1AXD,4XT0,5DQS,3GTU,1ML6,1VF1


Conserved Protein Domain Family
GST_N

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pfam02798: GST_N 
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Glutathione S-transferase, N-terminal domain
Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognized); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognized). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.
Statistics
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PSSM-Id: 335096
View PSSM: pfam02798
Aligned: 28 rows
Threshold Bit Score: 62.313
Threshold Setting Gi: 122113188
Created: 19-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AXD_A         1 APMKLYGAVMSWNLTRCATALEEAGSDYEI--VPINFataEHKS-PEHLVRNPF--GQVPALQ-DG------DLYLFESR 68  Zea mays
P40921         2 SVGTVYGKIGSPRVLFCVSVAAVAGVEVEH--VDVQPhnfP----ADLAAKFPL--QKMPVFV-GKd-----GFPLSETL 67  Schizosaccharom...
P36008         2 SQGTLYINRS-PRNYASEALISYFKLDVKI--VDLEq--sSE-----FASLFPL--KQAPAFL-GPk-----GLKLTEAL 63  Saccharomyces c...
P29547         2 SQGTLYANFR-IRTWVPRGLVKALKLDVKV--VTPDa--aAEQ----FARDFPL--KKVPAFV-GPk-----GYKLTEAM 64  Saccharomyces c...
P40582         3 LPIIKVHWLDHSRAFRLLWLLDHLNLEYEI--VPYKRdanFRAP-PELKKIHPL--GRSPLLE-VQdretgkKKILAESG 76  Saccharomyces c...
P34345        23 GSFRVYNMRFCPWAERAMLYVAAKGIEAEV--VNLNVtd-----kLEWYWTKHYq-GKAPAVE-Hn------gKVVIESG 87  Caenorhabditis ...
P26641         2 AAGTLYTYPENWRAFKALIAAQYSGAQVRVlsAPPHFhfgQTNRtPEFLRKFPA--GKVPAFE-GDd-----GFCVFESN 73  human
5DQS_A         4 AAGTLYTYPENWRAFKALIAAQYSGAQVRVlsAPPHFhfgQTNRtPEFLRKFPA--GKVPAFEgDD------GFCVFESN 75  human
1VF1_A         5 PVLYYFNGRG--KMESIRWLLAAAGVEFEE--VFLET---REQY-EKLLQSGILmfQQVPMVE-ID------GMKLVQTR 69  chicken
XP_012809037   2 aGGTLYTYPDNWRAYKPLIAAQYSGFPIKVasSPPEFqfgVTNKtSEFLKKFPL--GKVPAFE-GNd-----GFCLFESS 73  western clawed ...
1AXD_A        69 AICKYAAR 76  Zea mays
P40921        68 AIAFYLAS 75  Schizosaccharomyces pombe 972h-
P36008        64 AIQFYLAN 71  Saccharomyces cerevisiae S288c
P29547        65 AINYYLVK 72  Saccharomyces cerevisiae S288c
P40582        77 FIFQYVLQ 84  Saccharomyces cerevisiae S288c
P34345        88 FIPEYLDD 95  Caenorhabditis elegans
P26641        74 AIAYYVSN 81  human
5DQS_A        76 AIAYYVSN 83  human
1VF1_A        70 AILNYIAg 77  chicken
XP_012809037  74 AIAHYVGn 81  western clawed frog
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