Conserved Protein Domain Family
Hydantoinase_A

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pfam01968: Hydantoinase_A 
Hydantoinase/oxoprolinase
This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds.
Statistics
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Aligned: 32 rows
Threshold Bit Score: 165.133
Threshold Setting Gi: 74532646
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8R733   192 RTRTAAINACILPKMIETANMTEDSVKKSGIK--APLMIMRGDGGVMNIAEVRKRPILTLLSGPAAGVAGALM---YEKV 266 Caldanaerobacter su...
AAK90980 203 RAIVSVLNAFVKRRMNEYIGAVETYVAERLPG--SQLFVTRSNGGAMAASEARNFPVHTLLSGPASGVTAVQYlgrALGE 280 Agrobacterium fabru...
Q987J7   216 RSSTAILNGYVHPRVSSYLTALEARLKDRGVP--ARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWlarQAGE 293 Mesorhizobium loti
Q9RD55   194 RTRTAVVNAAILPRMLATADLVDASITKAGVT--APLMVMRCDGGVMSLDEMRRRPLLTVLSGPAAGVAGALM---QERV 268 Streptomyces coelic...
Q8RAT0   180 RVYTSYLNSAVHSIFNEFLNNIKKSLEKEGIN--APVFILKADGGTMNISTAEKKPVETILSGPAASLMGINAm--LPTN 255 Caldanaerobacter su...
Q58250    53 DYVALVMTAELADCYKTKKEGVEDIIDKVEKAfnCPVYVFDVNGNFLTSEEAKKNYLDVSASNWNATAKFVAEf--IKDS 130 Methanocaldococcus ...
Q8TZ27    69 DVVGLTMTGELADAFNTRREGVEYIVRTVTSAchAPVYVVTSDGSTVPPEEALRRWREVASANWRATAEVLAHv--RPGS 146 Methanopyrus kandleri
Q97XP8   198 RTSTAVLNAYVMPKMSKYLSKLENEFKNRGFK--GNYFAMLSNGGMATFDYAKRFPIYTLESGPVAGVIGAIKisdILGE 275 Saccharolobus solfa...
Q982K1   198 RFTLASIRATILPVMADYFERLQARLLEGGFS--GNLMILKSNGGMMGVDQARLRVEELVESGPAGGVGYATEiarTAGF 275 Mesorhizobium loti
O25402   222 RMNTTILEAYAAEPSRQTLSKVSNRFKEHGAK--FDLRVMATHGGTISWK--AKELARTIVSGPIGGVIGSKLlgeTLGY 297 Helicobacter pylori
Q8R733   267 SDGIFLEVGGTSTDISAIKAGKVMVNYAEI-------GGHKTYLNSLDVRTVGIAGGSMIr-LGDKDIEDVGPRSAHIAG 338 Caldanaerobacter su...
AAK90980 281 HNILTMDMGGTSTDISLVRDGEALTSTSAEv------GEFPVVMPVTSIEAIGAGGGSVV--TIDGGVLRIGPRSAGSYP 352 Agrobacterium fabru...
Q987J7   294 NRILTLDIGGTSADFALIIDGEPQFGTGELi------GEFPLHIPSVSVSSIGVGGGSIAs-VDAQTVLRVGPESAGSTP 366 Mesorhizobium loti
Q9RD55   269 SEGVFLETGGTSTDISVVRRGKVAVRHAVL-------LGRTSYLNALDVRTVGVGGGSMVr-VSGGRVTGTGPRSAHIAG 340 Streptomyces coelic...
Q8RAT0   256 EDAILLDIGGTTTDIFFLADGVPLFEPWGIr-----iGKYKTLIRAIYSVSIGLGGDSSIcvRNG----RIKIGPQREGV 326 Caldanaerobacter su...
Q58250   131 --CILVDMGSTTTDIIPIKDKEV--------------LAEKTDLDRLMNNQLVYVGTLRTpvSFLANKIEFRGKLTNLSS 194 Methanocaldococcus ...
Q8TZ27   147 --YLLVDLGSTTLDLIPIIRGEVA-------------AEGRTDLERMKNGELAYLGALRTpiSFLLREVEIDGEPVPVSY 211 Methanopyrus kandleri
Q97XP8   276 KNIIAMDGGSTTTKASLVRNLEPNINTDYYvgrdkynPGYPVKVPTLDIVEIGNGGTSIAr-IDETSNLKVGPRAAGAYP 354 Saccharolobus solfa...
Q982K1   276 PNIIHTDMGGTSFDASIIEDGQGLITREYEi-----eFDMPVAVPMLDIRSIGAGGGSVGw-VDSGGSLRVGPMSAGSVP 349 Mesorhizobium loti
O25402   298 DNIACSDIGGTSFDMALIVKSNFNIASDPDm------ARLVLSLPLVAMDSVGAGAGSFVriDPHSRSVKLGPDSAGYRV 371 Helicobacter pylori
Q8R733   339 LPyavysdpeeiiepeivyikpkkndpdnyvaiKSKNGKIFAVTVSCAANVLGYVKPEdYA--------YGNQEAARKAL 410 Caldanaerobacter su...
