1UHR,1V31,4HBM


Conserved Protein Domain Family
SWIB

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pfam02201: SWIB 
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SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumor suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
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PSSM-Id: 308037
View PSSM: pfam02201
Aligned: 372 rows
Threshold Bit Score: 36.3206
Threshold Setting Gi: 300705966
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1UHR_A        11 QFKLDPRLARLLGIHtqTRPVIIQALWQYIKTHKL--QDP-HEREFVLCDKYLQQIF--ESqRMKFSEIPQRLHALL 82
gi 749157523  83 VYRLSPMLSQLLDKTalSRSQAIKLIWKYIKDHDL------NDGHVIACDKALRTCF--DTdYLHFFSLTAYLTPHL 151
gi 695390247 364 LYKLSPSLSHLLGKSelTRPAAIKEFWAYVKEHKL--QDP-KDGRLIHPNQEMKDVFs-VD-EIGFTQVMGLLSKHL 435
gi 301105769 299 LYRLSPALSNMLGKSelTRPAAIKEFWAYVKKHEL--QDP-KDGRMIHPNAEMMNVFk-VE-EIKFTQVMGLVSKHL 370
gi 667634463 189 ryKLAAPVRKLFNKEteTKTGLLIDLWKYIRLNRL--ITE-TSDFIVTCDEKLREIF--DCdHFKILDMPRLVSALL 260
gi 440491853 153 ryKLISPVRQLFKKEteTKTGLLIDIWKYIRLNRL--VIE-ADDFTVVCDEKLKEIF--GCdQFKILDMPELVSPLL 224
gi 667639848 147 IYRLSPALSCLFNKLtdTRYNIIKDIYKYVNTYKL--NDY--ATSNVFCDENLENVF--NIkNFNFNNIQSILEPHL 217
gi 209876171 169 hYSLSNILEDFMGTSisSLPNIIKRLWQYIEINGL--HSIqQHPTSIKLDSLLKNIFceDIdIIQLSDIPDLLKKHL 243
gi 484852762 164 LYKLSRVLREIINKFtdSKPNAITALWKYIHKNGL--IKP-GEIE-IKADDKLKKLV--NKdKFLFTDIPEIITDHL 234
gi 523780826 322 lHKLSPKLSYLLKRKvgTKTDIIIDIWKYIKTTKLpiQQI-ENDKRVTCDTLLNSIF--NIdSFTYKQIPILINDHL 395
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