5M5P,5O9Z,5M5P


Conserved Protein Domain Family
Sec63

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pfam02889: Sec63 
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Sec63 Brl domain
This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Statistics
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PSSM-Id: 397157
View PSSM: pfam02889
Aligned: 85 rows
Threshold Bit Score: 129.626
Threshold Setting Gi: 521281198
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5M5P_C        732 ATDLGNIASSFYINHASMDVYNRELDEHT-TQIDLFRIFSMSEEFKYVSVRYEEKRELKQLL-EK--------------- 794  Saccharomyces...
Q9VF56       1821 PTFLGRISSYYYLSYRTMKHFLEDLQPGM-NTKKVLLAIADSYEFDQLPVRHNEDKHNEEMA-EV--------------- 1883 fruit fly
O60072       1618 PTTLGRIVSYYYLFHTTIRNFVQKITENA-EFDLALQLLAEASEFDDLAIRHNEDLINIEIN-KS--------------- 1680 Schizosacchar...
WP_020445466  486 PTALGRLASRFYLRLDTARGFHDLATREQiDDAGILRAVATAVEFDDVAARSDEADAVDAVLgER--------------- 550  Salinarchaeum...
Q6BM64        479 CTEYGDVMTKYYILYPTMRNIIRSKAGN--TLLDVLTIFSRSSEFSEFSIKYNEKKLYKAINlSPyi------------- 543  Debaryomyces ...
EEC73605      457 PLEPGRLMTKFYLKFDTMKLIVKA--SACcTLEDLLHIICHSAEITWIQLRRNEKKLLNEINaDK--------------- 519  long-grained ...
CBI34887      532 PLEPGRLMTKYYLKFGTMKHIMQT--PLNcSLEDALHIICRSEEIAWIQLRRNEKKFLNDINmDK--------------- 594  wine grape
Q5D892        534 PEEPGRLMTKYYLKFETMKYIINT--PTSySLDEALHIVCHAEEISWIQLRRNEKKTLNDVNaDK--------------- 596  thale cress
Q16RG8        556 ATLYGRLMAQYCLNFRTVKLLRK-IKGTE-PLLEIFTLLTYCDEFAVFKCRNSDKRTLNELNrSStrs-----------t 622  yellow fever ...
XP_552976     538 PSACGRLMARNQLSFPTLQLLQQGLKGRE-TLDEMLVLITRAHEFGEFTCRQGEKKILNTLNgPTisasfcdggddvtgg 616  Anopheles gam...
5M5P_C        795 --APIPIr--------------eDIDDPLAKVNVLLQSYF-SQLKFEG--------FALNSDIVFIHQNAGRLLRAMFEI 849  Saccharomyces...
Q9VF56       1884 --SRFRPps-------------sSWDSSYTKTFLLLQAHF-ARQSLPN--------SDYLTDTKSALDNATRVMQAMVDY 1939 fruit fly
O60072       1681 --LKYSAacl-----------nlPMVDAHVKAFILTQAHM-ARLKLPV--------DDYVTDTSTVLDQVIRIIQSYIDV 1738 Schizosacchar...
WP_020445466  551 --At-------------------DLPDGQRKVLAILQAAVaGTTP-----------NSLRSDAWIIRQNALRMLAALGAV 598  Salinarchaeum...
Q6BM64        544 -rFPLHSt---------------EFQDSD-KVMLLLQYEL-CGLDFPNspelmklyYSFEGDKCYVFKQASRIIRCMIDV 605  Debaryomyces ...
EEC73605      520 ------EgrlwfhvvgangkrkkRIQTREEKIFILANDCLtGDPLVHD--------LSLNQEMNSICSNGCRVAKCMREY 585  long-grained ...
