Conserved Protein Domain Family
TFIIF_beta

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pfam02270: TFIIF_beta 
Transcription initiation factor IIF, beta subunit
Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.
Statistics
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PSSM-Id: 308083
View PSSM: pfam02270
Aligned: 72 rows
Threshold Bit Score: 78.0747
Threshold Setting Gi: 74863108
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IHS1         15 FKNKNIKLIKVPKFVSNKWLqynnkdivgllgcnnnnNNDSE-----------------------ITELYVQKD------ 65  Plasmodium fal...
24_pfamImport   6 CAKRGVWLVKVPRYLSEMWE-------------------KNVgh--------------------dVGRLVIKAAngktdl 46 
39_pfamImport   5 RAKDGVWLVKVPKYLAELWR------------------KSGPdg--------------------vVGKVVIASSpapgqa 46 
1_pfamImport    6 RAKDGVWLVKVPNYLADLWL------------------KANTdr--------------------tVGKVVMSTVdnvlgs 47 
2_pfamImport    6 RAKDGVWLVKVPNYLCDLWM------------------KGNTek--------------------vVGEVVITATdpnsns 47 
67_pfamImport   6 KQNTGVWLVKVPKYLSQQWA------------------KATGrg--------------------eVGKLKICKKrnqgka 47 
55_pfamImport   6 KDASSVWALKVPNFLLQRWQ-----------------TVQEPgv--------------------eLGRLVVDNSvtppni 48 
44_pfamImport   6 MGQSKIWAMKVPRFLLERWE-----------------RVNVGgv--------------------hLGTLtqppkitlklp 48 
XP_002505524  134 RGEHLAWLVKVPAFVTRAWRa---------------aSDALDevseldggvgteidggkvddkelLGRMRMTVDpfappe 198 Micromonas sp....
XP_003063631  185 RAESLSWLVKVPAFVTRAWRatae---------alanADEIDdvdamdaeggaegkdgggddgdaLGEMKIAVDpfappe 255 Micromonas pus...
Q8IHS1         66 -----------------------------------DSDNVKKL------------RCNKNNTV----------------- 81  Plasmodium fal...
24_pfamImport  47 vfksnttlleknpsghdkeasssnsflsslsgnslSASRSNRIgfakckeanftmPNEHSFVIgdi-------------- 112
39_pfamImport  47 egnrrpvgs-------------qvtlvtdpdllahagETGDLI------------PKEHQFFIqtsastssaassrpgqs 101
1_pfamImport   48 kdqkqkad---------------vylitddgliadagENSDLI------------PREHKFLVqsapsskspptrnr-lg 99 
2_pfamImport   48 kdqsnvc------------------lvtddaliaeagENSDVI------------PKQHKFLVqmlssehpsdkk----s 93 
67_pfamImport  48 evsftln------------------eelatitdigdkSSTVKA------------PRDHPFTMqsv-------------- 83 
55_pfamImport  49 tlkltna----------------eegteegerakrAKYDVEGL------------PDEFKVEVpme-------------- 86 
44_pfamImport  49 i----------------------qeegseeppnkrARLNVEGI------------PDEYEVVMpse-------------- 80 
XP_002505524  199 krq------------------------rhfltledNVSAANRI------------PKEYDMVMtpd-------------- 228 Micromonas sp....
XP_003063631  256 krq------------------------rhfltlsnRVSETHRV------------PAAYDMLInpe-------------- 285 Micromonas pus...
Q8IHS1         82 -----------NTYILK--------------------------------------QNV---------------------- 90  Plasmodium fal...
24_pfamImport 113 --------rnqSLAVLC--------------------------------------EDK---------------------- 124
39_pfamImport 102 sqrrvsalsgqELIILA--------------------------------------EDD---------------------- 121
1_pfamImport  100 ssrissamegqELVILC--------------------------------------EED---------------------- 119
2_pfamImport   94 spgsisamtgqELVVLC--------------------------------------EED---------------------- 113
67_pfamImport  84 --------ggqTLAVFT--------------------------------------ESS---------------------- 95 
55_pfamImport  87 --------rskNTFLFS--------------------------------------EVK---------------------- 98 
44_pfamImport  81 --------rakNTYVFT--------------------------------------EHE---------------------- 92 
XP_002505524  229 ---------dqPIHVFSdvrentaaaaaraaarlaaeralagrgsgenqlslphdEFV---------------------- 277 Micromonas sp....
XP_003063631  286 ---------eqPIHVFSg------------------------------------aREDtaaaaaaaaaataracavaaas 320 Micromonas pus...
Q8IHS1         91 ---------------IKlkstnksvsnsagtlnnksndytntnkgkntmnnlskdnsdkhkefdyvvcadliKTCDYTYS 155 Plasmodium fal...
