Conserved Protein Domain Family
Porin_2

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pfam02530: Porin_2 
Porin subfamily
This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to pfam00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.
Statistics
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PSSM-Id: 308243
View PSSM: pfam02530
Aligned: 16 rows
Threshold Bit Score: 123.055
Threshold Setting Gi: 490821644
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130   25 DLPVKAK--AVEYVKICSLYGAGFYYIPGTDTCIKLGGYLRADANLNTnsdfnPNqggvagaRNRLMNYYTFRAREDLNi 102
gi 585612     24 DAIVAAEpePVEYVRVCDAYGTGYFYIPGTETCLKIEGYIRFQVNVGD-----NP-------GGDNDSDWDAVTAVRFS- 90
gi 81920201   24 DVIVPHEvaPT--VISAPAFSWTGFYIGGqvg---------------------------nfsSKVEITDPNKKDKLFSKd 74
gi 75398508   24 DAIVLAEpePVEYVKICDVYGAGYYYIPGTETCLRIGGYVRYDIGLGDvvsydKArtt-dvkTGEAQGIWQNHTRFTFKt 102
gi 81776563   24 DAVVVAEpePAEYVKICDVYGAGYFYIPGTETCLRIGGYLRYDIGVGDsgtfdGVnnvadhkDGGTNDTWYKNMRFTLRt 103
gi 75398467   24 DAITVAEpePAEYVKICDVYGAGYFYIPGTETCLRIGGYVRWDASAGQegsfnERrav-dheDGSINDTWHKKARLSLRt 102
gi 2496627    26 DAIVAAEpePMDYVRVCDAFGIGYFYIPGTETCLKINGYARFQVSFGP-----DEvnkrqgwGAQGTSDWDAFSRAYIAf 100
gi 81634879   24 DAIVAAEpePMEYVRVCDAFGMGYFYIPGTETCLKIGGYIRVQGDFGR-----DNvnhltsfDDDGTSDWDMFSRAYISf 98
gi 499493042  24 SKAV-AEpePVKYVRVCDAYGKGYFYIPGTETCIRVSGNIRADFLGGD-----NIdattnsqLANKKKTYGASSRLTLVf 97
gi 499273945  24 DAIVAAEpePLEYVRVCDAFGTGFFYIPGTETCLKFSGYVRFQTNFGR--------------DQSGTSDWNSFTRAQFNv 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130  103 DTRTATEYGVVRTFFDGVFTWTTGNYTPtgsatggtqysgtlglnaagtglvgsngsgsvngtdgntsagaLGVYYAFIQ 182
gi 585612     91 SRKSDTEYGPLTGVIVMQFNADNASDQD-------------------------------------------AILDSAYLD 127
gi 81920201   75 DTPKPSGF------------------------------------------------------------------------ 82
gi 75398508  103 WTGQESELGTLQTYIETRMNYG-KHTAYsgsdspr-----------------------------yyafsqgITLTFAWVQ 152
gi 81776563  104 YTGQETELGTLKTFTETRWQFGNKSGDYdgsastd-----------------------------wqgvnkgTTLNFAWIQ 154
gi 75398467  103 WTGQETELGTLKTYTETKFNYSdgs--------------------------------------------nsSSLNFAWIQ 138
gi 2496627   101 SAKSDTELGTLTGFFASEFNADNDSDVGds----------------------------------------lINLDEAYIQ 140
gi 81634879   99 DAKSDTEYGTLTGFFASEFNSDTDSASDggg-------------------------------------dshIDVDEAYIE 141
gi 499493042  98 QAASETEMGTLRSYARIFSSWSngkd------------------------------------------kdgAKLAAAYIE 135
gi 499273945  90 DTRTDTELGALRGFIEFRADAGNGQSSSsgl-----------------------------------------eaRQAFIE 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130  183 FAGFTMGKAVSQFDApWTNYPGNITDNlvggsgTVTGVTQFTYTADFGQgITASFSAEDATQYYQagnlnmtg---ataa 259
gi 585612    128 VAGFRAGLFYSWWDD-GLSGETDDIGS------VVTLHNSIRYQYESGT-FYAGLSVDELEDGVYqgtft--------pg 191
gi 81920201   83 MGGIYAGSNMDLGNNmILGVETDAVWA---------------DREDAKTsSAEAIGQDELETFRD--------------- 132
gi 75398508  153 LGGLRVGKDWSAFDM-FIGYAGDVLNQmli-pyGAFDTNVVQYYFDAGNgFTAVVSLEEGSGLVGti------------- 217
gi 81776563  155 LGGLRVGKDETVYDQ-FIGYAGNVIQDtii-pyGIKDTNVVSYYFDAGSgFSGVVSLEEGTG-ANti------------- 218
gi 75398467  139 LGGLRVGKDESAFDT-FIGYAGDVINDslv-pyGDFDTNVVQYYFDAGNgFSAVVSLEEGSGVVGti------------- 203
gi 2496627   141 LGGFKAGFFYSWWDK-GLNGETDSLAN-------ITEFNSIAYLYEGGA-FQAGVAINELEGATT--------------- 196
gi 81634879  142 LGGFRAGFFYSWWDK-GLNGETDSIGE-------NTEFNSVRYTYDGGT-FQVGVAVDELEGTST--------------- 197
gi 499493042 136 LGGFRVGLDDTIFNS-WTGGYGNVINDnsiapaGNIRTNFISYTFSGDTgFSAIIGAELGNATGPdtkdlkyyyidkdgk 214
gi 499273945 129 LGGLRVGKFYSWWDD-DLSGETDLLSS-------NTLFNSIRYTYDTGS-FWAGISVDELEGTGSqfati--------tg 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130  260 gmiGGSYGTNAIg-gSRSPNLVGQVRVDQAWGLFQASVAahdnhvgyyganettgHPDDKWGWAVQLALSIKnipTGAGd 338
