4RUL,5D5H,2GAI,5VAZ,1D6M,1GL9,4DDT,2V1C,5GVE,4CHT,5GUJ,1NUI,2AU3,5W33,4E2K


Conserved Protein Domain Family
Toprim

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pfam01751: Toprim 
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Toprim domain
This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Statistics
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PSSM-Id: 366790
View PSSM: pfam01751
Aligned: 149 rows
Threshold Bit Score: 30.0017
Threshold Setting Gi: 145322219
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RUL_A   6 ALVIVESPAKAKTINKYLGSDYV-VKSSVGHIRDLPTsgsaakksadststktakkpkkdergalvnrmgvdpwhnweah 84  Escherichia coli DH1
Q38030 120 VVLITEGPGDALTAVSV---GYDaVAVRGASLVNNPEl------------------------------------------ 154 Streptomyces virus ph...
Q9ZXI8 168 ELWIVEGIFDAIALLHH---GIDaVSAMSSNAFPEQS------------------------------------------- 201 Pseudomonas virus phiCTX
P47256 112 SIYLVEGDFDWLAFRKA---GILnSLPLCGLTISNQQ------------------------------------------- 145 Mycoplasma genitalium...
P75099 106 TIYLVEGDFDWLAFRKG---GILnCLPLCGLTLSDKQ------------------------------------------- 139 Mycoplasma pneumoniae...
P75426 267 KLYLVEGYFDVFALTSA---GIGdVVGLMGLALSESH------------------------------------------- 300 Mycoplasma pneumoniae...
P47492 268 QLFIVEGYFDVFTLTNSK----FeAVALMGLALNDVQik----------------------------------------- 302 Mycoplasma genitalium...
P95980 170 NLIIVEGRADVINLLRY---GYKnVIAVEGATSRIPE------------------------------------------- 203 Saccharolobus solfata...
O26977 174 AILVVEGRSDVLNLLKY---GIKnAIAVEGVSVPKTV------------------------------------------- 207 Methanothermobacter t...
2AU3_A 246 faILVEGYFD---LLRLFSEGIRnVVAPLGTALTQn-------------------------------------------- 278 Aquifex aeolicus
4RUL_A  85 yevlpgkekvvseLKQLA--EKAD--HIYLA-TDLDREGEAIAWHLRev---iGGDDAr--YSRVVFNEI 144 Escherichia coli DH1
Q38030 155 -------------VAELAegLKGF--QVIVC-GDNDTAGVGFTLRLS------EGLAGh--GIDAYALNV 200 Streptomyces virus phiC31
Q9ZXI8 202 -------------LRELAtaRGGKlpKLIWA-LDNEPGAHRYTRRWV--------TEAralGYVCEAAQL 249 Pseudomonas virus phiCTX
P47256 146 -------------VQWLKq-KKIK--KIFIC-FDNDLAGKNGAKNLK------EYLTKq--GFITKVIEI 190 Mycoplasma genitalium G37
P75099 140 -------------MKFFQq-SKIE--KVVLC-LDNDFAGKVAAANLE------RILKNa--GFQVKVVQL 184 Mycoplasma pneumoniae M129
P75426 301 -------------IIAFQqqLKAL--ETVVLaLDNDTAGHDATFKLL------QELNAh--GIIVEVVDW 347 Mycoplasma pneumoniae M129
P47492 303 ------------aIKAHF--KELQ--TLVLA-LDNDASGQNAVFSLI------EKLNNn--NFIVEIVQW 347 Mycoplasma genitalium G37
P95980 204 -------------TLINL--SKMK--KTVIAfLDGDHGGDLILKELLsnnvkiDFVARa--PIGREVEEL 254 Saccharolobus solfataricus P2
O26977 208 -------------ADLTR-----K--KTVTAfVDGDRGGELILKELLqvg-eiDYVTRa--PKGKEVEDL 254 Methanothermobacter thermautotr...
2AU3_A 279 ------------qANLLS--KFTK--KVYIL-YDGDDAGRKAMKSAIpl---lLSAGVe--VYPVYLPEg 326 Aquifex aeolicus
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