5U8S,5DGO


Conserved Protein Domain Family
CDC45

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pfam02724: CDC45 
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CDC45-like protein
CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus, among others.
Statistics
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Aligned: 122 rows
Threshold Bit Score: 344.192
Threshold Setting Gi: 75031595
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U8S_E               28 VIFVSC-LNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHY-------SQLDDN---------IN-----SLLLVG 85  Saccharo...
Q4Q3V5               25 INVLVA-PTADAAAASLSLTYLMKVFLFPFQLHPTSSYDELKWFI-------EQANFAqdse-reddISlriddLFILVG 95  Leishman...
EDP08478             27 vmCFAAcTDADSVCASQQLMNLFNREGIFFTLIPVDSYEEVKAHC-------EPLVQAe-------eVK-----TVVLIN 87  Chlamydo...
EJW82893              2 VLIIAN-VDADAVCATQILLDLFAADDVAYTLVPVDGWEGFRTAL-------VEHGEQ---------AH-----SVVLLN 59  Wucherer...
WGS:AAPU:GI14991-PA  19 ILIIVN-YDVDAICASKILQSLFKYDHMLYTVVPIMGVTGLKRAY-------SEHQAD---------VK-----YVLLIN 76  Drosophi...
XP_003532278         25 VLIFPStSDVDSLCALKIIFHILESDSIQYACYPVSSFHEIHKYT-------NSSSNDe--------PL-----SVVLVN 84  soybean
EFH59832             27 llifPStSDVDSLCALKVITHILESDSIQYSCFPVSSFLEIHKYAgpaglcsTSSESP---------PV-----TILLIN 92  Arabidop...
XP_003763378         19 VLLFVA-SDVDALCACKILQALFQCDHVQYTLVPVPGWQELETSF-------LEHKDQ---------FH-----YFILIN 76  Tasmania...
XP_020187916         32 lliLPSaADADSLCALRILAHVLSADSVRFSVYPVASTADAAELL-------ASFSGAtassplsppPL-----CVLLIN 99  Aegilops...
XP_022351695         19 VLLFVA-SDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF-------LEHKEQ---------FH-----YFILIN 76  Enhydra ...
5U8S_E               86 FGGVIDLEAFLEIDPqeyvidtdeksgeqsfRRDIYVLDAHRP-WNLDNIFGSqI----IQCF---DDGT--V---DDTL 152 Saccharo...
Q4Q3V5               96 LGAPVLLEDYFDFT-----------------RHIVIVLDAYRP-FHLGNLCR--------------EDGDrcIiwgSDRI 143 Leishman...
EDP08478             88 CGATDDIRSLCELPD----------------NVRIVIIDHHRPvWHGHNV----EddtnTLVLvdeDDPV---------- 137 Chlamydo...
EJW82893             60 CGATEPLIPYLRS------------------GMTLYVIDSRRP-LDLSNVYYE-------------DNIRliV------- 100 Wucherer...
WGS:AAPU:GI14991-PA  77 CGGCVDIVELLQPAE----------------DVTFYICDSHRP-LDVCNVYsd----rqVCIL---GDPA---------- 122 Drosophi...
XP_003532278         85 WGNHRDLSNTLNLPS----------------NARVFVVDSHRP-IHLRNLS---DqndaVVVLftkEDEG------QSDL 138 soybean
EFH59832             93 WGCHRDLKLVLKLGP----------------AARVFVVDSHRP-IHLHNLS---DyneqVVVLhtdDDER------QADL 146 Arabidop...
XP_003763378         77 CGANVDLLDILQPEE----------------DRIFFICDTHRP-VNVVNVYnd----tqI-------------------- 115 Tasmania...
XP_020187916        100 WGARSDLLRGI-LPR----------------GSTAFVVDSHRP-VNLRNLA---AgndrVIVLftaDDER------AADL 152 Aegilops...
XP_022351695         77 CGANVDLLDILQPDE----------------DAIFFVCDTHRP-VNVVNVY---------------NDAQ--I------- 115 Enhydra ...
5U8S_E              153 GEQKE---AYYKLLELDEEs-----GDDE---------------------LS-----------------GDEndnnggDD 186 Saccharo...
