1JEQ


Conserved Protein Domain Family
Ku

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pfam02735: Ku 
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Ku70/Ku80 beta-barrel domain
The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer.
Statistics
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PSSM-Id: 335067
View PSSM: pfam02735
Aligned: 241 rows
Threshold Bit Score: 37.1887
Threshold Setting Gi: 802680931
Created: 19-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JEQ_B       253 IGSNLSIRIAAYKSIlQErVKKTWTVVDAKTlkKEdiQK---ETVYCLND---------D-D--EtEVL--KEDIIQGFR 315
gi 74803823  191 LSDDVSLAVNVYSLR-RRpRYPKKVRLLRTT--NEviVS---KRVHMSSTfsdereeedTk---V--LL--PGEQRKSIA 257
gi 226694180 264 LGPNLSMSVQYYNYF-QRrAYPRKVQILRRD--NSvvRT---KRVITVQK---------QkD-----DG--SQDIEHEYQ 321
gi 312067421 248 fGDRLKFSVGIYSLL-CSeKIPQPAALNAET--NEimQR---SHIYVNKE---------T-D--E-EVSvlNKEIIQKRQ 308
gi 512889909 223 IGNNVSIGISIYKLL-KSnIEPKKVYLSNET--NAvvTSdtkTTKVLVKPdtdmdidrvEeQemP--LL--KSELLHCQE 295
gi 195157892 264 LGPNLSMSVQYYNYF-QRrALPRKVQIMRRD--NSvvST---KRQIIVRK-----------------HE--GEEIKHEYQ 318
gi 194743446 264 IGPNLSMSVQYYNYF-QKhNYPKKVQILRRD--NNvvRS---KRVIMVQ----------QkD-----EE--SQEVKHEYQ 320
gi 195037739 258 LGPNLAISVQFYNYF-QRrAYPNKVHILRRD--NSvvRK---KRMIMVR----------KqD-----EE--TQEITHEYQ 314
gi 568257724 266 LSKDIALAVNIYSFT-RKpRFPKKVKLLRST--NEivES---KRVHIATSsled-gepdTsTstT--LL--PGDQRKCIS 334
gi 541038568 248 LSNDLKLAVGIYSLI-RPeKVPSAVALDAES--NEvvQR---SFTYAKKQ---------TgEeiP--LF--DKEITRRQE 308
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JEQ_B       316 Y--GSd---------IVPFSKVDEEQMKYKS-EgKCFSVLGFCKSSQvQRRFFmgNQVLKVFAardDEAaAV-ALSSLIH 382
gi 74803823  258 I--GGe---------KVSFKPEEVAQMKQ-LlP-PGIRLLGFKPA-SvIKMTNhlRSSLFLYPnesYINgSTtLYRALYE 323
gi 226694180 322 IkvTGgwytcnvgerDLRISMDQLNRVRN-LhK-PQMMLLGFKHR-SsLPEVSyiKPANFMYPddqSIIgSKrLFRALWE 398
gi 312067421 309 I--GGe---------TVNLSADEIEKLRRLT-P-PGILLLGFKPLSc-LKITHhvRSSQFVYPlekDILgSVrMYRTLYD 374
gi 512889909 296 Y--GNe---------IIAFTDNEFKTINNPFgP-AKLKLLGFKPETFlCKEKWflKNCSFLFPnekSIEgSTtALKAMHQ 363
gi 195157892 319 MkaNQgwykfdlgekSLRLTMTRMDMVRN-MhK-PHMQLLGFKHR-SaLPEVLysKPSNFMYPddqSIIgSKrLFRGLWE 395
gi 194743446 321 IkaTGgwyncnvggeNLRIGIDKINSVRN-LhK-PRMMLLGFKHR-SsMPEFSysKPSNFMYPddrSIIgSKrLFRGLWE 397
gi 195037739 315 IktTGgwhecrvgdqVLRVTTEQLNRVRN-LhP-PGMMLLGFKHR-SaLPDIHysKPCSFMYPddqNIVgSKrLFRALWQ 391
gi 568257724 335 L--GGe---------SISFRPEEMNLMKQIL-T-PGIRLLGFKPA-SiVTITNhvRSSLFVYPdeaHIHgSTvLLRTLYE 400
gi 541038568 309 V--GGa---------QVNMTAEEIEKLRR-LtP-PGLLLLGFKPI-SsLKLSHhvRSSQYVYPmesQITgSTrLYRTLLE 374
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JEQ_B       383 ALDDLDMVAIVRYAYDKRANpqVGVAFPH-------Ikh-------------nyE-CLVYVQLPFMEDLRqymfSSlk-- 439
gi 74803823  324 KCLEKNQVAICMLTMRRKQPskLVALVPQtelahdpLgea------------drHcGFRVDFIPFAGDIRklpfl----- 386
gi 226694180 399 RCLVRDKIAICLFMCKRKSIprYVALVPVeapdngeDknyr---------sllcGdGFKIVYLPEAKHIRhldlq----- 464
gi 312067421 375 VCMKQRKMIICRYTQKANVPpkLVALVPQ-------AsvaednskgefsskscyP-GFHLVYLPFAEDKR----DLreqm 442
gi 512889909 364 ACIETKTVAICVICSRINSKpnIVALSPCtrplgldId----------------I-GFDVIPLPFSENVR---------- 416
gi 195157892 396 RCLQREKIIVCLFMSKRKSIprYVVLVPVqvd-kseVksyr---------sqlcGdGFKIVYLPEAKHIRhidmc----- 460
gi 194743446 398 RCLARDKIAICLFMSKRNSTprYVALIPVeapergqDtsyr---------sllcGdGFKIVYLPEAKHIRhidmc----- 463
gi 195037739 392 RCLERQKIAICLFMCKRKSVprYVALLPVeaa-qpdDtnyr---------sllsGdGFKIVYLPEAKHIRnidmc----- 456
gi 568257724 401 KCLERNQVAYCTLTVRRKQPskLVALVPQkealdt-------------ngeryrQaGFRVEFIPYAADIRnlaf------ 461
gi 541038568 375 VCENKKKIIICRYTQKENTPpkLVALVPQsssesvhDskaka-------sdkfrYpGFHLVYLPFFEDKRdlseqm---- 443
                        250
                 ....*....|....*
1JEQ_B       440 ---nsKKyAPTEAQL 451
gi 74803823  387 -eesaTApEVTDEQT 400
gi 226694180 465 -dwnnTEnTADEQKV 478
gi 312067421 443 ihpdgDWpAASKEQI 457
gi 512889909 417 -----DLsSLFSDEI 426
gi 195157892 461 -dwnnTAnSADDEKV 474
gi 194743446 464 -dwnsAGnSASDEGV 477
gi 195037739 457 -ewnsIKnTSSDEGV 470
gi 568257724 462 -leeaEApTISTEQV 475
gi 541038568 444 fchdgEWpKATQQQI 458
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