4FVM,4PTF,5IUD


Conserved Protein Domain Family
DNA_pol_B_exo1

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pfam03104: DNA_pol_B_exo1 
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DNA polymerase family B, exonuclease domain
This domain has 3' to 5' exonuclease activity and adopts a ribonuclease H type fold.
Statistics
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PSSM-Id: 335220
View PSSM: pfam03104
Aligned: 34 rows
Threshold Bit Score: 146.023
Threshold Setting Gi: 3023653
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FVM_A         27 KDDNCVSAMVQINGLCRELF-------FLPR---E-------GKTPTDIHEEIIPLLMDKy---------GLDNIRAKPQ 80   Saccharomyces...
P33609        373 SVKTHVSCCVMVKNIERTLYflpremkFDLN---T-------GKET-AIPVTMKDVYEEFdski--sakyKIMKFKSKIV 439  house mouse
P28040        354 ATKQYVSCFLKVDGIMRSLY-------FLPRpssS-------SVSEDSIAAQTKDVYDEVanll---skrGVKEWKSRVS 416  Schizosacchar...
O31096         33 PESQKIVHWTDNTGHKPYCY-------TRQP------------------PSELGELEGREdvl----------gtEQVMR 77   Cenarchaeum s...
Q38087         19 YIDSNGRERTREVEYKPSLF-------AHCP------------------ESQATKYFDIYgkp---------------ct 58   Enterobacteri...
P21402         23 INRESNVIFIR-FNYYYHYV-------YDAS------------KELEYKPNECIDLGPFKiin-----------idEKLS 71   Fowlpox virus...
Q9EMZ8         80 KDYDTEEIIYILFDIYEYFL-------CDYElseS-------NTKLKNIKNNIDKYKNSFnssylvledyKIITNE-VNI 144  Amsacta moore...
Q9YW56         72 KNIDTDELIFFIFDFYHYFL-------CSKElvnN-------NNDLKDLINIIDEYKIGEyeil---enlKILDVD-LIP 133  Melanoplus sa...
5IUD_A         32 saETHVSCCVMVKNIERTLY-------FLPR---EmkidlntGKETGTPIS-MKDVYEEFdeki--atkyKIMKFKSKPV 98   human
WP_011011325   20 KKENGKFKIEHDRTFRPYIY-------ALLR---D-------DSKIEEVKKITGERHGKIvri------vdVEKVE---- 72   Pyrococcus fu...
4FVM_A         81 KMKYSFELPDIPsesdYLKVLLPYQTPKSSRDTIPSDlssdtFYHVFGGNSNIFESFVIQN-RIMGPCWLDIKg------ 153  Saccharomyces...
P33609        440 EKNYAFEIPDVPe--kSEYLEVRYSAEVPQLPQNLKge---tfSHVFGTNTSSLELFLMNR-KIKGPCWLEVK------- 506  house mouse
P28040        417 KYKYAFELEDVPrtadYLEVIYSYSYPALPTDLTgs-----sfSHVFGTNTALFEQFVLSR-RVMGPCWLKIQq------ 484  Schizosacchar...
O31096         78 HDLIADKDVP------VTKITVADPLAIGGTNSEKSir---niMDTWESDIKYYENYLYDK-SLVVGRYYSVSggkviph 147  Cenarchaeum s...
Q38087         59 RKLFANMRDASQ----WIKRMEDIGLEALGMDDFKla----ylSDTYNYEIKY------DHtKIRVANF----------- 113  Enterobacteri...
P21402         72 TDIRYVEPRN------YYTSELVLVKDLKRNR-----------EKQYLQEYLDITWFYLLN-NITPDGCYKID------- 126  Fowlpox virus...
Q9EMZ8        145 QYYYNYTED--------SKITLNNNDLVLFMTPYKie----kiYSKYNIFINQYRWFYVLN-NIEPSGSYRINm------ 205  Amsacta moore...