Q4Q3V5              144 QVEVD---DFFRKQRAEEAqrrrrhRRRLd-------------------mKRhegharrqrtegggaqdDDVysdessIS 201 Leishman...
EDP08478            138 --PKAsvpVYNPNEQEEDEedsgseAS------------------------EaekddeedqeagvsgdgDEDeddlgvRP 191 Chlamydo...
EJW82893            101 --SRD---EWEQLDIPNICdvevsdSSSSeesgdedetgmdagnerdifeRTeqleeddevsesrtsvsEQLeiarssSD 175 Wucherer...
WGS:AAPU:GI14991-PA 123 --LEEnipGFESIFYDSEGe--------D---------------------GDddddededgdengdsgaGESddgngdGD 171 Drosophi...
XP_003532278        139 AYDFD-------LTTLANAa-------------------------------TtvdsdsdsesesesdsdSDSgsertgSR 180 soybean
EFH59832            147 AYDFD-------VLKLANEsfqlhvEEG----------------------GEsdeeeeeeedeeeededDDDddgdgdRP 197 Arabidop...
XP_003763378        116 -----------KLLIKQDDd-----LEV------------------------------------------PAyddifrDD 137 Tasmania...
XP_020187916        153 SYDFD-------ASSLADAsdltaeGDADdd------------------hLRaseeeesd-tsdydsgaEg------gRR 200 Aegilops...
XP_022351695        116 -----------KLLIKQDDdlevpaYDDIf--------------------RDeeedeehsg------------------- 145 Enhydra ...
5U8S_E              187 EATDA---DEVTDEDE------EDEDetISNKRGNSSi--gPND--LSKRKQ---RKKQIHEYEG---VLEEYYSQGTTV 247 Saccharo...
Q4Q3V5              202 TSSEEeesADSDGDEAadlfdgEDDDatPSQSQDRVD------------------WRSAPGEVPA---YLEALYYACSCA 260 Leishman...
EDP08478            192 GRKRRrrsTGADQEERpakrspEARAqaRAERRKLAE-------------------------------LIDAYYSDCNGY 240 Chlamydo...
EJW82893            176 GENEM---EKSDADDDteqtddTEELedSTNRRRRWVsdvaDSV--GRREAKrrrRMELKRHRED---VLWKYHEN-SWY 246 Wucherer...
WGS:AAPU:GI14991-PA 172 SSERv-----------------------RAPKLSRMQ-----------KHEQrilRQRARRQWESerdRIMFDYTQFSYY 217 Drosophi...
XP_003532278        181 KRRKKnpqDDDDGDDEd-----Pi----KLYRKLKKG-----------------------------------YYKLGTFH 216 soybean
EFH59832            198 SKRRKmgdGv------------------KVFKKLKRD-----------------------------------YYKMGTFH 224 Arabidop...
XP_003763378        138 EEEDE---EDEEQSGS------ESEGsePSGKRTRRE----EDVieRTLKRR---QRREWEARRK---EILFDYEQYEYH 198 Tasmania...
XP_020187916        201 KRRWAsddAEADGDDPv-----------RLFGRLRRE-----------------------------------YYRLGTFH 234 Aegilops...
XP_022351695        146 --------------------sesdngsePSEKRTRLEe--eIVA--RTMKRRqrrEWEAQr------rDILFDYEQYEYH 195 Enhydra ...
5U8S_E              248 VNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAY---AQ-----VYNRLYPLLQ------DEVKRLTP-S------- 305 Saccharo...
Q4Q3V5              261 GRSSAVEVYDLSVILHRFNDTILWHAAVGVCDLYLRRlvdYA-----TYLVEMGPLEeavslqQSVRRgil--------- 326 Leishman...
EDP08478            241 GKPSSLLLFALVNTAQHDDNFHLWCAIVGLTEQLLFHqisKQ-----QYNTWREGLE------QKTHVqadp-------- 301 Chlamydo...
EJW82893            247 SPSSAVLMLEVAHSVGRTTVEMMWAAVVGISSQLVEYlisHDcyttvCFDRLRAFRMkfcpdgSDIVR------------ 314 Wucherer...
