Conserved Protein Domain Family
tRNA-synt_1f

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pfam01921: tRNA-synt_1f 
tRNA synthetases class I (K)
This family includes only lysyl tRNA synthetases from prokaryotes.
Statistics
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Aligned: 30 rows
Threshold Bit Score: 414.732
Threshold Setting Gi: 27805740
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9X895  11 TDWVSRFADEVIAES-ERRapgkPGVVVASGLSPSGPIHLGNLREVMTPHLVADEVRRR-GHEVRHLISWDDYDRYRKVP 88  Streptomyces coelicol...
Q57959   1 MHWADVIAEKLIEER-KA-----DKYIVASGITPSGHIHVGNARETLTADAIYKGLINK-GVEAELIFIADTYDPLRKLY 73  Methanocaldococcus ja...
P0CW67   1 MHWADATSEKIMKKR-NA-----EEYVVSSGITPSGHIHIGNARETLTADAVYKGMLKK-GAEAKLIFIADDYDPLRKLY 73  Methanococcus maripal...
O29052   1 MHWADVIAADLLKRS--------NSHRIATGISPSGHIHLGNLREMVTADAIRRALLDA-GGEAKIVYIADDFDPLRRRY 71  Archaeoglobus fulgidu...
Q6L1V1   1 MHWSESLLKDVS-----------GDQRISTGISPSGPIHIGNMREILTGDIIYKEALKL-GIKASFIYLCDDMDPLRKVY 68  Picrophilus torridus ...
P57677   4 LFWADALVKDLS-----------GPQRVSTGISPSGPIHVGNMREILTGDILFKAITKR-GLESDFIYLCDDMDPLRKVY 71  Thermoplasma acidophi...
Q8TWP6   4 EHWSEVKAREVTEHCrKHAdelpDEIVVASGASTSGRLHVGNARDVLTADAVARVLRERyHEDVRVVWISDDVDPLRRIP 83  Methanopyrus kandleri...
Q2NHG8   3 KHWTERIAEELSQQKkD-------EYIIGSGTSISGSVHIGNSCDIFIANAVSKELRKI-GENAKTVWIADDYDPLRKVP 74  Methanosphaera stadtm...
O27585  22 KHWIERIADELKERDvE-------EHVVASGTSISGSIHIGNSCDVFIASSIAKSLKKD-GFKSRTVWIADDHDPLRKVP 93  Methanothermobacter t...
Q73JY6   8 LHWADQTAEKIIRERgDL-----DVYTCASGITPSGTVHVGNFREIISVDLVVRALRSR-GKNVRFIYSWDDYDVFRKVP 81  Treponema denticola
Q9X895  89 AgvpGVDES--WAEHIGKPLTSVPAPKGSpHPNWAEHFKAAMVDSLAEMGV-EFDGISQTAQYTSGVYREQILHAMKH-- 163 Streptomyces coelicol...
Q57959  74 P---FLPKE--FEQYIGMPLSEIPCPEGC-CESYAEHFLRPYLESLDDLGV-ELTTYRADENYKKGLYDEKIKIALDN-- 144 Methanocaldococcus ja...
P0CW67  74 P---FLPKE--FEKYIGMPLSEIPCPQGC-CKSYADHFLMPFLNSLEDLGV-EITTHRANECYKAGMYNDAIITALEN-- 144 Methanococcus maripal...
O29052  72 P---FLPEE--YENYVGMPLCKIPDPEGC-HDSYSEHFLQPFLESLEILGI-PVEVRRAYQMYSEGLYENNTRIALKR-- 142 Archaeoglobus fulgidu...
Q6L1V1  69 P---FLPGS--YERYVGHPLSMIPAPDGD--KTYSEYFLEPFKETIDKIDV-RPEIISTTSLYKNGVLSRAIDIAMNN-- 138 Picrophilus torridus ...
P57677  72 P---FLSKD--YERYVGQPLKNIPAPQGA--GKYSDYYLEPFVRVMKEANI-PARVIKTSDLYESGMLAQACDIAINN-- 141 Thermoplasma acidophi...
Q8TWP6  84 R---DLDGRl-SEDYLGVPYKAIPVGD----EPYSDRWARNFVEELREFGA-EVEWISSAELYTDNGFVKLVREVVNDyy 154 Methanopyrus kandleri...
