4HI0,4IXN


Conserved Protein Domain Family
cobW

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pfam02492: cobW 
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CobW/HypB/UreG, nucleotide-binding domain
This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.
Statistics
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PSSM-Id: 280627
View PSSM: pfam02492
Aligned: 43 rows
Threshold Bit Score: 127.749
Threshold Setting Gi: 1170452
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4HI0_F   2 VKIGVCGPVGSGKTALIEALTrh-msKD---YDMAVITNDIYTKEDAEFMCKNSVMprerIIGVETGGCPHTaIREDASM 77  Helicobacter pylori 2...
P9WFE3  26 lrIGVGGPVGSGKTALVAALCr----QLrgeLSLAVLTNDIYTTEDADFLRTHAVLpddrIAAVQTGGCPHTaIRDDITA 101 Mycobacterium tubercu...
O64700  74 FTVGIGGPVGTGKTALMLALCrf-lrDK---YSLAAVTNDIFTKEDGEFLVKNGALpeerIRAVETGGCPHAaIREDISI 149 thale cress
P72955   6 LRIGIAGPVGSGKTALLEALCka-lrQK---YQLAVVTNDIYTQEDAQFLVRAEALtpdrILGVETGGCPHTaIREDASL 81  Synechocystis sp. PCC...
A6TE45   8 lrVGVGGPVGSGKTALLEALCk----AMrdtWQLAVVTNDIYTKEDQRILTEAGALaperIVGVETGGCPHTaIREDASM 83  Klebsiella pneumoniae...
Q7VUD5  17 lrVGVGGPVGSGKTTLLEMVCk----AMypqFDLIAITNDIYTKEDQRLLTLSGALpperILGVETGGCPHTaIREDASI 92  Bordetella pertussis ...
A3N2R0   5 ikIGVAGPVGAGKTALIERLTr----EIaskYSVAVITNDIYTQEDAEFLTKNSLLpperIMGVETGGCPHTaIREDASM 80  Actinobacillus pleuro...
Q5M604   6 vIIGVGGPVGSGKTLLLERLT-----RRmsdLNLAVITNDIYTKEDALFLAKNSSLdedrIIGVETGGCPHTaIREDASM 80  Streptococcus thermop...
Q56561   5 LIIGVGGPVGAGKTMLIERLTrylstKG---YSMAAITNDIYTKEDARILLNTSVLpadrIAGVETGGCPHTaIREDASM 81  Ureaplasma parvum ser...
Q2G273   5 ikIGIGGPVGAGKTQLIEKVVk----RLskeMSIGVITNDIYTKEDEKILVNSGVLpesrIIGVETGGCPHTaIREDASM 80  Staphylococcus aureus...
4HI0_F  78 NLEAVEEMHgr-fPnLELLLIESGGdNLSATFNPELADFTIFVIDVaegdKIPRKGGPGITRSDLLVINKIDLAPYVgAD 156 Helicobacter pylori 2...
P9WFE3 102 NLDAIDELMaa-hDaLDLILVESGGdNLTATFSSGLVDAQIFVIDVaggdKVPRKGGPGVTYSDLLVVNKTDLAALVgAD 180 Mycobacterium tubercu...
O64700 150 NLGPLEELSn--lFkADLLLCESGGdNLAANFSRELADYIIYIIDVsagdKIPRKGGPGITQADLLVINKTDLAAAVgAD 227 thale cress
P72955  82 NLAAIADLEar-fMpLDMVFLESGGdNLAATFSPELVDLTLYVIDVaagdKIPRKGGPGITKSDLLVINKIDLAPMVgAD 160 Synechocystis sp. PCC...
A6TE45  84 NLAAVEALSek-fGnLDLIFVESGGdNLSATFSPELADLTIYVIDVaegeKIPRKGGPGITKSDFLVINKTDLAPYVgAS 162 Klebsiella pneumoniae...
Q7VUD5  93 NLIAIDQMLeq-fPdADIVFVESGGdNLAATFSPELSDLTLYIIDVasgeKIPRKGGPGITKSDLFIINKTDLAPYVgAD 171 Bordetella pertussis ...
A3N2R0  81 NLEAVDEMVar-fPeVELIFIESGGdNLSATFSPDLADVTIFVIDVaqgeKIPRKGGPGITRSDLLVINKTDLAPFVgAD 159 Actinobacillus pleuro...
Q5M604  81 NFEAIETLQerfnHdLDVIFLESGGdNLAATFSPDLVDFTIYIIDVaqgeKIPRKAGQGMIKSDLFLINKTDLAPYVgAN 160 Streptococcus thermop...
Q56561  82 NFAAIEEMCdk-hPdLQLLFLESGGdNLSATFSPDLVDFSIYIIDVaqgeKIPRKGGQGMIKSDLFIINKVDLAPYVgAN 160 Ureaplasma parvum ser...
Q2G273  81 NFAAIDELLer-hDdIELIFIESGGdNLAATFSPELVDFSIYIIDVaqgeKIPRKGGQGMIKSDFFVINKTDLAPYVgAS 159 Staphylococcus aureus...
4HI0_F 157 lKVMERDSKKMRGEKPFIF 175 Helicobacter pylori 26695
P9WFE3 181 lAVMARDADAVRDGRPTvl 199 Mycobacterium tuberculosis H37Rv
O64700 228 lSVMERDSLRMRDGGPFVF 246 thale cress
P72955 161 lGIMDRDAKKMRGEKPFVF 179 Synechocystis sp. PCC 6803 substr. Kazusa
A6TE45 163 lEVMASDTQRMRGDRPWtf 181 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Q7VUD5 172 lAVMEADTRRMRGDKPFVm 190 Bordetella pertussis Tohama I
A3N2R0 160 lSVMERDARRMRNGQPFIf 178 Actinobacillus pleuropneumoniae serovar 5b str. L20
Q5M604 161 lDRMREDTLHFRNEDSFif 179 Streptococcus thermophilus LMG 18311
Q56561 161 vEVMKADTLKSRGNKDFFV 179 Ureaplasma parvum serovar 3 str. ATCC 700970
Q2G273 160 lEQMAEDTKVFRGKRPFtf 178 Staphylococcus aureus subsp. aureus NCTC 8325
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