2EKI,1WWT,1QF6,4A9A


Conserved Protein Domain Family
TGS

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pfam02824: TGS 
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TGS domain
The TGS domain is named after ThrRS, GTPase, and SpoT. Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role.
Statistics
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PSSM-Id: 335112
View PSSM: pfam02824
Aligned: 59 rows
Threshold Bit Score: 57.5576
Threshold Setting Gi: 141353
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EKI_A  12 VRIYTkPKGQLPDYTSPvvlpysrTT-VEDFCMKIHKNLIKEFKYALVWGlsvkhnpQKVGKDHTLEDEDVIQIVK 86  human
P52709  82 IQITL-PDGKIHEGKTW-------RTtPFEIAERISKGLAEAAVIAKVNG-------AVWDLDRPFEGNAKLELLK 142 Caenorhabditis elegans
P04801  75 LKIVL-KDGAVKEATSW-------ETtPMDIAKGISKSLADRLCISKVNG-------QLWDLDRPFEGEANEEIKL 135 Saccharomyces cerevisiae ...
Q9RSP3   1 MHVTL-PDGKQLDLQPG-------AT-ALDAAKAIGPRLAQDALGATANG-------ELTDLMTPLSDGASITLIT 60  Deinococcus radiodurans R1
P56881   1 MTVYL-PDGKPLELPEG-------AT-AKDVARALGEGWERRAVGAIVDG-------ELYDLLKPLPQGAKVRLLT 60  Thermus thermophilus HB8
O84585   1 MIHVT-CNQEAFELPEG-------AS-AMDLANKMKQSHCF--AGALIND-------QEKDLSTTLQDGDTVLFLT 58  Chlamydia trachomatis D/U...
O25466 418 IVVFS-PHGDTYTLPVG-------AI-ALDFAYMVHSDLGDKATDAYINS-------KKALLNQELRSGDVVKIIK 477 Helicobacter pylori
P43811 362 IYVFT-PKGRIVELPMG-------AT-AVDFAYAVHSDVGNTCVGVTVEH-------KPYPLSKALESGQTVNIIT 421 Haemophilus influenzae Rd...
O69970 446 ITVFR-PDGGTLGLPDG-------AT-CVDAAYAQYGEDAHATIGARVNG-------RLAPMSTVLRDGDTVQLLM 505 Streptomyces coelicolor
1WWT_A  12 IKVTL-PDGKQVDAESWk------TT-PYQIACGISQGLADNTVIAKVNN-------VVWDLDRPLEEDCTLELLK 72  human
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