2YW2,1GSO,2QK4,2XD4,2IP4


Conserved Protein Domain Family
GARS_N

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pfam02844: GARS_N 
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Phosphoribosylglycinamide synthetase, N domain
Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam00289). This domain is structurally related to the PreATP-grasp domain.
Statistics
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PSSM-Id: 335123
View PSSM: pfam02844
Aligned: 1018 rows
Threshold Bit Score: 61.2062
Threshold Setting Gi: 530555862
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YW2_A         2 KVLVVGNGGREHAIAWKVAQSPLVKELYVAKGNAGIweiakrv--disptdvEK------LAEFAKNEGVD--FTIVGPE 71
gi 123746096   2 KVLVIGNGAREHAIVWKLSQSPKVTKIYVAPGNAGTsliaenv--aisctniKG------LLAFAKDNSID--ITFVGPE 71
gi 31340311    2 NILVVGNGGREHAISWKIAQSIFSKKIYVAPGNAGTeidyklknidissndiNK------LVKFAKEKKID--LTIVGPE 73
gi 503144853   2 KVLVIGSGGREHVLTWKIAQSPKVDKIYCAPGNGGMakiaecv--dlsvediDG------CVKFAREKGID--LTVVGPE 71
gi 504122039   2 KVLMIGSGGREHVLTWKIAQSPRVEKIYAAPGNGGMaalaecv--dlsvediPG------CLDFAKKHDID--LTVVGPE 71
gi 645064863   2 KVLVIGNGGREHAIVWTLSKSQRVDKIYCAPGNAGTaaiaenv--disadniDA------LLDFAKKNDIG--LTVVGPE 71
gi 501881948   2 KILVVGSGGREHALTWKISQSTMVDKIYCAPGNAGTtqyaenl--aikaddiEA------LGLFAKENGVD--LTVVGPE 71
gi 408365458   2 NVLIVGSGGREHAIGWKISQSRHVDKIYFAPGNGGtfenld-----ikqndiDK------LVSFAKKQRSKklLTIVGPE 70
gi 501490868   2 KVLILGSGAREHALAWAIARHPSVQKIYVAPGNGGIhhlgei-----aenipfKaddidgLLKFAKENKIG--LTIVGPE 74
gi 501496810   2 KVLVIGSGAREHALVRSISNSQRVGKVFAAPGNGGTaimggk-----vqnvalKatdieaLLAFVTSEDID--LTVVGPE 74
                         90       100       110
                 ....*....|....*....|....*....|.
2YW2_A        72 APLVEGIVDEFekR--GLKIFGPNKEAAKLE 100
gi 123746096  72 APLAGGVVDVF--AsaGLRIFGPCREAAQLE 100
gi 31340311   74 EPLSNGISDVF--SyyKLPIFGPKKFSAKLE 102
gi 503144853  72 VPLVMGMTDAF--EkeGMRVFGPNAKCAEFE 100
gi 504122039  72 VPLVMGMVDAF--EaeGLKVFGPNKQCAQFE 100
gi 645064863  72 VPLVLGIVDLF--EseGQRIFGPNRQCAMLE 100
gi 501881948  72 VPLSMGIVDHF--EsmGLRAFGPNKKAAQLE 100
gi 408365458  71 EPLSLGIVDAF--EkeDLRIFGPTRQAAMLE 99
gi 501490868  75 QPLEKGIVNRFknH--GLKIFGPSQEAAQLE 103
gi 501496810  75 QPLEMGIVDRFrsE--GLSIIGPDRYAAQLE 103
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