1DVK


Conserved Protein Domain Family
Prp18

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pfam02840: Prp18 
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Prp18 domain
The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles.
Statistics
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PSSM-Id: 367213
View PSSM: pfam02840
Aligned: 98 rows
Threshold Bit Score: 146.865
Threshold Setting Gi: 7546208
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DVK_A    38 YIHEILSRWKASLEAY--HPE---------------LFLDTKKALFPLLLQLR-RNQLAPDLLISLATVLYHLQQpKEIN 99  baker's yeast
ETO10516 233 FFKRLLRDWEKSLLQR--SEEakqsve---gkhetmRQKQTRRDIRPLFKQLK-NRTVPIDVLDKSEKIVKAVEK-RDYS 305 Reticulomyxa filosa
Q22HI6   212 WSQKTLRDWEQKLEQRftTDEqkksvl---arkligNFRQTSEYLKPLFKLLK-EKKCSQDILDGLYIVVNYALQ-REYV 286 Tetrahymena thermop...
EEA06207 181 WISIQLEELKKQLKNR--SIEeaesnk---gkqesaQYYQTERDLKPLIRLLRsESQMDKEVLDKLYEIVQYCCS-REYI 254 Cryptosporidium mur...
Q4Z6M5   137 WIKNTMKEWNEEIENN--IDDkkki--------kqaTYLQTHKDLKPLEKKLK-QKTLDYDILEKIYNIVYHCEK-KNFK 204 Plasmodium berghei
EDO07478 145 WVSTTLNKWEQHILSQ--REEflqegnvaearrrdaMLAQTKKDLQPLINMLK-SQTLEEEILEKMYNVVICCEK-KDYQ 220 Babesia bovis
Q4UJ31   264 WISMKLNEMEEEMMKK--KLElikegkefeikkneaTLVQTKKDIKPLLKLIK-LNKLDEEILEKMYNIIISCDE-GNYK 339 Theileria annulata
Q4N6I7   171 WVSRMLREWESRIVES--KGDlikegkefeakkneaMLVQTKKDIKPLLKLIK-SNKLDQEILDKMEQIVNHCNN-GQFK 246 Theileria parva
CDI79766 201 WARKMLSLWEDELKHR--SEDekatae---grqqtaLHRQTKKDLKPLFKKLK-QRDLEADILEKLFSIVQLCDE-RRYR 273 Eimeria acervulina
ESS29569 273 WIRTMLQEWEAELKAR--PEEkknsae---gklmtsLQRQTRKDLKPLLRKLR-HKELENDILQKLHIMVQCCEE-RKYR 345 Toxoplasma gondii VEG
1DVK_A   100 LAVQSYMKLSIGNVAWPIGVTSVG-------------------IHARSAHSkiqggrnaanIMIDERTRLWITSIKRLIT 160 baker's yeast
ETO10516 306 LAKTIFLELAIGNAPWPMGVTMVEsllflfiyfslfsfcksciFHLKKKKD----------VMNDETQRKYIHAMERIIS 375 Reticulomyxa filosa
Q22HI6   287 KANDKYLALAIGNAAWPMGVTMVG-------------------IHERAGRSkifss-qvahILNDETTRKYLQSMKRLVT 346 Tetrahymena thermop...
EEA06207 255 KAHDKYIELAIGNAPWPMGVTMVG-------------------IHERASRTkifss-hiahVLNDETTRKYIQMFKRLIT 314 Cryptosporidium mur...
Q4Z6M5   205 AAHDAYMLLAIGNAAWPMGVTMVG-------------------IHERAGRSkifas-evahILNDETTRKYIQMIKRLLS 264 Plasmodium berghei
EDO07478 221 AAHEAYMLLAIGNAAWPMGVTMVG-------------------IHERAGRSkifts-evahILNDEKTRKYIQMIKRLLS 280 Babesia bovis
Q4UJ31   340 KAYDIYMLLAIGNAAWPMGVTMVG-------------------IHERAGRSkiyts-evahILNDETTRKYIQMFKRLIT 399 Theileria annulata
Q4N6I7   247 KAHDIYMLLAIGNAAWPMGVTMVG-------------------IHERAGRSkifts-evahILNDETTRKYIQMFKRLIS 306 Theileria parva
CDI79766 274 DAHGAFMLLAIGNAAWPMGVTMVG-------------------IHERAGRSklnts-qvahILNDETTRKYIQMFKRLMS 333 Eimeria acervulina
ESS29569 346 SAHDTYMLLAIGNAAWPVGVTMVG-------------------IHERVGRSklfss-qvahILNDETTRKYIQMFKRLMS 405 Toxoplasma gondii VEG
1DVK_A   161 FEEWY 165 baker's yeast
ETO10516 376 FGQTK 380 Reticulomyxa filosa
Q22HI6   347 VQQLM 351 Tetrahymena thermophila SB210
EEA06207 315 HCQRQ 319 Cryptosporidium muris RN66
Q4Z6M5   265 FCQRK 269 Plasmodium berghei
EDO07478 281 FAQNq 285 Babesia bovis
Q4UJ31   400 FSQNK 404 Theileria annulata
Q4N6I7   307 FSQSK 311 Theileria parva
CDI79766 334 FAQRK 338 Eimeria acervulina
ESS29569 406 FCQRR 410 Toxoplasma gondii VEG
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