3O4X,2Z6E,1Y64


Conserved Protein Domain Family
FH2

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pfam02181: FH2 
Click on image for an interactive view with Cn3D
Formin Homology 2 Domain
Statistics
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PSSM-Id: 280362
View PSSM: pfam02181
Aligned: 41 rows
Threshold Bit Score: 261.432
Threshold Setting Gi: 74963826
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3O4X_H   19 PKKVYKPEVQLRRPNWSKFV-AEDLSQDc---------FWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKdqe----- 83   house mouse
Q2V2M9  883 GQPTFTKKKKTIRLFWNEVR-PFDWPCKnnrr--crefLWSKLEPI----KVDTSRLEHLFESKSKELSVSK-------- 947  human
Q9Y613  616 DSSALPTKRKTVKLFWRELK-LAGGHGVsasrfgpcatLWASLDPV----SVDTARLEHLFESRAKEVLPSK-------- 682  human
Q9JL04 1139 RKQLIEPCRPMKPLYWTRIQ-LHSKRDSsp------slIWEKIEEP----SIDCHEFEELFSKTAVKERKKPi------- 1200 house mouse
Q9SRR2  469 EGTTDRPKPKLKPLPWDKVR-PSSRRTN----------TWDRLP----------------YNSSNANSKQRS-------- 513  thale cress
O22824  438 EKKVETMKPKLKTLHWDKVR-ASSSRVM----------VWDQIKSNSFQVNEEMIETLFKVNDPTSRTRD---------- 496  thale cress
Q9FJX6  452 DGDTDPSKPKLKPLHWDKVR-ASSDRAT----------VWDQLKSSSFQLNEDRMEHLFGCNSGSSAPKEPV-------- 512  thale cress
Q19479  614 SAVVYRKQKKTAFVRWPKLTmQMQDAGT----------VFNDSLCVDFN-EDERTKMEEVFEEAPVKQLNRKiagsvgra 682  Caenorhabditis elegans
Q9TYU9  127 FLPKKEKKTKTRTVQWSKIN-ASVVQDDs---------VWGKLAKASNV-DIDFDLLDNFFGIESLAVSGAA-------- 187  Caenorhabditis elegans
Q9C0D6   87 GYSHLGKKKRMRSFFWKTIP-EEQVRGKt--------nIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLprr----- 152  human
3O4X_H   84 ---------ggeEKKSVQKKKVKELKVLDSKTAQNLSIFLGSF-RMPYQEIKNVILEVNEavLTESMIQNLIKQMPEPEQ 153  house mouse
Q2V2M9  948 --------------KTAADGKRQEIIVLDSKRSNAINIGLTVL--PPPRTIKIAILNFDEyaLNKEGIEKILTMIPTDEE 1011 human
Q9Y613  683 ---------------KAGEGRRTMTTVLDPKRSNAINIGLTTL--PPVHVIKAALLNFDEfaVSKDGIEKLLTMMPTEEE 745  human
Q9JL04 1201 ------------SDTISKTKAKQVVKLLSNKRSQAVGILMSSL-HLDMKDIQHAVVNLDNsvVDLETLQALYENRAQSDE 1267 house mouse
Q9SRR2  514 -------------LSCDLPMLNQESKVLDPRKSQNVAVLLTTL-KLTTNDVCQALRDGHYdaLGVELLESLARVAPSEEE 579  thale cress
O22824  497 ---------------GVVQSVSQENRFLDPRKSHNIAILLRAL-NVTADEVCEALIEGNSdtLGPELLECLLKMAPTKEE 560  thale cress
Q9FJX6  513 -------------RRSVIPLAENENRVLDPKKSQNIAILLRAL-NVTREEVSEALTDGNPesLGAELLETLVKMAPTKEE 578  thale cress
Q19479  683 fgkslrattsssEFNPMSARSPTNPQVLVSPKALTIEILIKKLkPMEFTQLIEKLDANDTegIKVDLMTTLNNNFPDKVE 762  Caenorhabditis elegans
Q9TYU9  188 ------------EVVKKSTRKDAHVELLTAKRSQNVAIMLKQF--KNIDELIDDVSQNKPv-AEIDALQNLFGMLPQSEE 252  Caenorhabditis elegans
Q9C0D6  153 ----------grTLNSSFREAREEITILDAKRSMNIGIFLKQF-KKSPRSIVEDIHQGKSehYGSETLREFLKFLPESEE 221  human
3O4X_H  154 LKML--SELKEEy------dDLAESE-QFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFS 224  house mouse
Q2V2M9 1012 KQKIqeAQLANPe------iPLGSAE-QFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLG 1084 human
Q9Y613  746 RQKIeeAQLANPd------iPLGPAE-NFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFR 818  human
Q9JL04 1268 LEKI--EKHSRSskdkenakSLDKPE-QFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVM 1344 house mouse
Q9SRR2  580 EKKL--ISYSDDsv-----iKLAPSE-RFLKELLNVPFVFKRVDALLSVASFDSKVKHLKRSFSVIQAACEALRNSRMLL 651  thale cress
O22824  561 EDKL--KELKDDddg--spsKIGPAE-KFLKALLNIPFAFKRIDAMLYIVKFESEIEYLNRSFDTLEAATGELKNTRMFL 635  thale cress
Q9FJX6  579 EIKL--REYSGDv------sKLGTAE-RFLKTILDIPFAFKRVEAMLYRANFDAEVKYLRNSFQTLEEASLELKASRLFL 649  thale cress
Q19479  763 LDPF--L--KVEy------aTLTHASdQFCWHIARNKHLRLRIELFISKENVTAEIGKFQSQIELLQTGCQ-LARGEIVQ 831  Caenorhabditis elegans
