5GAN,4F91,5GAN,4KIT


Conserved Protein Domain Family
Sec63

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pfam02889: Sec63 
Click on image for an interactive view with Cn3D
Sec63 Brl domain
This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Statistics
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PSSM-Id: 308503
View PSSM: pfam02889
Aligned: 93 rows
Threshold Bit Score: 131.54
Threshold Setting Gi: 521281198
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5GAN_B       1846 TLSNGLIASHYGVSFFTIQSFVSSLSNTS-TLKNMLYVLSTAVEFESVPLRKGDRALLVKLS-KR------LPLRFpeh- 1916 baker's yeast
O60072       1618 PTTLGRIVSYYYLFHTTIRNFVQKITENA-EFDLALQLLAEASEFDDLAIRHNEDLINIEIN-KS------LKYSAacl- 1688 Schizosacchar...
Q6BM64        479 CTEYGDVMTKYYILYPTMRNIIRSKAGN--TLLDVLTIFSRSSEFSEFSIKYNEKKLYKAINlSPyi---rFPLHSt--- 550  Debaryomyces ...
Q5D892        534 PEEPGRLMTKYYLKFETMKYIINT--PTSySLDEALHIVCHAEEISWIQLRRNEKKTLNDVNaDK----------Egrlr 601  thale cress
Q16RG8        556 ATLYGRLMAQYCLNFRTVKLLRK-IKGTE-PLLEIFTLLTYCDEFAVFKCRNSDKRTLNELNrSStrstirFPLRg---- 629  yellow fever ...
A2PYH4        777 PTEAGRLMAWYYITFETVKKFYT-ISGKE-TLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNkDPnritirFPMEg---- 850  human
A2RUV5        646 PTETGKLMALYYIAFNTAKLFHT-IRGTE-TLAELVSLISSCSEFSDVQLRANERRVLNTLNkDKnrvtirYPMEg---- 719  tropical claw...
XP_001704428 2044 PTPLGEIVSRYYIRTRSGALINTWLTGEThTLQSYLDMLVRCEEFQEIPIRHNEDRDSALLL-QK------YLWDGk--- 2113 Giardia lambl...
CBI34887      532 PLEPGRLMTKYYLKFGTMKHIMQT--PLNcSLEDALHIICRSEEIAWIQLRRNEKKFLNDINmDK----------Dgqlr 599  wine grape
EEE57380      447 PLEPGRLMTKFYLKFDTMKLIVKA--SACcTLEDLLHIICHSAEITWIQLRRNEKKLLNEINaDK----------Egrlw 514  Japanese rice
5GAN_B       1917 ---------tssG-----------------SVSFKVFLLLQAYF-SRLELP---------VDFQNDLKDILEKVVPLINV 1960 baker's yeast
O60072       1689 ----------nlPm---------------vDAHVKAFILTQAHM-ARLKLPv--------DDYVTDTSTVLDQVIRIIQS 1734 Schizosacchar...
Q6BM64        551 ------------Ef---------------qDSD-KVMLLLQYEL-CGLDFPnspelmklyYSFEGDKCYVFKQASRIIRC 601  Debaryomyces ...
Q5D892        602 fhindnkgkrkkRi---------------qTREEKLFVLANDWLtGDPSVHd--------LSMTQDANSICSNGSRIARC 658  thale cress
Q16RG8        630 ------------Ri---------------qSTTAMASCLMQAVF-GNLPIEd--------GSLQQEATKMINIGRRLIKC 673  yellow fever ...
A2PYH4        851 ------------Ri---------------kTREMKVNCLIQAQL-GCIPIQd--------FALTQDTAKIFRHGSRITRW 894  human
A2RUV5        720 ------------Ki---------------kTKEMKVNCLIQAHL-GCILVQd--------FSLTQDISKIFRHGTRLAKC 763  tropical claw...
XP_001704428 2114 -----------rEfsgalirynmpdditctEPSFKAHILLQAQL-VRSSLQgafe--lpvVDYWLDLVTIIDAAIRITVA 2179 Giardia lambl...
CBI34887      600 fhilgdkgkrkrRi---------------qTREEKIFVLANDCLtGNPSVHd--------LSLTQDANAICSNGCRIAKC 656  wine grape
EEE57380      515 fhvvgangkrkkRi---------------qTREEKIFILANDCLtGDPLVHd--------LSLNQEMNSICSNGCRVAKC 571  Japanese rice
5GAN_B       1961 VVDILSANGY---------LNa--TTAMDLAQMLIQGVW-DVDNPLRQIPHFNNKIL------EKCKEINVETV------ 2016 baker's yeast
O60072       1735 YIDVSAELGY---------SHv-cLQYISLMQCLKQACY-PSEIYRASLPGLNASSE------KEARDYLNKFA------ 1791 Schizosacchar...
Q6BM64        602 MIDVFRYKKD---------CVs-lLNTLRFSRCVAGRCWeNSVTELKQLDGIDEECI------KKLRKNNISGF------ 659  Debaryomyces ...
Q5D892        659 MKEYFIYKKN---------YKg-tLSSTLLAKSLYQKLWdDSPYLLKQLPGIGMVTA------KALHSMGVRSF------ 716  thale cress
Q16RG8        674 MTEFIYVGQGtigqdgggvYQa-lLSTVVLSQCLETKLWeNSPYITKQLKGIGAIYA------GQLAARGKISF------ 740  yellow fever ...
A2PYH4        895 LSDFVAAQEKk--------FAv-lLNSLILAKCFRCKLWeNSLHVSKQLEKIGITLS------NAIVNAGLTSF------ 953  human
A2RUV5        764 LSEFLALQENk--------FSa-fLNALILTKCFKSKLWeNSSHISKQLEKIGVTLA------NAMVNAGLTTF------ 822  tropical claw...
