Conserved Protein Domain Family
DDHD

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pfam02862: DDHD 
DDHD domain
The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.
Statistics
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PSSM-Id: 367219
View PSSM: pfam02862
Aligned: 164 rows
Threshold Bit Score: 82.129
Threshold Setting Gi: 384485021
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IAY0        225 KIHYLFMLGSPLSALLSLYkpeyindGLKlnnGL------------------------------------KFYNIFHGFD 268  Plasmodium fa...
GAC94672      786 NTHSFFAVGAPVALFFVLH-------RAQliaRSglvrssrfvrdepgv-------tldaegrfgclavtSFYNIWNQYD 851  Pseudozyma hu...
KIS66873      779 NTHSFFAVGAPVALFFVLH-------RAQliaRSgvvrssrfvrdepgi-------tlngegrfgclavtSFYNIWNQYD 844  Ustilago mayd...
CBQ69580      798 NTHSFFAVGAPVALFFVLH-------RAQliaRSglvrssrfvkdepgv-------tlasegkygclaitNFYNIWNQYD 863  Sporisorium r...
XP_016293157  791 NTHSFFAVGAPIALFFVLH-------RAQliaRSgrvrssrfvqdkpgv-------tldqagqygclavtQFYNIWNQYD 856  Kalmanozyma b...
KIS69730      667 NVKNLFLIGSPVAFFFHLN-------GGQliaRSgtqrhpnndsdav----------dgdtgrygclaaeNVYNIFNPND 729  Ustilago mayd...
XP_016290775  538 NVKNLFFIGSPVAFFFHLD-------GGQliaRSgtdrhpdnhgdal----------dgekgrygclateNVYNIFNPND 600  Kalmanozyma b...
KDE07713      486 DTRLFILVGSPLAFFLHLG-------QGQliaRRgrartqnvgrdia----------ldragrygcmaidAVYNVYHETD 548  Microbotryum ...
XP_016270395  679 DTRVLFLVGSPLAFFLHLG-------KGQliaRAgrertkhvardia----------leragrygclavdAVYNVYQETD 741  Rhodotorula t...
EHS63636      617 DTSKVFLVGSPVAFFFHLH-------RAQliaREgvssstrldsknsaewrkanrvstdevgqygclaaeTIYSVYISTD 689  Puccinia gram...
Q8IAY0        269 PVAFRIEPLIYPGI-KNIpEPVLINYWRNnGARYw----------------------FEWDKNMQNAKLAIVQNLNDFTS 325  Plasmodium fa...
GAC94672      852 PVATRASPCVDVQYaKMV-KPVPLNKAIRsILRAdpeadnhdiaedggsqsfgsgnaFDSNSGTAKRRAA--KRTKGFFG 928  Pseudozyma hu...
KIS66873      845 PVATRASPCVDVQYaKQL-KPVPLNKAIRsILRAdpeaenhdiaedggtwsfgsgnaADPDARVAKRKAAAVKRTKGFFG 923  Ustilago mayd...
CBQ69580      864 PVATRASPCVDVQYaKLL-KPVPLNKVIRsILRAdpdaenldiaedggsqsfgshnaPDSDAGTAKRKAAAAKRNKGFFG 942  Sporisorium r...
XP_016293157  857 PVATRATPCVDVQYaKLL-KPVPLNKAIRsVLRAdaeadnhdiaedggsqsfgsgreGDSDSGIAKRKAAAAKRTKGFFG 935  Kalmanozyma b...
KIS69730      730 PVAFKLAPTVDSAYaKLI-KPVAIESAAEaVLRTl----------------------SLPRMSVTQVFEKYKDHPFQGVG 786  Ustilago mayd...
XP_016290775  601 PVAFQLAPTVDSAYaKLI-KPISIESATEvILRSl----------------------SLPRISVSRVFEKYKDRPFQGVG 657  Kalmanozyma b...