Q9TYU9  253 EEAL--RRYTGDi------sLLSPPS-SFFYRLVQIQFYRLRIETQIFLSDFSRLMRELAPNVEILIRTSQEILTSPTLP 323  Caenorhabditis elegans
Q9C0D6  222 VKKL--KAFSGDv------sKLSLAD-SFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELH 292  human
3O4X_H  225 SLLELTLLVGNYMNAGSRN-AGAFGFNISFLCKLRDTKSADQKMT--LLHFLAELCEN---------------------- 279  house mouse
Q2V2M9 1085 FILSTLLAIGNFLNG-----TNAKAFELSYLEKVPEVKDTVHKQS--LLHHVCTMVVE---------------------- 1135 human
Q9Y613  819 CILATLLAVGNFLNG-----SQSSGFELSYLEKVSEVKDTVRRQS--LLHHLCSLVLQ---------------------- 869  human
Q9JL04 1345 QVLGLVLAFGNYMNAGNKTrGQADGFGLDILPKLKDVKSSDNSRS--LLSYIVSYYLRnfd------------------- 1403 house mouse
Q9SRR2  652 RLVGATLEAGMKS-------GNAHDFKLEALLGLVDIKSSDGRTS--ILDSVVQKITEseg------------------- 703  thale cress
O22824  636 KLLEAVLKTGNRMNIGTNR-GDAHAFKLDTLLKLVDIKGADGKTT--LLHFVVQEIIKfegarvpftpsqshigdnmaeq 712  thale cress
Q9FJX6  650 KLLEAVLMTGNRMNVGTNR-GDAIAFKLDTLLKLVDIKGVDGKTT--LLHFVVQEITRsegttttkdeti---------- 716  thale cress
Q19479  832 VLLRKCLQYGNYLNQGSMF-AEAAGFQFSYLIQLLQMKGKGQHTSvrLVDLIVAYCDL---------------------- 888  Caenorhabditis elegans
Q9TYU9  324 RLLLIFVNMGNYLNGNNSQ-GNAFGFTLNSLWKLIDLKGNKQEFS--LLHLLVTC------------------------- 375  Caenorhabditis elegans
Q9C0D6  293 SILHLVLQAGNIMNAGGYA-GNAVGFKLSSLLKLADTKANKPGMN--LLHFVAQEAQK---------------------- 347  human
3O4X_H  280 ------------DHPEVLKFP-DELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQNFPA----ATDEKDKFVEKMTS 342  house mouse
Q2V2M9 1136 ------------NFPDSSDLY-SEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAK-----HEMKPVLKQRMSE 1197 human
Q9Y613  870 ------------TRPESSDLY-SEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-----HELAPALRARLTH 931  human
Q9JL04 1404 ----------edAGKEQCVFPlAEPQELFQASQMKFEDFQKDLRKLKKDLKACEAEAGKVYQv--sSAEHMQPFKENMEQ 1471 house mouse
Q9SRR2  704 ----------ikGLQVVRNLS-SVLNDAKKSAELDYGVVRMNVSKLYEEVQKISEVLRLCEEtghsEEHQWWKFRESVTR 772  thale cress
O22824  713 safqddlelkklGLQVVSGLS-SQLINVKKAAAMDSNSLINETAEIARGIAKVKEVITELKQ-----ETGVERFLESMNS 786  thale cress
Q9FJX6  717 -lhgnndgfrkqGLQVVAGLS-RDLVNVKKSAGMDFDVLSSYVTKLEMGLDKLRSFLKTETT--------QGRFFDSMKT 786  thale cress
Q19479  889 ------------ATAEVEEVQ-SRMGSVRP---LNLKDLEDVVGQVQRSIRKLEGQLRSSSE---------ETLIAAYEP 943  Caenorhabditis elegans
Q9TYU9  376 ------------EPDLVAHLQ-EELSTLKDASQISFDEIKISLKTLRDGRCKLEKQLETCSG---------ASFTQFLEL 433  Caenorhabditis elegans
Q9C0D6  348 ------------KDTILLNFS-EKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGE-----------LCQQMED 403  human
3O4X_H  343 FVKDAQEQYNKLRMMHSNMETLYKELGDYF---VFDPk----KLSVEEFFMDLHNFRNMFL 396  house mouse
Q2V2M9 1198 FLKDCAERIIILKIVHRRIINRFHSFLLFMghpPYAIr----EVNINKFCRIISEFALEYR 1254 human
Q9Y613  932 FLDQCARRVAMLRIVHRRVCNRFHAFLLYLgytPQAAr----EVRIMQFCHTLREFALEYR 988  human
Q9JL04 1472 FISQAKIDQESQEAALTETHKCFLETTAYY---FMKPklgekEVSPNVFFSVWHEFSSDFK 1529 house mouse
Q9SRR2  773 FLETAAEEIKKIEREEGSTLFAVKKITEYFh-vDPAKe----EAQLLKVFVIVRDFLKILE 828  thale cress
O22824  787 FLNKGEKEITELQSHGDNVMKMVKEVTEYFh-gNS-------ETHPFRIFAVVRDFLTILD 839  thale cress
Q9FJX6  787 FLKEAEEEIRKIKGGERKALSMVKEVTEYFh-gNAARe----EAHPLRIFMVVRDFLGVLD 842  thale cress
Q19479  944 FVNQTNEKLQNVQNGLSDLKARETELQVYL---CAg------NMTLQAIFETLEQSMKIVS 995  Caenorhabditis elegans
Q9TYU9  434 IKIDCKFELDEFGANYDKLTELQYQLADYF---CENRn----TFQLDECLKIFNFLMNRLQ 487  Caenorhabditis elegans
Q9C0D6  404 FLQFAIEKLRELECWKQELQDEAYTLIDFF---CEDKk----TMKLDECFQIFRDFCTKFN 457  human
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