4S2E,1NMX,3TMK


Conserved Protein Domain Family
Thymidylate_kin

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pfam02223: Thymidylate_kin 
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Thymidylate kinase
Statistics
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PSSM-Id: 280400
View PSSM: pfam02223
Aligned: 22 rows
Threshold Bit Score: 132.041
Threshold Setting Gi: 389592323
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4S2E_A        5 FEGIDGSGKTTQAKKLYEYLKQKGYF-VSLYREPGGTKVGEVLREILL----TEELDERT---ELLLFEASRSKLIE--- 73
gi 8247943    8 LEGIDGSGKTTQGDLLLAHFQRQGLA-AVLSPEPTNGPVGRLIRQALQgdlfTYNDARQFeaqMGYLFAADRHYHLYhpg 86
gi 6016460    5 FEGIDGSGKTTHAALTASWLRENGYM-VHEVREPTDSNIGSLIRSMLSsp-dARTPDVQRm--LALLFAADR-LTLR--- 76
gi 1170718    8 IEGINGVGKSTQAMRLKKALECMDYNaVCIRFPNPDTTTGGLILQVLNk---MTEMSSEQ---LHKLFTKHHSEFSA--- 78
gi 14286144  12 IEGLDRSGKSTQCQLLVDKLISQHEKaELFKFPDRTTAIGKKIDDYLKe---SVQLNDQV---IHLLFSANR-WETI--- 81
1NMX_A       14 LEGVDRAGKSTQSRKLVEALCAAGHRaELLRFPERSTEIGKLLSSYLQk---KSDVEDHS---VHLLFSANR-WEQV--- 83
gi 462468     9 FEGLDKSGKTTQCMNIMESIPTNTIK--YLNFPQRSTVTGKMIDDYLTr---KKTYNDHI---VNLLFCANR-WEFA--- 76
3TMK_D       10 IEGLDRTGKTTQCNILYKKLQPNCK---LLKFPERSTRIGGLINEYLTd--dSFQLSDQA---IHLLFSANR-WEIV--- 77
gi 74548680   2 IDGLDGAGKDTHAELIRRRYLERGEhvVFRSHPEDDNPYGKRAREALLr---GGKVNHIR---AAIFYALDVIRSLW--- 72
gi 81556222  66 IEGIDGSGKTSITNKLKALCNDESR--YYFTKEPSSGIIGEMIRKQLMn--fENPLEEST---FAYLYAADRHDHLYkkg 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4S2E_A       74 EKIIPDLKRDKVVILDRFVLSTIAYQGYGKGlDVEFIKNLNEFATrgvKPDITLLLD-IPVDIALRRLKEKNR------- 145
gi 8247943   87 DGVEAKLAQQCHVITTRYYFSSLAYNCHTEA-DWEFVQRLNQSFP---QPDWVIYLD-LPVDLALQRLGDRQQledqapr 161
gi 6016460   77 SKIEGDWAE-DVVVSDRCYYSSMVYQGPEE-----WVCEINRFAP---RPDVVILLD-IDVEVAMERCGGTDE------- 139
gi 1170718   79 -EIAALLKLNFIVIVDHYIWSGLAYAQA------DGITIETKNIF---KPDYTFFLS-SKKPLNEKPLTLQRLfe----- 142
gi 14286144  82 QYIYEQINKGVTCILDRYAFSGIAFSAAKG---LDWEWCKSPDRGl-pRPDLVIFLN-VDPRIAATRGQYGEErye---- 152
1NMX_A       84 PLIKEKLSQGVTLVVDRYAFSGVAFTGAKEN--FSLDWCKQPDVGl-pKPDLVLFLQ-LQLADAAKRGAFGHErye---- 155
gi 462468    77 SFIQEQLEQGITLIVDRYAFSGVAYATAKG---ASMTLSKSYESGl-pKPDLVIFLE--SGSKEINRNVGEEIye----- 145
3TMK_D       78 DKIKKDLLEGKNIVMDRYVYSGVAYSAAKGTnGMDLDWCLQPDVGl-lKPDLTLFLStQDVDNNAEKSGFGDErye---- 152
gi 74548680  73 LYHWRSNPGPDTLIFSRYLMGVAYLPGPLSSvLYRLLSRVLPT-----TEYMFFLDV--SPEESLRRLMERDEhe----- 140
gi 81556222 139 GILEILNTKSRKIITDRYLFSSIAYQG-------KLGYELNKNFP---LPEKVFFIE-TDPNIAYERIQKNRTqsd---l 204
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
4S2E_A      146 --FENKEFLEKVRKGFLELAK-EEENVVVIDASGE-EEEVFKEI 185
gi 8247943  162 ecYEQREKLISVHRNYDRIFAhYQGQLCRLDASLP-VEQLHQAI 204
gi 6016460  140 --FEDPLYLAGVRERYLELAD--KNGFYTVNAERG-VNLIQRDI 178
gi 1170718  143 tkEKQETIFTNFTIIMNDVP---KNRLCIIPATLN-KEIIHTMI 182
gi 14286144 153 kiEMQEKVLKNFQR-LQKEFReEGLEFITLDASSS-LEDVHSQI 194
1NMX_A      156 ngAFQERALRCFHQ----LMKdTTLNWKMVDASKS-IEAVHEDI 194
gi 462468   146 dvAFQQKVLQEYKK-MIEEGE--DIHWQIISSEFE-ED-VKKEL 184
3TMK_D      153 tvKFQEKVKQTFMKLLDKEIRkGDESITIVDVTNKgIQEVEALI 196
gi 74548680 141 -mFENLDDLTSTREKALRLA---DGWYIIN-TEDP-IEDVQSRI 178
gi 81556222 205 feLEKYKTFEQIALKYLKIFKkLEKKINVIYINNS-IKDNLDKN 247
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