1YE8


Conserved Protein Domain Family
NTPase_1

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pfam03266: NTPase_1 
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NTPase
This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.
Statistics
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Aligned: 29 rows
Threshold Bit Score: 161.647
Threshold Setting Gi: 125860780
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YE8_A           2 KIIITGEPGVGKTTLVKKIVERL---GKRAIGFWTEEVRdpETKKRTGFRIITt-EGKKKIFSSKFf-----TSKKLVGS 72  Aquifex aeolicus
jgi:Memar_0034   7 VFIITGGQGQCKTTFLHLVLGLIvglNVRVRGVIAPGHL--RDGRRSGFTLVDlaTGEHEELCSIDp----dPRCEAHGR 80  Methanoculleu...
Q9HJH0           7 KIGITGPVGSIKSEALQKIIDMLkndNLNVQGVLVSKVT--NNGKLTGYTIEDieSKRKAQFCFDNf-----VSRVKIDK 79  Thermoplasma ...
CAL84458         3 NLFLTAPSGTGKSTIIEKVLCNL---NVSIGGFQVKRYL--NKKGKMCFNMISvvDEKGNNLIGEC---------INNKN 68  Clostridium b...
Q9VP84           8 TIILTGPPGVGKTTLVHKICSALqdrGRILQGFYTEEMRgeGTSQRIGFDVVTl-AGKRAILSRKNpg--dqLRRPKVGE 84  fruit fly
EDO34330         7 HVLLTGPPGIGKTTLCSKVKQALasrGVPTQGFYTEEIRgpGGGARVGFDVVTl-DGGRGPLARVKttg-skQRGPSVGS 84  starlet sea a...
ALO23619         4 HVFLTGPPGIGKTTLIQKVTQALkssDVPIDGFYTEEVK--EGGRRRGFDVVTl-SGKRGPLSRVSsdsstsRRECRVGQ 80  chicken
Q9CQA9           4 HVFLTGPPGVGKTTLIQKAIEVLqssGLPVDGFYTQEVR--QEGKRIGFDVVTl-SGAQGPLSRVGsqplpgKPECRVGQ 80  house mouse
Q9WXP3           2 KILITGRPGVGKTTLIKKLSRLLq----NAGGFYTEEMR--EGEKRIGFKIITl-DGEEGILARTDl-----PSPYRVGK 69  Thermotoga ma...
XP_021336237    19 HVFLTGVPGVGKTTLVKKVCDTLs--GLSVSGFYTEEVR--EHGRRVGFDVVTv-SGDRGRLSRVSsgsaagGREYRVGQ 93  zebrafish
1YE8_A          73 YGVNVQY--FEELAIPILERAYr--EAKkdrrkVIIIDEIGKXELFSKKFRDLVRQIXhD-PNVNVVATIPIRD--VHPL 145 Aquifex aeolicus
jgi:Memar_0034  81 FYFRPEGlvFGRRALAPPDPr----ETD-----LMVIDEVGRFELQGAVWAEQLDHLL-AhPHPPMVWTVRRR------L 144 Methanoculleu...
Q9HJH0          80 LGVDTKI--LEEILIPSLQKARe--TAD-----VIVIDEIGKLENTTKKVHAEIEETL-K-CGKPLIVTLHKRS--RNPV 146 Thermoplasma ...
CAL84458        69 ITPNLYA--FENKGVEILNTSLk--NSD-----LIILDEIGFLEEKAENFKHSIRRVL-N-SNKVVLGVLKEF---DSPF 134 Clostridium b...
Q9VP84          85 YSVFVQD--FDSLALPVLGTQDsqpEPD-----LLVVDEVGKMELLSKRFESAMADLL-K-KKRALLVTIPEKS--TLAL 153 fruit fly
EDO34330        85 YLVDIQS--FEQLALPAITKTv---GSG-----IIIIDEIGKMELFSQTFSRAIQDLF-DgGHSPILATVPIARqkPIHL 153 starlet sea a...
ALO23619        81 YVVDVVS--FEQLVLPVLRNVNq--GSDaa-kkICVIDEIGKMELFSQAFIQAVRQML-AgSGTVVLGTIPIPKgkPLDL 154 chicken
Q9CQA9          81 YVVNLDS--FEQLALPVLRNAGs--SCGpk-hrVCIIDEIGKMELFSQPFIQAVRQML-StPGIIVVGTIPVPKgkPLAL 154 house mouse
Q9WXP3          70 YYVNLKD--LEEIGVRSLERAFq--EKD-----LIIVDEIGKMELLSRKFREVVEKIF-D-SEKDVIATIKKS---SDPF 135 Thermotoga ma...
XP_021336237    94 YVVDLQS--FESLALPLFRNMQegsGKQ-----LFVMDEVGKMELFSQPFIRAVRQIL-EkSCCSVLGTIPVPKgkPLAL 165 zebrafish
1YE8_A         146 VKEIRRLp---gAVLIELTPENRDVILEDIL 173 Aquifex aeolicus
jgi:Memar_0034 145 LDTVVERwkitnAVVVDVGAASVMATAEAVM 175 Methanoculleus marisnigri JR1
Q9HJH0         147 LQEIKSLe---gVRVFDITPINKNILPFKVM 174 Thermoplasma acidophilum DSM 1728
CAL84458       135 LNEIRSRk---dISILKVTLNNRDYITNHIL 162 Clostridium botulinum A str. ATCC 3502
Q9VP84         154 VEQLRKSa---gSKIYQVTKFNRNALAGEIT 181 fruit fly
EDO34330       154 VEQLKQRs---dVTLLEVSKCNRNTLQDKVV 181 starlet sea anemone
ALO23619       155 VEEIRSRk---dVEVFTVSKENRNNILQDIL 182 chicken
Q9CQA9         155 VEEIRKRr---dVKVFNVTRDNRNSLLPDIv 182 house mouse
Q9WXP3         136 VEKIKNRn---dVVIFELNEKNRNSLLNEIL 163 Thermotoga maritima MSB8
XP_021336237   166 VEELRSRa---dVKIFMVTKENRDVIFDDIV 193 zebrafish
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