1V31,1UHR,4HBM


Conserved Protein Domain Family
SWIB

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pfam02201: SWIB 
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SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumor suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
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PSSM-Id: 334844
View PSSM: pfam02201
Aligned: 373 rows
Threshold Bit Score: 39.7733
Threshold Setting Gi: 300705966
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1V31_A         10 EKFKLSTALMDVL-G-----IEv--eTRPRIIAAIWHYVKARKLQNPNDPSF--FNC-DAALQKVFGe-eKLKFTM-VSQ 76
gi 82237499    22 klVKPTPLLLSLL-KsagaqKEt--fTMKEVIYHLGQYIMAKQLYDEKQQHI--VHCsNDPLGELFG----VQEFS-VKE 91
gi 754400664  214 ikliTSNELSSLL-G-----VNe--lTQHDAVYSIWQYIQFNNLQAPEDKRI--INC-DENLSKLFNv-pRFNFRD-LIE 280
gi 552839538  263 vQYRLSSALAGAL-------ALrglhSMPFVMQMLWGYIKAKQLYEPSDKGSvcVRC-DERLRPLFgt-dSVELGK-MAE 332
gi 915013517  135 RPVRLSAALQQLLqL-----PLy--sSKVDVIRGLWGYVKQQQLQQQGAPHI--VCC-NQQLQQLFGgleSVNLFSdINR 204
4HBM_A         21 tlVRPKPLLLKLL-KsvgaqKDt--yTMKEVLFYLGQYIMTKRLYDEKQQHI--VYCsNDLLGDLFG----VPSFS-VKE 90
gi 524982971   22 alVKPKPLLLKLL-KlagaeKDt--fTMKEVIFYIGQYIMSKQLYDEKQQHI--VHCaNDLLGDLFG----VASFS-VKE 91
gi 1012011084  25 kqVRPKLPLLKIL-QaagaqGEi--fTVTEVMHYLGQYITMKQLYDPREQHM--VYCgGDLLGELLG----CQSFS-VKD 94
gi 972984146   23 klVKPKTKLHALL-QhagadKDi--fTMKEIMFYLGQYIMDKQLYDKKQQHI--VHCtNDLLGDVLG----VNSFS-VKE 92
gi 1020607965  19 klVRPKVQLKSLL-EdagadKDv--fTMKEVMFYLGKYIMSKELYDKQQQHI--VHCgEDALGAVLG----VKSFS-VKE 88

                  ....*.
1V31_A         77 KISHHL 82
gi 82237499    92 PRRLYA 97
gi 754400664  281 LLSKHL 286
gi 552839538  333 ALKQHL 338
gi 915013517  205 LLLPHI 210
4HBM_A         91 HRKIYT 96
gi 524982971   92 HRRLYS 97
gi 1012011084  95 PSPLYa 100
gi 972984146   93 PRNLYA 98
gi 1020607965  89 PRALFa 94
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