1UK0,3C49,1GS0


Conserved Protein Domain Family
PARP_reg

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pfam02877: PARP_reg 
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Poly(ADP-ribose) polymerase, regulatory domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
Statistics
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PSSM-Id: 335134
View PSSM: pfam02877
Aligned: 188 rows
Threshold Bit Score: 80.2658
Threshold Setting Gi: 470306492
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UK0_A         2 SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQ-GSs------DSQ-ILDLSN 73   human
XP_001769461 638 SRLHPRVINLMKMLFDLETYKAAMMEFEINMSEMPLGKLSKRHIERGYEVLTEIQNILKE-AVhgp--reQGL-LVDASN 713  Physcomitrella...
XP_002969183 616 SNLHPRVVSLMKMLFDIETYKSAMLEFEINPNEMPLGKLTKAHIAKGFDVLTRIQNVLKR-EQqdp--rrQVE-LIDGSN 691  Selaginella mo...
XP_018687013 454 CKLEPLVAKFMKVLCSQEIYRYAMMEMGYDCPDLPMGMVTDLHLERCEEELLNFREDIKKaPDssd--kaNVL-WLDFTN 530  wild Malaysian...
CBI28338     466 CKLEPLVANFMKVLCSQEIYRYAMMEMGLDSPDLPMGMLSNIHLKRCEEVLLNFIETVKS-IKemd-ikaKAT-WSDFSQ 542  wine grape
XP_002960621 343 CKLDPKVARFCKCLFSQAVYRHAMFEMGINSPELPLGSLSEFHFKRCEECLLEFADFLQK-ESdsk--khEQM-CLDFSN 418  Selaginella mo...
XP_015688619 497 CKLDPSVTFIMKQLCSQEIYRYALTEMGHDLPDLPIGMLTDLHLKRGEEILLQSKQDAES-VPesg--pvADAfWIEMSN 573  malo sina
XP_006591922 412 CKLEPLVANFMKVLCSQEIYKYALMEMGYDCPDLPIGMVTNLHLKKCEDVLLEFIDKVKS-LKetg--pkAEAvWTDFSQ 488  soybean
EMS61650     460 CKLDPAISFLLKQLCGQEIYRYALTEMAQDLPDLPVGMLTDLHLKRGEEVLLEWIRDAEA-VPesg--paADAlWIEISN 536  Triticum urartu
EMT10594     136 SSLAPQVLELMMMLFNVETYRAAMMEFEINMAEMPLGKLSKENIQKGFEALTEIQNLLDD-TGnqelalrESL-IVAASN 213  Aegilops tauschii
1UK0_A        74 RFYTLIPHdfgmkKPPLLNNADSVQ-AK-VE-MLDNLLDIEVAYSLL--RGGSDDSSkDPIDVNY 133  human
XP_001769461 714 RFFTLIPTv----hPMIISDEQTLK-SK-IH-MLDALRDIEIASEFLgsKVEEGTEEeDPLDTHY 771  Physcomitrella patens
XP_002969183 692 QFNTLIPSt----hPTLIDDEDVLK-TK-IQ-MLEALRDIEIASQLI--KSADEDDEsDPLDVHY 747  Selaginella moellendorffii
XP_018687013 531 KWFTFMHSv----RPFIMKNFQELAdHV-AA-GLECIRDINVASRLV--GDMSGATVdDPLSDRY 587  wild Malaysian banana
CBI28338     543 RWFTLLHSt----RPFIFRDHQEIAdHA-AA-ALEIVRDITVASHLV--GDLTGSTLdDPLFDRY 599  wine grape
XP_002960621 419 KWFSLVPSt----hPTVISDIAHLT-ELgAS-VLESLKAISVASHII--GDMTGDTLdDPLSDRY 475  Selaginella moellendorffii
XP_015688619 574 KWFTLFPTt----RPYTIRGYEQIA-DN-VAsGLETVRDINVASRLI--GDTFSSTLdDPLSQCY 630  malo sina
XP_006591922 489 RWFTLMHSt----RPFNFRDYQEIAdHA-AA-ALEGVRDITQASHLI--GDMTGSTIdDPLSETY 545  soybean
EMS61650     537 KWFTLFPTt----RPYIMRGFEQIA-DN-VAsGFETIRDINVASHLI--GDVFGSTLdDPLSECY 593  Triticum urartu
EMT10594     214 RFFTLIPSv----hPHIIRDKDHLT-MK-AK-MLEALQDIEIASKLV--GFDGDNDE--SLDDKY 267  Aegilops tauschii
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