1CF7,4YO2,1CF7


Conserved Protein Domain Family
E2F_TDP

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pfam02319: E2F_TDP 
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E2F/DP family winged-helix DNA-binding domain
This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Statistics
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PSSM-Id: 334892
View PSSM: pfam02319
Aligned: 199 rows
Threshold Bit Score: 29.6946
Threshold Setting Gi: 123975409
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CF7_A         8 HEKSLGLLTTKFVSLLqe-akDGV-----LDLKLAADTLA---------VrQKRRIYDITNVLEGIGLIEKKSKNSIQWK 72  human
XP_004996905 224 HDKSLGLATLRVLGVLlrlnpPFV-----LPLSILSELLQ---------V-KRRRLYEIINLLEALNFARRGGRNKLVWL 288 Salpingoeca ros...
XP_001314177   3 QDGSLKTISAVIADKLk---aAGT-----MNASDLTAMMIspiqgpsqqTsMKRRVYDVIGVLAAADIITKTG-TTITWV 73  Trichomonas vag...
XP_001328116  15 RQDSFTASTHKLIHYCss-dkNGV-----YSLNKLCTKLG---------F-HQRRFYDVINVLNTVGFCTKRDSTKLQWN 78  Trichomonas vag...
XP_001312045  15 TAVSLKSVAEKVIGFFns-qiSTI-----FDINDVSIKLN---------V-PKRRLYDVLNIMAPLGLVGRNGRGRYIWT 78  Trichomonas vag...
XP_020435369 248 TNKSLKSICDSFLEEYeg-ntRKR-----IKIEMLSQKIA---------V-DNRRFYEIIKVMQCLGLVEKEGKNEYYWV 311 Polysphondylium...
XP_020436757 244 SEKSLKKICDILLDEFrd-csRMK-----MDLETLKTKLK---------V-NKRRFYEILNVMECLGVVTKEERDTFFWN 307 Polysphondylium...
XP_004355483 464 VDKSLKVLCDGLFAYLgrqpiNQV-----IDLAGASEELN---------V-TPRRFYEILNIFECLELVSKSDRN-YVWL 527 Dictyostelium f...
XP_012895104  58 RQKSLQFITTEMVLIIlr--rQANgestsVNPSALSDQLH---------I-TRRRIYDIIHVLSCLALLSRTCYRYYGWE 125 Blastocystis ho...
XP_001743052 167 MDKTLGRIALGFIEFCkd-rqDPE-----VNLSDAAAALE---------V-ERRRIYDVINVFEALELVSRKAKNTYTWR 230 Monosiga brevic...
1CF7_A        73 G 73  human
XP_004996905 289 G 289 Salpingoeca rosetta
XP_001314177  74 G 74  Trichomonas vaginalis G3
XP_001328116  79 G 79  Trichomonas vaginalis G3
XP_001312045  79 G 79  Trichomonas vaginalis G3
XP_020435369 312 G 312 Polysphondylium pallidum PN500
XP_020436757 308 G 308 Polysphondylium pallidum PN500
XP_004355483 528 G 528 Dictyostelium fasciculatum
XP_012895104 126 G 126 Blastocystis hominis
XP_001743052 231 G 231 Monosiga brevicollis MX1
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