2IDX,3KE4,1RTY,2ZHY,2AH6,3GAJ,1WVT,1WOZ,1NOG


Conserved Protein Domain Family
Cob_adeno_trans

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pfam01923: Cob_adeno_trans 
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Cobalamin adenosyltransferase
Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.
Statistics
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Aligned: 593 rows
Threshold Bit Score: 40.1725
Threshold Setting Gi: 134053803
Created: 3-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IDX_A            5 YTKTGDKGFSST-FTGE--RRPKDDQVFEAVGTTDELSSAIG-FALelvTEKghtFAEELQKIQCT-LQDVGSA--LATP 77  human
Q8ZVA6           12 gacPGDLGDTEVlWRGRhlCVSKASGIVKLFGALEAALGYIN-FAAmscKR----QKRCLFRAYWS-LFYLGLY--LST- 82  Pyrobaculum ...
Q8ZWM6           15 FTCPGDSGDTVVyWKGSarPVRKDDPVVKLYGALDTAIAYSH-KAAnliPRP---QARIMRLVAFS-LMELGFY--LAT- 86  Pyrobaculum ...
jgi:Lebu_0074    90 iydkkpeyMTQL-FGDN--LVVKNHKRIILRGKFDILQAEII-KYW--------------KKYEKN--KKLESD--F--- 144 Leptotrichia...
jgi:Hprae_0283   97 yfkekpeaMTQI-FANK--LVYKDHPLIEYRGKLDSFQSQIL-EVM--------------LVVETEeIPGLYQD--L--- 153 Halanaerobiu...
jgi:Dred_1300    79 fsekkpehMTQL-KGKN--LVDKRHPVIRLRGKLDSFQALAI-DTI--------------IDLQTFgYGQMAKE--L--- 135 Desulfotomac...
CBK79491        109 vlsvkpenMTHL-HGNV--LVPKTHPQIAFRGMLDSLEAKIM-SLQ--------------VVASENgLHRLTDA--L--- 165 Coprococcus ...
jcvi:TREAZ_1560   3 vlskkpehKTHL-AGNR--LVSKSHGRIAFRGMIDVLEAEVL-EAQ----------------VLASgLGEEWYCtcL--- 59  Treponema az...
jgi:Clole_4086   80 klnekpehMTHL-RDNL--LVFKDHPRIVFRGAIDSLEAEIV-MTQ--------------IFAEKEhLPQIIAD--L--- 136 Cellulosilyt...
jgi:Xaut_5023     8 satAGDAGMTRL-AIGT--RVEKDSPTIELFGTLEELAAWIAvLADdplSPE---DRRILATVEND-LHELLQQ--VAAP 78  Xanthobacter...
2IDX_A           78 cssareahlkYTTFK-AGP----------I---------LE-LEQWID-KYT-SQLP-----------P----LTAFILP 119 human
Q8ZVA6           83 ------------------GndfyynkslyM------------LRKSLRcVLPmLPDS-----------P----LG-WVYC 116 Pyrobaculum ...
Q8ZWM6           87 ------------------GraeyldtataL------------YRRALKlAYAaAPEG-----------R----LGSWLAC 121 Pyrobaculum ...
jgi:Lebu_0074   145 ----------------AQ-----------TyrfvrdlfiSEmTDMEFQ-ERNvLGYDidtlkdithntVkyfkT-GHLFE 195 Leptotrichia...
jgi:Hprae_0283  154 ----------------EE-----------SleimrnvlaAEvRDQELK-LDTiIGLTaaeirarshnpQkyfsVK-HILP 204 Halanaerobiu...
jgi:Dred_1300   136 ----------------EE-----------VltlaravlrAEvTGEELP-EPGfAGLTsneireishhpDkhlgVK-HFLP 186 Desulfotomac...
CBK79491        166 ----------------DE-----------VlayvrqilsAEvLDKELG-EIHlLGLDsaglryeshhiKeiygIP-HPMP 216 Coprococcus ...
jcvi:TREAZ_1560  60 ----------------GE-----------VldylraimiAEvKSEPFP-SLKlFGLAldeihqqshdvKaafgLARHPLP 111 Treponema az...
jgi:Clole_4086  137 ----------------EE-----------IikfirrllrNEvCGEPIG-EFTlQGLDakelrehshhpSkyygIK-HFLP 187 Cellulosilyt...
jgi:Xaut_5023    79 g---------TPLLSpPY-----------V---------QR-LDVLMD-GME-RRLP-----------P----APSGAFP 111 Xanthobacter...
2IDX_A          120 S-G--GKISSALHFCRAVCRRAERRVVPL---VqmgetD-ANVAKFLNRLSDYLFTLARY 172 human
Q8ZVA6          117 L----DRCCAAVNNARAWVRWAERRLAAIeegR-------EAIL-VLNHLSSLLFEIMRT 164 Pyrobaculum aerophilum
Q8ZWM6          122 A----SPECSAVDEARVWIRWAERRLVSLgeaP-------AAKL--LNQLSNLAFEVMRT 168 Pyrobaculum aerophilum
jgi:Lebu_0074   196 InIdyDESVIDLNYLRALSRECELAAVEAfykEgk--vErLDMLKALNRLSSILYLMMLK 253 Leptotrichia buccalis C-1013-b
jgi:Hprae_0283  205 S-TdlGKILIKLNSLRSSVREVEIAAVKAfrdEkg--iKrPDIIKALNRMSSVFYVMMCK 261 Halanaerobium praevalens DSM 2228
jgi:Dred_1300   187 S-PahGKIMARLNLLRTSIRETELVAADGfvrEng-etErKDIMETLNRMSSMIYIMMCK 244 Desulfotomaculum reducens MI-1
CBK79491        217 E-YrmGRICIGLNELRTFVRETELAAARAfqsg--dtcTrPDIVEAMNRLSSVIYILFCr 273 Coprococcus catus GD/7
jcvi:TREAZ_1560 112 D-QsmGPLVARINYLRARVREGELLAVRIfgr---ltgRrQDLITAMNRLSSALWWLCCk 167 Treponema azotonutricium ZAS-9
jgi:Clole_4086  188 H-YkqGEMVAYLNKLRTLTRQTELIAYKAfkdEyg-qvSrEDIIKSLNRLSSLFWVMMFK 245 Cellulosilyticum lentocellum DSM...
jgi:Xaut_5023   112 G-G--SPRAAFAAVARSVCRRAERRLVAQcdiDrgl--paASGIAYLNRLGDLLQQMARL 166 Xanthobacter autotrophicus Py2
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