AAK90980 353 GP-------------------------------ACFSRGGTEPTLTDAFLLAGYLPEA-LLgg----dmQLDRHAAERAM 396 Agrobacterium fabru...
Q987J7   367 GP-------------------------------ACYGRGGERATVTDAMVVCGWLGHSeMAyg----qlRIDTQLAHRAV 411 Mesorhizobium loti
Q9RD55   341 LPyacyadpadlrdakl-ttisplpgdpadyavLDAAGGRFALTMTCAANALGRVPEGdFA--------HADPDTARAAL 411 Streptomyces coelic...
Q8RAT0   327 PY----------------------------------AFGGPKPTPTDAMITLELIDENaFSlt------qDNVKKAYEAM 366 Caldanaerobacter su...
Q58250   195 EY---------------------------------------FAITADISLILNKITEEdYTcdtpdgagKDFESCLTRLV 235 Methanocaldococcus ...
Q8TZ27   212 EY---------------------------------------FSIVADALLLLGEIDPEdYTpetpdgrgKSPEECARRLA 252 Methanopyrus kandleri
Q97XP8   355 GP-------------------------------VAYGKGGKDVTVTDAYIVCGFLNQEeLLgg----kiKVNKRLAEEAI 399 Saccharolobus solfa...
Q982K1   350 GP-------------------------------ACYGRGGTRPAITDANLVLGRISPDlsg------kfKLDVQAARDAI 392 Mesorhizobium loti
O25402   372 GT-------------------------------CWKDSGLDTVSVTDCHIVLGYLNPDnFLgg----liKLDVDRAKKHI 416 Helicobacter pylori
Q8R733   411 -EPIAKKLNKT---VEEVAERIMNIASMKVAKVVEQL-------------LNDYKLDKDTTILVGGGGGS-ASIVPYVA- 471 Caldanaerobacter su...
AAK90980 397 -APIAETLKTD---VLSAAEMCVTVASSNMVAGVLPY-------------LARQGVDPEDLTVLVYGGAG-AIQGPLLA- 457 Agrobacterium fabru...
Q987J7   412 -GDLAARLGRT---VEQTAQAILDIAVSEMFVEVEKL-------------ASRAGVDLRDFTLMPFGGGG-PMLGAFLA- 472 Mesorhizobium loti
Q9RD55   412 -APLAAALGTD---VDTAAARLLDAGTDQVKSVVDDL-------------VREYRLDTDTAVLVGGGGGA-ASVTPHLA- 472 Streptomyces coelic...
Q8RAT0   367 -TLLGKELNLS---AKDMAKLILSTMGDIIKNKVDELlheinsrpvytvkELLYGKKIKPKLINIIGGPS-KVLAPVLE- 440 Caldanaerobacter su...
Q58250   236 rVLCADREMVKddeLIDFANKLYNKLLELIRENVDTI------------------AKRYNLNDVVITGLGeEILKDAL-- 295 Methanocaldococcus ...
Q8TZ27   253 rTVCSDPEELGwegVMDLAKTAVRALLGQLLKHIELK------------------LQEHGLDTVVAAGAG-DFLIEMACk 313 Methanopyrus kandleri
Q97XP8   400 -SNIAKYYNMS---IEEVSYGIVKIANDNAVNAVRLI-------------SVQRGYDPREFTLVAYGGSG-PMFAPFVA- 460 Saccharolobus solfa...
Q982K1   393 -ETIATKLNLT---IEQCAEGMIRIATEAMAQAVKLV-------------LASRGRDPRDYCFASFGGAG-PLHACAVA- 453 Mesorhizobium loti
O25402   417 kEQIADPLGIS---VEDAAAGVIELLDLELKEYLRSN-------------ISAKGYSPSDFVCFSYGGAG-PVHTYGYT- 478 Helicobacter pylori
Q8R733   472 -KIMGMHHRIAKNA--QVISTIGVALAMVREI 500 Caldanaerobacter subterraneus subsp. tengcongensis
AAK90980 458 -AEIGVNRVLVPATp-SVFCALGGLVSDLSND 487 Agrobacterium fabrum str. C58
Q987J7   473 -RELGMKRVMAPRRp-GVVSALGGLVANLRSD 502 Mesorhizobium loti
Q9RD55   473 -ARTGMTGRIARHS--EVISPIGVALALVREQ 501 Streptomyces coelicolor
Q8RAT0   441 -EKFNLPCYYPKNY--SVANAVGAALARPTTE 469 Caldanaerobacter subterraneus subsp. tengcongensis
Q58250   296 -DEYNIISIKETYGkdVSLATPSFAVAKLLQK 326 Methanocaldococcus jannaschii DSM 2661
Q8TZ27   314 rIGVEVEPFDEIFGk-GSEVAPAVGAAFLAIR 344 Methanopyrus kandleri
Q97XP8   461 -EELDIKKIIVPFLpaGVFSAWGMLVSDIRHD 491 Saccharolobus solfataricus
Q982K1   454 -EALGTPTVIVPRYs-GVASAYGALRLAIKHD 483 Mesorhizobium loti
O25402   479 -EGLGFKDVVVPAWa-AGFSAFGCACADFEYR 508 Helicobacter pylori
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