Conserved Protein Domain Family
LUC7

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pfam03194: LUC7 
LUC7 N_terminus
This family contains the N terminal region of several LUC7 protein homologs and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).
Statistics
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PSSM-Id: 308688
View PSSM: pfam03194
Aligned: 72 rows
Threshold Bit Score: 200.156
Threshold Setting Gi: 470251816
Created: 16-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74952488    2 DQIRATLAELMGKYEQKEDLDSTK--------PFTDPDVCRQYLTGICPHDLFENTKFYmGECSRIHSEKLRERYQNERK 73
gi 74583639    9 AEQRKLVEQLMGRDFSFRHNRYSHqkr---dlGLHDPKICKSYLVGECPYDLFQGTKQSlGKCPQMHLTKHKIQYEREVK 85
gi 74625847    3 AEQRKIIEQLMGSNLSNFTSRGLV--------HFTDRKVCRSFLCGICPHDIFTNTKMDlGPCPKIHSDKLKSDYERASY 74
gi 595483286   3 aearkaleALMGAEALGGVPDHM---------KYDDDKVCRNYLCGLCPHDLFTNTKMDlGACPKMHSERLKSEYEEAKK 73
gi 213409125   3 AEQAKIIEQLMGSNLSNFSSRGQV--------QFTDRKVCRSFLCGICPHDVFVNTKMDlGPCPKIHSDKLKADYEAASY 74
gi 452848229   3 AEQRKLLAQLMGDQL-----LAGPtshvapvlTITDPKVCRSFLCGGCPHDLFTNTKQDlGPCDKVHQPNLKEEWQAAPD 77
gi 667838686   3 AEQRKLLEQLMGEQL-----MSGPgtra-pqlSITDPKVCRSYLVGTCPHDLFTNTKQDfGPCPKTHSEALKNEYDSASE 76
gi 685411883   3 AEQRKLLEQLMG---------GGIaarp-sqlSLTDAKVCRSYVAGTCPHDLFTNTKQDlGPCLRVHAEALKVEYEALPE 72
gi 521770620   3 AEQRKLLEQLMG---------ASHssht-sqiSITDPKLCRSFLVGTCPHDLFTNTKQDlGPCPKIHSEPLKSEYDASPE 72
gi 340373897   5 DQMSKMLDQLMGQNRDGNDKNKER--------RFSDSDVCRPFLLGICINELFINTREEmGDCNKIHSIALKNEYERAQQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74952488   74 NHF--YGYELETLKIIQPMIDDCDKKIARGKARVEEDLVRRktlDPMiIEEAKKIDSQIQSRMARADELGRNGEVEESFK 151
gi 74583639   86 QGKtfPEFEREYLAILSRFVNECNGQISVALQNLKHTAEERmkiQQV-TEELDVLDVRIGLMGQEIDSLIRADEVSMGML 164
gi 74625847   75 SHD--YGYEWDYLEDLERHVDDCNKRIDIAEARREKTKEEEeriDEL-MRDIIHTDHSIEVIITEMEALAKRKLVNDAVK 151
gi 595483286  74 RKE--CDYEAEFERNLANFVADCDRKIASAQKRLDKTPEDSakvTQL-TKEIESLATEISELTKEVEVLGEEGKVTESIK 150
gi 213409125  75 SHD--YGYEWDYLQDLERHVTECNKRIDIAEARREKTREEIdrtDAL-MKEILHLDHTISVLIDEIKALASKGRVNESIQ 151
gi 452848229  78 EKKreWGFEFDYQRDIGKYVNECDRRIDTAQRRLEKTPDEIrqtTAL-LKQIGDLSRTIEAGITEVEIMSEQGAVNLAVQ 156
gi 667838686  77 EQKkrWGFEYDYLRDMQKYVDECNRRIDTAQRRLEKTPDEIrqtNAL-LKQISDLTITIESGLFEVQILAEEGAVNTAVT 155
gi 685411883  73 KEKarLGFDYDYMRDLSKYIDECNRRIDQAQRRLERTPDEIrqhNEL-LRTINDLQSSINCGITEVEILGEESLVIQSLE 151
gi 521770620  73 LQKqkWGFEYDYMRDLQKYIDDCNCRIDVAQRRLEKTPDEIrqtNAL-LKQISDLNKSIESGLLEIQVLGEASEVSRAYE 151
gi 340373897  77 RRD--YHYEEEVLEYLQSFIKENERKIETNKKRIENVEEDTvqqKL--AQEIHECAVLIGEKVTKSEALGSEGNIDESLL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74952488  152 IVEEVELLKRTKLEML--------EKGGDASYQSRLKPCDVCGALLSATDSDRRLTEHYSGKIHVGFQKLRDMSKTLSAY 223
gi 74583639  165 QSVKLQELISKRKEVAkrv--rniTENVGQSAQQKLQVCEVCGAYLSRLDTDRRLADHFLGKIHLGYVKMREDYDRLM-- 240
gi 74625847  152 HFIELNRLKTYRKELYdevismneIPSQASTTHQKLQVCDICSAYLSRLDNDRRLADHFSGKMHLGYAMLRNIARDLRAQ 231
gi 595483286 151 LLQDVDAKKVIKTEKEkel--kssAEGSGPSQQQKLRVCEVCSAYLSIFDSDRRLADHFGGKMHLGYLKIRDLLKELKEK 228
gi 213409125 152 RFTAYNKVKQTKKELVqevlsineLPSQASSTHQKLQVCDVCSAYLSRLDNDRRLADHFSGKMHLGYAQIRDAAKELRQL 231
gi 452848229 157 EFHNLKLKKVQKEERErel--kslSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHLGYAQMRKEHERLSKE 234
gi 667838686 156 EFFKVKQAKHTKEDRErel--kalSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRKTYEELQKQ 233
gi 685411883 152 EYVRVRQTEVSKAERErel--kvlLDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRKAYEAFPKE 229
gi 521770620 152 EFFRIRQAMQTKSEKErdl--kslSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYANMRKTFEAFPKE 229
gi 340373897 153 VLQQVEEIKLKKKKLEdey---hsHLPRHAQQQQKLRACEVCGAFLSMYDNDRRLADHFGGKLHMGFVQIREKMESLEEI 229
                        250
                 ....*....|.
gi 74952488  224 IQENRHRLNGR 234
gi 74583639  241 ----KNNRTTN 247
gi 74625847  232 LEDREKSRDKK 242
gi 595483286 229 NKDRGNDIREG 239
gi 213409125 232 LEKRELEKKGE 242
gi 452848229 235 LKGRAPPRREE 245
gi 667838686 234 LKGRPPPQRQE 244
gi 685411883 230 LRQRGGRGDRG 240
gi 521770620 230 LRGRRAPAETD 240
gi 340373897 230 IAKKKERLEKE 240
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