Conserved Protein Domain Family
Exonuc_VII_L

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pfam02601: Exonuc_VII_L 
Exonuclease VII, large subunit
This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.
Statistics
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PSSM-Id: 334998
View PSSM: pfam02601
Aligned: 543 rows
Threshold Bit Score: 176.874
Threshold Setting Gi: 503960182
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q21PB7       141 INRNRYLDKPKDFCRVAVVSPESAAGLGDFKTiaDRLEKYNLCKFNYYPSLFQGANAVASIVSAIsqvvvdiengnqyDA 220 Saccharophagus ...
CDE57328     147 iglNRSVPWGDMPQRIAVISAPGAAGYGDFSHqlSHNEAHLRFTTGLFPAVMQGQNTSTTVISALkdvia---erirwDC 223 Prevotella sp. ...
WP_015808016 157 FTRNGSLALNRVLQRIAVISSATSAGYQDFKHtlENNTFGYRFIIDDYFTPVQGEANARQFLAKIvevfq---sgkpyDT 233 Pedobacter hepa...
WP_012025752 150 stlnsRLKLGAVIQRVAVISSSSSAGNEDFRHtmQHNDFGYVFQIDDYHTVVQGDNNAKLFLNKLievyn---tgipyDV 226 Flavobacterium ...
WP_012794762 151 MTRNKALRLNPVIQRIAVISSASSAGYQDFMHtmQSNAYKYIFYTDNYFTAVQGEANATQVCIQLdaiia---sgkqyDT 227 Chitinophaga pi...
WP_011735756 143 FQPNKECFVPLLPQNIGLISSFGSAAYNDFIQtlTTSMFGF--KIHMADAMMQGEQTEKSVLRAMdalc-----klgvEL 215 Pelobacter prop...
WP_012468323 138 FETNKERFVPILPIRLGLITSSGSAAYNDFIQtlTASGYGF--KIYLADAMVQGDQTEKSVLRALdalt-----gldvDL 210 Geobacter lovleyi
WP_014546966 140 LEKNKQLELADVPLRVGLITGENTAAYKDFTTrlEASP--FAFEVTTIYARMQGNETEDSIIAALeqlqs----dsnlDV 213 Fibrobacter suc...
WP_015443298 155 IDLNKQWPLSPIPLRIGVATSLDSAAWADFHH--EIEKSGFGFHLTVADTRVQGDGAERMVAGAIgtlarg-arkgvlDA 231 Ilumatobacter c...
WP_012238030 250 LDRNRSLPFPALPLRVGLVTSLGSDAYNDVLG--TFRESGFAFRVVAHGVRVQGRQTEPSVLNALdyfra---raaelDV 324 Sorangium cellu...
Q21PB7       221 LAIVRGGGDKAGLYQLNEIKIARCICRSPIPVLVGIGHERDSTILDEVANCRLATPSLVASFIQEAIvknardakfnyel 300 Saccharophagus ...
CDE57328     224 VVIIRGGGSTSDLDAFNDYALAAAVARCPLPVIVGIGHERDHTILDEVAKVSTKTPTAAAEWLIAKGks----------- 292 Prevotella sp. ...
WP_015808016 234 LVIIRGGGAQTDFLIFDNYELSRAIAKFPVPVITGIGHQKNETIADLMAHTATKTPTKAAELIIAHNra----------- 302 Pedobacter hepa...
WP_012025752 227 IVITRGGGSQSDFLIFDNYNIGRAVAKFPIPVITGIGHQKNISITDLMAHTHTKTPTKAAEFIIAHNrs----------- 295 Flavobacterium ...
WP_012794762 228 VVIIRGGGAQTDLLLFDQYALGKAVAGFPVPVITGIGHHKNETITDMLAHTATKTPTRAAELIIAHNrt----------- 296 Chitinophaga pi...
WP_011735756 216 IVIARGGGSKTDLYFLDNEAVARKIAACTIPVWTGIGHEIDTSVLDYVANKSFKTPTAVAEELVARFiq----------- 284 Pelobacter prop...
