3W2X,5CFE,4QH9,1AKO,2VOA,3K55,1DNK,1ZWX,2DDR,4F1R,4B8C,2F1N


Conserved Protein Domain Family
Exo_endo_phos

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pfam03372: Exo_endo_phos 
Click on image for an interactive view with Cn3D
Endonuclease/Exonuclease/phosphatase family
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.
Statistics
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Aligned: 331 rows
Threshold Bit Score: 31.4352
Threshold Setting Gi: 197703021
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3W2X_A     10 ISWNVNGlr------------------------aVHRKGFLKWFMEE-KP-------------------------D---- 35   Methanothermobact...
OCT76096  257 ATWNLQNcsldkan-------------npgvrevVCMTLLENSIK----------------------------------- 288  African clawed frog
BAH79979  360 IFWNSRGll-----------------------dlAKYRYVAENIKEH-NL-------------------------D---- 386  long-grained rice
CAN77450  310 ISWNCRGlg-----------------------npRTVLALCEINKSR-KP-------------------------D---- 336  wine grape
Q9ZVF0    390 GEVSILSnsysalng-----------kdesgediITADSVEKQAEET----------------------------Qnstq 430  thale cress
Q9SIS9    366 GFWNCQGlg-----------------------qpLTVRRLEEVQRVY-FL-------------------------D---- 392  thale cress
Q9SN65    347 MLYNQAEaeeesavlghi-----rkrdkkgigvpLTQSQLSNLCKVF-KF-------------------------D---- 391  thale cress
Q9SIQ5    113 LHAKLAGvktdapvekdlllessdnaqnefvfmkRKRVRLEEMYQQVeAAdemgvlsqlckkgrktesagscsihD---- 188  thale cress
O22148      4 LSWNCQGvg-----------------------ntPTVRHLREIRGLY-FP-------------------------E---- 30   thale cress
Q9ZQF8      4 ISWNCQGvg-----------------------pkTTSRRLEEMCRMY-SP-------------------------G---- 30   thale cress
3W2X_A     36 ---------------ILCLQEIKAAPEQLPRK-Lrh---------------------vEGYRSFFtp------------- 65   Methanothermobact...
OCT76096  289 ---------------LLAVQELSDKDALEKLCtElnqpslpnirkwkgmrgswkciisEKSLCGPsekeeyfgflwdvsa 353  African clawed frog
BAH79979  387 ---------------FVALLETRKNDVSKTNLdHl----------------------aGGADFVWhc------------- 416  long-grained rice
CAN77450  337 ---------------FIFLIETLVHSAQVEKLkSk-----------------------LGFEGAFcv------------- 365  wine grape
Q9ZVF0    431 dppqekkwvdeqnfqFGCLIETRVKEENSQWLgSklfk-----------------dwsMLTNYE---------------- 477  thale cress
Q9SIS9    393 ---------------MLFLIETKQQDNYTRDLgVk-----------------------MGFEDMCii------------- 421  thale cress
Q9SN65    392 ---------------VLFLIETLNKCEVISNLaSv-----------------------LGFPNVItq------------- 420  thale cress
Q9SIQ5    189 ------------------GLETLNQCDKVCKLaYd-----------------------LGFPNVItq------------- 214  thale cress
O22148     31 ---------------VIFLCETKKRRNYLENVvGh-----------------------LGFFDLHtv------------- 59   thale cress
Q9ZQF8     31 ---------------FLFLSETKNDLVYLQNVqVs-----------------------LGFDCLKtv------------- 59   thale cress
3W2X_A     66 -----------aERKGYSGVAMYTKVPPSSLREGFGVERFDTEGRIQIADFDDFLLYniyfpngkmseERLKYKLEFYDA 134  Methanothermobact...
