Conserved Protein Domain Family
TMP-TENI

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pfam02581: TMP-TENI 
Thiamine monophosphate synthase
Thiamine monophosphate synthase (TMP) (EC:2.5.1.3) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate. This Pfam family also includes the regulatory protein TENI, a protein from Bacillus subtilis that regulates the production of several extracellular enzymes by reducing alkaline protease production. While TenI shows high sequence similarity with thiamin phosphate synthase, the purified protein has no thiamin phosphate synthase activity. Instead, it is a thiazole tautomerase.
Statistics
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Aligned: 82 rows
Threshold Bit Score: 132.666
Threshold Setting Gi: 81534115
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8G7X1  18 AYFVVGPEDCk-GRPLTDVVDQALHGG-ATFIQLRAKEADASELTDMARDIAQIIEdnEKsdSVAFVIDDRADVVWQarr 95  Bifidobacterium longu...
Q87VY6   6 LYAITDSQLL--TGKFLSYVEAALDGG-VTLLQYRDKTGDDSRRLREATELLKLCE--RY--KTRLIINDDAELAAR--- 75  Pseudomonas syringae ...
Q7M9N9   9 LYGISESGWYkrPHEAIELLLEAIEGG-MKIFQLREKEGSDEEILPLARALWNHCR--QK--GVLFILNDRLDLALS--- 80  Wolinella succinogene...
Q7VF49   8 IYAISDEILTp-YEILPQCLESALKAG-VKIFQLRDKSHSDSWLYPQAKKLMALCE--KY--NALFVMNDRLNLALK--- 78  Helicobacter hepaticus
Q8P5R7  10 VYLITPDTRD--TAQLLACTLPLLPH--ITWLQYRNKQADAALRLAQATALRAACT--AH--GVPLIINDDAALAQQ--- 78  Xanthomonas campestri...
Q9PGC4  37 IYLITPDETD--TARLIARTAPLLN-G-IVWLQYRNKLANTALRTEQAQALLALCR--QT--GIPLLINDDLELAQT--- 105 Xylella fastidiosa 9a5c
Q7W049  10 LYGITPEWDD--TDRLLAAVRAAAAGG-MTALQLRRKLADERLRAAQARALAPLCR--EL--GVVFLVNDHWKLALD--- 79  Bordetella pertussis ...
Q82UQ7  16 LYAITPDMAD--TGRLCDAVRQALAGG-VSWLQYRNKTADSRLRLVQAAEIHLLCR--QF--QVPLIVNDHLDLAME--- 85  Nitrosomonas europaea...
Q6FCY2   4 LYLITNDDPL---ELLLDKLEIALSTGhIAILQYRRKKVPKTDQAFEVEQIKVLCE--AY--QVPFVINDDLVLAAQ--- 73  Acinetobacter sp. ADP1
Q9HIQ4  11 LYLVTEDYSR---KNFFNIIEEAIIGG-VDIVQYRDKSNPRSVRLDVARKVKQICN--RY--DILFFIDDDVQLAIE--- 79  Thermoplasma acidophi...
Q8G7X1  96 kgIKVDGVHIGQTDMEPREARALLGDEAIVGLSAETESLvrlINELPDGCIDYIGAGPLHVSTTKPEASVGGNDGSGKTL 175 Bifidobacterium longu...
Q87VY6  76 --LGV-GVHLGQTDGSLPDARALLGHKAIVGATCHGQLEl--AEQAKADGATYVAFGRFFNSQTKPGAPAVPLDLIAQVR 150 Pseudomonas syringae ...
Q7M9N9  81 --LGVDGVHLGIDDAEASRARILL-PHGIIGISCYGDLDr--AHKAKEEGASYVAFGSCFPSPTKPASSVIDLTLFKKAQ 155 Wolinella succinogene...
Q7VF49  79 --LNAPALHLGKDDGVIAQARERF--KGILGASSYADLQr--AKDLESLGVNYVAFGAFFASPTKPNAPLTPLEILESAK 152 Helicobacter hepaticus
Q8P5R7  79 --VGADGVHLGEDDGEVAAARALLGASAIIGVSCYDEIEr--ARAAAAAGANYVAFGAFFPTATKVTTRRATPALLHEAA 154 Xanthomonas campestri...
Q9PGC4 106 --IGADGVHLGMHDSNPSIARAQLGPHAIIGVSCYNQIEr--AKQAIKAGASYVGFGTFYPSHTKTTPYRATPELLRQTT 181 Xylella fastidiosa 9a5c
Q7W049  80 --VGADGAHLGRDDADPATVRAQAGAGLLLGVSCYNDLRr--ADALLAAGADYVAFGTVFASPTKPEAVHAPLQTLTEAR 155 Bordetella pertussis ...
Q82UQ7  86 --IDAEGLHVGGDDISPAVARCHLGQDKIIGVSCYNQLDr--AIEAEEAGADYVAFGAFYPSMTKTGTYQAPIELLTAAK 161 Nitrosomonas europaea...
Q6FCY2  74 --FDL-GVHLGQSDGEISDAVNRLTSGAVIGRTCLNSLVl--AEKAIADGATYIAFGAVYATATKPEAGNVGIEVIKQAR 148 Acinetobacter sp. ADP1
Q9HIQ4  80 --VQADGVHIGKDDMPLPDARRIF--DGLIGYSTYGDREm--AIFAEKNGADYVAFGPFFHTDTKKDADVYDIHVLEGIH 153 Thermoplasma acidophi...
Q8G7X1 176 DAAQinticVasefPVVVGGGVTAADMAMLADTKAAGWFVVSAI 219 Bifidobacterium longum NCC2705
Q87VY6 151 ARVH-----L----PIAVIGGITLENAPQLVEHGADLLAVVHGL 185 Pseudomonas syringae pv. tomato str. DC3000
Q7M9N9 156 EELA-----I----PLCAIGGIEAQNVGELI--HCDMIAVISSL 188 Wolinella succinogenes DSM 1740
Q7VF49 153 AILN-----I----PICAIGGISTQNIYLLK--NADMFAVISAL 185 Helicobacter hepaticus
Q8P5R7 155 ALGL----------PRVAIGGITPSQVPELVTAGADLIAVVSGV 188 Xanthomonas campestris pv. campestris str. ATCC 33913
Q9PGC4 182 H-LG-----V----PRVAIGGLTPKNIAPIIEAGAELLAVISGI 215 Xylella fastidiosa 9a5c
Q7W049 156 ARVLacpa---prpAVVAIGGITPANVSQVAQAGADSAAVISGL 196 Bordetella pertussis Tohama I
Q82UQ7 162 KKLG-----I----PVVAIGGIDLDNAGMLIASGCDAVAVSQAL 196 Nitrosomonas europaea ATCC 19718
Q6FCY2 149 QKFN-----T----PICAIGGLTVENSKVVIESGADLCAVISDI 183 Acinetobacter sp. ADP1
Q9HIQ4 154 KYIR-----I----PVFVIGGINISNIRTFSGYGIDGVAVVSAI 188 Thermoplasma acidophilum DSM 1728
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