WP_012468323 211 VLILRGGGSKTDLYFLDNEAISRKIAGYPKPVWTGIGHEIDTSILDYIANRSFKTPTAAAEELVARFvq----------- 279 Geobacter lovleyi
WP_014546966 214 VCIVRGGGAKTDLNFFDSEALCRAVANYPTPVFTGIGHEIDRCLLDEVAYLSCITPTDCAKRLVERVtd----------- 282 Fibrobacter suc...
WP_015443298 232 IVVIRGGGARNELAVFDTEIIARTIAAVPVPVFTGIGHEIDRSIADEAAHTALKTPTACAGALIDRVsn----------- 300 Ilumatobacter c...
WP_012238030 325 LLICRGGGSRTDLAWFDSEPIARAVATFPLPVVVGIGHERDISALDFVGFRE-KTPTAAAAMLVQRVs------------ 391 Sorangium cellu...
Q21PB7       301 lvrssqsissfaKQELRDYRA-----------------------------NISLLSHKKLesarrqvtehntslthvpnl 351 Saccharophagus ...
CDE57328     293 -----------aLRRFADLGN-----------------------------TMALLAQKILadn----------------- 315 Prevotella sp. ...
WP_015808016 303 -----------fEENLLGMQK-----------------------------MMLIKTYQLInyhkdrlaqlnqttistsrg 342 Pedobacter hepa...
WP_012025752 296 -----------fELGILALQK-----------------------------NIVIKSQQLFlqyhnelnslknavahnark 335 Flavobacterium ...
WP_012794762 297 -----------fEEALLTQQS-----------------------------QIIIRMQQMIagrkkqlsslhtgiinrsrd 336 Chitinophaga pi...
WP_011735756 285 -----------mQRQLEEASNtlqtvwayrfkidreyldraiigihqgprKLLEVTVSNLreqaqdlrhlvserlstehi 353 Pelobacter prop...
WP_012468323 280 -----------mRRQLDEATNtlktvwayrlkidqdylaravtgiqqgprKLLDVTASCLreqaqelrarvqrrlsteqi 348 Geobacter lovleyi
WP_014546966 283 -----------sWNRMTEAMA-----------------------------SIADGARDLLten----------------- 305 Fibrobacter suc...
WP_015443298 301 -----------fVANTEMAWQ-----------------------------AIERRATATLdaa----------------- 323 Ilumatobacter c...
WP_012238030 392 -----------------dARD-----------------------------EVESSLLSILdqg----------------- 408 Sorangium cellu...
Q21PB7       352 liQNAKRQneenyiniklfsgrsiqqakelvsesfrsaindtkvnirsigshIQQLK--------IDVIrR--------- 414 Saccharophagus ...
CDE57328     316 -----rtR--------------------------------------------YTEAA--------YALPsT--------- 329 Prevotella sp. ...
WP_015808016 343 llH----------------------------------------------------------------------------- 345 Pedobacter hepa...
WP_012025752 336 liSVQKEE--------------------------------------------LMMAR--------QHIVqT--------- 354 Flavobacterium ...
WP_012794762 337 llSVHRDG--------------------------------------------LTRAK--------QAIPqR--------- 355 Chitinophaga pi...
WP_011735756 354 qlESKRSQ--------------------------------------------LKSLPlaviqkqiERLSsKkqnigtqvk 389 Pelobacter prop...
WP_012468323 349 giGRRREK--------------------------------------------LRSLPltltknhmERLAaKrqelssgvt 384 Geobacter lovleyi
WP_014546966 306 -----nkQ--------------------------------------------LGTMG--------NQLQqK--------- 319 Fibrobacter suc...
WP_015443298 324 -----erR--------------------------------------------Lgdvg-----hriAARTqS--------- 340 Ilumatobacter c...
WP_012238030 409 -----rrV--------------------------------------------LRSASsdlt-rraARVPrS--------- 429 Sorangium cellu...