XP_001704428 2180 TVEIALAKRL---------SRsivQTVVQLSQGLVQGLW-PNMEPMLSISSLRNALQsnkktfQKLSANGISTLqqlvde 2249 Giardia lambl...
CBI34887      657 MKEYFIYKKS---------YKg-aLNSILLSKCLLQKLWdDSPYLLKQLPGIGMVTA------KALHSMGIVSF------ 714  wine grape
EEE57380      572 MREYFIYKKN---------YKs-aISSMLLAKCLHQKLWeSSPFLLKQLPGIGIVTA------KALKTAGIDSF------ 629  Japanese rice
5GAN_B       2017 YdIMALEDEERDEILTLTDSQLAQVAAF--VN-Ny-PNVEL-TYSLnnsdSLISG-----VKQK-----ITIQLTrdvep 2081 baker's yeast
O60072       1792 ----GNKTDELYQMLCNDPNVFDIESLV--NSlIsyPKMNI---------EVSQS-----SSDK-----LLLYLRrlnqp 1846 Schizosacchar...
Q6BM64        660 AeAKYLSQLQLEYFLGIEPGTGKNIAQS--LQ-Sl-PKFKInATLA----SNKVR-----TDLEtleisLIVSIGidnme 726  Debaryomyces ...
Q5D892        717 EaLAEADPRRIEIVTGRKYPFGNTIKES--LS-SlpPKVEIkVEEV----DCQKQ-----GISK-----LAVTLSrvsqp 779  thale cress
Q16RG8        741 QeLLDTNPRELEVILKKNPPFGSDLIAF--VR-Tl-PVFSI---------DLVLK-----KDYF-----LEVTVNqkndc 797  yellow fever ...
A2PYH4        954 KkIEETDARELELILNRHPPFGTQIKET--VM-Yl-PKYELkVEQI----TRYSD-----TTAE-----ILVTVIlrnfe 1015 human
A2RUV5        823 KkIEDTNARELELIVNRHPPFGNQIKES--VA-Hl-PKYEIkFQQL----AKYRA-----TTAE-----VVLTVLltnfk 884  tropical claw...
XP_001704428 2250 FhKLGRKQLTEFLGKHQLLSGIQRKELCeeLM-Ky-PNLII-RATI----TRINRpanipDKSKhtgkfVCVIISlkhvs 2322 Giardia lambl...
CBI34887      715 EaLAEADPRRIEIVTGRKYPFGNHIKES--LS-SlpPKVELkIEEI----ECQRQ-----GKSK-----IVLILTrlsqs 777  wine grape
EEE57380      630 EsLATADARKIESVTGRNYPFGDSIKSY--LP-SlgPKIDInIEDA----G-NRQ-----GKST-----IIVTLTrlsqa 691  Japanese rice
5GAN_B       2082 e--nlqvtsEKYPFDK-----LESWWLVLGEVSKKELYAIKK---VTLNKEtqq------yeLEFDT-P-TSgkhnLTIW 2143 baker's yeast
O60072       1847 lnpdfyifaPLFPKPQ-----SEGFFVLIIDSETQELFAIRR---ASFAGRrnddsirlslrISMDI-PpTCrnrnVKVM 1917 Schizosacchar...
Q6BM64        727 r---gnskiK-----------HNFINTIIG-LSTGELLDFRRiaiLELVEGni-------nsFRLTAnVtDRqq-kIHCH 783  Debaryomyces ...
Q5D892        780 ----------------lqstkRHYADLIVGSEEENLIHFHEK------I-RmedfsspysvtVLLERpHqQTkv-tVKAD 835  thale cress
Q16RG8        798 ----------------yskklAVKISILVGDSNNNVLFFKEN------LDAnpggscwyqesFKLSDaTvAT----ATGH 851  yellow fever ...
A2PYH4       1016 ql-qtkrtaSD----------SHYVTLIIGDADNQVVYLHKI------TDSvllkagswakkIAVKRaLkSEd---LSIN 1075 human
A2RUV5        885 ql-qkkrtaPD----------SHFVMLVIGDDDNQAIFKQKI------MDSslfktgswtrkIEIKRaSkSTn---VCLN 944  tropical claw...
XP_001704428 2323 si-qaspfpQQFSSEVykkskPHTWFLVLSESETDTVIDYKR---LSGfar--------ersQEFIIpFvSS----LCIS 2386 Giardia lambl...
CBI34887      778 ----------------fqsikRYYADMVVGLEEDNLILFHEK------ISRvdefsspysttILLSTp-qQGkl-tVKAD 833  wine grape
EEE57380      692 ----------------vgsskQNYADMVVGSEEDNAILFHEK------Inpy-------svkLYVPCp-pNAra-tLKVD 740  Japanese rice
5GAN_B       2144 CVCDSYLDADKELSFE 2159 baker's yeast
O60072       1918 VVCDGYPLIYEHKIVl 1933 Schizosaccharomyces pombe 972h-
Q6BM64        784 ILSEDMVNIDARYVLS 799  Debaryomyces hansenii
Q5D892        836 LIFEEYIGIDLHETLL 851  thale cress
Q16RG8        852 VICSNWTGLDCSKSIV 867  yellow fever mosquito
A2PYH4       1076 LISSEFVGLDIQQKLT 1091 human
A2RUV5        945 LISSEYVGLDIQQSFN 960  tropical clawed frog
XP_001704428 2387 ALSDCFLGMDKEITID 2402 Giardia lamblia ATCC 50803
CBI34887      834 LIFEEYIGIDLHQKLL 849  wine grape
EEE57380      741 VIFEEYVGLDIHKKHV 756  Japanese rice
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