1EIZ,2NYU,5KS2,3DOU,3OPN,4N48,3EVA


Conserved Protein Domain Family
FtsJ

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pfam01728: FtsJ 
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FtsJ-like methyltransferase
This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N-terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.
Statistics
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Aligned: 238 rows
Threshold Bit Score: 55.2749
Threshold Setting Gi: 75015528
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EIZ_A      2 LRSRAWFKLDEIQQSDK-------LF--K--PG---------MT----VVDLGAAPGGWSQYV-----VTQI------GG 46   Escherichia coli
Q80LP2     35 VRDRCYHKLHEIDKKY---------FvcQ--HV---------KT----FIDLCGGPGQFAKYI-----FDSN------FE 79   Adoxophyes honmai...
Q0N437     47 VRNRCYHKLREIDQQFN-----------VcqNV---------NL----FLDLCGGPGQFAKYV-----IDNN------PG 91   Clanis bilineata ...
Q77K73     43 RHRRCWHKMKELDERFN--------L--C--RNv--------RL----YVDLCGGPGQFANYI-----SNNStl------ 87   Helicoverpa armig...
P41469     35 RRPRCWRKLSEIDKKFH-----------VcrHV---------DT----FLDLCGGPGEFANYT-----MSLN------PL 79   Autographa califo...
Q9UAS6    110 FVTVAWCKLFECLHRYP-------LV--Tk-PA---------VN----SMHLCEAPGAFIASL-----NHYL------HS 155  fruit fly
EDO05407  127 LVTNAWVKLYEILEFYK--------V--V--ETliprlaedgGTi--nSFHLSECPGGFIAAL-----NHAI------KQ 181  Babesia bovis
Q4UCQ7    148 LVTNAWLKFYEILEVYKlveylkpNF--Kt-EG---------GTl--tSFHISECPGAFIASL-----NHNLksknynGE 208  Theileria annulata
Q7Q7A5    108 FVTQAFAKLYECVSAYE--------LidGqqQE---------LY----SVHLCEAPGAFVTGL-----NHYI------RL 155  Anopheles gambiae...
Q174Y1    120 FVTQAFAKLYECVATYE--------LvpPfsVG---------KHrefySVHLCEAPGAFITGLnhylkLNR-------GD 175  yellow fever mosq...
1EIZ_A     47 k-------GRIIACDL-LPM------------D----PIv--GVDFL-------------QGDFRDELVMK--------A 79   Escherichia coli
Q80LP2     80 --------CRGYGVTLnNALry--------qfK----NRnftKIYGHd-----------nSGNIFDTSVQF--------E 120  Adoxophyes honmai...
Q0N437     92 --------CKGFGTTLrNSCdy--------qyK----HEdfkKIYGKh-----------nSGNIFEESLRY--------E 132  Clanis bilineata ...
Q77K73     88 -------nSQGYGVTLrNHLd-----------Y----NVfvpNFCAVygd--------anTGDIFEEDIQN--------K 129  Helicoverpa armig...
P41469     80 --------CKAYGVTLtNNSvc--------vyK----PTvrkRKNFTtitg------pdkSGDVFDKNVVF--------E 125  Autographa califo...
Q9UAS6    156 kyekdeikWRWRSTTL-NPYyegn-----ainQ----MIs--DDRFIvhtldnwffhkdlTGNLLDVANID--------H 215  fruit fly
EDO05407  182 rns--tanLSWQATSL-NPYhegnshmeclaeDilyrDTvtnWLTGSd-----------eSGNINKTANIE--------Y 239  Babesia bovis
Q4UCQ7    209 --------LKWYATSL-NPY-----------------YEgnnHNVVL-------------AEDILLKETYQ--------N 241  Theileria annulata
Q7Q7A5    156 hcap-rtkWAWFACTLnPHYeg--------ncP----GNmipDDRFIlhtlgswcfgadgTGDIMVRENRD--------A 214  Anopheles gambiae...
