1CF7,4YO2,1CF7


Conserved Protein Domain Family
E2F_TDP

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pfam02319: E2F_TDP 
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E2F/DP family winged-helix DNA-binding domain
This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Statistics
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Aligned: 194 rows
Threshold Bit Score: 30.081
Threshold Setting Gi: 121896338
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CF7_A            8 HEKSLGLLTTKFVSLLqeakDGV----LDLKLAADTLA--------------------VrQKRRIYDITNVLEGIGLIEK 63  human
14_pfamImport     1 NGKGLRHFSMKVCEKLh--eRGAplsqCTWPTVSGSFGsfgnhslh-----pqaydqkN-IRRRVYDALNVLMAMNIISK 72 
Q5H9I0          107 NGMGLCRLSMKVWETVq--rKGT----TSCQEVVGELVakfraasnhaspnesaydvkN-IKRRTYDALNVLMAMNIISR 179 human
EFN59258          1 -GKGLRHFSLKVCEKVe--sKGD----TTYEEVANELIadlaaevaag-tveqlhdekN-IRRRVYDALNVLEAIGMINK 71  Chlorella va...
jgi:OSTLU_38105  74 EQKGLRHFSMRVCEKVe--eKKH----TSYNEVANELVeelrvtaee---tnadfdekN-VRRRVYDALNVLMALEIIRK 143 Ostreococcus...
A0BSR6          135 SQKGLRNLSVKVRDIVle-lKS-----TSYKDVAQRLIqdlgsdgqiv-eldnpkdeqN-IKRRVYDALNVMIASKVLRK 206 Paramecium t...
CBY20527        126 ARGGLRICAKDVCDKVf--eKGR----TTYFEVANEIVgdslgt--------gdvdekN-LKRRVYDALNVLMALNIVHK 190 Oikopleura d...
XP_018655389    329 KTNGLRRYARCVCNKVk--eKGI----TSYSEVADELVheyaaehpmipseqlhyiqkN-IRRRVYDALNVLMALNVLQK 401 Schistosoma ...
XP_015688293     65 TGWGLREFSKIVSKKVe--aKGR----TTYNEVADEIFaelksith----nglefdekN-IRRRVYDAFNVLIAIRVIAK 133 malo sina
XP_002763336    107 DGIGLQHFSMKVWEKVq--kKGT----TSSKEVVGELVtefkaannhlppheiacdlkN-IKRRVYDALNVLMAMNIISR 179 white-tufted...
1CF7_A           64 KSK---NSIQWKG 73  human
14_pfamImport    73 E-K---KEIKWIG 81 
Q5H9I0          180 E-K---KKIKWIG 188 human
EFN59258         72 N-K---KAIQWKG 80  Chlorella variabilis
jgi:OSTLU_38105 144 K-K---KEIFWNG 152 Ostreococcus lucimarinus CCE9901
A0BSR6          207 EGKrviSDVYCkh 219 Paramecium tetraurelia
CBY20527        191 E-RnkeKTISWVG 202 Oikopleura dioica
XP_018655389    402 E-K---KEIRWVG 410 Schistosoma mansoni
XP_015688293    134 D-K---KEIKWMG 142 malo sina
XP_002763336    180 E-G---KMIKWIG 188 white-tufted-ear marmoset
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