1M2G,4IAO,1MA3,5OL0,1S5P


Conserved Protein Domain Family
SIR2

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pfam02146: SIR2 
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Sir2 family
This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organisation and DNA damage repair processes.i
Statistics
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Aligned: 24 rows
Threshold Bit Score: 239.06
Threshold Setting Gi: 74964621
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M2G_A        20 GAGVSAESGIPTFRG-KDGLWNRYRPEE-LANPQAFAKDPEKVWK-WYAWRMEKV-F-NAQPNKAHQAFAELERLG-VLK 93  Archaeoglobus f...
O07595        19 GAGMSTESGIPDFRS-AGGIWTEDASRMeAMSLDYFLSYPRLFWPkFKELFQMKMsG-SFEPNEGHLLLAELEKQG-KQV 95  Bacillus subtil...
P75960        48 GAGISAESGIRTFRA-ADGLWEEHRVED-VATPEGFDRDPELVQA-FYNARRRQLqQpEIQPNAAHLALAKLQDALgDRF 124 Escherichia col...
P9WGG3         8 GAGISAESGVPTFRDdKNGLWARFDPYE-LSSTQGWLRNPERVWG-WYLWRHYLVa--NVEPNDGHRAIAAWQDHA--EV 81  Mycobacterium t...
O30124        23 GAGISAESGIPTFRg-EDGLWRKYDPEE-VASISGFKRNPRAFWE-FSMEMKDKLf---AEPNPAHYAIAELERMG-IVK 95  Archaeoglobus f...
O67919        11 GAGISAESGIPTFRg-KDGLWNKFKPEE-LATPEAFFRNPKLVWE-WYDWKRQLIaK--AQPNEGHKILTKMEEEF-PNF 84  Aquifex aeolicu...
Q20481        35 GAGISTESGIPDYRSkDVGLYTKTALEP-IYFQDFMKSKKCRQRY-WSRSYLNWPrFaQALPNFNHYALSKWEAAN-KFH 111 Caenorhabditis ...
Q20480        35 GAGISTESGIPDYRSkDVGLYARIAHKP-IYFQDYMRSNRCRQRY-WSRNFLAWPrFgQAAPNINHYALSKWEASD-RFQ 111 Caenorhabditis ...
WP_005574246  10 GAGISAESGIPTYRA-EDGLWAGHKIED-VCTPEALQWNRKQVLA-FYNERRRNCa--EAKPNAAHKVLVELERSY--NV 82  Aggregatibacter...
1MA3_A        23 GAGISAESGIPTFRG-EDGLWRKYDPEE-VASISGFKRNPRAFWE-FSMEMKDKLf---AEPNPAHYAIAELERMG-IVK 95  Archaeoglobus f...
1M2G_A        94 CLITQNVDDLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESA---PK--IPPLP------------------------- 143 Archaeoglobus f...
O07595        96 DIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLlerEV--PECTAag----------------------- 150 Bacillus subtil...
P75960       125 LLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWtg---dVT--PEDKC------------------------- 174 Escherichia col...
P9WGG3        82 SVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTD-ALpemPEpaIEVEP------------------------- 135 Mycobacterium t...
O30124        96 AVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHE--TYDWSefvED--FNKGei------------------------ 147 Archaeoglobus f...
O67919        85 YLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGN-ERYEYTtplPE--IPp--------------------------- 134 Aquifex aeolicu...
Q20481       112 WLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIETRQTYqdrLN--YANPGfkeqfvspgqqeldadtalplgseq 189 Caenorhabditis ...
Q20480       112 WLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYqdrLD--YANPGfkeehvapgelapdgdiilplgtek 189 Caenorhabditis ...
WP_005574246  83 QIITQNVDDLHERAGSTNVLHLHGELTKARSS-----FDPDYIvpcMG--DQSVN------------------------- 130 Aggregatibacter...
1MA3_A        96 AVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFvedFN--KGEIP------------------------- 148 Archaeoglobus f...
1M2G_A       144 -----KCDKCGS-LLRPGVVWFGEMLpP-DVLDRAMREVERADVIIVAGTSAVVQP 192 Archaeoglobus fulgidus
O07595       151 ----nNGDICGT-VLKTDVVLFGDAV-M--HFDTLYEKLDQADLLLVIGTSLEVAP 198 Bacillus subtilis subsp. subtilis str. 168
P75960       175 -----HCCQFPA-PLRPHVVWFGEMP-L--GMDEIYMALSMADIFIAIGTSGHVYP 221 Escherichia coli K-12
P9WGG3       136 -----PVCDCGG-LIRPDIVWFGEPL-PeEPWRSAVEATGSADVMVVVGTSAIVYP 184 Mycobacterium tuberculosis H37Rv
O30124       148 ----pRCRKCGSyYVKPRVVLFGEPL-PqRTLFEAIEEAKHCDAFMVVGSSLVVYP 198 Archaeoglobus fulgidus DSM 4304
O67919       135 -----KCEKCGG-LLRPGVVWFGESL-PvDALSRAYELSREAHVFIVVGTSGVVYP 183 Aquifex aeolicus VF5
Q20481       190 gfkipECLNCGG-LMKTDVTLFGENL-NtDKIKVCGKKVNECNGVLTLGTSLEVLS 243 Caenorhabditis elegans
Q20480       190 gfqipECPSCGG-LMKTDVTFFGENV-NmDKVNFCYEKVNECDGILSLGTSLAVLS 243 Caenorhabditis elegans
WP_005574246 131 -----DKDPNGH-PMRPHIVFFGESV-P--VLEPAIDLVSQADIVLVIGTSLQVYP 177 Aggregatibacter actinomycetemcomitans
1MA3_A       149 -----RCRKCGSyYVKPRVVLFGEPL-PqRTLFEAIEEAKHCDAFMVVGSSLVVYP 198 Archaeoglobus fulgidus DSM 4304
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