Conserved Protein Domain Family

pfam03271: EB1 
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EB1-like C-terminal motif
This motif is found at the C-terminus of proteins that are related to the EB1 protein. The EB1 proteins contain an N-terminal CH domain pfam00307. The human EB1 protein was originally discovered as a protein interacting with the C-terminus of the APC protein. This interaction is often disrupted in colon cancer, due to deletions affecting the APC C-terminus. Several EB1 orthologues are also included in this family. The interaction between EB1 and APC has been shown to have a potent synergistic effect on microtubule polymerization. Neither of EB1 or APC alone has this effect. It is thought that EB1 targets APC to the + ends of microtubules, where APC promotes microtubule polymerization. This process is regulated by APC phosphorylation by Cdc2, which disrupts APC-EB1 binding. Human EB1 protein can functionally substitute for the yeast EB1 homolog Mal3. In addition, Mal3 can substitute for human EB1 in promoting microtubule polymerization with APC.
PSSM-Id: 335279
View PSSM: pfam03271
Aligned: 163 rows
Threshold Bit Score: 38.6219
Threshold Setting Gi: 484854369
Created: 21-Mar-2017
Updated: 23-May-2017
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
4E61_A        37 LEIEREFYFNKLRDIEILVhttqdlinegvykfndetitghgnGNGGaLLRFV--KKVESILYA 98  baker's yeast
Q8IQA0       254 MKQERNFYLSKLRAIDHIC------------------------QKYNsGRDRVilEKITKIIYS 293 fruit fly
Q59W48       246 VESERDFYFNKLRAIEILVqhak-----------------emeGLSGdVLQFA--NEIEKIMYE 290 Candida albicans
A0E6G5       191 LKCERDFYYVKLKDLDGLMdq--------------------hlQQALtADQLC--KGIKEILYN 232 Paramecium tetraurelia
A0BWJ6       189 LKQEREFYFLKFKELDNFIe----------------------gASQLtQEQMQ--RGIKDILYc 228 Paramecium tetraurelia
A0BDM4       190 LKQEKDYYFQKFKDLDFFIe----------------------gASQLtQEQMY--KGIKDILYS 229 Paramecium tetraurelia
XP_001022408 240 LKDERNFYFSKIQSIDQMLdni-------------------sdKNPMtINDIK--KYIKTILYS 282 Tetrahymena thermophila SB210
EMG49735     248 MQSERNFYFNKLRAIEILVqhak-----------------emdGLSSdLLQFA--NEIEKIMYE 292 Candida maltosa Xu316
XP_002141406 209 VDKERMFYFNKLRAIEILCe-----------------------TLRNqKQSNVslNKISDILYd 249 Cryptosporidium muris RN66
XP_001022872 300 LQEEREFYFSKLKNIDHLLely------------------eelNLGDeVDELV--FKIKDILYS 343 Tetrahymena thermophila SB210
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