Conserved Protein Domain Family
DENN

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pfam02141: DENN 
DENN (AEX-3) domain
DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Statistics
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PSSM-Id: 307995
View PSSM: pfam02141
Aligned: 35 rows
Threshold Bit Score: 151.957
Threshold Setting Gi: 74858664
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626318   362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQAEDLdfipssdlnslksLNLQSFVKNiCCDVPLPPKGLLQLQ--VNVGP 439
gi 121930346  168 WIPYCLSFLSRYPLYNLL-GDYLRGMWIHWNKAT--------------NLFHAEEVSrILSFPAPRLNDLVRI--DMKDY 230
gi 121937700  440 WTPRAFGILGRDPAKMGFwKEWLRAVTVPMTDGAVmrispsspkvgrwQPLERYVINlCTEAFSPLSSLTQVE--LGVRE 517
gi 121737812  423 WIPRAYGILGREENMTSFwKEWLKAVVVPMTDGGVqrippssprmgvwQPLERYVMNlCTEAFSPNSSKTQVE--LAVRE 500
gi 121925604  418 WIPRAYGVMGRDASLTPFwKEWLKAVVVPMTNGAIlrvpassprigmwQPLERYVVNlCAEALSPITSITQVE--LAVRE 495
gi 158513218  187 FVPFAVCVVSRFPYYNSL-KDCLSCLLTHLKLCKDfe---------vdNHIKDFAAR-LSLIPSPPPGPLHLI---FNMK 252
gi 122068476  106 YAPKCLVIVSRLDYIETF-RNCLGTIYTVYLESLK-------------FHLHHLIGSiLGCIQVPPPGGPQVRfsIGAGD 171
gi 74750502   116 FAPKSLVLVSRLYYPEIF-RACLGLIYTVYVDSLN-------------VSLESLIANlCAC-LVPAAGGSQKLfsLGAGD 180
gi 123909909  117 YAPRSLVLVSRLDHTEVF-RNCLSLIYTVHVDGLT-------------VPMETVIGNlLTC-IIPIAGGSQRTitLGAGD 181
gi 154292204  466 WIPRAYGILGRDGSMTSFwKEWLKAVVVPMTDGGIlrvpasspkigrwQPLERYVVNlCTEALSPISSKTQIE--IAVRE 543
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626318   440 LNLYAFRSpVNEIpg-wNDVDLYpLFRALSIPNILVLFEAALM-EAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIP 517
gi 121930346  231 ALCYQFPSsPTGF----QNFAMWpLFTCLSIPNIVGVIEAAVSpTRRIIFTSHYPAMLTIAAETVRFCVRVYEWSGLYVP 306
gi 121937700  518 LRLYARKEaANEIpg-sRTIDIYaLFRCLSLENIVLLLECAMS-EARIIFLSSHTGMLHLACHALANLLYPLKWASIFIP 595
gi 121737812  501 LRLFARKEaANELpg-sRNTDLYaLFRTLSLSNIVILFEYALT-ESRIIFLSSHTSMLYLATRALVDLLFPITWTGVLIP 578
gi 121925604  496 LRMYARKEaLNEIpg-sRNIDIYaLFRCLSIPNIVTLFEFVLS-ESRIILLSSHTAMLHLASMAIVNLLYPFQWAGVFIP 573
gi 158513218  253 PLQVVFPS-RADPespiVDLDLHlPLLCFRPEKVLQILTCILT-EQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVP 330
gi 122068476  172 KQVLQPPI-SPTIp--vTGSCVSlLFHQLGIKNVMLLFCAVMT-EHKILFHSTSYSRLTDSCRALTALMYPFRYSHVYIP 247
gi 74750502   181 RQLIQTPL-HDSLp--iTGTSVAlLFQQLGIQNVLSLFCAVLT-ENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIP 256
gi 123909909  182 RQVIQTPI-NDSLp--vSGCSVAqLFRQLGIVNVLCLFCAALT-EHKILFLSSSYQRLTDACRALLAIMFPLKYSFTYVP 257
gi 154292204  544 LRLFARKEaPNELpd-sRNTDIYaLFRALSIPNIVALVEFMLS-ESRIILLSSHTAMLHLASKALVSLLYPLKWASIFIP 621
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 74626318   518 VLPRRLISCF-EAPCSYIIGTLSYFFHMDDVPLDNIPLVvcDLDKN 562
gi 121930346  307 VVHARHVKDLvQEPGPYILGVTSECRS-LFTAPTDALVV--DLDRN 349
gi 121937700  596 VLPARLISAL-EAPCPYIVGVERRYEK-IELPDDDYVLV--DLDRD 637
gi 121737812  579 VLPARLIQAL-EAPCPYIVGIERRYEK-VELPSDDFVLV--DLDAD 620
gi 121925604  574 ILPARLVQTI-EAPCPYIVGIERRYEP-TDYPEDEYVLI--DLDAN 615
gi 158513218  331 ILSGQMLDFV-MAPTSFLMGCHLDHFEEVRKEADGLVLI--DIDHG 373
gi 122068476  248 ILPASLVEVL-STPTPFIMGIHSSMQT-EVTEVLDVIIA--DLDGG 289
gi 74750502   257 ILPAQLLEVL-SSPTPFIIGVHSVFKT-DVHELLDVIIA--DLDGG 298
gi 123909909  258 ILPGKLLEVL-SSPTPFIIGVNSHFRS-ETQELLDVIIA--DLDGG 299
gi 154292204  622 VLPARLISAL-EAPCPYIVGIERRYDN-IELPEDDYVFV--DLDQD 663
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