CBI34887      595 ------DgqlrfhilgdkgkrkrRIQTREEKIFVLANDCLtGNPSVHD--------LSLTQDANAICSNGCRIAKCMKEY 660  wine grape
Q5D892        597 ------EgrlrfhindnkgkrkkRIQTREEKLFVLANDWLtGDPSVHD--------LSMTQDANSICSNGSRIARCMKEY 662  thale cress
Q16RG8        623 irFPLRg----------------RIQSTTAMASCLMQAVF-GNLPIED--------GSLQQEATKMINIGRRLIKCMTEF 677  yellow fever ...
XP_552976     617 vrFRWPr----------------RICTTGAKVYCLVQAVF-GNLPIND--------HGLHQEAAKMVTVGGRIARFVIGL 671  Anopheles gam...
5M5P_C        850 CLKRGW---------GHPTRMLLNLCKSATTKMW-PTNCPLRQFKTCPVEVIKRLEASTVPWGD-----------YLQLE 908  Saccharomyces...
Q9VF56       1940 TAERGW---------LSTTLVVQQLMQSVIQARW-FDGSEFLTLPGVNEDNLDAFLNIPHDDYDyltlpvlkelcKQEYE 2009 fruit fly
O60072       1739 SAELGY---------SHVCLQYISLMQCLKQACY-PSEIYRASLPGLNASSEKEARDYLNKFA--------------GNK 1794 Schizosacchar...
WP_020445466  599 LGEFAG---------PAAANECRRLEARIEHGVG-PDAAALTAIEGVGEGRARSLAQAGFESPA-----------EIAAA 657  Salinarchaeum...
Q6BM64        606 FRYKKD---------CVSLLNTLRFSRCVAGRCWeNSVTELKQLDGIDEECIKKLRKNNISGFAe----------AKYLS 666  Debaryomyces ...
EEC73605      586 FIYKKN---------YKSAISSMLLAKCLHQKLWeSSPFLLKQLPGIGIVTAKALKTAGIDSFEs----------LATAD 646  long-grained ...
CBI34887      661 FIYKKS---------YKGALNSILLSKCLLQKLWdDSPYLLKQLPGIGMVTAKALHSMGIVSFEa----------LAEAD 721  wine grape
Q5D892        663 FIYKKN---------YKGTLSSTLLAKSLYQKLWdDSPYLLKQLPGIGMVTAKALHSMGVRSFEa----------LAEAD 723  thale cress
Q16RG8        678 IYVGQGtigqdgggvYQALLSTVVLSQCLETKLWeNSPYITKQLKGIGAIYAGQLAARGKISFQe----------LLDTN 747  yellow fever ...
XP_552976     672 LTAKRDhpld--ggcFRALVSAATLLQCFQTKLWeDSPYVAKQLGQIGPRLARHLAERGKGTFGa----------IRHSD 739  Anopheles gam...
5M5P_C        909 TPAEVGRAIRSEKYGKQVYDLLK-R-FPKMSV-TCNA-------------------------QPITRSVMR-----FNIE 955  Saccharomyces...
Q9VF56       2010 VLAKPLRDAFEEHEIEKMYKVIQ-D-LPEIAI-QIFVegrhmeneyakrplslsddtrgewmSLHANEDYV-----LIVN 2081 fruit fly
O60072       1795 TDELYQMLCNDPNVFDIESLVNSlIsYPKMNI------------------------------EVSQSSSDK-----LLLY 1839 Schizosacchar...
WP_020445466  658 TPATVAAAGVGDGVAERIVDAAA-D-LPRIEIeWGDLpdsipa-------------gdrdfsEATIHNRGDgaqagVRVT 722  Salinarchaeum...
Q6BM64        667 QLQLEYFLGIEPGTGKNIAQSLQ-S-LPKFKInATLA-------------------------SNKVRTDLEtleisLIVS 719  Debaryomyces ...
EEC73605      647 ARKIESVTGRNYPFGDSIKSYLP-SlGPKIDInIEDA-------------------------G-NRQGKST-----IIVT 694  long-grained ...