Q174Y1    176 evk---wrWFANTLNPyYEGnc--------lgN----MIaddRFILHtmdswc--fgadyTGDIMRKENLGeivrrskdF 238  yellow fever mosq...
1EIZ_A     80 LL------ERV-Gd---------SK-----VQVVMSDMA-PNMSGT-PAVDIPRA---M-YLVELALEMCRDVLAPGGSF 132  Escherichia coli
Q80LP2    121 LQmlcennT---------------------VDLIVADGA-VDVSGN-ENHQETIN---F-LIINEECKIILkLLKVNGNC 173  Adoxophyes honmai...
Q0N437    133 IN-------MWcG----------GL-----CDLVMADGA-VDVSGReNEQEQIML-----PLLKREIEICLENVRPGGAC 184  Clanis bilineata ...
Q77K73    130 LN-------MLcG----------HR-----CDLVVADGG-IDVYG--KENDQELI---MlPLIAKQCEIILDCLRVGGNS 181  Helicoverpa armig...
P41469    126 IS-------IKcG----------NA-----CDLVLADGS-VDVNG--RENEQERLnfdL-IMCETQLIL--ICLRPGGNC 177  Autographa califo...
Q9UAS6    216 LV------E---Rc---------EVefqgqVDLVTADGS-IDCAAQ-PDCQEEIV---V-RLFFAEVLSALRILSSGGNF 271  fruit fly
EDO05407  240 IW------DRVsRaskfnkgrapVL-----VDIVTADGS-FCCQAD-PNNQETLT---A-PLKLSEVVCALGLMRVGAIF 302  Babesia bovis
Q4UCQ7    242 WL-------LGyDns-------gNI-----TKSSTADGS-FNCQFD-PNNQELLT---S-PLKFAEVVCALgLLRVGGCF 296  Theileria annulata
Q7Q7A5    215 II------KRSqRf---------PT-----VHLVTADGSiDCLNVPeEQEERVAK---L-HLAETVLAL--SVLSPGQHF 268  Anopheles gambiae...
Q174Y1    239 PM----------------------------INLVTADGSiDCLDVPeAQEEHVSK---L-HLAEAVTAL--KILTTDGCF 284  yellow fever mosq...
1EIZ_A    133 VVKVFQ--GEGFD-EYLRE-IR-SLFTKVKVRKPDSSRARSREVYIVATGR 178  Escherichia coli
Q80LP2    174 VVKVFDt-FNDETvCLLER-FV-THFENSYIFKPSSSRAANSERYLVCKNR 221  Adoxophyes honmai nucleopolyhedrovirus
Q0N437    185 VLKIFDtyQEDTV-ALLEYfVS--HFSEHTVFKPKSSRAANSEKYLVCQRR 232  Clanis bilineata nucleopolyhedrovirus
Q77K73    182 VLKIFD--TFARN-TFVVLeSFiSNFSEFYVFKPVSSRPANAERYLVCLNR 229  Helicoverpa armigera nucleopolyhedrovirus
P41469    178 VLKVFD--AFEHE-TIQMLnKFvNHFEKWVLYKPPSSRPANSERYLICFNK 225  Autographa californica nucleopolyhedrovirus
Q9UAS6    272 LVKMFTl-FEACSvSLLYT-LN-CIFEEVHIFKPATSKRGNSEVYVICLNY 319  fruit fly
EDO05407  303 ILKMFTl-FEESSlSIFTI-LK-MCFKTVEVYKPHLSKSNGSEVYVVCIGF 350  Babesia bovis
Q4UCQ7    297 IIKMFNl-FEEPSmSIIAL-LS-LCFKRLEVYKPFLSREANSEVYVICLDF 344  Theileria annulata
Q7Q7A5    269 VLKMFTl-FEHSSvSLLFL-LN-HCFDELHVFKPCTSKPGNSEVYIVAKHY 316  Anopheles gambiae str. PEST
Q174Y1    285 ILKMFTf-FEHSSvDLLYL-LY-VCFRELHVFKPATSKPGNSEVYVIAKYF 332  yellow fever mosquito
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