gi 585612    192 vipGTTDFTADDg--PNNVGVAFGIGGTAGAFSYQVTGG----------------WDVDNEDGAIRAMGTVE---IGPG- 249
gi 81920201  133 ----SLKKANAAfaqGKTSDNVAAVDKHTDSLALK-----------------------EKWSGATRVRIGFT---AADRi 182
gi 75398508  218 --------------dSYVPHLVGGVKYTQHWGAITGVVA----------------YDSNYESVAGKVRIDVD---VTDQl 264
gi 81776563  219 --------------dSYVPHVVGGLKYKADWGAITGVVA----------------YDSNYEEVAGKVRLDVN---VTKEl 265
gi 75398467  204 --------------dSYVPHVVGGVKYTQGWGAITGVVA----------------YDSNYEEVAGKVRLDVT---ATEAl 250
gi 2496627   197 ---K-----------ANGIGVQGIVSATVGGVSIDLLGG----------------YDTEVEEGAIRALVSAE---LGPG- 242
gi 81634879  198 ---K-----------PNGVGVEGIVSASLGGVTFDLLGS----------------YDTEWEEGAIRALLSAD---AGPG- 243
gi 499493042 215 ianVSNDSLPSKgikNYTPNLVFGVKFMQQWGGFSTVAA----------------YDAYYKKWAGKARLDFN---INDRv 275
gi 499273945 192 aadPVTGLFPLSqepDNNVGITAGVGGKFGAATLQLIGS----------------YDVDQEEGAIRAMVFAD---IGPG- 251
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130  339 TINIQAVYTDGATRYnfqnlsgssyalygnsgvagaygsigfanapdtvfvTGSSQetvktwgfrgaythnwdaaWNTai 418
gi 585612    250 TFGLAGVYSSGPNSY------------------------------------YSSAE-------------------WAV-- 272
gi 81920201  183 MPYVAGGVSYA--------------------------------------------------------------------- 193
gi 75398508  265 SLFGMFGYGSSG---------------------------------------KLNDDvtnaidahgrgfykswggnWGF-- 303
gi 81776563  266 SLFVMGGYGTDD---------------------------------------NLKDPsnfvnahgr-sqykpwggnWAV-- 303
gi 75398467  251 SLFIMAGYGTDD---------------------------------------NLNDPtyaipagdr-gfykqwggnWAI-- 288
gi 2496627   243 VFQIAGVWASDPNVY------------------------------------FAASE-------------------WTV-- 265
gi 81634879  244 TFQVAGIWASGSNAY------------------------------------WHDSE-------------------WAV-- 266
gi 499493042 276 NLWVMGGYKNNVDYY------------------------------------TADEDntlsrqntt--iyanwggkWAA-- 315
gi 499273945 252 TLGLAGVWASGPNAY------------------------------------YALSE-------------------WTV-- 274
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81735130  419 ygaYAQAQFGTLAKTTLCGAg----GAGGVfggla-----gvtsCNPDFAIGQLGLVTRWTPVKNLTFSADLSWTHldqk 489
gi 585612    273 ---AAEYAIKATDKLKITPGrw-hgHVPED--------------FDGLGDAWKVGLTVDYQIVENFYAKASVQYLD---- 330
gi 81920201  194 -------QVQAVSSTKVTQAaddaeIATAQlf-----------dKTKTLVGFTLGGGVDFAMTDNVLLRAEYRYSDfgkk 255
gi 75398508  304 ---WAGATYKLNETTSLNLQls-----------------------gDQLRNYGVAANVAYAFLADFTITAELDYDRygdf 357
gi 81776563  304 ---WGGGTYKFNDKTAFNVQas-----------------------aDDDKNYALAANVAYTIVPGFTITTEVDWDHygny 357
gi 75398467  289 ---WGGGTYTVNEKTAFNLQvs-----------------------yDEAKEFGLAANVAYKIVPGLTITAEVDWAHndhd 342
gi 2496627   266 ---ATSYRYNATEKLAITPGlhywgDYGF----------------VSDADQWRGGLAVDYKITSGLASRVSVQYTSrd-- 324
gi 81634879  267 ---AASYRFNVSDKLAITPGaqywgGLNESdkl--------ggrFDNDADQWRVGLTADYDITEGLATRFAINYTD---- 331
gi 499493042 316 ---WAGTTYKLNQKANLNAQvs-----------------------ySAVKTFATSVNIAYTLIPGFIITPELTYISwkdn 369
gi 499273945 275 ---AAEYAIKATDRLTITPAvqylgNVGDKitvvntgataivsnDWSNRDAWTAGATIDYKITDGLSTKITANYYD---- 347
                        490       500       510
                 ....*....|....*....|....*....|.
gi 81735130  490 ysgtvgvtpnvvtakpaatyELKDQDSIAMI 520
gi 585612    331 --------------------PQDGEDSTSGY 341
gi 81920201  256 kfe-----------kegsefSYKTNDFRVGV 275
gi 75398508  358 avgk--------vdpsiswaNANKKSSVGGI 380
gi 81776563  358 gnp----------slygnwtKANKKDSVGGI 378
gi 75398467  343 sng-----------ynwtgiPAGKSNAVGGI 362
gi 2496627   325 -------------------iGADTEDFVSGF 336
gi 81634879  332 --------------------PSNAPDSVSGF 342
gi 499493042 370 rtfrg------vdnntiyshALNGKSALQGM 394
gi 499273945 348 --------------------EDGQDDQVTGF 358
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