1DVK


Conserved Protein Domain Family
Prp18

?
pfam02840: Prp18 
Click on image for an interactive view with Cn3D
Prp18 domain
The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles.
Statistics
?
PSSM-Id: 335121
View PSSM: pfam02840
Aligned: 100 rows
Threshold Bit Score: 142.233
Threshold Setting Gi: 7546208
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1DVK_A        42 ILSRWKASLEAYHPE--------------LFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQpKEINLAVQSYMK 107 baker's yeast
XP_012894992  42 LLKEWADDLAARPLEekkspe--greatkQCQQVADTLKGFFKLCTKRRIPYDIRRNLLKIRDQMEE-GDYREAYRTYLL 118 Blastocystis ho...
XP_001291917 109 IFKEWRYRLNELPDEelaqk----rdelcNMWYCLFALQPVFDGLNNRTLSTELTVNIERIVDALKK-TDFSKAYGAYND 183 Trichomonas vag...
XP_002956229 239 WMREWEDDLEHRPDVvkdsss--giqatfAYKQTARNMEPLYDRLRNRQLADELLTGLWMMVQAMRN-RNYLHANDIYLK 315 Volvox carteri ...
XP_001693701  14 WMKEWEEDLDRRPDAmkdsisgacinstyAFEQTKRNLVPLYDRLKHRQISDELLTGLWMMVQAMRS-RNYLHANDIYLK 92  Chlamydomonas r...
EJK76248     236 LIRQWEEDLALRPEAvkksma--grnetkTLKQCKDYIRPLFQLCKRRELEEDLQLHLFNIVTYCEQ-GEFVKANDSYMD 312 Thalassiosira o...
XP_002292101   9 LLRQWEEDLAQRSDAikrtaa--gknetkTVKQCKDYIRPLFQMCKRRELEVDMEKHLLKIVTFCEQ-GEFVRAHDAYLD 85  Thalassiosira p...
XP_002180690  27 LLREWEDDLEKRTDDlkrtvg--grnetkTLKQCKDYIKPLFKLCKNRRLEESLLNNILKIVDDCQA-GEFVRAHDTYMD 103 Phaeodactylum t...
XP_009037226 200 HLKSWEATLVARADAakrapq--grvetkTYKQCKDYIRPLVKLCKKRELNAGLKAALVEMIDFCEA-GEFVKANDAYIL 276 Aureococcus ano...
CBJ28860     296 LLKEWEMDLNARPDHvkrtvq--gkletkTQKQAKDYMRPLFKLCKQKALPDGILNNLVTMINFMKE-GEFVRANDIYIL 372 Ectocarpus sili...
1DVK_A       108 LSIGNVAWPIGVTSVGIHARSAHSKIqG----GRNAANIMIDERTRLWITSIKRLITFEEWYTSN 168 baker's yeast
XP_012894992 119 ITVGNAAWPIGVAATGIYERSSRERI-T----QSSVGHAMLNDTVRIYLTMIKRLMNYKESKSPg 178 Blastocystis hominis
XP_001291917 184 LAIGNNVWPIGVTQYSIHWKFSMDLM-D----SKNVLHIFNSEAGRNAVLSLRRFINIYKQIHNP 243 Trichomonas vaginalis G3
XP_002956229 316 LAIGNAPWPIGVTSVGIHERSAREKI-ShvmnTNGQAHIMNDEATRKYFQSIKRLITQLQRLYPT 379 Volvox carteri f. nagariensis
XP_001693701  93 LAIGNAPWPIGVTSVGIHERSAREKI-ShvmnSTSHAHIMNDEATRKYFQGMKRLVTIVQRLYPT 156 Chlamydomonas reinhardtii
EJK76248     313 VAIGRAAWPIGVTMVGIHARSGRARI-E----SSNVAHVMNSELHRKYLTSVKRLMRYAQNKRPd 372 Thalassiosira oceanica
XP_002292101  86 VAIGRAAWPIGVTMVGIHARSGREKI-G----SANVAHVMNSEFHRKYLTSVKRLMSYDQRKrvd 145 Thalassiosira pseudonana CCMP1335
XP_002180690 104 VAIGRAPWPIGVTQVGIHSRTGRAKI-E----SQNVAHVMNSELQRKYLTSIKRLMTFAQTKrtd 163 Phaeodactylum tricornutum CCAP...
XP_009037226 277 VAIGNSAWPIGVTSVGIHTRTARENV-E----QKNVAHVMNNEMQRKYLTSMKRLMKFAQDQRPd 336 Aureococcus anophagefferens
CBJ28860     373 TAIGNAPWPIGLTMVGIHERSGRERI-S----SKNVAHIMNNEAQRKYLVSVKRLMTYLQDKRPd 432 Ectocarpus siliculosus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap