5CEH,3OPT,4UF0,3LD8,3PTR


Conserved Protein Domain Family
JmjC

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pfam02373: JmjC 
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JmjC domain, hydroxylase
The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.
Statistics
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PSSM-Id: 334913
View PSSM: pfam02373
Aligned: 35 rows
Threshold Bit Score: 88.5163
Threshold Setting Gi: 3122969
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CEH_A       460 WLYVGMCFSSFCWHIEDHWSYS---INYLHWGEPKTWYGVPSHAAEQLE---EVMRelaPELFESQPDl-LHQLVTIMNP 532
gi 74964052  611 QVYCKPPGARTTAHLENQALGS---ININHGPGDCVWYGVPMEYSGRME---VLIK---KH-R-------LNVYKSGYWP 673
gi 74834556  150 LVYIGSNGTYTPGHIDMCGSLSqnlMVSSDQDAFAWWFIVPTEYKDEAL---KFWG---DK------GgdVYNESRFIRP 217
gi 74869387  199 FVYMGPKNSWTSYHADVFGSFS----WSTNIVGLKKWLIMPPGEELKLN----------DR---------LGNLPFSIDE 255
gi 67461003  174 WFVMGPPRSGTGIHIDPLGTS----AWNALVQGHKRWCLFPTSTPRELI---KVTR---DE-GGNQQDeaITWFNVIYPR 242
gi 67461086  179 WFVMGPARSGTGIHIDPLGTS----AWNTLIRGHKRWCLFPTQTPKELL---KVTS---AMG-GKQRDeaITWFSTIYPR 247
gi 34098760  236 YCLICVKDSYTDFHIDSGGAS----AWYHVLKGEK---IFYLIRPASAN---ISLY---ERW-RSASNhsEMFFADQVDR 301
gi 75097143 1458 KDSLSNNSCQDDVHLGTQNGS----AVWDIFRRHDVPKLTEYLKKHHREfrhIINL---PVNSVIHPIhdQILYLNEKHK 1530
gi 74581933  225 FAYLGSHLTTTGLHTDVYASHS----FSVNLCGVKCWLFIDPKDLQTIA---SLYD---DQQ--------LPSWITKDDL 286
3LD8_A       174 WFVMGPPRSGTGIHIDPLGT-S---AWNALVQGHKRWCLFPTSTPRELI---KVTR---DEGGNQQDEa-ITWFNVIYPR 242
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
5CEH_A       533 NV--L--MEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNF 576
gi 74964052  674 SEqeL--RNEKIPSQKFLQKPGDMVYVGIGTFHWVQSNDFAINVSWNV 719
gi 74834556  218 ID--L--LGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAW 261
gi 74869387  256 KM--L--DEHNVRYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNW 299
gi 67461003  243 TQlpT--WPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNF 288
gi 67461086  248 TQlpS--WPEQYRPIEVLQGAGETVFVPGGWWHVVLNMDDTIAITQNF 293
gi 34098760  302 CYk-------------CTVKQGQTLFIPSGWIYATLTPVDCLAFAGHF 336
gi 75097143 1531 KQlkL--EYG-VEPWTFEQHLGEAVFIPAGCPHQVRNRKSCIKVAMDF 1575
gi 74581933  287 FRgpL--VNHRHLIKILFQYPGQTVFVPSGWYHQVLNIGTTLSINHNW 332
3LD8_A       243 TQ--LptWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNF 288
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