Q2NHG8  75 Y---PLPEN--YSKYLGQPYYEIPCPEGC-CENFVEHFQKPFVNSLKPFDIeNLEIKSGAQMYKNGVYTEATKVALEN-- 146 Methanosphaera stadtm...
O27585  94 Y---PLPES--YEKYLGVPYSMIPCPEGC-CESFVEHFQRPFLEALERFRI-GVEHYSGARMYTEGLYNDYIRTSLER-- 164 Methanothermobacter t...
Q73JY6  82 A---NMPKPevLEKYLRYPITMVPDTFER-DENYARHHEHDVEAVLPRVGI-HPEYLYQAERYQKGMYAEGMKKALDN-- 154 Treponema denticola
Q9X895 164 --RRDIDAILDQYRTKKapakKSQKpldeaeleaaegsgaaaeddgssgsagYFPYKPYCGNCEK-DLTTVTAYDdDSTE 240 Streptomyces coelicol...
Q57959 145 --REKIMEILNKFRANP----LPDD---------------------------WWPINIVCENCGKl-KTKVIKYDsEKEE 190 Methanocaldococcus ja...
P0CW67 145 --RLKIKELLDSYRKEP----LADD---------------------------WYPLNVVCEKCGKmHETKVINYNsEDKT 191 Methanococcus maripal...
O29052 143 --RDEIARIIAEVTGRE----LEER---------------------------WYPFMPLCENCGRiNSTRVTSFD--ENW 187 Archaeoglobus fulgidu...
Q6L1V1 139 --REKIKNILNSIGNYK----ITGD---------------------------WYPYEPVCKSCGRiNTTTVISYN--YPY 183 Picrophilus torridus ...
P57677 142 --REKIKDILETVSGRK----IEGD---------------------------FYPYEPLCEKCGRiSTTHVISYS--YPY 186 Thermoplasma acidophi...
Q8TWP6 155 ggGGRLASVLERF--------GLED---------------------------ARVYMPVCEECGRiATTRVVDVD--GWR 197 Methanopyrus kandleri...
Q2NHG8 147 --TERIREIFNEYREHP----LSED---------------------------WLPYNAICSECGRvNTTHAYDFE--GTN 191 Methanosphaera stadtm...
O27585 165 --APEIREIFNRFRDRP----LRDD---------------------------WLPYNPICEKCGRvNTTEAYDFS--GDT 209 Methanothermobacter t...
Q73JY6 155 --REELKDILNTYRDESh--kITEE---------------------------YWPVSVFCTACNK-DTTKIESWD-GDWT 201 Treponema denticola
Q9X895 241 LTYaC-----------TACGFSETVRLSEFNr--------GKLVWKVDWPMRWAYEGVVFEPSGVDHSSpgsSFQVGGQI 301 Streptomyces coelicol...
Q57959 191 ITYrC-----------EICGFENTVKPYKGR---------AKLPWRVDWPARWSIFNVTIEPMGKDHAAaggSYDTGVLI 250 Methanocaldococcus ja...
P0CW67 192 ITYvC------------KCGFENTVKPFNGI---------GKLPWRVDWPARWNIFGVTAEPMGKDHAAsggSYDTGIKI 250 Methanococcus maripal...
O29052 188 IYYeC------------DCGHSGRVGYVGG----------GKLTWRVDWAARWQILSITCEPFGKDHAAaggSYDTGVRI 245 Archaeoglobus fulgidu...
Q6L1V1 184 AEYkC------------KCGYTGKADIRTDD---------GKMPWRVEWPAKWFSLHVTIEPFGKDHGAaggSYDTGKAI 242 Picrophilus torridus ...
P57677 187 AEYaC------------KCGHHGFADIRKAE---------GKMPWRVEWPAKWFALKVTVEPFGKDHGApggSYDTGRRI 245 Thermoplasma acidophi...
Q8TWP6 198 IEYvCegrheigdavlEGCGHRGELDLRKPIevngfeippGKLGWKIEWPTRWVYLGVACEPFGKDHYVaggSYEVGSAI 277 Methanopyrus kandleri...
Q2NHG8 192 IKYkC------------DCGHEGEVDYTTGM---------GKLTWRVEWAARWKILNITCEPFGKDHAAsggSYDVSKII 250 Methanosphaera stadtm...
