Conserved Protein Domain Family
POT1

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pfam02765: POT1 
Telomeric single stranded DNA binding POT1/CDC13
This domain binds single stranded telomeric DNA and adopts an OB fold. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms.
Statistics
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Aligned: 47 rows
Threshold Bit Score: 54.6705
Threshold Setting Gi: 549066
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2Q1P8    34 YVELAKASlTSGESQNFYGVIIDATFPYK--TNKDKYICSLKVVDPSqhik----------glkgTGDGNDYATVVLYAK 101 Eschaneustyla sp. L...
Q330J1   314 DRSVEKA--ALKQDVSLSAVVLTEIDKKHanLPVHSLQDLFHNIDNDk-----------------EISGKDTLRTQFFVS 374 Paraurostyla weissei
Q2Q1P7   299 EKQPDKA--SLKKGVNMQAVVLTEIDKKHanLPNTPLSELFHHADTDp-----------------ELQNKNTFRTTFQVI 359 Urostyla grandis
P29549   318 SVEVA----SLKKNVSLNAVVLTEVDKKHaaLPSTSLQDLFHHADSDk-----------------ELQAQDTFRTQFYVT 376 Sterkiella nova
Q330J0   307 DKALEKA--ALRQDVSLSAVVLTEVDKKHaaLPTHSLQDLFHNVDTDr-----------------ELAGKDTFRTQFYVT 367 Uroleptus sp. WJC-2003
P29550   313 dkSVEKA--ALKQDVSLSAVVLTEVDKKHagLPTHSLQDLFHNADTDk-----------------EISSKDTFRTQFYIT 373 Stylonychia mytilus
O76380   316 drAVEKA--ALKQDVSLSAVVLTEVDKKHagLPAHSLHDLFHNADSDk-----------------ELSSKDTFRTQFYVT 376 Sterkiella histriom...
Q6CJ70   527 VSNIVPS--ASSRYYTVIGLAVTVKY-----TGGKTLVLSFTDFTANpkvnygyd--sflgsfqeRIPENEHVHALIYLN 597 Kluyveromyces lactis
EDO14425 411 FKDLVLNE-SEIKYVTMMGLLVSCSFEHK--SFAKLIFTDFTKNNVTqnflfdr----flidynnKIDIDEGFRVVMYLN 483 Vanderwaltozyma pol...
Q75E25   511 ALSIDQLS-ATTSSATIFAMLICAR------VDPGSKVHHFSFTDFTenllisckldpylndycnRLKATECIYVKSYPE 583 Eremothecium gossypii
Q2Q1P8   102 EFKDLPIVSRIGDIIRVHRATLRLHNHQRQFNASIFFNSS-------WSLFSTDKKtpaqeaggaegqqnENVPYQFSGK 174 Eschaneustyla sp. L...
Q330J1   375 KIEP-SDVKEWVKAYDRKTKKATSLKGAAAAKGGENIFQVqflakdaSTQLNSNTYri-----------lLYTHEGLGAG 442 Paraurostyla weissei
Q2Q1P7   360 KIEP-SDVKEWAKSYDKKTKQASSLKG---GKGANPIFQVqflvkdaSTQVNNHTYri-----------lLYTHDGLGAN 424 Urostyla grandis
P29549   377 KIEP-SDVKEWVKGYDRKTKKSSSLKGAS-GKGDNIFQVQflv-kdaSTQLNNNTYrv-----------lLYTQDGLGAN 442 Sterkiella nova
Q330J0   368 KVEP-SDVKEWVKSYDKKTKKSASIKGAAAKGDNLIYQVQllv-kdaSTQLNNNTYrv-----------lLYTHDGLGAN 434 Uroleptus sp. WJC-2003
P29550   374 RVEPVDVK-EWVKSYDRKTKKPSSHKGAGAKGGENIFQVQflv-kdaSTQLNNNTYrv-----------lLYTQDGLGAN 440 Stylonychia mytilus
O76380   377 KIEP-SDVKEWVKAYDRKTKKVTSLKGSAAKGGDNIFQVSflv-kdaSTQLNNNTYrv-----------lLYTHDGLGAN 443 Sterkiella histriom...
Q6CJ70   598 RVESLNE--KLQSIIKMGLMECADKGNSNITHRSIIFKFTv-----kCQLFQGKLNtv-----------iLDADPITPTT 659 Kluyveromyces lactis
EDO14425 484 QFEKFEK--SIIEAYGYEIKKMFINDNENLTHKGIICKLSl-----kVKMFNGKLNai-----------lRECSLIRNEG 545 Vanderwaltozyma pol...
Q75E25   584 YIHNLDAY----TLRHYNRRLVDCHNGRDTNLTNFGMVFRlk---ldVKSYQQRINgi-----------iREAVLITGDT 645 Eremothecium gossypii
Q2Q1P8   175 HYTFEKHEGAI-LSNLRKWAS 194 Eschaneustyla sp. LCW-2005
Q330J1   443 FFGAVKPDNLYkNNEARKKLE 463 Paraurostyla weissei
Q2Q1P7   425 FFGINADNLHK-NDGARKKLE 444 Urostyla grandis
P29549   443 FFNVKADNLHK-NADARKKLE 462 Sterkiella nova
Q330J0   435 FFPVKADNLYK-NNDARKKLE 454 Uroleptus sp. WJC-2003
P29550   441 FFNVKPDNLYK-NNDARKKLE 460 Stylonychia mytilus
O76380   444 FFNGVKADNLHkNADARKKLE 464 Sterkiella histriomuscorum
Q6CJ70   660 PV--TTEEYKL-LKPLRNKIF 677 Kluyveromyces lactis
EDO14425 546 IQNLKIDEKLQ-LESIHKQIL 565 Vanderwaltozyma polyspora DSM 70294
Q75E25   646 RF--TGDEERL-LEAFYNRAF 663 Eremothecium gossypii
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