1EIZ,4K6M


Conserved Protein Domain Family
FtsJ

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pfam01728: FtsJ 
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FtsJ-like methyltransferase
This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N-terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.
Statistics
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PSSM-Id: 334653
View PSSM: pfam01728
Aligned: 232 rows
Threshold Bit Score: 55.6662
Threshold Setting Gi: 75015528
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EIZ_A          2 LRSRAWFKLDEIQQSDK-------LF--K--PG---------MT----VVDLGAAPGGWSQYV-----VTQI------GG 46
gi 123876257   47 VRNRCYHKLREIDQQFN-----------VcqNV---------NL----FLDLCGGPGQFAKYV-----IDNN------PG 91
gi 75556643    43 RHRRCWHKMKELDERFN--------L--C--RNv--------RL----YVDLCGGPGQFANYI-----SNNStl------ 87
gi 1175093     35 RRPRCWRKLSEIDKKFH-----------VcrHV---------DT----FLDLCGGPGEFANYT-----MSLN------PL 79
gi 745755583  110 FVTVAWCKLFECLHRYP-------LV--Tk-PA---------VN----SMHLCEAPGAFIASL-----NHYL------HS 155
gi 74951828   148 LVTNAWLKFYEILEVYKlveylkpNF--Kt-EG---------GTl--tSFHISECPGAFIASL-----NHNLksknynGE 208
gi 82051434   105 IVTNAWLKMYELLNTMN--------F--N--NTs-------------qAFCNCELPGGFISAI-----NHFN------YT 148
gi 74802917   108 FVTQAFAKLYECVSAYE--------LidGqqQE---------LY----SVHLCEAPGAFVTGL-----NHYI------RL 155
gi 122094571  120 FVTQAFAKLYECVATYE--------LvpPfsVG---------KHrefySVHLCEAPGAFITGLnhylkLNR-------GD 175
gi 156082982  127 LVTNAWVKLYEILEFYK--------V--V--ETliprlaedgGTi--nSFHLSECPGGFIAAL-----NHAI------KQ 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EIZ_A         47 k-------GRIIACDL-LPM------------D----PIv--GVDFL-------------QGDFRDELVMK--------A 79
gi 123876257   92 --------CKGFGTTLrNSCdy--------qyK----HEdfkKIYGKh-----------nSGNIFEESLRY--------E 132
gi 75556643    88 -------nSQGYGVTLrNHLd-----------Y----NVfvpNFCAVygd--------anTGDIFEEDIQN--------K 129
gi 1175093     80 --------CKAYGVTLtNNSvc--------vyK----PTvrkRKNFTtitg------pdkSGDVFDKNVVF--------E 125
gi 745755583  156 kyekdeikWRWRSTTL-NPYyegn-----ainQ----MIs--DDRFIvhtldnwffhkdlTGNLLDVANID--------H 215
gi 74951828   209 --------LKWYATSL-NPY-----------------YEgnnHNVVL-------------AEDILLKETYQ--------N 241
gi 82051434   149 mmh--yptFNWVASSL-YPSsetda--ledhyGly-qCNpdnWLMQSpllkk---nvdynDGDVTIASNVK--------N 211
gi 74802917   156 hcap-rtkWAWFACTLnPHYeg--------ncP----GNmipDDRFIlhtlgswcfgadgTGDIMVRENRD--------A 214
gi 122094571  176 evk---wrWFANTLNPyYEGnc--------lgN----MIaddRFILHtmdswc--fgadyTGDIMRKENLGeivrrskdF 238
gi 156082982  182 rns--tanLSWQATSL-NPYhegnshmeclaeDilyrDTvtnWLTGSd-----------eSGNINKTANIE--------Y 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EIZ_A         80 LLERV-Gd---------SK-----VQVVMSDMA-PNMSGT-PAVDIPRA---M-YLVELALEMCRDVLAPGGSFVVKVFQ 138
gi 123876257  133 IN-MWcG----------GL-----CDLVMADGA-VDVSGReNEQEQIML-----PLLKREIEICLENVRPGGACVLKIFD 190
gi 75556643   130 LN-MLcG----------HR-----CDLVVADGG-IDVYG--KENDQELI---MlPLIAKQCEIILDCLRVGGNSVLKIFD 187
gi 1175093    126 IS-IKcG----------NA-----CDLVLADGS-VDVNG--RENEQERLnfdL-IMCETQLIL--ICLRPGGNCVLKVFD 183
gi 745755583  216 LVE---Rc---------EVefqgqVDLVTADGS-IDCAAQ-PDCQEEIV---V-RLFFAEVLSALRILSSGGNFLVKMFT 277
gi 74951828   242 WL-LGyDns-------gNI-----TKSSTADGS-FNCQFD-PNNQELLT---S-PLKFAEVVCALgLLRVGGCFIIKMFN 302
gi 82051434   212 LALRAtQr--------lTP-----IHLYTADGG-INVGHD-YNKQEELN---L-KLHFGQALTGLLSLSKGGNMILKHYT 272
gi 74802917   215 IIKRSqRf---------PT-----VHLVTADGSiDCLNVPeEQEERVAK---L-HLAETVLAL--SVLSPGQHFVLKMFT 274
gi 122094571  239 PM----------------------INLVTADGSiDCLDVPeAQEEHVSK---L-HLAEAVTAL--KILTTDGCFILKMFT 290
gi 156082982  240 IWDRVsRaskfnkgrapVL-----VDIVTADGS-FCCQAD-PNNQETLT---A-PLKLSEVVCALGLMRVGAIFILKMFT 308
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
1EIZ_A        139 --GEGFD-EYLRE-IR-SLFTKVKVRKPDSSRARSREVYIVATGR 178
gi 123876257  191 tyQEDTV-ALLEYfVS--HFSEHTVFKPKSSRAANSEKYLVCQRR 232
gi 75556643   188 --TFARN-TFVVLeSFiSNFSEFYVFKPVSSRPANAERYLVCLNR 229
gi 1175093    184 --AFEHE-TIQMLnKFvNHFEKWVLYKPPSSRPANSERYLICFNK 225
gi 745755583  278 l-FEACSvSLLYT-LN-CIFEEVHIFKPATSKRGNSEVYVICLNY 319
gi 74951828   303 l-FEEPSmSIIAL-LS-LCFKRLEVYKPFLSREANSEVYVICLDF 344
gi 82051434   273 l-NHAFTlSLICV-FS-HFFEELYITKPTSSRPTNSETYIVGKNR 314
gi 74802917   275 l-FEHSSvSLLFL-LN-HCFDELHVFKPCTSKPGNSEVYIVAKHY 316
gi 122094571  291 f-FEHSSvDLLYL-LY-VCFRELHVFKPATSKPGNSEVYVIAKYF 332
gi 156082982  309 l-FEESSlSIFTI-LK-MCFKTVEVYKPHLSKSNGSEVYVVCIGF 350
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