O27585 210 VRYrC------------ECGFDGEMDIKSGL---------GKLTWRVEWAARWKILGVTCEPFGKDHAAsggSYDVSSII 268 Methanothermobacter t...
Q73JY6 202 LKYsC------------ECGHCEALDLRKAKs--------VKLGWRVDWPMRWAFEKTVFEPAGKDHHSqggSFDTASLV 261 Treponema denticola
Q9X895 302 V-GIFGGEQPIGPMYAFVGISGMA---KMSSSKGGVPTPADALKIMEPQLLRWLYARrRPNQSFKIAFDqEIQRLYDEWD 377 Streptomyces coelicol...
Q57959 251 AkEIYNYIPPKKVVYEWIQLKVGDkaiPMSSSKGVVFAVKDWTNIAHPEILRFLLLRsKPTKHIDFDLK-KIPDLVDEYD 329 Methanocaldococcus ja...
P0CW67 251 ArQIFNYQAPEKMVYEWIQLKVGDkamPMSSSSGVVFAVKDWTEICHPEVLRFLILKgKPTKHIDFDLK-AISNLVDDYD 329 Methanococcus maripal...
O29052 246 ArEIFDYEPPYPVPYEWIHLKGKG---AMKSSKGIVLPVREMVEVIPPEIVRYITIRvKPERHIEFDPGlGLLDLVEEFE 322 Archaeoglobus fulgidu...
Q6L1V1 243 AsDIFNINPPLPLLYERIFLKGKG---VMHSSTGVVIPASEMIKFSPPEIIRFLIAKnNPGRHIDFDPGpGLLNLIDEYE 319 Picrophilus torridus ...
P57677 246 ArEVFGIEPPVPLMYERIILKGKG---AMHSSTGLAIAASEIMEVIPPDLLRYMIARvNPGRHIDFDPGmGILALSDELE 322 Thermoplasma acidophi...
Q8TWP6 278 AeEFFGFPAPVPVPYEWITLDGK----AMSSSKGHYVTLSDWGEVCHREVLRYLVLRgKPLKHLDLDLRfGLLQAVDDYD 353 Methanopyrus kandleri...
Q2NHG8 251 SdEIFNYPAPYPVPYEWITLDGD----AMSKSKGVFFSPEAWLKIGKPETLNYYIFRnKPLKPKDFTPKmGFLDLMDQYD 326 Methanosphaera stadtm...
O27585 269 SeEIFDYPAPYPVPYEWITLRGE----AMSKSRGVFFTPGQWLEIGPPESLNYFIFRsKPMKHKDFNPDmPFLDLMDQFD 344 Methanothermobacter t...
Q73JY6 262 SdRIYNWPAPVSFRYDFIGLKGVPg--KMASSKGKVVSLAEVLEVYQPEVARYLFAGtRPNTEFVISFDlDVIKIYEDYD 339 Treponema denticola
Q9X895 378 RLDAKVAdg------sALPADAAAHARAVGTAAGE 406 Streptomyces coelicolor A3(2)
Q57959 330 RLEDFYFnnk---dkdELSEEEQEKIRIYELSTPK 361 Methanocaldococcus jannaschii DSM 2661
P0CW67 330 ELERKYFeliekqkteELNDNENEKISLYELVTPK 364 Methanococcus maripaludis S2
O29052 323 E-------------------KFKEKDRSVELSLVG 338 Archaeoglobus fulgidus DSM 4304
Q6L1V1 320 KYERAYFg--------LDSVKDDDYKEVYELSRLK 346 Picrophilus torridus DSM 9790
P57677 323 KLQDAYFe--------NRASLDEDQAAMVEYSLVN 349 Thermoplasma acidophilum DSM 1728
Q8TWP6 354 ELEKRYF----------AGEADERERRIYELSRVD 378 Methanopyrus kandleri AV19
Q2NHG8 327 RVERIAYgqe----eaSNEKEKEKLTKIYEVSQIN 357 Methanosphaera stadtmanae DSM 3091
O27585 345 RTERIYYgme----daASEKEEQKLRNIYRVSMIE 375 Methanothermobacter thermautotrophicus str. Delta H
Q73JY6 340 KTERIAWkae----kaKNDETFEKEYRIYELSQID 370 Treponema denticola
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