KDE07713      549 PVAFALNATVDREYaKLI-KPIAIPSTNStLFENl----------------------SDTYSRISNVLDISRFWSSP--- 602  Microbotryum ...
XP_016270395  742 PVAFLLAPTVDVRYaKLI-KPVAIPSSNQtLLQNl----------------------SDAYHRVSKIFDMSS-------- 790  Rhodotorula t...
EHS63636      690 PVAYSMNACVDCGHsKRI-KPIDAHSFTKkF-----------------------------------LETMRRKRPIAEPE 733  Puccinia gram...
Q8IAY0        326 AITng---------------------------------------fyKFlgknenndedqstlnknicynkceskdinifl 366  Plasmodium fa...
GAC94672      929 SWSrragaaaavrkpqaa--------------dkgdgeqtgdesacRSsm------------------------------ 964  Pseudozyma hu...
KIS66873      924 TWSrrteaataprktqav-------------eeddgekigdddsalRSsm------------------------------ 960  Ustilago mayd...
CBQ69580      943 SWSrkageatraarpktka------------agegdgeqtgdegvpRSsm------------------------------ 980  Sporisorium r...
XP_016293157  936 SWSkkageaaktvnqarlaans-----iakaaaegdgdqtgdesvpRSsm------------------------------ 980  Kalmanozyma b...
KIS69730      787 KIIrqarilekddtalpcdlspdeqrhvsrrekgkciveasdyiqtVRkw------------------------------ 836  Ustilago mayd...
XP_016290775  658 KIVrqarilenkqdalpsdlseleekhlkqrklgkrivdasdyiqtVRkw------------------------------ 707  Kalmanozyma b...
KDE07713          -------------------------------------------------------------------------------- Microbotryum ...
XP_016270395      -------------------------------------------------------------------------------- Rhodotorula t...
EHS63636      734 ST------------------------------------------------------------------------------ 735  Puccinia gram...
Q8IAY0        367 lkVKENQRKIALQKKKIHRYNKknnitykenvaekknahyNSIHNINDNNicdnicdnicenicdnicdnirdnirdnmr 446  Plasmodium fa...
GAC94672      965 -eVSEADEAKDARPDVQGLRSKlaekareeekrkeerermADEERK---------------------------------- 1009 Pseudozyma hu...
KIS66873      961 -dVSETEEAREARTEAESLRSKfaakareeedrkeerkriADEERK---------------------------------- 1005 Ustilago mayd...
CBQ69580      981 -dVSETDEVREAREDAEGLRSKlaakarqeekrkeereriADEERK---------------------------------- 1025 Sporisorium r...
XP_016293157  981 -dVSDTDESKGSR-QVEDLRSKiaakareeekrkverdriADEDRK---------------------------------- 1024 Kalmanozyma b...
KIS69730      837 -qHLRDASATACDLGAAGS-ARemeterasrltrrtrsttLIWDRSSA-------------------------------- 882  Ustilago mayd...
XP_016290775  708 -hKLQNADPGSADAGAATPEKReleteegrrkkmlqpetaLRTSSIPGEE------------------------------ 756  Kalmanozyma b...
KDE07713      603 --EKNEALEGSKNEGPPGSNSGteaysaekvgrgqsssnlAAKPKMPARRptnk-------------------------- 654  Microbotryum ...
XP_016270395  791 --LWGSSGATTGEDGKPKSGEEakeqtvkqeqekvesakpARRPSGPKRMpte--------------------------- 841  Rhodotorula t...
EHS63636      736 --LTRNVSLSSLSSLVASSWMGstkkrepddlintnngnpQATLIGDVIRpscsplppsdppprpprptsmini------ 807  Puccinia gram...
Q8IAY0        447 dnirdnicdhhlndisyndedsqdtyfghekykrkydhndeqkkegtyyskeenssyIDSTKSICASQDSNSEYSffdhe 526  Plasmodium fa...
