4TNM


Conserved Protein Domain Family
IBB

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pfam01749: IBB 
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Importin beta binding domain
This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.
Statistics
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PSSM-Id: 334663
View PSSM: pfam01749
Aligned: 180 rows
Threshold Bit Score: 56.8142
Threshold Setting Gi: 537177207
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4TNM_A        12 RRNRYKVAV--DAEEGRRRREDNLVEIRKNKREENLQKKRFT-------SSm------AF-----------G-------- 57  thale cress
XP_003964379   7 RLNRFKNKGk-DANELRRRRVEVNVELRKAKKDDQMFKRRNV-------AAf------PEeatsp--lqerS-------- 62  torafugu
XP_004071868   6 RLTQFKNKGk-DANELRRRRVEVNVELRKAKKDDQMFKRRNV-------AAa------PE-----------Eatsplqer 60  Japanese medaka
XP_013121631  10 RLNQFKNKGk-DADELRRRRAEVNVELRRAKKDDHILKRRNVhslldepTSp------LQ-----------E-------- 63  Nile tilapia
XP_014822598  10 RLFQFKNKGk-DVNELRRRRSEFNVELRKAKRDVQILKRRNA-------QSs------AE-----------Dpisplhlk 64  Poecilia mexicana
XP_975293      6 RIRSFKNKGk-DCEEMRRRRAGQTIELRKAKKEDQLLKRRNI-------SLqeeastpLQ-----------E-------- 58  red flour beetle
XP_008204292  11 RISKFKFQGkfD--EARRRRTEVSVELRKAHKDNQLLKKRNI----------------NIedeplsp------------- 59  jewel wasp
EFX68294       9 RLKDFKNKGr-DVEEMRRRRTEVNVELRKAKKEDHLLKRRNL----------------EIddepl-----------splq 60  common water flea
XP_002432063  12 RLANFKHKGk-DIEEMRRRRNSVTINLRKASRYDQLLKKRNVsvnesp-----------------yafqdgN-------- 65  human body louse
XP_007252192  11 RLNQFKNKGk-DANELRRRRIEVSVELRKAKKDDQILKRRNVs---------------CFpddasspfyeqN-------- 66  Mexican tetra
4TNM_A        58 -SatgqteqdlSSANQLKDNLPAMVAGIWSEDSNSQLEAT 96  thale cress
XP_003964379  63 -Q---------NQQATKQWTVEEIVAGVTSDSPELQLQAT 92  torafugu
XP_004071868  61 tQ---------NCQNSRQWTIEEIVSGLNSGSRESQLQAT 91  Japanese medaka
XP_013121631  64 -K---------DPNPPHHWTVEEIVGGVNSENLDYKLQAT 93  Nile tilapia
XP_014822598  65 aL---------NVQPTQDWSLEDIVGGVSSVNTEHQLLAT 95  Poecilia mexicana
XP_975293     59 -N---------NSVSLITMSAEEILMGMMSPDENLQFKAT 88  red flour beetle
XP_008204292  60 --------psdqkspVFNMSIDEIIAGMTSEDDQAMLQAT 91  jewel wasp
EFX68294      61 eQ---------NRMAAANMSIEDIVNGINSGDENKEITAT 91  common water flea
XP_002432063  66 -A---------STQSNSVMTVPEIMSAITSGDENFVFEAL 95  human body louse
XP_007252192  67 -H---------NAQsSQHWSVEEIVCGVNSQSLDHQLQAT 96  Mexican tetra
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