2KOU


Conserved Protein Domain Family
Dicer_dimer

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pfam03368: Dicer_dimer 
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Dicer dimerization domain
This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer. It is a divergent double stranded RNA-binding domain. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity. This domain has weak dsRNA-binding activity. It mediates heterodimerization of Dicer proteins with their respective protein partners.
Statistics
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PSSM-Id: 367465
View PSSM: pfam03368
Aligned: 240 rows
Threshold Bit Score: 47.8679
Threshold Setting Gi: 1005951622
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KOU_A           6 SISMMYKYCSRLPH-DEff-qPKPEFQFKPV------------------------------------------------D 35   thale cress
13_pfamImport    1 SVACLSQFCDTLPGlDTyd--qRPQYTVKRHpvssgmslatkqykkkklkynsklydkiddcradadaktaknnaadedN 78  
14_pfamImport    1 SIQCVNQFCQALPA-NLftvdYKTMYSFSQSvr---------------------------------------------gK 34  
EEY56422       605 SITCINQFCQSLPT-RLftvdAKRLYTITEAry---------------------------------------------gG 638  Phytophthora...
ESK86769       554 SIALLNHLCTLIPR-DLytapHVPVYTG---------------------------------------------------- 580  Moniliophtho...
EFI28455       571 ALSLINHLCALIPR-DSfteaYKPQFIG---------------------------------------------------- 597  Coprinopsis ...
EED81071       562 AVGLLNHLCSLIPH-DKytptHLPRYTG---------------------------------------------------- 588  Postia place...
EFJ01334       540 AIGLLGHLCSLIPR-DPfsppPAPVYTG---------------------------------------------------- 566  Schizophyllu...
ELU43989       571 AIGLLHLWCSQLEV-DRftkpPAPEFHIT--------------------------------------------------- 598  Rhizoctonia ...
CCA77779       543 SISLLNNLCSLIPR-DDhtrsLQPVYETDP-------------------------------------------------- 571  Serendipita ...
2KOU_A          36 EfGGTICRITLPANAP----I-SEIES-SLLPSTEAAKKDACLKAVHELHNLGVLNDFLLPDSKDE 95   thale cress
13_pfamImport   79 R-FQFAAELKLPMSLG----IkKKLAS-HKVSTVAEAKGIVAFKACQELIKKGLLDRHFRSKLIED 138 
14_pfamImport   35 T-PVFRAKLQLPPELE----I-EPFES-EFMLAKTMAKASVAFQAGRALWEKGLLDDSLNSVYRKS 93  
EEY56422       639 K-SMFTAELNLPMELE----L-ETFRS-DPMPSKASARASAAFSACQKLLEQQLIDDSLNSIYRTC 697  Phytophthora infestans T30-4
ESK86769       581 ---DFQATLDLPASLPlhpnD-LSYEG-PLKHSKKEAKRAVAFKAVKRLRELDVFDEYLLPVASEN 641  Moniliophthora roreri MCA ...
EFI28455       598 ---DFQSRMRLPASLPlqprD-LVYLG-YPKRSKQEAKRSVAFQAVKRLLKLNVFDDYLLPVSSER 658  Coprinopsis cinerea okayam...
EED81071       589 ---DFTSTLQLPSSLPltpaD-LSFMG-PEKRSKKEAKRAVAFLAVKRLHELGVFDDYLLPAQSSG 649  Postia placenta Mad-698-R
EFJ01334       567 ---DFISTVQLPRSIPlppaE-LVFQG-ATKATKKEAKRSAAFRTVRYLHAKDVFDAYLLPMGSRK 627  Schizophyllum commune H4-8
ELU43989       599 --GKYMCKISAPPCILnp-aLsGPIHG-PLKKTRDGARRAAAFLFVQKLHKLEIFDDYLLPFKKRS 660  Rhizoctonia solani AG-1 IA
CCA77779       572 --VTFRTTNRLPPALPipreD-LLFVSdPFCRTKKAAKRNAAFKAVLRLYELGVFDDFLLPIRREK 634  Serendipita indica DSM 11827
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