24_pfamImport 125 ---------------SGlnedadic----------------------------------------sgrlsieGRVVKRAD 149
39_pfamImport 122 ---------------LAvagpsstgtvcssetdtsatr--------------psspfsnsssarysrrlslfGRVNSRAE 172
1_pfamImport  120 ---------------SQapissnesasssap---------------------------paqrarsgkryslfGRVYSRAE 157
2_pfamImport  114 ---------------IHqassdpssslaig-----------------------------sqrnrssrrysffGRVNSRAE 149
67_pfamImport  96 ---------------SGqseeksdssspdls---------------------------giktgteedkialeGVVVQRAE 133
55_pfamImport  99 ---------------KIydkgnrdgtqqadapr-----------------------dawgkrkrekahpkllARVDHEGH 140
44_pfamImport  93 ---------------RTwvaapgeesssakrk-------------------------rekvgrrtrprgfcpPDPEREVP 132
XP_002505524  278 ---------------LE-------------------------------------------------------GAVSEKFD 287 Micromonas sp....
XP_003063631  321 gipgpvvelprddfiLE-------------------------------------------------------GTVSEKFD 345 Micromonas pus...
Q8IHS1        156 FLP--TLDQDYSSILKERHYKTNVKKERFTIIETRNeenmdathtlfkyytsedklnneSKDKNmknnkrlftDNDNLNT 233 Plasmodium fal...
24_pfamImport 150 CRP--PQTADYMRMKIKQIEKSSQPKRHVKQMEK---------------------------------------AEVKFKP 188
39_pfamImport 173 CRP--PPNTRYMMLKAQQMKEINRPKHEVRLLYE---------------------------------------PVRNYKP 211
1_pfamImport  158 CQP--PRNANYMKLKALQLKAKNRARHEVRVLDK---------------------------------------PVQTHLP 196
2_pfamImport  150 CRP--PDNLRYMKLKAKQLKAKNRAKHNICILEK---------------------------------------PVQTNLP 188
67_pfamImport 134 CRP--AVNENYMKLKKLQIEESSKPARLSQQLDKa--------------------------------------VTTNYKP 173
55_pfamImport 141 IQP--IRTQKYLDFLKARRMEAEQSRRPVVRMEDTGls--------------------qAEQNQl--------ASGFRSA 190
44_pfamImport 133 QDP--S-------AASSRERELETANRPARRQEH---------------------------VPGqaqsaclrfLQRVEYA 176
XP_002505524  288 VRPasVTDEAYRATHLRRIEEATKKTRVM-----GD-----------------------VKGPQ---------RTVPLPK 330 Micromonas sp....
XP_003063631  346 VRPadVDDSLYREVSARRIAEATRKTRVVQ-----A-----------------------SKGPS---------RVAPLPT 388 Micromonas pus...
Q8IHS1        234 VSHSTSKQKAKQSKkmhvfdlDKAKI--------SIFKIFERegqngvpFSFFTKS-----FNIPANHIKGILDEIAIKG 300 Plasmodium fal...
24_pfamImport 189 IAVHAEMQAREKQKke----gAKTVRadkdvvrqAIFHAFEK-------HQYYRLVdlqklTSQPPGFVKEILTEIAVYN 257
39_pfamImport 212 VANHISNIEYEARKra----eGKNLRrekddvmqDLFKAFER-------HQYYTIRdlillTKQPVTYLTEILKEIAIFN 280
1_pfamImport  197 VANHAFDIEYGVRKkr----eGKNLRreredvlqDLFKAFEK-------HQYYAFKdllllTKQPVAYLTELLKEIAVFN 265
2_pfamImport  189 VSKPVFEVQLENRKki----eGKNLRreredvlqDLFKAFEG-------HQYYTFKdlvnlTKQPANYLQEILKEIGVFN 257
67_pfamImport 174 VANHTYNVEYEKKKke----eGKRARadkqqvldMLFSAFEK-------HQYYNIKdlvdiTKQPVIYLKEILRGIGIYN 242
55_pfamImport 191 NSTFGRNMILASKQas----gERFARlerheltdRIFQCFRD-------HPYWALGalkqtLEQPDAWLREVLRDVAEQV 259
44_pfamImport 177 RQGHGSDMQLGAARva---pgERFARlernelidRLFALFTE-------KPYWSITalkqtLKQPDAWLREVLKDVASLI 246
XP_002505524  331 ARNITQRLDGKEDVk------EKAERlekplledRLMGLFER-------QSLWSFKqlvaeTRQPAVWLKEVLTELAVLN 397 Micromonas sp....
XP_003063631  389 ARNIVKREDG---Ked---trERAERmergaledKLMGLYER-------RSLWSFKqlkeeTRQPAMFLKETLDGLATLN 455 Micromonas pus...
Q8IHS1        301 KRdTDKKTVYFLK 313 Plasmodium falciparum 3D7
24_pfamImport 258 TM-PPHKSMWELK 269
39_pfamImport 281 PR-APHKNMWELK 292
1_pfamImport  266 SR-PPHQNMWELK 277
2_pfamImport  258 SR-PPHQNMWELK 269
67_pfamImport 243 VK-GTHKNTWELK 254
55_pfamImport 260 KE-GQYQGYWQLK 271
44_pfamImport 247 KE-GQYANMWELK 258
XP_002505524  398 RR-GPNTGMYVLK 409 Micromonas sp. RCC299
XP_003063631  456 RR-GPNVGMYSLK 467 Micromonas pusilla CCMP1545
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