Conserved Protein Domain Family
tRNA-synt_1f

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pfam01921: tRNA-synt_1f 
tRNA synthetases class I (K)
This family includes only lysyl tRNA synthetases from prokaryotes.
Statistics
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PSSM-Id: 307851
View PSSM: pfam01921
Aligned: 30 rows
Threshold Bit Score: 414.732
Threshold Setting Gi: 27805740
Created: 16-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808679   11 TDWVSRFADEVIAES-ERRapgkPGVVVASGLSPSGPIHLGNLREVMTPHLVADEVRRR-GHEVRHLISWDDYDRYRKVP 88
gi 3183557     1 MHWADVIAEKLIEER-KA-----DKYIVASGITPSGHIHVGNARETLTADAIYKGLINK-GVEAELIFIADTYDPLRKLY 73
gi 332321729   1 MHWADATSEKIMKKR-NA-----EEYVVSSGITPSGHIHIGNARETLTADAVYKGMLKK-GAEAKLIFIADDYDPLRKLY 73
gi 3183169     1 MHWADVIAADLLKRS--------NSHRIATGISPSGHIHLGNLREMVTADAIRRALLDA-GGEAKIVYIADDFDPLRRRY 71
gi 74579532    1 MHWSESLLKDVS-----------GDQRISTGISPSGPIHIGNMREILTGDIIYKEALKL-GIKASFIYLCDDMDPLRKVY 68
gi 11387135    4 LFWADALVKDLS-----------GPQRVSTGISPSGPIHVGNMREILTGDILFKAITKR-GLESDFIYLCDDMDPLRKVY 71
gi 27805740    4 EHWSEVKAREVTEHCrKHAdelpDEIVVASGASTSGRLHVGNARDVLTADAVARVLRERyHEDVRVVWISDDVDPLRRIP 83
gi 121731873   3 KHWTERIAEELSQQKkD-------EYIIGSGTSISGSVHIGNSCDIFIANAVSKELRKI-GENAKTVWIADDYDPLRKVP 74
gi 3183168    22 KHWIERIADELKERDvE-------EHVVASGTSISGSIHIGNSCDVFIASSIAKSLKKD-GFKSRTVWIADDHDPLRKVP 93
gi 81831331    8 LHWADQTAEKIIRERgDL-----DVYTCASGITPSGTVHVGNFREIISVDLVVRALRSR-GKNVRFIYSWDDYDVFRKVP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808679   89 AgvpGVDES--WAEHIGKPLTSVPAPKGSpHPNWAEHFKAAMVDSLAEMGV-EFDGISQTAQYTSGVYREQILHAMKH-- 163
gi 3183557    74 P---FLPKE--FEQYIGMPLSEIPCPEGC-CESYAEHFLRPYLESLDDLGV-ELTTYRADENYKKGLYDEKIKIALDN-- 144
gi 332321729  74 P---FLPKE--FEKYIGMPLSEIPCPQGC-CKSYADHFLMPFLNSLEDLGV-EITTHRANECYKAGMYNDAIITALEN-- 144
gi 3183169    72 P---FLPEE--YENYVGMPLCKIPDPEGC-HDSYSEHFLQPFLESLEILGI-PVEVRRAYQMYSEGLYENNTRIALKR-- 142
gi 74579532   69 P---FLPGS--YERYVGHPLSMIPAPDGD--KTYSEYFLEPFKETIDKIDV-RPEIISTTSLYKNGVLSRAIDIAMNN-- 138
gi 11387135   72 P---FLSKD--YERYVGQPLKNIPAPQGA--GKYSDYYLEPFVRVMKEANI-PARVIKTSDLYESGMLAQACDIAINN-- 141
gi 27805740   84 R---DLDGRl-SEDYLGVPYKAIPVGD----EPYSDRWARNFVEELREFGA-EVEWISSAELYTDNGFVKLVREVVNDyy 154
gi 121731873  75 Y---PLPEN--YSKYLGQPYYEIPCPEGC-CENFVEHFQKPFVNSLKPFDIeNLEIKSGAQMYKNGVYTEATKVALEN-- 146
gi 3183168    94 Y---PLPES--YEKYLGVPYSMIPCPEGC-CESFVEHFQRPFLEALERFRI-GVEHYSGARMYTEGLYNDYIRTSLER-- 164
gi 81831331   82 A---NMPKPevLEKYLRYPITMVPDTFER-DENYARHHEHDVEAVLPRVGI-HPEYLYQAERYQKGMYAEGMKKALDN-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808679  164 --RRDIDAILDQYRTKKapakKSQKpldeaeleaaegsgaaaeddgssgsagYFPYKPYCGNCEK-DLTTVTAYDdDSTE 240
gi 3183557   145 --REKIMEILNKFRANP----LPDD---------------------------WWPINIVCENCGKl-KTKVIKYDsEKEE 190
gi 332321729 145 --RLKIKELLDSYRKEP----LADD---------------------------WYPLNVVCEKCGKmHETKVINYNsEDKT 191
gi 3183169   143 --RDEIARIIAEVTGRE----LEER---------------------------WYPFMPLCENCGRiNSTRVTSFD--ENW 187
gi 74579532  139 --REKIKNILNSIGNYK----ITGD---------------------------WYPYEPVCKSCGRiNTTTVISYN--YPY 183
gi 11387135  142 --REKIKDILETVSGRK----IEGD---------------------------FYPYEPLCEKCGRiSTTHVISYS--YPY 186
