3TDU,4GBA,2IS9


Conserved Protein Domain Family
Cullin_binding

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pfam03556: Cullin_binding 
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Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Statistics
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PSSM-Id: 335375
View PSSM: pfam03556
Aligned: 207 rows
Threshold Bit Score: 82.2157
Threshold Setting Gi: 146099852
Created: 19-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3TDU_A        77 KLKAQIPKMEQEL-K-EP-Gr-FKDFYQFTFNFAKn---PGQ--KG--LDLEMAIAYWNLVLNGR---------FKf--- 133
gi 122015924 116 AMRSHVDEIDEVL-H-KDpDq-FRKFYRFIFGWVRspetTARslGElgMNIATAVELWQMLFPEYk--------TFl--- 181
gi 122123813 115 ALRNHVETLDGAL-R-GDvTk-FRHFYRFIYKWVQspltMERnmGQvgMSIETAVELWRMLFPHYr--------EFk--- 180
gi 75030506  118 aahdAIVDLNNTI-R-SNeEk-RSKFYQFLYNWCLkgndASD-------RVDSAKELWSCFFSASpvsltveeaRRkfta 187
gi 255718575 126 QIKEKVKELDEKL-RrDS-Ay-FEHIYSFTYTLALe---PNE--KQ--LDLETAIAYWHLLFPTD---------GAyaiq 186
gi 366991833  55 QMKQVLVDLNDKL-HsDK-Qy-FIDIYNYTFGLITd---PD---KD--LEVETAVAYWKLFLQPK---------EGefpv 114
gi 444314105 138 DIKNLLNEFDNKLkT-NG-Ey-YTFIYDSCFNLLLe---EGK--KT--IDSETAQEYWDLFFACQ---------NYpikv 198
gi 154336869 125 QLRQKLGEWVKDV-R-ES-SgaFLLMYTYMYDYIRg---EED--RR--MTRTTAINGWDVFFGQNk-------------- 180
gi 403216805 134 EMKTVLADLNGKL-E-KDrGy-FKEIYMYTFPLLVe---PDQ--NK--LDAASTIEYWKLFFDQEkk-----ypMIidq- 197
gi 254584160 125 QMGKLVQRLDHKL-R-TDqDy-TAQIYNYTFELALd---PGA--KT--LETHTAVQYWTLFFATGqy-----pvIVeq-- 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3TDU_A       134 ------LDLWNKF-LLEHHkr--------------sIPKDTWNLLLDFSTMIa---dD---MS----NYDE---EGAWPV 179
gi 122015924 182 -----kMNDWITF-CTTKEifh-----------reaISRDLWEQLLEFTSLT-----R---YD----TYDV---NDAWPS 229
gi 122123813 181 -----rLDDWITFcMSKKLfph------------giISRDLWEQLLEFTFVT-----D---YS----KYDV---SDAWPS 228
gi 75030506  188 yvcfprINQWLDF-ITMLGekatesksgrvaveqsgVSFDTWTQLLLFArf-----dN---YD----AYDD---EDSWPV 251
gi 255718575 187 i-pqkrLCSWTAF-LT--Rnv-------------srIHHDIWKMFLKFARMFp---dNktlKQ----GYNE---DDAWPV 239
gi 366991833 115 rvdptlLNLWFQF-LDEENkk--------------fITQDYWHMLVVFFQKFp---nLnviKE----GYDE---TAAWPY 169
gi 444314105 199 --qsdqYQQWFKY-LSNANik--------------eITKDQWAMLLRFFKKFp----S---LSelqrKYSE---DSAWPY 251
gi 154336869 181 -----rYAKWKTW--AVANlt-------------gdVSRDLWRQLGIFLTMDt---dA---TQ----SSDDqvlALSWPS 230
gi 403216805 198 ----elLDPWFVY-LGEQSen-------------msVTEDIWKMVYQFFNRFrslgdV---KQ----GYDE---MAAWPI 249
gi 254584160 188 ----qfFQLWISF-VQQEQs----------------ISRDTWRMLFPFFNRFsnlqsV---RD----NYNE---ADAWPY 236

                 ....*...
3TDU_A       180 LIDDFVEF 187
gi 122015924 230 AIDDFVEY 237
gi 122123813 229 AMDDFVEY 236
gi 75030506  252 TMDDFVVY 259
gi 255718575 240 LIDeyyey 247
gi 366991833 170 IIDEYYEY 177
gi 444314105 252 IFDEYYEY 259
gi 154336869 231 AIADFIEt 238
gi 403216805 250 LIDEFIEY 257
gi 254584160 237 IIDEFYEY 244
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