1NIJ,4HI0


Conserved Protein Domain Family
cobW

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pfam02492: cobW 
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CobW/HypB/UreG, nucleotide-binding domain
This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.
Statistics
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Aligned: 45 rows
Threshold Bit Score: 125.422
Threshold Setting Gi: 1170452
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NIJ_A   6 VTLLTGFLGAGKTTLLRHILn----EQ-HGYKIAVIENEFGeVSVDDQLIGDRATQ----IKTLTNGCICCS-RSNELED 75  Escherichia coli K-12
P9WFE3  27 rIGVGGPVGSGKTALVAALCr----QLrGELSLAVLTNDIY-TTEDADFLRTHAVLpddrIAAVQTGGCPHTaIRDDITA 101 Mycobacterium tubercu...
O64700  75 TVGIGGPVGTGKTALMLALCrf-lrDK---YSLAAVTNDIF-TKEDGEFLVKNGALpeerIRAVETGGCPHAaIREDISI 149 thale cress
P72955   7 RIGIAGPVGSGKTALLEALCka-lrQK---YQLAVVTNDIY-TQEDAQFLVRAEALtpdrILGVETGGCPHTaIREDASL 81  Synechocystis sp. PCC...
A6TE45   9 rVGVGGPVGSGKTALLEALCk----AMrDTWQLAVVTNDIY-TKEDQRILTEAGALaperIVGVETGGCPHTaIREDASM 83  Klebsiella pneumoniae...
Q7VUD5  18 rVGVGGPVGSGKTTLLEMVCk----AMyPQFDLIAITNDIY-TKEDQRLLTLSGALpperILGVETGGCPHTaIREDASI 92  Bordetella pertussis ...
Q09066   3 KIGVCGPVGSGKTALIEALTrh-msKD---YDMAVITNDIY-TKEDAEFMCKNSVMprerIIGVETGGCPHTaIREDASM 77  Helicobacter pylori 2...
A3N2R0   6 kIGVAGPVGAGKTALIERLTr----EIaSKYSVAVITNDIY-TQEDAEFLTKNSLLpperIMGVETGGCPHTaIREDASM 80  Actinobacillus pleuro...
Q5M604   7 IIGVGGPVGSGKTLLLERLT-----RRmSDLNLAVITNDIY-TKEDALFLAKNSSLdedrIIGVETGGCPHTaIREDASM 80  Streptococcus thermop...
Q56561   6 IIGVGGPVGAGKTMLIERLTrylstKG---YSMAAITNDIY-TKEDARILLNTSVLpadrIAGVETGGCPHTaIREDASM 81  Ureaplasma parvum ser...
1NIJ_A  76 ALLDLLDNldkgN----IqFDRLVIECTG-MADPGPIiqtffshevlcqRYLLDGVIALVDAvhadeqmNQFTIAQSQVG 150 Escherichia coli K-12
P9WFE3 102 NLDAIDEL----Maa-hDaLDLILVESGGdNLTATFS------------SGLVDAQIFVIDVag---gdKVPRKGGPGVT 161 Mycobacterium tubercu...
O64700 150 NLGPLEEL----Sn--lFkADLLLCESGGdNLAANFS------------RELADYIIYIIDVsa---gdKIPRKGGPGIT 208 thale cress
P72955  82 NLAAIADL----Ear-fMpLDMVFLESGGdNLAATFS------------PELVDLTLYVIDVaa---gdKIPRKGGPGIT 141 Synechocystis sp. PCC...
A6TE45  84 NLAAVEAL----Sek-fGnLDLIFVESGGdNLSATFS------------PELADLTIYVIDVae---geKIPRKGGPGIT 143 Klebsiella pneumoniae...
Q7VUD5  93 NLIAIDQM----Leq-fPdADIVFVESGGdNLAATFS------------PELSDLTLYIIDVas---geKIPRKGGPGIT 152 Bordetella pertussis ...
Q09066  78 NLEAVEEM----Hgr-fPnLELLLIESGGdNLSATFN------------PELADFTIFVIDVae---gdKIPRKGGPGIT 137 Helicobacter pylori 2...
A3N2R0  81 NLEAVDEM----Var-fPeVELIFIESGGdNLSATFS------------PDLADVTIFVIDVaq---geKIPRKGGPGIT 140 Actinobacillus pleuro...
Q5M604  81 NFEAIETL----QerfnHdLDVIFLESGGdNLAATFS------------PDLVDFTIYIIDVaq---geKIPRKAGQGMI 141 Streptococcus thermop...
Q56561  82 NFAAIEEM----Cdk-hPdLQLLFLESGGdNLSATFS------------PDLVDFSIYIIDVaq---geKIPRKGGQGMI 141 Ureaplasma parvum ser...
1NIJ_A 151 YADRILLTKTDVAGEA----EKLHERLARINARAPVY 183 Escherichia coli K-12
P9WFE3 162 YSDLLVVNKTDLAALVgadlAVMARDADAVRDGRPTv 198 Mycobacterium tuberculosis H37Rv
O64700 209 QADLLVINKTDLAAAVgadlSVMERDSLRMRDGGPFV 245 thale cress
P72955 142 KSDLLVINKIDLAPMVgadlGIMDRDAKKMRGEKPFV 178 Synechocystis sp. PCC 6803 substr. Kazusa
A6TE45 144 KSDFLVINKTDLAPYVgaslEVMASDTQRMRGDRPWt 180 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Q7VUD5 153 KSDLFIINKTDLAPYVgadlAVMEADTRRMRGDKPFV 189 Bordetella pertussis Tohama I
Q09066 138 RSDLLVINKIDLAPYVgadlKVMERDSKKMRGEKPFI 174 Helicobacter pylori 26695
A3N2R0 141 RSDLLVINKTDLAPFVgadlSVMERDARRMRNGQPFI 177 Actinobacillus pleuropneumoniae serovar 5b str. L20
Q5M604 142 KSDLFLINKTDLAPYVganlDRMREDTLHFRNEDSFi 178 Streptococcus thermophilus LMG 18311
Q56561 142 KSDLFIINKVDLAPYVganvEVMKADTLKSRGNKDFF 178 Ureaplasma parvum serovar 3 str. ATCC 700970
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