5Y3R,5Y3R


Conserved Protein Domain Family
Ku

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pfam02735: Ku 
Ku70/Ku80 beta-barrel domain
The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer.
Statistics
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PSSM-Id: 397035
View PSSM: pfam02735
Aligned: 218 rows
Threshold Bit Score: 93.4065
Threshold Setting Gi: 149389057
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y3R_B         248 IGSNLSIRIAAYKSIlQErVKKTWTVVDAKTlkkEDi----------------------QKETVYCLNDDdE-------- 297
ybcl:Ecym_2476 227 dpycmcINVEGYPAT-KAvTSLSRKQVQKtedgs---------------------yiplKSVVEYEIHEP-Sekedq--- 280 Eremothecium ...
XP_002552929   231 sydsITVKVEGYPAT-KAvSSLNRRVVAKsedgt---------------------fgpvKSVIEYEAIDD-Gedse---- 283 Lachancea the...
XP_003671653   239 dpdciSIKVEGYPAT-KAvSSLNRKNVIKTP---KTentsae-----------ftyepiKSVIEYEIKTR-Kedkpgndd 302 Naumovozyma d...
A0BLP5         249 INDEISVQVLIYKRC-FEeRLPTLRK-HSTL---GEfqtdt-------------nknhvRNDLIYYNPED-Pn------- 302 Paramecium te...
XP_001023138   240 LAPNLNIAVQMFTKT-SEeKLPGLKM-YSLA---VDfnphc-------------esgqiERDVIMALQED-Pn------- 293 Tetrahymena t...
EXX62611       239 gsasllIEVELIART-MKaKPKSFKKYSALA---EAa----------------------N---------N-Ienktyevs 282 Rhizophagus i...
Q9HGM8         237 KDTSISIQVERYPRT-RLtKPPTSSAFYEND---MSknyeclniensnvenksmesdavSTVRSYMVRD--Pktn----- 305 Schizosacchar...
XP_013022516   237 neNSVSMHVERYPRT-RLtKPPTSSAFNASL---KQpkeeenqeqfsssqekpwesnavSTVRSYVVRD--Sqtt----- 305 Schizosacchar...
XP_009530013   273 FGDALGIPVYCYLKT-KTaTLPTLSK-ESQS---Syekea---------------agkvKLDRRYTSPQN-Id------- 324 Phytophthora ...
5Y3R_B         298 ------------------TEVLKEDIIQGFRYGSdIVPFSKVDEE--QMKYKS-EgKCFSVLGFCKSSQvQRRFFmgNQV 356
ybcl:Ecym_2476 281 --------------eyeaITVSKDHIVKAFRYGAdYISLPDVLASerIYQT---T-PGLDIRGFIDLFNvPRQYLc-gES 341 Eremothecium ...
XP_002552929   284 ---------------ggvASVSKEYVTKAYRYGSdYVVLPQAIESerTYKT---K-PGLDLRGFVGNESiPRHFLs-sES 343 Lachancea the...
XP_003671653   303 angdgaevaasqdedfvsITVSQNSITKAYRYGAdYVVLPPSLQEqlTYET---W-PSLDIRGFLDKDSlPRYLLt-sES 377 Naumovozyma d...
A0BLP5         303 -----------------mTPIEKDNIIRGYQYGRnLVPVDQIMEDkmKYQC---P-RQFQLLGFVDRSHiPRYYYt-sTV 360 Paramecium te...
XP_001023138   294 -----------------lNPIDKSNITKAYHYGKqLIPVTQALEAqmNYTS---N-RELKVLGFVDSKKvPRQSFm-aGV 351 Tetrahymena t...
EXX62611       283 hsrt--ysitvdenvnekVDVPQDELDKAYALGKtFIPLPKQDENifSFET---T-PCLSIISFIRTEEfRRELVl-sNV 355 Rhizophagus i...
Q9HGM8         306 ----------------dsFEVKREDLESGYSYGRtIVPISRSDED---VLALDtI-PGYEILGFIPKSS-LPIYYtiSDT 364 Schizosacchar...
