1UHR,4HBM,1V31


Conserved Protein Domain Family
SWIB

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pfam02201: SWIB 
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SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumor suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
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Aligned: 368 rows
Threshold Bit Score: 39.3808
Threshold Setting Gi: 239604317
Created: 3-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UHR_A        10 PQFKLDPRLARLL-G-----IHt--qTRPVIIQALWQYIKTHKLQDP-HEREF--VLC-DKYLQQIFe-S-QRMKFSE-I 74  house mouse
ELK03330      25 kqVRPKLPLLKIL-QaagaqGEi--fTVTEVMHYLGQYITMKQLYDP-REQHM--VYCgGDLLGELLg-----CQSFS-V 92  black flying fox
Q6P3Q9        22 klVKPTPLLLSLL-KsagaqKEt--fTMKEVIYHLGQYIMAKQLYDE-KQQHI--VHCsNDPLGELFg-----VQEFS-V 89  tropical clawed...
EEA05179     168 phYSLSNILEDFM-G-----TSi--sSLPNIIKRLWQYIEINGLHSIqQHPTS--IKL-DSLLKNIFceDiDIIQLSD-I 235 Cryptosporidium...
EFN57724     263 vQYRLSSALAGAL-------ALrglhSMPFVMQMLWGYIKAKQLYEP-SDKGSvcVRC-DERLRPLF--GtDSVELGK-M 330 Chlorella varia...
CDI77656     135 RPVRLSAALQQLLqL-----PLy--sSKVDVIRGLWGYVKQQQLQQQ-GAPHI--VCC-NQQLQQLFg-GlESVNLFSdI 202 Eimeria acervulina
4HBM_A        21 tlVRPKPLLLKLL-KsvgaqKDt--yTMKEVLFYLGQYIMTKRLYDE-KQQHI--VYCsNDLLGDLFg-----VPSFS-V 88  human
XP_005039489  22 alVKPKPLLLKLL-KlagaeKDt--fTMKEVIFYIGQYIMSKQLYDE-KQQHI--VHCaNDLLGDLFg-----VASFS-V 89  collared flycat...
XP_015208268  23 klVKPKTKLHALL-QhagadKDi--fTMKEIMFYLGQYIMDKQLYDK-KQQHI--VHCtNDLLGDVLg-----VNSFS-V 90  spotted gar
XP_016119088  19 klVRPKVQLKSLL-EdagadKDv--fTMKEVMFYLGKYIMSKELYDK-QQQHI--VHCgEDALGAVLg-----VKSFS-V 86  Sinocyclocheilu...
1UHR_A        75 PQRLHALL 82  house mouse
ELK03330      93 KDPSPLYa 100 black flying fox
Q6P3Q9        90 KEPRRLYA 97  tropical clawed frog
EEA05179     236 PDLLKKHL 243 Cryptosporidium muris RN66
EFN57724     331 AEALKQHL 338 Chlorella variabilis
CDI77656     203 NRLLLPHI 210 Eimeria acervulina
4HBM_A        89 KEHRKIYT 96  human
XP_005039489  90 KEHRRLYS 97  collared flycatcher
XP_015208268  91 KEPRNLYA 98  spotted gar
XP_016119088  87 KEPRALFa 94  Sinocyclocheilus grahami
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