GAC94672     1010 -------------------------------------------------------------KGMSDKRKARAEAR----- 1023 Pseudozyma hu...
KIS66873     1006 -------------------------------------------------------------KGISAKRQARAEAR----- 1019 Ustilago mayd...
CBQ69580     1026 -------------------------------------------------------------KGMSAKRKARAEAR----- 1039 Sporisorium r...
XP_016293157 1025 -------------------------------------------------------------KGISDKRKARAEAR----- 1038 Kalmanozyma b...
KIS69730      883 ----------------------------------------------------------RNVVS----------------- 887  Ustilago mayd...
XP_016290775  757 ---------------------------------------------------------ADDKHDFDLDSLERAERR----- 774  Kalmanozyma b...
KDE07713      655 -----------------------------------------------------rmpsEMPMGKREFESVSRAEQR----- 676  Microbotryum ...
XP_016270395  842 -------------------------------------------------------rvKSGAGSAEYEWVSRAEKR----- 861  Rhodotorula t...
EHS63636      808 ----------------------------------gwsdlvrkrtrvftassstenirDEHLKKSKHGEDTLGRMR----- 848  Puccinia gram...
Q8IAY0        527 lsdnsnnlyeenrrnyddhnkkresicnSNNINDALniRYDYQLQ-EFIMEHy---iYPLAVAKSHFNYFIIKDISFFIL 602  Plasmodium fa...
GAC94672     1024 ----------------------------LRALNPLH--RIDFCMPvEG-YSLlstinQYTELMTAHMSYWAKVDFADFLI 1072 Pseudozyma hu...
KIS66873     1020 ----------------------------LRALNPLH--RIDFYMPvEG-YSLlssinQYAELMTAHMSYWTKVDFADFLI 1068 Ustilago mayd...
CBQ69580     1040 ----------------------------LRALNPLH--RIDYYMPvEG-YSLlstinQYAELMTAHMSYWTKVDFADFVI 1088 Sporisorium r...
XP_016293157 1039 ----------------------------LRALNPLH--RIDYYMPvEG-YSLlssinQYAELMTAHMSYWTKVDFADFLI 1087 Kalmanozyma b...
KIS69730      888 -----------------------------APLNPHG--CIDYHLSeSISl------sAYLDALGAHLCYWTHRDFAVFVL 930  Ustilago mayd...
XP_016290775  775 ----------------------------FRALNPHG--CIDYHLSaSISl------sGYLDMFGAHLSYWGHRDFAVFIL 818  Kalmanozyma b...
KDE07713      677 ----------------------------FKALNPQG--CIDFYMPaEGi-------nQYIDALSSHASYWSSDSVATFVL 719  Microbotryum ...
XP_016270395  862 ----------------------------MKALNASG--TVDFYLPsEGi-------sQYIDALTSHQNYWTDRRFSTFVL 904  Rhodotorula t...
EHS63636      849 ----------------------------FLGLNPTG--SVDFVIPsLGl-------nQYVDMVTAHAAYWTDNRFARLVL 891  Puccinia gram...
Q8IAY0        603 KELI 606  Plasmodium falciparum 3D7
GAC94672     1073 TQLM 1076 Pseudozyma hubeiensis SY62
KIS66873     1069 TQLM 1072 Ustilago maydis 521
CBQ69580     1089 TQLM 1092 Sporisorium reilianum SRZ2
XP_016293157 1088 TQLM 1091 Kalmanozyma brasiliensis GHG001
KIS69730      931 TQLF 934  Ustilago maydis 521
XP_016290775  819 TQLF 822  Kalmanozyma brasiliensis GHG001
KDE07713      720 TQLF 723  Microbotryum lychnidis-dioicae p1A1 Lamole
XP_016270395  905 SQLF 908  Rhodotorula toruloides NP11
EHS63636      892 Iglf 895  Puccinia graminis f. sp. tritici CRL 75-36-700-3
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