CBI34887      722 PRRIEIVTGRKYPFGNHIKESLS-SlPPKVELkIEEI-------------------------ECQRQGKSK-----IVLI 770  wine grape
Q5D892        724 PRRIEIVTGRKYPFGNTIKESLS-SlPPKVEIkVEEV-------------------------DCQKQGISK-----LAVT 772  thale cress
Q16RG8        748 PRELEVILKKNPPFGSDLIAFVR-T-LPVFSI------------------------------DLVLKKDYF-----LEVT 790  yellow fever ...
XP_552976     740 PREIECIVKKPPPVGNDIVNFVS-G-LPEFTIkLCKV-------------------------EGAASGQPS-----FTCT 787  Anopheles gam...
5M5P_C        956 II-------------------ADWIWDMNV-HGSLEPFLLMLE--DTDGDSILYYDV---LFI-TPdivg---heftLSF 1006 Saccharomyces...
Q9VF56       2082 LQrlnvsgqrrgggqsytvhcPKYPKPK------NEAWFLTLG--SQANDELLAMKR---VSIrGQrct------nrISF 2144 fruit fly
O60072       1840 LRrlnqpln-----pdfyifaPLFPKPQ------SEGFFVLII--DSETQELFAIRR---ASFaGRrnddsirlslrISM 1903 Schizosacchar...
WP_020445466  723 VN-------------------GVEMTADETyLSDATTVPLALFgaDADE----------------------------LEL 755  Salinarchaeum...
Q6BM64        720 IGidnmer--------gnskiK------------HNFINTIIG---LSTGELLDFRRiaiLELvEGni-------nsFRL 769  Debaryomyces ...
EEC73605      695 LTrlsqa----------------------vgsskQNYADMVVG--SEEDNAILFHEKinpy-------------svkLYV 737  long-grained ...
CBI34887      771 LTrlsqs----------------------fqsikRYYADMVVG--LEEDNLILFHEKi------SRvdefsspysttILL 820  wine grape
Q5D892        773 LSrvsqp----------------------lqstkRHYADLIVG--SEEENLIHFHEKi-------RmedfsspysvtVLL 821  thale cress
Q16RG8        791 VNqkndc----------------------yskklAVKISILVG--DSNNNVLFFKENl------DAnpggscwyqesFKL 840  yellow fever ...
XP_552976     788 VAqnnth----------------------ydpeiAVSFCVLVG--DSSNRVLLHVDN----CTvESipvmg--ctwpLPV 837  Anopheles gam...
5M5P_C       1007 TYELKQHnqnnlppnFFLTLISENWWHSEFEIPVS 1041 Saccharomyces cerevisiae S288C
Q9VF56       2145 QA-TPRLgr----lqLTLYLMSDCLMGFDQQYDLQ 2174 fruit fly
O60072       1904 DI-PPTCrn----rnVKVMVVCDGYPLIYEHKIVl 1933 Schizosaccharomyces pombe 972h-
WP_020445466  756 AVEVVFPe-------LPLQPIEDR-----RTVAVE 778  Salinarchaeum sp. Harcht-Bsk1
Q6BM64        770 TANVTDRqq-----kIHCHILSEDMVNIDARYVLS 799  Debaryomyces hansenii
EEC73605      738 PCP-PNAra-----tLKVDVIFEEYVGLDIHKKHV 766  long-grained rice
CBI34887      821 STP-QQGkl-----tVKADLIFEEYIGIDLHQKLL 849  wine grape
Q5D892        822 ERPHQQTkv-----tVKADLIFEEYIGIDLHETLL 851  thale cress
Q16RG8        841 SDATVAT--------ATGHVICSNWTGLDCSKSIV 867  yellow fever mosquito
XP_552976     838 RDDSGAPie-----sLSAHLICQEWCGLDCSHTLW 867  Anopheles gambiae str. PEST
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