Q9YW56        134 KDYYNFEET---------DINIAKYRNLYLFKTIFki----qlESEFNHSFLDYRWFYVLN-NIDPSACYNIDi------ 193  Melanoplus sa...
5IUD_A         99 EKNYAFEIPDVPe--kSEYLEVKYSAEMPQLPQDLKGe---tFSHVFGTNTSSLELFLMNR-KIKGPCWLEVK------- 165  human
WP_011011325   73 KKFLGKPIT-------VWKLYLEHPQDVPTIREKVREhp--avVDIFEYDIPFAKRYLIDK-GLIPM------------- 129  Pyrococcus fu...
4FVM_A        154 -ADFNSIRNASHCAVEVSVDKPQNITPTTT--------KTm-----PNLRC----LS-LSIQT---------LMNPKENK 205  Saccharomyces...
P33609        507 -NPQLLNQPISWCKFEVMALKPDLVNVIKDvs-------------pPPLVV----MS-FSMKT---------MQNVQNHQ 558  house mouse
P28040        485 -PNFDAVKNASWCRVEIGCSSPQNISVSFE--------KNeitsktPPMTV----MS-LAFRT---------LINKEQNK 541  Schizosacchar...
O31096        148 dMPISDEVKLALKSLLWDKVVDEGMADRKEfrefiagwADllnqpiPRIRR----LS-FDIEVdse---egrIPDPKISD 219  Cenarchaeum s...
Q38087        114 ---------------DIEVTSPDGFPEPSQ--------AK------HPIDA----IThYDSIDdrfyvfdllNSPYGNVE 160  Enterobacteri...
P21402        127 --------IEHLTPIKKDCYHCDDVSKVFI--------QEi-----PIFEVkftyLL-FDIECqfd----kkFPSVFV-- 178  Fowlpox virus...
Q9EMZ8        206 -DNMQKIKTYNKNKTSYYCKNPKLLFSNYV--------KIdk--hiPASRV-----S-IDIECqhf----geFPTANK-- 262  Amsacta moore...
Q9YW56        194 -TSDNCKIFVTNIHFKFKTYYVSNPKKLFM--------NKi-----DPLPCkisrLS-FDIECkqt----gsFPDPKY-- 252  Melanoplus sa...
5IUD_A        166 -SPQLLNQPVSWCKVEAMALKPDLVNVIKD--------VSp-----PPLVV----MA-FSMKTm---------qNAKNHQ 217  human
WP_011011325  130 -----------------------------E--------GE------EELKI----LA-FDIETlyh-----egEEFGK-- 154  Pyrococcus fu...
4FVM_A        206 QEIVSITLSA-Yrn--iSLD-SPIPENIkpdd-----lctLVRPPQSTSFPLGLAALAKqKLPgRVR--------LFNNE 268  Saccharomyces...
P33609        559 HEIIAMAALVhH-----SFA-LDKAPPEppfqthfcvvskPKDCIFPCDFKEVISKKNM-----KVE--------IAATE 619  house mouse
P28040        542 QEVVMISARIfE-----NVDiEKGLPANdmpsysfslirpLKQIFPNGFEKLARQHKS------SIF--------CERSE 602  Schizosacchar...
O31096        220 RRVTAVGFAAtD-----GLKqv----------------fvLRSGAEEGEN-------GVtPGV-EVV--------FYDKE 262  Cenarchaeum s...
Q38087        161 EWSIEIAAKLqE-----QGGde----------------vpSEIID-------------------KIIy------mPFDNE 194  Enterobacteri...
P21402        179 NPISHISCWIiD-----KVTeyk---------------ftLINTDILPDKEPSILHHKDfSPKdRI---------TYCTE 229  Fowlpox virus...
Q9EMZ8        263 FPISHICIDWyM-----DKN---TNPIKki--------itLINYEIIKNYVGEKKDKFIyTEVnKLLntnkvyitIYCTE 326  Amsacta moore...
Q9YW56        253 MPISHICVECfY-----D-----DPKKNki--------liLTNCNLYEKNAKKNKKVYDmNECeKILnmnssvikIYTSE 314  Melanoplus sa...
5IUD_A        218 NEIIAMAALV-HhsfalDKA-APKPPFQsh--------fcVVSKPKDCIFPYAFKEVIEkKNV-KVE--------VAATE 278  human
WP_011011325  155 GPIIMISYAD-E-----NEAkv----------------itWKNID------------LP-----YVE--------VVSSE 187  Pyrococcus fu...
4FVM_A        269 KAMLSCFCAMLKVEDPDVIIGHRLQNVYLDV--LAHRMHDLNI----PTFSSIGRRL--RrtWPEKFGRGNSNMnh-fFI 339  Saccharomyces...
P33609        620 RTLIGFFLAKVHKIDPDILVGHNICSFELEV--LLQRINECKV----PYWSKIGRLRr-S--NMPKLGSRSGFG-----E 685  house mouse
P28040        603 VSLLNNFLNKVRTYDPDVYFGHD---FEMCYsvLLSRLKERKI----HNWSSIGRLRrsE--WPRSFNRSSQQF----VE 669  Schizosacchar...
O31096        263 ADMIRDALSVIGSY--PFVLTYNGDDFDMPY--MLNRAR--------------------R--LGVSDSDIPLYMm---RD 313  Cenarchaeum s...
Q38087        195 KELLMEYLNFWQQKTPVILTGWNVESFDIPY--VYNRIKNIFG----ESTAK--RLSphR--KTRVKVIENMYGs---RE 261  Enterobacteri...
P21402        230 IVMLL-IMKKILEHRFDFVITFNGNNFDIRY--ISGRLEILEKsfiyFSLPDATETVklK--IFERFVTGGTFTnk-tYH 303  Fowlpox virus...
Q9EMZ8        327 KYMLH-FVLYTLRQDFDYVLTYNGHNFDFTY--IQDRRK---I----NKLKGLCLDNvyS--TNEIKISKFSYNqdttYE 394  Amsacta moore...
Q9YW56        315 KNILIIFQCLLF-HEFDYILSFNGHEFDIPY--INTRMDIYNL----LKLRMLN-----P--FGFPNLNVIKGDassrYT 380  Melanoplus sa...
5IUD_A        279 RTLLGFFLAKVHKIDPDIIVGHNIYGFELEV--LLQRINVCKA----PHWSKIGRLK--Rs-NMPKLGGRSGFG-----E 344  human
WP_011011325  188 REMIKRFLRIIREKDPDIIVTYNGDSFDFPY--LAKRAEKLGI------KLTIGR----D--GSEPKMQRIGDM-----T 248  Pyrococcus fu...
4FVM_A        340 SDICSGRLICDIANEMGQS------LTPKcqSWDLSEM 371  Saccharomyces cerevisiae S288c
P33609        686 RNATCGRMICDVEISAKEL------IHCK--SYHLSEL 715  house mouse
P28040        670 KQIIAGRLMCDLSNDFGRS------M-IKaqSWSLSEI 700  Schizosaccharomyces pombe 972h-
O31096        314 SATLRHGVHLDLYRTFSNRsfqlyaFAAKytDYSLNSV 351  Cenarchaeum symbiosum
Q38087        262 IITLFGISVLDYIDLYKKF------SFTNqpSYSLDYI 293  Enterobacteria phage RB69
P21402        304 INNNNGVMFFDLYAFIQKT------ERLD--SYKLDSI 333  Fowlpox virus strain NVSL
Q9EMZ8        395 IDSTNGIIFLDLYNYIKKT------Y-PSsnSYKLSEI 425  Amsacta moorei entomopoxvirus
Q9YW56        381 HIEYSSILF-DLYVYTKKT------YVLP--EYKLETV 409  Melanoplus sanguinipes entomopoxvirus
5IUD_A        345 RNATCGRMICDVEISAKEL------IRCK--SYHLSEL 374  human
WP_011011325  249 AVEVKGRIHFDLYHVITRT------INLP--TYTLEAV 278  Pyrococcus furiosus
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