1YE8


Conserved Protein Domain Family
NTPase_1

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pfam03266: NTPase_1 
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NTPase
This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.
Statistics
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PSSM-Id: 397391
View PSSM: pfam03266
Aligned: 27 rows
Threshold Bit Score: 179.747
Threshold Setting Gi: 500994481
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YE8_A         2 KIIITGEPGVGKTTLVKKIVERL---GKRAIGFWTEEVRdpETKKRTGFRIITT-EGKKKIFSSKFf-----TSKKLVGS 72  Aquifex aeolicus
Q8TX49         4 NVVLTGRPGIGKTTVCLKVRNVLeeeGYTVGGIYCPEIR--EGGRRIGFEIVDLtEGDRYLLAREG------ASGPRVGR 75  Methanopyrus ka...
Q9HJH0         7 KIGITGPVGSIKSEALQKIIDMLkndNLNVQGVLVSKVT--NNGKLTGYTIEDIeSKRKAQFCFDNf-----VSRVKIDK 79  Thermoplasma ac...
Q9VP84         8 TIILTGPPGVGKTTLVHKICSALqdrGRILQGFYTEEMRgeGTSQRIGFDVVTL-AGKRAILSRKNpg--dqLRRPKVGE 84  fruit fly
XP_001626430   7 HVLLTGPPGIGKTTLCSKVKQALasrGVPTQGFYTEEIRgpGGGARVGFDVVTL-DGGRGPLARVKttg-skQRGPSVGS 84  starlet sea ane...
XP_021336237  19 HVFLTGVPGVGKTTLVKKVCDTLs--GLSVSGFYTEEVR--EHGRRVGFDVVTV-SGDRGRLSRVSsgsaagGREYRVGQ 93  zebrafish
ALO23619       4 HVFLTGPPGIGKTTLIQKVTQALkssDVPIDGFYTEEVK--EGGRRRGFDVVTL-SGKRGPLSRVSsdsstsRRECRVGQ 80  chicken
Q9CQA9         4 HVFLTGPPGVGKTTLIQKAIEVLqssGLPVDGFYTQEVR--QEGKRIGFDVVTL-SGAQGPLSRVGsqplpgKPECRVGQ 80  house mouse
Q9WXP3         2 KILITGRPGVGKTTLIKKLSRLLq----NAGGFYTEEMR--EGEKRIGFKIITL-DGEEGILARTDl-----PSPYRVGK 69  Thermotoga mari...
Q5TDF0         4 HVFLTGPPGVGKTTLIHKASEVLkssGVPVDGFYTEEVR--QGGRRIGFDVVTL-SGTRGPLSRVGlepppgKRECRVGQ 80  human
1YE8_A        73 YGVNVQYFEELAIPILERAYreaKKDrr-kVIIIDEIGKXELFSKKFRDLVRQIXHdPNVNVVATIPIRD--VHPLVKEI 149 Aquifex aeolicus
Q8TX49        76 YGVFVDNLER-AAESIERAVk--RTD----VVIVDEVGPMELKSNAFVDAVRRAAD-AHTPAIFVVHERS--RHPVVVDL 145 Methanopyrus ka...
Q9HJH0        80 LGVDTKILEEILIPSLQKARe--TAD----VIVIDEIGKLENTTKKVHAEIEETLK-CGKPLIVTLHKRS--RNPVLQEI 150 Thermoplasma ac...
Q9VP84        85 YSVFVQDFDSLALPVLGTQDsqpEPD----LLVVDEVGKMELLSKRFESAMADLLK-KKRALLVTIPEKS--TLALVEQL 157 fruit fly
XP_001626430  85 YLVDIQSFEQLALPAITKTv---GSG----IIIIDEIGKMELFSQTFSRAIQDLFDgGHSPILATVPIARqkPIHLVEQL 157 starlet sea ane...
XP_021336237  94 YVVDLQSFESLALPLFRNMQegsGKQ----LFVMDEVGKMELFSQPFIRAVRQILEkSCCSVLGTIPVPKgkPLALVEEL 169 zebrafish
ALO23619      81 YVVDVVSFEQLVLPVLRNVNq--GSDaakkICVIDEIGKMELFSQAFIQAVRQMLAgSGTVVLGTIPIPKgkPLDLVEEI 158 chicken
Q9CQA9        81 YVVNLDSFEQLALPVLRNAGs--SCGpkhrVCIIDEIGKMELFSQPFIQAVRQMLStPGIIVVGTIPVPKgkPLALVEEI 158 house mouse
Q9WXP3        70 YYVNLKDLEEIGVRSLERAFq--EKD----LIIVDEIGKMELLSRKFREVVEKIFD-SEKDVIATIKKS---SDPFVEKI 139 Thermotoga mari...
Q5TDF0        81 YVVDLTSFEQLALPVLRNADcssGPGq--rVCVIDEIGKMELFSQLFIQAVRQTLStPGTIILGTIPVPKgkPLALVEEI 158 human
1YE8_A       150 RRLp-gAVLIE----LTPEN-----------------RDVILEDIL 173 Aquifex aeolicus
Q8TX49       146 REErpdVVRFR----VTLSN-----------------RDELSDRIL 170 Methanopyrus kandleri AV19
Q9HJH0       151 KSLe-gVRVFD----ITPIN-----------------KNILPFKVM 174 Thermoplasma acidophilum DSM 1728
Q9VP84       158 RKSa-gSKIYQ----VTKFN-----------------RNALAGEIT 181 fruit fly
XP_001626430 158 KQRs-dVTLLE----VSKCN-----------------RNTLQDKVV 181 starlet sea anemone
XP_021336237 170 RSRa-dVKIFM----VTKEN-----------------RDVIFDDIV 193 zebrafish
ALO23619     159 RSRk-dVEVFT----VSKEN-----------------RNNILQDIL 182 chicken
Q9CQA9       159 RKRr-dVKVFN----VTRDN-----------------RNSLLPDIv 182 house mouse
Q9WXP3       140 KNRn-dVVIFE----LNEKN-----------------RNSLLNEIL 163 Thermotoga maritima MSB8
Q5TDF0       159 RNRk-dVKVFNspycVIEDQskfsscvsqstltepgwRQKLLQSLL 203 human
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