WGS:AAPU:GI14991-PA 218 GRSTALYIFELAWKLSKDNMDLLWWAIVGISEQLLLGkieSA-----AYTLELENIQ------SHVSRLTNk-------- 278 Drosophi...
XP_003532278        217 GKPSGCLMYELADKLRKNTNELLWIACISLTDQFVHErlsDE-----RYHDGVMELE------QHINS----Sgnlda-- 279 soybean
EFH59832            225 GKPSGCLLFELSHMLRKNTNELLWLACVALTDQFVHErltDE-----RYQAAVMELE------QHINS----Sgnidk-- 287 Arabidop...
XP_003763378        199 GTSSAMVMFDLAWVMSKDLNDMLWWAIVGLTDQWIQDkitQM-----KYVTDIGILQ------RHVSRHNH-R------- 259 Tasmania...
XP_020187916        235 GKPSGCLMYDLAHALRRNTNELLWLACVSLTDQFVHEritNE-----RYQDAGMELE------QHING----Sgnldpsg 299 Aegilops...
XP_022351695        196 GTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVQDkitQM-----KYVTDVGVLQ------RHVSRHNHrNedee--- 261 Enhydra ...
5U8S_E              306 ------S--RNSVKTPDTL------------TLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWN-ENGKKRLHKMFA 364 Saccharo...
Q4Q3V5              327 ------------rdRTDEAvnsyhrastnsmQLSNREEEQLYLLRHSTLWDAIWYDSQVASALDLHHvEDGRPRLSQLLA 394 Leishman...
EDP08478            302 -----------qeeLDNEAangllhiprqkvHVEPFDDLRLTLLRYWTIEDSLRYTGYVAARLQTWR-QKGLDNLRSLLT 369 Chlamydo...
EJW82893            315 --------------GDDIL------------RLKFDDEIMLPLYAHWSLYTSMVHNDFFFCLTQMWQ-QSGALIMKALLA 367 Wucherer...
WGS:AAPU:GI14991-PA 279 --------------TNDQNtms-------asKINFENDLHLVLYRHWTVTESMRYSRYSACKLKLWT-LRGEKRLHELLV 336 Drosophi...
XP_003532278        280 -vtsvtLkdGTKIRAPNSL------------RITYEDQPRLMLLQEWSLFDSMMCSSYIATKLKTWS-ENGIKKLKLLFG 345 soybean
EFH59832            288 -itsvtLkdGTKVRAPDCS------------RISYEEEPRLMLLREWTLFDSMLCSSYIATKLKTWS-DNGIKKLKLLLA 353 Arabidop...
XP_003763378        260 ------NedEENSLSIDCT------------RIAFEYDLRLALYQHWSLYDSLCNTCYTASRLRLWS-VQGQKRLQEFLA 320 Tasmania...
XP_020187916        300 vgsvvtLkdGTRIRAPETS------------RIAYEDEPRLMLLREWTLFDSMVCSSYVATRLKTWS-DNGLKKLKLLLA 366 Aegilops...
XP_022351695        262 -----------nalSVDCT------------RISFEYDLRLALYQHWSLHDSLCNTCYTAARFKLWS-VHGQKRLQEFLA 317 Enhydra ...
5U8S_E              365 -RMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGL--QDIIRD---------------GFVRTLGYRGSISASEFVE 426 Saccharo...
Q4Q3V5              395 sRCGVSIAMAQRPWCEVPTDVGSEALRRVQ----------VELQNWvnaqgnfiayrnrirCISRKVGYSTEVSTFDVCK 464 Leishman...
EDP08478            370 -YMCIPLKHATTAYKGLREVYNSQLRAQLPRFAPQHMLawDSLHLS---------------SFRLLYKHE-EISASDMVF 432 Chlamydo...
EJW82893            368 -ELEITLEESHQVYSALTSERKDAIFRHIYKHMDDEFA-----------------------SFTAHIGYSNRYNSCDFAR 423 Wucherer...
WGS:AAPU:GI14991-PA 337 -EMGLPLVHARQTYSAMDLILRKEFYSMVEQLAEKYGI--PDIVYG---------------TFTLSYGYRSRYAAADYVY 398 Drosophi...