XP_013022516   306 ----------------eaFEVDRKDLESGYSYGRtIVPISRSDED---ILALEtK-AGYEILGFIPKAS-LPFYYtiSDS 364 Schizosacchar...
XP_009530013   325 ------------------EEVPPDQQVKAYRYGAeKVPFASADVEffKFQT---E-KSLKVLGFLDKAQiNHAKFv-aGT 381 Phytophthora ...
5Y3R_B         357 LKVFAar--dDEAaAVALSSLIHALDDLDMVAIVRYAYDKRANp-qVGVAFPHikh--------------nyECLVYVQL 419
ybcl:Ecym_2476 342 VYIIAdtregSEAdFMAFSALVDAMITSKKLAIARYVQKNNSEv-qMVVLCPLlvgsnlkkrtsdnpeaepkRALVLCRL 420 Eremothecium ...
XP_002552929   344 TFIIPatkdgTRAdFVSFSALVDSMIKLRKFAIARYVQKLNGEv-qMCLLCPIlipkkrke---pgddetytRALVLNRL 419 Lachancea the...
XP_003671653   378 IFIMPdtrlgSQAdNVTFNVLVDVLLGQDKVAIARYVPKYYSEv-qMCVLVPLlvlhed--------gktliRAFVLNRL 448 Naumovozyma d...
A0BLP5         361 DMVIAve--nQKq-QKALAALVIALIATRKVALARFVGREKTAp-kLIMLLPHksk--------------nsQCFWMISL 422 Paramecium te...
XP_001023138   352 DIIIAnk--nDSVaKKGIAALCHSMIQTNKYAIARYVWRNNGAp-kLCVLTPQigk--------------dyECLYMCQI 414 Tetrahymena t...
EXX62611       356 FTVVPkk--dEPVaAQRLSSFIHVLYEKDSFAIVRYVKKPLESp-kLGVLVPYikp--------------pkECLYFARI 418 Rhizophagus i...
Q9HGM8         365 NIIVPkddfeSKL---NFSAFVQSLEREHRYALARFVSKDKGVp-vLLVLMPYvef--------------krhYLVDIQL 426 Schizosacchar...
XP_013022516   365 NIIIPrgdegNKQ---KFSSLVQSLEREHRYALARFVSKEKGAp-tLLVLMPFves--------------kkhYLVDVQL 426 Schizosacchar...
XP_009530013   382 DIFVAep--gKPHaATCFAALIDAMVELDQVIVARFVARKNAApkiVALIPHApssgq----------genyYAMWSQQL 449 Phytophthora ...
5Y3R_B         420 PFMEDLRqymfsSLknsKKyAPTEAQL 446
ybcl:Ecym_2476 421 PFAEDERacdflPF---TNkypkdedm 444 Eremothecium cymbalariae DBVPG#7215
XP_002552929   420 PFAEDERcsdypRL---AQaAASSDae 443 Lachancea thermotolerans CBS 6340
XP_003671653   449 PFAEDERvadfpRL---TKrKTTSGQP 472 Naumovozyma dairenensis CBS 421
A0BLP5         423 PTTEDIRhfqfaAL---KRsTPPQQMa 446 Paramecium tetraurelia
XP_001023138   415 PTSESVRdfqfnSL---KEsTKEQQDL 438 Tetrahymena thermophila SB210
EXX62611       419 PFKEDYRrftfpSLd--RIvTKTGKEL 443 Rhizophagus irregularis DAOM 197198w
Q9HGM8         427 PFAEDVRpysfsEFe-kLSnEEDMRQI 452 Schizosaccharomyces pombe 972h-
XP_013022516   427 PFAEDVRpyqfpDLe-eVSnPDEKHQL 452 Schizosaccharomyces cryophilus OY26
XP_009530013   450 PYEEDVRnyefaPLk-sRKyTPTDGQQ 475 Phytophthora sojae
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