OCT76096  354 gielknvnlsenMQTNGNGKHMYLQPYIAHFKVGTCDLTLVNIHLSPPTVETVK----------------HQNDTYKSAV 417  African clawed frog
BAH79979  417 ----------lpPRGRSGGILLGINAAVMDLSLIVEGEFYVKFHLRNKEDRFEWILMa---------vYGPAQDEFKSSF 477  long-grained rice
CAN77450  366 -----------dRVGRGGGLAFLWRKAGMFSLLXYSQSHIDMEVSEEDGLQWRVTGF-----------YGFPDRSQRHLS 423  wine grape
Q9ZVF0    478 -------------FNRRGRLWVVWRENVRFTPFYKSDQLITCSVKLESQEEEFFYSFvy-------asNFAEERKILWND 537  thale cress
Q9SIS9    422 -----------sPRGLSGGLVVYWKKHLSIQVISHDVRLVDLYVEYKNFNFYLSCI------------YGHPIPSERHHL 478  thale cress
Q9SN65    421 -----------pPQGHSGGLALLWKDSVRLSNLYQDDRHIDVHISINNINFYLSRV------------YGHPCQSERHSL 477  thale cress
Q9SIQ5    215 -----------pPNGRSGGLALMWKNNVSLSLISQDERLIDSHVTFNNKSFYLSCV------------YGHPTQSERHQL 271  thale cress
O22148     60 -----------ePIGKSGGLALMWKDSVQIKVLQSDKRLIDALLIWQDKEFYLTCI------------YGEPVQAERGEL 116  thale cress
Q9ZQF8     60 -----------ePIGNSGGLALFYSRDYPVKFIYVCDRLIDIETIIDGNRVFITFV------------YGDPVVQYRELV 116  thale cress
3W2X_A    135 FLEDVNRERDSGRNVIICGDFNTAHREIDLARPKENsnvsgflpverawidkfiengyvdtfrmfnsdpgqytwWSYRTR 214  Methanothermobact...
OCT76096  418 FGQALQETLKNERDVIILGCFSLPADSSEFDVLRKEkfhcl-----------------------------lplnTFTNIS 468  African clawed frog
BAH79979  478 LAELVRACQQNPHPKLIGGDFNILRSSTEKNDNRYNdrwpflfnavid--------------sfdlreialagrQFTWAN 543  long-grained rice
CAN77450  424 WNLLRSLYSASSLPWCCLGDFNDIVCNEEKRGSVPHppwlirgfcaalsd-----------cqlqdlxlkgypfTWERGR 492  wine grape
Q9ZVF0    538 LRDHMDSPIIRDKPWIIFGDFNEILDMDEHSRMEDHpavtsgmrdfqslv----------nycsfsdlashgplFTWCNK 607  thale cress
Q9SIS9    479 WEKLQRVSAHRSGPWMMCGDFNEILNLNEKKGGRRRsigslqnftnmin------------ccnmkdlkskgnpYSWVGK 546  thale cress
Q9SN65    478 WTHFENLSKTRNDPWILIGDFNEILSNNEKIGGPQRdewtfrgfrnmvs------------tcdlkdirsigdrFSWVGE 545  thale cress
Q9SIQ5    272 WQTLEHISDNRNAEWLLVGDFNEILSNAEKIGGPMReewtfrnfrnmvs------------hcdiedmrskgdrFSWVGE 339  thale cress
O22148    117 WERLTRLGLSRSGPWMLTGDFNELVDPSEKIGGPARkessclefrqmln------------scglwevnhsgyqFSWYGN 184  thale cress
Q9ZQF8    117 WKRLTRIGIVRSEPWFMIGDFNEIIGNHEKRGGKKRsessflpfccmiencgm----idfpstgslfswvgkrsCGVAGR 192  thale cress
3W2X_A    215 ARERNVGWRLDYF----------------------------------FVNEEFK-GKVKRSWILsdvmgSDH 251  Methanothermobacter therm...
OCT76096  469 TKNPQGNKSLDNIwiskslkkiftgyslvvregltnpwipdnwswggVA--------------------SEH 520  African clawed frog
BAH79979  544 SLANPTYEKLNRV----------------------------------LMTTEWEsKFPMVSVHAlergvLDH 581  long-grained rice
CAN77450  493 GSSHWVEEXLDRA----------------------------------LVNVSWLnLFXBAKLNNlvapvSDH 530  wine grape
Q9ZVF0    608 RDNDPIWKKLDRV----------------------------------MVNEAWKmVYPQSYNVFeaggcSDH 645  thale cress
Q9SIS9    547 RQNETIESCLDRV----------------------------------FINSDWQaSFPAFETEFlpiagSDH 584  thale cress
Q9SN65    546 RHSHTVKCCLDRA----------------------------------FINSEGAfLFPFAELEFleftgSDH 583  thale cress
Q9SIQ5    340 RHTHTVKCCLDRV----------------------------------FINSAWTaTFPYAETEFldftgSDH 377  thale cress
O22148    185 RNDELVQCRLDRT----------------------------------VANQAWMeLFPQAKATYlqkicSDH 222  thale cress
Q9ZQF8    193 KRRDLIKCRLDRA----------------------------------MGNEEWHsIYSHTNVEYlqhrgSDH 230  thale cress
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