XP_003532278        346 -TMGFALGDCQQKFQHMNLEVKRKMKKEFERFLPEYGL--TDFYYR---------------SFIRTLKYSSKISAADVVY 407 soybean
EFH59832            354 -RMGFALIECQQKFPYMSHEVKRKMKQEFDRFLPEYGL--NDFYYR---------------SFLRLHGYSSRVSAADVVY 415 Arabidop...
XP_003763378        321 -DMGLPLKQVKQKFQAMDVSLKENLREILEESANKFGM--KDMRVQ---------------TFSIHFGFKNKFLASDVVF 382 Tasmania...
XP_020187916        367 -RMGFPLADCQKGFQYMSMEVKRKMRDEFDRFLPEYGL--TEFYYR---------------SFLRVHGYKSKVCAADVVY 428 Aegilops...
XP_022351695        318 -DVGLPLKQVKQKFQSMDISLKENLREMIEESANKFGM--KDMRVQ---------------TFSIHFGFKHRFLASDVVF 379 Enhydra ...
5U8S_E              427 ALTALLEVGNstdkdsvkinndnnddtdgeeeEDNSAQKLTNLRKRWVSNFWLSWDALDd----rKVELLNRGIQLAQDL 502 Saccharo...
Q4Q3V5              465 LFTAEMAAVPpasvyvier----spanaslspEEVAALAQRKLVEFQRGQFWRASAVLDid---pNEKLFHEALAGALSL 537 Leishman...
EDP08478            433 ALLGLLTDAK------------------------------PKEKSWHRAAFNDASNALHvq---rNLNVVEKGIELAKRM 479 Chlamydo...
EJW82893            424 AIAGRISYG-------------------------------VVEVESPYDRFIGAQEILQkfvdggDKTPLSKAIESYKSC 472 Wucherer...
WGS:AAPU:GI14991-PA 399 ALLAILQS--------------------------------VKKHKTPEDCFMEASDALSr----qHKQLLNVGIDNAKLL 442 Drosophi...
XP_003532278        408 GVTALLESFV------------------------------RSDGSCASKQFGVAYDALSl----nNIDNLRTGMHHAIKI 453 soybean
EFH59832            416 GITALLESFL------------------------------GSGGSSASKQFGEAYDALSl----nNLDKLRSGMQQAIKV 461 Arabidop...
XP_003763378        383 ATTSLLE--------------------------------NIEKDASGTDNFIRALDSLSr----sNLEQLYQGLELAKKQ 426 Tasmania...
XP_020187916        429 GVTALLECMS--------------------------AESNDSKECSAAEQFWVAYSALSp----sNVDQLQKGMQSAIEI 478 Aegilops...
XP_022351695        380 ATMSLMES--------------------------------PKKDSSGTDNFIQALDSLSr----sNLDKLYHGLELAKKQ 423 Enhydra ...
5U8S_E              503 QRAIFNT-GVAILEKKL-IKHLRIYRLCVLQD--G--PDLD--LYRN-PLTLLRLGNWLIECCAESEDKQ------LLPM 567 Saccharo...
Q4Q3V5              538 QQAVADA-TGSMMQPGN-VQSSTGIHYALPSDpsKtsPTLE--SFCT-MRRLSVLAERLFFTLSMSRRRDrraltaLRPL 612 Leishman...
EDP08478            480 CSDVVHEcGLMITSGKVkGGRNADYRWVNVAE--S--NGLAnpRFTH-PAVLKYMALFLRDATSHRYSSNd----aRRPM 550 Chlamydo...
EJW82893            473 LTSLVNL-VFMSISQSL-IVSVGSFYLLCLPQ-----EDEA--RILHcRHFLYIFVHYVLRAFTVSSHSKnr---aNRPL 540 Wucherer...
WGS:AAPU:GI14991-PA 443 HAAIFRQ-VQSCLEAHQ-VHSTGSFFYYVLQE------EHA--FFSY-PYALALLAKFVLHGHVATTRVRqa---pDLPL 508 Drosophi...
