5CEH,3OPT,4UF0,6FQC,3PTR


Conserved Protein Domain Family
JmjC

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pfam02373: JmjC 
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JmjC domain, hydroxylase
The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.
Statistics
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Aligned: 35 rows
Threshold Bit Score: 88.5163
Threshold Setting Gi: 3122969
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5CEH_A  460 WLYVGMCFSSFCWHIEDHWSYS---INYLHWGEPKTWYGVPSHAAEQLE---EVMRelaPELFESQPDl-LHQLVTIMNP 532  human
Q19760  611 QVYCKPPGARTTAHLENQALGS---ININHGPGDCVWYGVPMEYSGRME---VLIK---KH-R-------LNVYKSGYWP 673  Caenorhabditis elegans
O97101  150 LVYIGSNGTYTPGHIDMCGSLSqnlMVSSDQDAFAWWFIVPTEYKDEAL---KFWG---DK------GgdVYNESRFIRP 217  Dictyostelium disco...
Q9VJ97  199 FVYMGPKNSWTSYHADVFGSFS----WSTNIVGLKKWLIMPPGEELKLN----------DR---------LGNLPFSIDE 255  fruit fly
Q5R6G2  174 WFVMGPPRSGTGIHIDPLGTS----AWNALVQGHKRWCLFPTSTPRELI---KVTR---DE-GGNQQDeaITWFNVIYPR 242  Sumatran orangutan
Q9VD28  179 WFVMGPARSGTGIHIDPLGTS----AWNTLIRGHKRWCLFPTQTPKELL---KVTS---AMG-GKQRDeaITWFSTIYPR 247  fruit fly
Q9WTU0  236 YCLICVKDSYTDFHIDSGGAS----AWYHVLKGEK---IFYLIRPASAN---ISLY---ERW-RSASNhsEMFFADQVDR 301  house mouse
O04698 1458 KDSLSNNSCQDDVHLGTQNGS----AVWDIFRRHDVPKLTEYLKKHHREfrhIINL---PVNSVIHPIhdQILYLNEKHK 1530 pea
O13977  225 FAYLGSHLTTTGLHTDVYASHS----FSVNLCGVKCWLFIDPKDLQTIA---SLYD---DQQ--------LPSWITKDDL 286  Schizosaccharomyces...
6FQC_A  174 WFVMGPPRSGTGIHIDPLGT-S---AWNALVQGHKRWCLFPTSTPRELI---KVTR---DEGGNQQDEa-ITWFNVIYPR 242  human
5CEH_A  533 NV--L--MEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNF 576  human
Q19760  674 SEqeL--RNEKIPSQKFLQKPGDMVYVGIGTFHWVQSNDFAINVSWNV 719  Caenorhabditis elegans
O97101  218 ID--L--LGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAW 261  Dictyostelium discoideum
Q9VJ97  256 KM--L--DEHNVRYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNW 299  fruit fly
Q5R6G2  243 TQlpT--WPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNF 288  Sumatran orangutan
Q9VD28  248 TQlpS--WPEQYRPIEVLQGAGETVFVPGGWWHVVLNMDDTIAITQNF 293  fruit fly
Q9WTU0  302 CYk-------------CTVKQGQTLFIPSGWIYATLTPVDCLAFAGHF 336  house mouse
O04698 1531 KQlkL--EYG-VEPWTFEQHLGEAVFIPAGCPHQVRNRKSCIKVAMDF 1575 pea
O13977  287 FRgpL--VNHRHLIKILFQYPGQTVFVPSGWYHQVLNIGTTLSINHNW 332  Schizosaccharomyces pombe 972h-
6FQC_A  243 TQ--LptWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNF 288  human
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