gi 27805740  155 ggGGRLASVLERF--------GLED---------------------------ARVYMPVCEECGRiATTRVVDVD--GWR 197
gi 121731873 147 --TERIREIFNEYREHP----LSED---------------------------WLPYNAICSECGRvNTTHAYDFE--GTN 191
gi 3183168   165 --APEIREIFNRFRDRP----LRDD---------------------------WLPYNPICEKCGRvNTTEAYDFS--GDT 209
gi 81831331  155 --REELKDILNTYRDESh--kITEE---------------------------YWPVSVFCTACNK-DTTKIESWD-GDWT 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808679  241 LTYaC-----------TACGFSETVRLSEFNr--------GKLVWKVDWPMRWAYEGVVFEPSGVDHSSpgsSFQVGGQI 301
gi 3183557   191 ITYrC-----------EICGFENTVKPYKGR---------AKLPWRVDWPARWSIFNVTIEPMGKDHAAaggSYDTGVLI 250
gi 332321729 192 ITYvC------------KCGFENTVKPFNGI---------GKLPWRVDWPARWNIFGVTAEPMGKDHAAsggSYDTGIKI 250
gi 3183169   188 IYYeC------------DCGHSGRVGYVGG----------GKLTWRVDWAARWQILSITCEPFGKDHAAaggSYDTGVRI 245
gi 74579532  184 AEYkC------------KCGYTGKADIRTDD---------GKMPWRVEWPAKWFSLHVTIEPFGKDHGAaggSYDTGKAI 242
gi 11387135  187 AEYaC------------KCGHHGFADIRKAE---------GKMPWRVEWPAKWFALKVTVEPFGKDHGApggSYDTGRRI 245
gi 27805740  198 IEYvCegrheigdavlEGCGHRGELDLRKPIevngfeippGKLGWKIEWPTRWVYLGVACEPFGKDHYVaggSYEVGSAI 277
gi 121731873 192 IKYkC------------DCGHEGEVDYTTGM---------GKLTWRVEWAARWKILNITCEPFGKDHAAsggSYDVSKII 250
gi 3183168   210 VRYrC------------ECGFDGEMDIKSGL---------GKLTWRVEWAARWKILGVTCEPFGKDHAAsggSYDVSSII 268
gi 81831331  202 LKYsC------------ECGHCEALDLRKAKs--------VKLGWRVDWPMRWAFEKTVFEPAGKDHHSqggSFDTASLV 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808679  302 V-GIFGGEQPIGPMYAFVGISGMA---KMSSSKGGVPTPADALKIMEPQLLRWLYARrRPNQSFKIAFDqEIQRLYDEWD 377
gi 3183557   251 AkEIYNYIPPKKVVYEWIQLKVGDkaiPMSSSKGVVFAVKDWTNIAHPEILRFLLLRsKPTKHIDFDLK-KIPDLVDEYD 329
gi 332321729 251 ArQIFNYQAPEKMVYEWIQLKVGDkamPMSSSSGVVFAVKDWTEICHPEVLRFLILKgKPTKHIDFDLK-AISNLVDDYD 329
gi 3183169   246 ArEIFDYEPPYPVPYEWIHLKGKG---AMKSSKGIVLPVREMVEVIPPEIVRYITIRvKPERHIEFDPGlGLLDLVEEFE 322
gi 74579532  243 AsDIFNINPPLPLLYERIFLKGKG---VMHSSTGVVIPASEMIKFSPPEIIRFLIAKnNPGRHIDFDPGpGLLNLIDEYE 319
gi 11387135  246 ArEVFGIEPPVPLMYERIILKGKG---AMHSSTGLAIAASEIMEVIPPDLLRYMIARvNPGRHIDFDPGmGILALSDELE 322
gi 27805740  278 AeEFFGFPAPVPVPYEWITLDGK----AMSSSKGHYVTLSDWGEVCHREVLRYLVLRgKPLKHLDLDLRfGLLQAVDDYD 353
gi 121731873 251 SdEIFNYPAPYPVPYEWITLDGD----AMSKSKGVFFSPEAWLKIGKPETLNYYIFRnKPLKPKDFTPKmGFLDLMDQYD 326
gi 3183168   269 SeEIFDYPAPYPVPYEWITLRGE----AMSKSRGVFFTPGQWLEIGPPESLNYFIFRsKPMKHKDFNPDmPFLDLMDQFD 344
gi 81831331  262 SdRIYNWPAPVSFRYDFIGLKGVPg--KMASSKGKVVSLAEVLEVYQPEVARYLFAGtRPNTEFVISFDlDVIKIYEDYD 339
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 27808679  378 RLDAKVAdg------sALPADAAAHARAVGTAAGE 406
gi 3183557   330 RLEDFYFnnk---dkdELSEEEQEKIRIYELSTPK 361
gi 332321729 330 ELERKYFeliekqkteELNDNENEKISLYELVTPK 364
gi 3183169   323 E-------------------KFKEKDRSVELSLVG 338
gi 74579532  320 KYERAYFg--------LDSVKDDDYKEVYELSRLK 346
gi 11387135  323 KLQDAYFe--------NRASLDEDQAAMVEYSLVN 349
gi 27805740  354 ELEKRYF----------AGEADERERRIYELSRVD 378
gi 121731873 327 RVERIAYgqe----eaSNEKEKEKLTKIYEVSQIN 357
gi 3183168   345 RTERIYYgme----daASEKEEQKLRNIYRVSMIE 375
gi 81831331  340 KTERIAWkae----kaKNDETFEKEYRIYELSQID 370
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