Conserved Protein Domain Family
CDC37_N

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pfam03234: CDC37_N 
Cdc37 N terminal kinase binding
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.
Statistics
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Aligned: 109 rows
Threshold Bit Score: 68.39
Threshold Setting Gi: 344239579
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGF80164               64 KWDSIELSDDEDFECHPNVDKKSMVRWKQAQVHKERKERQDQLDLLTLE-----HQTTEKYLADFKNQVKA----TFEAL 134 Batrac...
EGF98706                7 KWDALELSDDSDVEVHPNVDKRSFIRMKQRKIHQEREERKMKIESFKHE-----EELNQKLLKEMKDLIKEv--eSDGIQ 79  Melamp...
WGS:AAWC:PGTG_05453.3   7 KWDSVELSNDSDLECPPAINKEKNAPPKHCQTHQQHECRKAEDKAFKWT-----GKLNGINIKQLQQLLTNi--dKKGVI 79  Puccin...
WGS:AAWC:PGTG_04303.3   7 KWDSLQLSDDSDLEDPPAIDKEKDASHKHCQTHQQHECRQAEIEAIKWT-----GKLNAIVIKKLQQLLTNt--dKKGVI 79  Puccin...
WGS:AAWC:PGTG_11621.3   7 KWDALELSDDSDIECHPNVDKRSFIRLKQRQIHQKRDERKMKIDGLKKE-----GPMNAALLEKIEELVAKt--kQDGAD 79  Puccin...
EPB86829                7 KWDNLELSDDSDIEVHPNVDKRSMIKWKQEAIHRERAERKAKIDYLTQF-----VPQQENVLKKVQELTSMlkntEDDLA 81  Mucor ...
EIE85021              152 KWDNLEISDDSDIEVHPNVDKRSMIKWKREAIHRERAERKAKIDYLQTF-----IPQQKNVLKKLKDLQELt--qEPDGI 224 Rhizop...
EGV95682                6 IWDHIEVSDDED-ETHPNIDTASLFRWR----HKARVERVEQFQKEKDEldrccRECKQKVAERQHKLREL------EVA 74  Chines...
EPY52916                7 KWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAMRKQKMEDIKSA-----VSMNQRLKDRIAQMYTYl--qEYSPS 79  Schizo...
O94740                  7 KWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGA-----MAMNRRLLSRISEMETVl--eKESPS 79  Schizo...
EGF80164              135 SRPVTASAIIDTLkkiqtdTEKTYTDPMRTKSmscmnawpreweapnwgtvLrEHVPWHDTVakIQEAVSKISQEHAG 212 Batracho...
EGF98706               80 S-------MKKTA------SQLSATGGSVPPS-------------------EnK-EPTIQQM--VFNLLTQILSKVEK 122 Melampso...
WGS:AAWC:PGTG_05453.3  80 H-------LREAS------AKLLARGQGDSAR----------------------------TA--LFRYIDDTLHRIKD 114 Puccinia...
WGS:AAWC:PGTG_04303.3  80 H-------LRQAA------AKLSTQGHGKSSL----------------------RKDSARTA--VFRYIDDILYRIKD 120 Puccinia...
WGS:AAWC:PGTG_11621.3  80 H-------LRKTA------SKLSAEGHAKPPS-------------------SsEDQPSIDQM--IFNLISQILTKIKD 123 Puccinia...
EPB86829               82 GIKKVVQVLDQQQ------TEADPNMKVPSAG---------------------GKEMDVAQV--FSAMKTQIAAGLAS 130 Mucor ci...
EIE85021              225 Q--KVLETLEHYQ---------SEASGLPKAQ---------------------GSEITVKEI--FAAMKAQITTGMAQ 268 Rhizopus...
EGV95682               75 E------------------GSGQVELERPRAE---------------------PQQQCKEEQswKQKLGDTPKKSMPW 113 Chinese ...
EPY52916               80 E---PLTYLSSFL-------QSKSQEDSEQAV---------------------EGGMSYHQM--LVALLDTIKKAIEE 124 Schizosa...
O94740                 80 D---PYVLLGSFL-------EAKKSEDMDSAI---------------------PGGMSYHHM--LMSLLKVIKDAEDT 124 Schizosa...
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