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pfam03587: EMG1 
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EMG1/NEP1 methyltransferase
Members of this family are essential for 40S ribosomal biogenesis. The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases.
Statistics
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PSSM-Id: 335385
View PSSM: pfam03587
Aligned: 138 rows
Threshold Bit Score: 135.704
Threshold Setting Gi: 123473705
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3BBE_A         5 IILAKSALELIPEEiknki-------rksrvYKYDILDSNYH----------------------YKA--MEK---LKDKE 50
gi 20532171    3 LVLAESALELVPKEiwnhpavladarrrgkrPGEILLDRARH----------------------HPAm--RL---LADAK 55
gi 74862787  208 IVLLFSPLALTSIkn---------------kQKTCIINADDHmnmfmnklenlenaikfekkekEKRklEQIiqsVKNKL 272
gi 74972163  184 fFLVFSPLAITSIk-----------------NKSSVINADEHmdflekklesldeliditrnyrERQnlQQTrdnIKNKL 246
gi 500076215   6 LVLADAGLELVPRElwshpavkshakrrgknPGRMLLDISVH----------------------YAA--MKT---LNEYW 58
gi 350275708  27 LILAESSLELIPPEiqshplilrdarrrgkePRSILLDKARH----------------------YKA--MRG---LPKSE 79
gi 383796172  22 igLVESSLEPLPKElvnskkavilsrrfniePKYLILDKSLF----------------------YEE--MKV---LKEKE 74
gi 850995427   4 LILVDAALEPIPPElrndkgivktarrlgrdPIYMPLDKALH----------------------FKA--MSK---LKGKE 56
gi 156103301 256 IFLLFCPLAVTSIr-----------------NRRCVINADEHmsflqnklksvesllacarnakESAflRSKaeaVENKL 318
gi 503102135   6 lLLTEASLETIPKEllsdpviirdakrrgvnPRYLILDRARH----------------------HRAm--TR---LPNAE 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3BBE_A        51 MRGRPDIIHISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLK------GERNHLIKMEEK 124
gi 20532171   56 RRGRPDIVHQVLLAFQYSLLAKRGLGKAYIHTRDDYVIAVSPEARVPKNYNNFVALIEQLFAlgkvppKGE-PLMELYRK 134
gi 74862787  273 ENIRLDILFFTLLSLRDSILNKKGKLQIYIYTVNGSFIFVSPLFRVPRNFTLFKKVMLNLLKrgvvydDQKNVLLKIIFN 352
gi 74972163  247 DNIRLDILFFTLLSLRDSIINKKKQIQIYIHTINGLLIYVSPIFRVPRNFFIFKKVMLSLMKnnivtdENKNTLLKILPN 326
gi 500076215  59 KRGRPDIVHVSLLVAQDSVLNRLGYLHTVIHTYDGKLVELDPSMVVPRNYNRFVGLFEQLLEkgqvppGSEKPLAKLRTG 138
gi 350275708  80 KRGRPDIVHMSMLAFQYSVLNMKGMGRMFVHTINDVVIRLRSDARIPKNYWNFVGLMEQLLNagavppW-GEPLLIAERK 158
gi 383796172  75 KRGRPDIIHQFLLATQYSYLNLKGKLKVFIHTINNDIIEVNPITRIPKNYFQFVSLIQNLYKykk-vpRSGEALLILRKN 153
gi 850995427  57 SRGRPDIVHKFLLDSLNSLLAKRGMLTVYIHTVTGRVIEVAPGERPPQNYFNFLGLMEQLFKhgsvppSGKW-LLRFMDV 135
gi 156103301 319 KNVRLDVLFFTLLCLRDSVINKRGRLQIYLHTVNGLLIYVSPSFRVPRSFSLFKKVMLNLMLrnvvldPGGRPLLKVLPH 398
gi 503102135  59 KRGRPDILHQALLLIQGSLLARNNLVKTYVHTVNDLVIDVDPEIRPPRNYDNFIGLMSQLFEvgrvppVGK-PLMRFVN- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3BBE_A       125 -TLEDLLNEi-N--AK--KIAiMTKT-GKlTHPKllke-------ydtFI-IGGFPYGKLkinKE----Kvfg------d 179
gi 20532171  135 -DLATLLQEl-G--GV--WAV-FHES-GArkplsqmg----sellksvVV-VGGFPHGDF---QN----Kwvve----ka 190
gi 74862787  353 -DITSYVED-----AV--CIA-ISNK-GFptdvkkltdkikqtknnyfFF-ISLSNSHDV---TKfmdiIkkektktfsy 418
gi 74972163  327 -PVKYYVGS-----ST--CVW-ISND-GFptdakkfadklkvsngkysFF-LSLSNSYNL---TYfmekTknrneenihf 392
gi 500076215 139 rNLGEVLKE--M--GVdaVYR-LSEK-GEpVKPLdlarria-gsdvpaVI-IGAFQRGEF---SK----Evlsi-----e 198
gi 350275708 159 -SLRELLREl-G--GR--WIV-LHEE-GNrVDPLelgra----lansvVV-VGGFPHGDF---ED----Krilr----da 214
gi 383796172 154 vKLSEYLKE--KniEK--PIL-LHEK-AEkVEYnelekf---yfppcsFL-IGGFPHGDF---SK----Dtkmv-----a 211
gi 850995427 136 -SISELVESmnE--SL--IIL-LERD-GEpIKVTelarli--iknggaVVmIGGMPKG-----SS----Evara----la 193
gi 156103301 399 -PVQRYVGS-----SV--CIG-ISHM-GFpadvkklskqiketkndysFF-LSLSSAYDL---THfiesIsrthsecfpf 464
gi 503102135 137 -GINYVLNTesP--DR--KIL-LDDVkGKevslksfid-yvknfkrplIM-IGAFPRGSF---EE----Rtygl-----a 196
                        250       260
                 ....*....|....*....|....*.
3BBE_A       180 ikEISI-YN-KGLMAWTVCGIICYSL 203
gi 20532171  191 avVYSL-GE-ESLDAAQVICKAVTAA 214
gi 74862787  419 dyLVRL-SD-LQLSAVALTSKL-THF 441
gi 74972163  393 nyHIKL-SD-FKLSPVTICSKL-SHF 415
gi 500076215 199 aeEYSI-FR-EALPAWTVVAEVVVSL 222
gi 350275708 215 ssVFRI-SD-MPLDAWQVVFRAVTLA 238
gi 383796172 212 wrSISLkKD-FIMDAWMVADRIICHL 236
gi 850995427 194 rrVFSL-ANgESLTTSHVVNSLIISI 218
gi 156103301 465 dyVVRV-SD-LPLSTVAVCSKL-THF 487
gi 503102135 197 ddVLKI-GK-YIMDTSSILCRLLTAL 220
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