Conserved Protein Domain Family
SBF

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pfam01758: SBF 
Sodium Bile acid symporter family
This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae - this is a putative transmembrane protein involved in resistance to arsenic compounds.
Statistics
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PSSM-Id: 307739
View PSSM: pfam01758
Aligned: 17 rows
Threshold Bit Score: 130.099
Threshold Setting Gi: 74571068
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O29775        75 AIGLILMMYPPLAKVRYEEMGKVFSN---LKLLAFSLTQNWIVGPVVMFLLAIallrDM-------------------PE 132 Archaeoglobus f...
O34524        41 TIFLGIIMFGMGLTLQADDFKELVRK---PWQVIIGVIAQYTIMPLVAFGLAF----GLhl----------------pAE 97  Bacillus subtil...
Q8VYY4       128 VPALGFLMFAVGINSNEKDFLEAFKR---PKAILLGYVGQYLVKPVLGFIFGLaavsLFql----------------pTP 188 thale cress
Q1EBV7       132 TLGLGFLMLSMGLTLTFEDFRRCLRN---PWTVGVGFLAQYMIKPILGFLIAM----TLkl----------------sAP 188 thale cress
P74311        61 AICLFFMMYPIMVKIDFSQARQAVKA---PKPVILTLVVNWVIKPFTMVIFAQfflgYLfaplltateiirgqevtlaNS 137 Synechocystis s...
O26986        62 AIGLILMMYPPLAKVHYEDLPDVFRN---FRILGLSLLQNWIIGPVLMFILAIvflmDH-------------------PE 119 Methanothermoba...
P45946        49 AIGLVLMMYPPLAKVRYEEIGRVFKD---IKVLILSLVQNWIIGPTLMFILAIiflpDK-------------------PE 106 Bacillus subtil...
O58645        46 PIALFMMLFQPMVFMDIKKAFTTRTRvktKYLILLTFFYTLLF-PVLTWIFLKfwlrMMpn---------------tePQ 109 Pyrococcus hori...
P73938        12 PLALFLIMFGMGLGLTIKDFNRIWLE---PKAVAIGLIAQLVMLPMVGFGLSS----LFsl----------------sPE 68  Synechocystis s...
WP_057366451  62 ALGLLIMMYPVLAKVRYDRLDTVTGD---RKLLLSSLLLNWVLGPALMFALTWlllaDL-------------------PE 119 Mycobacterium t...
O29775       133 FMIGVILVGLARCIAMVIVWNELAEGDR-ELAVGLVAFNAIFQILFY-AVYIYIFITFAlnalglvegveANVSIVEAAK 210 Archaeoglobus f...
O34524        98 IAVGVILVGCCPGGTASNVMTFLAKGNT-ALSVAVTTISTLLAPVVT-PLLIMLFAKEW-----------LPVSPGSLFI 164 Bacillus subtil...
Q8VYY4       189 IGAGIMLVSCVSGAQLSNYATFLTDPALaPLSIVMTSLSTATAVLVT-PMLSLLLIGKK-----------LPVDVKGMIS 256 thale cress
Q1EBV7       189 LATGLILVSCCPGGQASNVATYISKGNV-ALSVLMTTCSTIGAIIMT-PLLTKLLAGQL-----------VPVDAAGLAL 255 thale cress
P74311       138 YIAGCILLGIAPCTAMVLMWGYLSYSNQ-GLTLVMVAVNSLAMLFLYaPLGKWLLAASN-----------LTVPWQTIVL 205 Synechocystis s...
O26986       120 YMIGLILIGLARCIAMVIVWNELAMGDR-EYAAGLVAFNSLFQVFFY-SIYAWVFITLLpplfg-vqgtaIDVSIFEIAK 196 Methanothermoba...
P45946       107 YMIGLIMIGLARCIAMVIVWNDLSKGDT-EYAAGLVAFNSIFQMLFF-SVYAYIFVTVIpqwlg-megavVNITMAEVAK 183 Bacillus subtil...
O58645       110 LLAGMVLIGLAPLPSSSPAFTNLAGGRF-QLTLVGVMWTFLLSIFVM-PFYAKLILHTI-----------IQVPIEMLLK 176 Pyrococcus hori...
P73938        69 LAVGLMILAACPGGSTSNVITYLLKGNV-ALSITLTAISSLVTIITI-PLVVNLAANYFmge-----qfaLQLPFLKTVL 141 Synechocystis s...
WP_057366451 120 YRTGLIIVGLARCIAMVIIWNDLACGDR-EAAAVLVALNSIFQVAMF-AALGWFYLSVLpgwlg-leqttIATSPWQIAK 196 Mycobacterium t...
O29775       211 TVFIYLGIPFIMGVATRYGSFRlkgrewFENVLAPKISLITPAALLFTIVVMFSLKGEYIVEL 273 Archaeoglobus fulgidus
O34524       165 SILQAVLFPIIAGLIVKMFFRK------QVAKAVHALPLVSVIGIVAIVSAVVSGNRENLLQS 221 Bacillus subtilis subsp. subtili...
Q8VYY4       257 SILQVVIAPIAAGLLLNKLFPK------VSNAIRPFLPILSVLDTACCVGAPLALNINSVMSP 313 thale cress
Q1EBV7       256 STFQVVLVPTIIGVLANEFFPK------FTSKIITVTPLIGVILTTLLCASPIGQVADVLKTQ 312 thale cress
P74311       206 SVLIYVGLPLAAGIYSRYWILKhkgrqwFESQFLHYLSPIAIVALLLTLILLFAFKGELIVNN 268 Synechocystis sp. PCC 6803 subst...
O26986       197 SVFIYLGIPFIAGFLTRYILRRrkgsewYDTRFIPRISPLTLMALLFTIVVMFSLKGDYIVQI 259 Methanothermobacter thermautotro...
P45946       184 SVFIYLGVPFIAGMVTRYIFVKvkgkewYEKVFIPKISPITLIALLFTIIVMFSLKGDVIVSL 246 Bacillus subtilis subsp. subtili...
O58645       177 SLILYIITPLIIGQLTKYIILHwkgtdaLISLKKPLIG-ISLIGMYWMIVVVFGINAKVIVER 238 Pyrococcus horikoshii
P73938       142 QIAVITIIPVSLGMIFYHFLPK------IAMVMEKNVKWLSLFFLGIIIVAILVKERENLADF 198 Synechocystis sp. PCC 6803
WP_057366451 197 SVLIFLGIPLLAGYLSRRIGEKtkgrnwYESRFLPKVGPWALYGLLFTIVILFALQGDQITGR 259 Mycobacterium tuberculosis
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