1YE8


Conserved Protein Domain Family
NTPase_1

?
pfam03266: NTPase_1 
Click on image for an interactive view with Cn3D
NTPase
This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.
Statistics
?
PSSM-Id: 308733
View PSSM: pfam03266
Aligned: 28 rows
Threshold Bit Score: 162.031
Threshold Setting Gi: 500168465
Created: 16-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1YE8_A         2 KIIITGEPGVGKTTLVKKIVERL---GKRAIGFWTEEVRdpETKKRTGFRIITT-EGKKKIFSSK----Ff-----TSKK 68  Aquifex aeolicus
Q9HJH0         7 KIGITGPVGSIKSEALQKIIDMLkndNLNVQGVLVSKVT--NNGKLTGYTIEDIeSKRKAQFCFD----Nf-----VSRV 75  Thermoplasma ac...
Q24SW5         2 HIFLTGEIQVGKSTIVDKALALC---QVTYAGFRTYFGP--DRGSPNRRLYLAAaSGEKVYQEEN----Sv-----VHFS 67  Desulfitobacter...
Q9VP84         8 TIILTGPPGVGKTTLVHKICSALqdrGRILQGFYTEEMRgeGTSQRIGFDVVTL-AGKRAILSRK----Npg--dqLRRP 80  fruit fly
Q9CQA9         4 HVFLTGPPGVGKTTLIQKAIEVLqssGLPVDGFYTQEVR--QEGKRIGFDVVTL-SGAQGPLSRV----GsqplpgKPEC 76  house mouse
Q9WXP3         2 KILITGRPGVGKTTLIKKLSRLLq----NAGGFYTEEMR--EGEKRIGFKIITL-DGEEGILART----Dl-----PSPY 65  Thermotoga mari...
Q5TDF0         4 HVFLTGPPGVGKTTLIHKASEVLkssGVPVDGFYTEEVR--QGGRRIGFDVVTL-SGTRGPLSRV----GlepppgKREC 76  human
XP_001626430   7 HVLLTGPPGIGKTTLCSKVKQALasrGVPTQGFYTEEIRgpGGGARVGFDVVTLd-GGRGPLARVkttgSk-----QRGP 80  starlet sea ane...
ALO23619       4 HVFLTGPPGIGKTTLIQKVTQALkssDVPIDGFYTEEVK--EGGRRRGFDVVTL-SGKRGPLSRV----SsdsstsRREC 76  chicken
NP_001003463   3 HVFLTGVPGVGKTTLVKKVCDALs--GLSVSGFYTEEVR--EHGRRVGFDVVTV-SGDRGRLSRV----SsgsaagGREY 73  zebrafish
1YE8_A        69 LVGSYGVNVQYFEELAIPILERAYreaKKDrr-kVIIIDEIGKXELFSKKFRDLVRQIXHdPNVNVVATIP--IRD--VH 143 Aquifex aeolicus
Q9HJH0        76 KIDKLGVDTKILEEILIPSLQKARe--TAD----VIVIDEIGKLENTTKKVHAEIEETLK-CGKPLIVTLH--KRS--RN 144 Thermoplasma ac...
Q24SW5        68 ENSPPQVFTERFDGYGAELVRCAGn--QAQ----LIVMDECGSLEREALVFQQEILAAIE-GPVPILGVIK--QA---SS 135 Desulfitobacter...
Q9VP84        81 KVGEYSVFVQDFDSLALPVLGTQDsqpEPD----LLVVDEVGKMELLSKRFESAMADLLK-KKRALLVTIP--EKS--TL 151 fruit fly
Q9CQA9        77 RVGQYVVNLDSFEQLALPVLRNAGs--SCGpkhrVCIIDEIGKMELFSQPFIQAVRQMLStPGIIVVGTIP--VPKgkPL 152 house mouse
Q9WXP3        66 RVGKYYVNLKDLEEIGVRSLERAFq--EKD----LIIVDEIGKMELLSRKFREVVEKIFD-SEKDVIATIK--KS---SD 133 Thermotoga mari...
Q5TDF0        77 RVGQYVVDLTSFEQLALPVLRNADcssGPGq--rVCVIDEIGKMELFSQLFIQAVRQTLStPGTIILGTIP--VPKgkPL 152 human
XP_001626430  81 SVGSYLVDIQSFEQLALPAITKTV---GSG----IIIIDEIGKMELFSQTFSRAIQDLFDgGHSPILATVPiaRQK--PI 151 starlet sea ane...
ALO23619      77 RVGQYVVDVVSFEQLVLPVLRNVNq--GSDaakkICVIDEIGKMELFSQAFIQAVRQMLAgSGTVVLGTIP--IPKgkPL 152 chicken
NP_001003463  74 RVGQYVVDLQSFESLALPLFRNMQegsGKQ----LFVMDEVGKMELFSQPFIRAVRQILEkSCCSVLGTIP--VPKgkPL 147 zebrafish
1YE8_A       144 PLVKEIRRLpgAVLIE----LTPEN-----------------RDVILEDIL 173 Aquifex aeolicus
Q9HJH0       145 PVLQEIKSLegVRVFD----ITPIN-----------------KNILPFKVM 174 Thermoplasma acidophilum DSM 1728
Q24SW5       136 GWTDRIRCHpkVKLVS----VCREN-----------------RDALPHIIa 165 Desulfitobacterium hafniense Y51
Q9VP84       152 ALVEQLRKSagSKIYQ----VTKFN-----------------RNALAGEIT 181 fruit fly
Q9CQA9       153 ALVEEIRKRrdVKVFN----VTRDN-----------------RNSLLPDIv 182 house mouse
Q9WXP3       134 PFVEKIKNRndVVIFE----LNEKN-----------------RNSLLNEIL 163 Thermotoga maritima MSB8
Q5TDF0       153 ALVEEIRNRkdVKVFNspycVIEDQskfsscvsqstltepgwRQKLLQSLL 203 human
XP_001626430 152 HLVEQLKQRsdVTLLE----VSKCN-----------------RNTLQDKVV 181 starlet sea anemone
ALO23619     153 DLVEEIRSRkdVEVFT----VSKEN-----------------RNNILQDIL 182 chicken
NP_001003463 148 ALVEELRSRadVKIFT----VTKEN-----------------RDVIFDDIV 177 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap