4RH7,5NUG,3VKH


Conserved Protein Domain Family
Dynein_heavy

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pfam03028: Dynein_heavy 
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Dynein heavy chain and region D6 of dynein motor
This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Statistics
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Aligned: 481 rows
Threshold Bit Score: 59.0063
Threshold Setting Gi: 323447728
Created: 11-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RH7_A         2872 GAD---------------PSQELQELAN--AErsgECY-HQVAMGQG-QAD-LAIQMLKECARNGDWLCLKNLHLV-VSW 2930 synthetic c...
EKC41076       4735 EAEa--------------AQSRFLDFSGrrQA---PRLmVTITDNSQ-ATRsKVRKTIRKAIAEGSWVYLHNAHNA-PNV 4795 Pacific oyster
EEN60223       4554 ESDl--------------AETLFVEFAVkkQE---PRQvVYLSSGSP-QEErRVRRAITKAAEEGHWLLLHNAHNA-LHF 4614 Florida lan...
110_pfamImport    9 DAN---------------IMKSMLQYASewRQ---LKNmCILTIGQK-SNK-EIIEAYRRASLLECWIVIKNCYLW---- 64  
Q170I1          843 ENK---------------PLEEVHNLHKiyn-gksNKTlQHVNMGTE-SFE-TTVKHLKNCVKSQNWLYLNQCWQS-RQF 903  yellow feve...
EEN46873       4811 SLNsssqpniaaidikkhPVEVLKSLAK-------GIPvEHVAVGDGcES--RVDVAIDTAHNNDGWVIIEDIHLAsPQF 4881 Florida lan...
EGB03639       2493 TAA---------------AANMVIATGK--HM---DRFiAQILVVPGcRSS--GDATLAQARSRGTWVLVRNPQLC-PEF 2549 Aureococcus...
EGB05010       1411 KAS---------------AVSFVVGAAN--RM---GRNvSHILVVAS-RTG-VARRTLTQGLSSSSWVIIQNLQLC-PGF 1467 Aureococcus...
XP_027838171   3414 GSD---------------PTKDLTNLAEknDItg--pTfKVLSLGTF-NEN-VIYLALKSALYRGNWLIIQNCNFS-AQF 3473 cotton aphid
XP_015211261    533 EAEe--------------PRRLVLELCSqrSC---KTEvVFVSEDSA-SEErRIKDVIENGQSKGSWVLLENIHNS-MHL 593  spotted gar
4RH7_A         2931 ---LP-VLEKE-------LN--TlqpKd---TF----------RLWL-----TAEVHPN-FTPILLQSSLKITYE----- 2973 synthetic c...
EKC41076       4796 ---LN-SLESFlvek------------pnpeGF----------RLWV-----ACQADPEvIPVRLLQNSIKAVVD----- 4839 Pacific oyster
EEN60223       4615 ---LQ-TLDTTlqekk----------lpadsNF----------RLWV-----SAQPHPK-LPIHLLQHAIKVVVD----- 4659 Florida lan...
110_pfamImport   65 ---TE-ELDEI-------LEih--------sALpksgdkcitcRLWL-----TTCYTTE-MPKELLRRSIKVEGKtcils 119 
Q170I1          904 ---LA-NFELIhqy-lrtIDqk--------sGF----------RLWI-----VMHNRKTlFPVHVLHNCLKYRCS----- 950  yellow feve...
EEN46873       4882 lheLKlHLARVsht-atgLKdrsaq-dggrsSF----------QVWL-----TSEPSAT-IPEDLLNSLHKVAWDvigph 4943 Florida lan...
EGB03639       2550 ---SL-RLEEVclg-wasVDtn--------tKF----------RLWFvvdieNVLSTN------VLRLATKFAYE----- 2595 Aureococcus...
EGB05010       1468 ---TT-HLEEVffnnggpVSah--------vNF----------RAWCvmdvnHILTTN------LLKAATKFVYE----- 1514 Aureococcus...
XP_027838171   3474 ---LY-EIEYI-------LEqaN---EswhpNF----------RLWLifngdSLLCDS--FPISLLLRSLKVIIE----- 3522 cotton aphid
XP_015211261    594 ---MT-SIESMihlnk-----------npnkQF----------RLWI-----SAQANTS-IPVRLMHVSLRIVVD----- 637  spotted gar
4RH7_A         2974 ----------------SPPGL 2978 synthetic construct
EKC41076       4840 ----------------TPKVM 4844 Pacific oyster
EEN60223       4660 ----------------TPMMM 4664 Florida lancelet
110_pfamImport  120 fvv------vvqnqrcLPEIM 134 
Q170I1          951 ----------------SPTGI 955  yellow fever mosquito
EEN46873       4944 llggqeaqgpallahgSPQGM 4964 Florida lancelet
EGB03639       2596 ----------------PLCGV 2600 Aureococcus anophagefferens
EGB05010       1515 ----------------PPRGV 1519 Aureococcus anophagefferens
XP_027838171   3523 ----------------PSNHM 3527 cotton aphid
XP_015211261    638 ----------------TPKNM 642  spotted gar
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