1UHR,1V31


Conserved Protein Domain Family
SWIB

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pfam02201: SWIB 
SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumor suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
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PSSM-Id: 396672
View PSSM: pfam02201
Aligned: 337 rows
Threshold Bit Score: 39.3869
Threshold Setting Gi: 300705966
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UHR_A        11 QFKLDPRLARLLG-----IHt--qTRPVIIQALWQYIKTHKLQDPHEREF--VLC-DKYLQQIFESq-RMKFSEIPQRLH 79  house mouse
XP_016119088  20 lVRPKVQLKSLLEdagadKDv--fTMKEVMFYLGKYIMSKELYDKQQQHI--VHCgEDALGAVLG----VKSFSVKEPRA 91  Sinocyclocheilu...
XP_015208268  24 lVKPKTKLHALLQhagadKDi--fTMKEIMFYLGQYIMDKQLYDKKQQHI--VHCtNDLLGDVLG----VNSFSVKEPRN 95  spotted gar
ELK03330      26 qVRPKLPLLKILQaagaqGEi--fTVTEVMHYLGQYITMKQLYDPREQHM--VYCgGDLLGELLG----CQSFSVKDPSP 97  black flying fox
XP_005039489  23 lVKPKPLLLKLLKlagaeKDt--fTMKEVIFYIGQYIMSKQLYDEKQQHI--VHCaNDLLGDLFG----VASFSVKEHRR 94  Collared flycat...
Q00987        27 lVRPKPLLLKLLKsvgaqKDt--yTMKEVLFYLGQYIMTKRLYDEKQQHI--VYCsNDLLGDLFG----VPSFSVKEHRK 98  human
Q6P3Q9        23 lVKPTPLLLSLLKsagaqKEt--fTMKEVIYHLGQYIMAKQLYDEKQQHI--VHCsNDPLGELFG----VQEFSVKEPRR 94  tropical clawed...
XP_005849826 264 QYRLSSALAGAL------ALrglhSMPFVMQMLWGYIKAKQLYEPSDKGSvcVRC-DERLRPLF-GtdSVELGKMAEALK 335 Chlorella varia...
XP_001616132 264 fFELSPQLKNFMQ-----SPe--eTMPEVIKRIYEYSLEKEL---IDSNG--IMRtDEVLRDVL-EvdEYEFCELPRILQ 330 malaria parasit...
XP_011271235 215 kliTSNELSSLLG-----VNe--lTQHDAVYSIWQYIQFNNLQAPEDKRI--INC-DENLSKLFNVp-RFNFRDLIELLS 283 Wickerhamomyces...
1UHR_A        80 ALL 82  house mouse
XP_016119088  92 LFa 94  Sinocyclocheilus grahami
XP_015208268  96 LYA 98  spotted gar
ELK03330      98 LYa 100 black flying fox
XP_005039489  95 LYS 97  Collared flycatcher
Q00987        99 IYT 101 human
Q6P3Q9        95 LYA 97  tropical clawed frog
XP_005849826 336 QHL 338 Chlorella variabilis
XP_001616132 331 KHV 333 malaria parasite P. vivax
XP_011271235 284 KHL 286 Wickerhamomyces ciferrii
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