XP_003532278        454 QRAILRQ-GSAAITKNGcIRSGRSFRWLKLED--S--NDAT--LLGY-PQALTKFCYFIMDALREKGAK-------MKPL 518 soybean
EFH59832            462 QRAILRQ-GSAAITKTGcIRSGRKFRWVKIED--S--MDAK--YLGY-PQALTKFCYFLMDALREKGAR-------MKPM 526 Arabidop...
XP_003763378        427 LRAIHQT-VASCICTNL-VISQGPFLYCYLME--Gt-PDVK--LFSK-PASLGLLSKYLLQSFICSTKNKrc---kLLPL 495 Tasmania...
XP_020187916        479 QRAILRQ-GSSAITKSGfIRSAKKFRWVKLDD--P--VDTS--KLCH-PQALTKFCFFLMDALKERGAR-------TKPL 543 Aegilops...
XP_022351695        424 LQATQQT-IASCLCTNL-VISQGPFLYCSLME--Gt-PDIA--LFSK-PASLTLLSRYLLKSFVFSTKNRrc---kLLPL 492 Enhydra ...
5U8S_E              568 VL-AS-IDENT--DTYLVAGLTPRYprgldtihT-Kk--------PILNNFSMAFQQITAE-TDAKVRIDNFESSIIEIR 633 Saccharo...
Q4Q3V5              613 ILsCV-LPQAR-------LAAPPTAssg---sgSgLpcgpgtdalVPAVHWSRASGGVPSA-SAATAAGGVFMGGGAQV- 679 Leishman...
EDP08478            551 VV-AG-PPDEG--GMCCVVAVHAKHisg---nkLq------------KNPFARPFIETASA-LHIFQQKSAFENTTFHLR 610 Chlamydo...
EJW82893            541 FV-AV-PMSGEntGWFLITGSMPANtdy---edSn-----------QKSFIGRAMQKVVENfVRDGARRDFFDSAMVLIR 604 Wucherer...
WGS:AAPU:GI14991-PA 509 IAtCP-LDASQ--GMCLLVGIAP----------VrEd--------SPKNFFGKAFDQAAQK-SKTNLLQDFFEPSIVQLR 566 Drosophi...
XP_003532278        519 IC-AC-VSQEP--GKVLIVGVCGRPrlg---gaQ-------------GNAFGIAFRTAAEE-IGTEFFHELFESSWIVLD 577 soybean
EFH59832            527 LC-AC-ASQQP--GKLLVVGVCGKPrlg---avR-------------GNAFGNAFRKAAQE-SRADYFHELFESSWIVLD 585 Arabidop...
XP_003763378        496 VM-AApMSMER--GTMIVVGIPPETes-----------------sDKKNFFGRAFEKAAES-TSSRTLHNHFDMSVIELK 554 Tasmania...
XP_020187916        544 VC-AC-LGREP--EKVLVVGVWGKPrlg---avQ-------------GNSFGNAFRSAAGE-IGADYFHDMFESSWIVLD 602 Aegilops...
XP_022351695        493 VMaAP-LSVEQ--GTVTVVGIPPETdss-----------------drKNFFGRAFEKAAES-TNSRTLHNHFDLSVIELK 551 Enhydra ...
5U8S_E              634 REDLSPFLEKLTLS 647 Saccharomyces cerevisiae S288C
Q4Q3V5              680 -EDTAEYVVVLTHA 692 Leishmania major
EDP08478            611 KEEVGPFLDRLQHV 624 Chlamydomonas reinhardtii
EJW82893            605 SDQKARFFDGLQAt 618 Wuchereria bancrofti
WGS:AAPU:GI14991-PA 567 QSDLTRFLDALTVL 580 Drosophila mojavensis
XP_003532278        578 ASAVNSFMVRLTKK 591 soybean
EFH59832            586 ASAVNSFMIRLTEk 599 Arabidopsis lyrata subsp. lyrata
XP_003763378        555 VEDRGKFLDALisl 568 Tasmanian devil
XP_020187916        603 VVAVSSFMIRLTEk 616 Aegilops tauschii subsp. tauschii
XP_022351695        552 AEDRSKFLDALVSl 565 Enhydra lutris kenyoni
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