Q21PB7       415 ---------------------AHHSTSTAKSSVQHYNIQMRQGASNsahqakssvlykyeeslkatkyyLGQQRNAIENE 473 Saccharophagus ...
CDE57328     330 ---------------------AQRAIADAQHALRSYATSLYRDVADtisdatrtllqsasaighaatsaITTRRNALDAA 388 Prevotella sp. ...
WP_015808016 346 ---------------------------EQQLHIISLSRMVLGNPRi----------------------iLSNRQKDLSNL 376 Pedobacter hepa...
WP_012025752 355 ---------------------GRSLLNDKKQQLLLTAQLTLQRPQg----------------------iIQQKNSNLRHL 391 Flavobacterium ...
WP_012794762 356 ---------------------ARHTLLRQRNAISQLSGQLLAKPGq----------------------vTASRLQELAHI 392 Chitinophaga pi...
WP_011735756 390 falsgwtgtmsrlkgrfdknrYIKRLQVESDAHDKSSQQLLSRFTa----------------------aVKLLTMQQWNR 447 Pelobacter prop...
WP_012468323 385 hcltrtgetlsglkqrfekerFLRRLAVERERNEKNRQQLKARFFs----------------------vFKMKYMLLTNI 442 Geobacter lovleyi
WP_014546966 320 ---------------------VFGLIQNEKSKHVLIAASIKKDTAf----------------------yIKSEHERLNRN 356 Fibrobacter suc...
WP_015443298 341 ---------------------A---IDRSNERLDMRLDVLGTVAPa----------------------vLERAHDRLDTA 374 Ilumatobacter c...
WP_012238030 430 ---------------------ASLLIARRAGQLQEAVRQLRQGARr----------------------dLDAASHRVDEM 466 Sorangium cellu...
Q21PB7       474 SKSLrv------naAQSLTAIKSDIKILVERVLLLDPSKILAKGFALIMSnEKKVLTTKKDVLKQKNVSLRLKDGFVEAH 547 Saccharophagus ...
CDE57328     389 AATIpp------aiNARLHIADSLLKSKATLLDALSPEKVLARGYSLTYGaDGHILTEADAVAVGDIITTRLAGGSIIqs 462 Prevotella sp. ...
WP_015808016 377 IGNMqs------ynRMYFANKRGYIGHFQSVVRLMSPQNILNKGFAILKv-KGKIAGNAEDIEAGTELTVRLAATEIKTT 449 Pedobacter hepa...
WP_012025752 392 KANLki------ftSHYLRSRKLQLEDCRKTIKLLSPQHVLSRGYAVVRv-HDKIINGAGSIQEGEQIEILLKDAILKST 464 Flavobacterium ...
WP_012794762 393 RKDIqv------yaRKLLQQQQQKLVHHETVVRIMSPAALLQKGFAMVQh-KGQIITSAAQLSPGDEITVQMADAGVHAT 465 Chitinophaga pi...
WP_011735756 448 KERFrvekvkqrimVERKSLNDKMAT-----IRATDPQNALQRGFALVYRqDGQLIRSIHDINKSDTIRTHVVDGTVISE 522 Pelobacter prop...
WP_012468323 443 KGRLkqervlqriaLARTSLNDKMAT-----LKAIDPQTVLKRGFALVYSqQGTLVRSIADVAEKQLIQTRLADGSLISE 517 Geobacter lovleyi
WP_014546966 357 QEGLkq------gsRKILDLAKSQFELVSEKVKNADPKTTLAKGYSLTLDeNGKFIRKASQLKSGDTIKTRLADGDVLsv 430 Fibrobacter suc...
WP_015443298 375 AERLie------rsSLRVERETGRLDLLAARVAAVDPAVQLARGWSITRTaSGQIVRSADDVATGDTLTTALLDGEITSv 448 Ilumatobacter c...
WP_012238030 467 ASLLgp------rsSRRLALESERLESRERRLRLLDPRRVVERGYAILRTtEGAVLTDAARAPQGTTLIAELKRGVLrlr 540 Sorangium cellu...
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