6IUB,4PFS,1HYQ,2OZE,1DAM


Conserved Protein Domain Family
CbiA

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pfam01656: CbiA 
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CobQ/CobB/MinD/ParA nucleotide binding domain
This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.
Statistics
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PSSM-Id: 366743
View PSSM: pfam01656
Aligned: 84 rows
Threshold Bit Score: 61.1973
Threshold Setting Gi: 494421953
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IUB_A  18 IAVANQKGGVGKTTTAVNLAASLAVHEKKILLID-FDPQANATS------SLGFR--RDKIDY--DIYHVLIGRKQISQV 86  Helicobacter pylori 2...
P0A6E9   5 FFITGTDTSVGKTVVSRALLQALASQGKTVAGYKpVAKGSKETP-------EGLRnkDALVLQ--SVSTIELPYEAVNPI 75  Escherichia coli K-12
P13000   5 YFVTGTDTEVGKTVASCALLQAAKAAGYRTAGYKpVASGSEKTP-------EGLRnsDALALQ--RNSSLQLDYATVNPY 75  Escherichia coli K-12
O06899   5 YFVTGTDTEVGKTVASCALLQAAAQAGWQTAGYKpVASGSEMTP-------EGLRnsDALALQ--HNSTLALRYEAVNPY 75  Pseudescherichia vuln...
P36572   5 WFVTGTDTEVGKSVASSALLQAANRAGYPSAGYKpVASGSEMTA-------EGLRngDALALQ--ANSGVALDYDEVNPY 75  Serratia marcescens
Q57908   5 IMVVGTSSNSGKTTITAGLCRILANKGYKVAPFK-SQNMSLNSR------VAKEDgeIAIAQYtqSLACRVEPSVHFNPI 77  Methanocaldococcus ja...
P9WP95   4 LLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFK-AQNMSNNSMvcrgpdGTGVEigRAQWVQ--ALAARTTPEAAMNPV 80  Mycobacterium tubercu...
Q9RJ20   5 LLVAGTTSDAGKSVVTAGICRWLVRQGVKVAPFK-AQNMSLNSFv----tRDGAEigRAQAMQ--AQACRVEPTAHMNPV 77  Streptomyces coelicol...
Q55860   4 IMVVGTTSHAGKSFLTTGLCRLLRRRGDRVTPFK-GQNMALNAFv----tIDGGEmgHAQAVQ--AWAAGTVPRVAMNPI 76  Synechocystis sp. PCC...
O28931   4 LMVGGTTSSAGKSLLAAAFCRILARRGYDVAPFK-AQNMSLNSFv----tSKGKEiaIAQAYQ--AFAAGIEPDERMNPV 76  Archaeoglobus fulgidu...
6IUB_A  87 ILKTQMPF---LDLVPSNLGLAGfektFYdsqdENKRGELm--LKNALESVVGLYDYIIIDSPPALG-PLTINSLSAAHS 160 Helicobacter pylori 2...
P0A6E9  76 ALSEEe----sSVAHSCPINYTL--------------------ISNGLANLTEKVDHVVVEGTGGWR--SLMNDLRPLSE 129 Escherichia coli K-12
P13000  76 TFAEPTSPhiiSAQEGRPIESLV--------------------MSAGLRALEQQADWVLVEGAGGWF--TPLSDTFTFAD 133 Escherichia coli K-12
O06899  76 TFAEPTSPhivSAALGQPIEAET--------------------LSAGLRMLEAQAEWVLVEGAGGWF--TPLSETLTFAD 133 Pseudescherichia vuln...
P36572  76 VFAEPTSPhivSADEGRPIDAAR--------------------LSDGLRRLEQRADWVLVEGAGGWF--TPLSAEYTFAD 133 Serratia marcescens
Q57908  78 LLKPKGNFi-sQVIVHGRPYKDMnyneYR----KNKDFFLk-kIKESLEILDREYDYVIMEGAGSCCeINLLKDDIANLR 151 Methanocaldococcus ja...
P9WP95  81 LLKPASDHr-sHVVLMGKPWGEVasssWC----AGRRALAe-aACRAFDALAARYDVVVAEGAGSPAeINLRAGDYVNMG 154 Mycobacterium tubercu...
Q9RJ20  78 LLKPGGERs-sQVVLLGRPVGEMsargYH----GGRQERLlgtVLDSLAELRGTYDAVICEGAGSPAeINLRRTDIVNMG 152 Streptomyces coelicol...
Q55860  77 LLKPQGDMt-sQVIMLGQAVGTTraqeYY----QNYFDRGwqaIANSLETLAQDFDVVVCEGAGSPAeINLKHRDLTNMR 151 Synechocystis sp. PCC...
O28931  77 LLKPKGNFv-sQLVVMGEAVGDVdsrkYY----GVKVEWLkrvVEEAYLSLAEEYDFVVIEGAGGMAeINLYERDLPNIH 151 Archaeoglobus fulgidu...
6IUB_A 161 VIIPIQCEFFALEGTKLLLNTIRMLQKStn-----pkLKIRGFLPTMHVPQLnLTKgvlaeLFKYfds---effRDSATG 232 Helicobacter pylori 2...
P0A6E9 130 WVVQEQLPVLMVVGIQE-GCINHALLTAqaia--ndgLPLIGWVANRINP---GLA-----HYAEiidvlgkklPAPLIG 198 Escherichia coli K-12
P13000 134 WVTQEQLPVILVVGV-KLGCINHAMLTAqviq--hagLTLAGWVANDVTPP--GKR-----HAEYmttl-trmiPAPLLG 202 Escherichia coli K-12
O06899 134 WATQEQLPVILVVGV-KLGCINHAVLTAqavq--qagLRLAGWVANDVVPP--GQR-----HTEYlatl-krmlPAPFLG 202 Pseudescherichia vuln...
P36572 134 WVRQEQLPVILVVGI-KLGCINHAVLTAqavq--qagLTLAGWIANDVGGAP-GRR-----HQEYlatl-rrmlPRRCWA 203 Serratia marcescens
Q57908 152 IAELVNAKAILVADIDR-GGVFASIYGTikllpenwrKLIKGIIINKFRGN--VEV-----LKEGieki-eeltGIPVLG 222 Methanocaldococcus ja...
P9WP95 155 LARHAGLPTIVVGDIDR-GGVFAAFLGTvallaaedqALVAGFVVNKFRGD--SDL-----LAPGlrdl-ervtGRRVYG 225 Mycobacterium tubercu...
Q9RJ20 153 IARGAGLPVLVVGDIDR-GGVFASFFGTvallapedqALVAGFLVNKFRGD--VSL-----LEPGldml-hgltGRRTYG 223 Streptomyces coelicol...
Q55860 152 VATHLQAATILIADIDR-GGVFAHVVGTlqllepeerKLIKGIVINKFRGQ--RSL-----LDSGitwl-eeytGIPVLG 222 Synechocystis sp. PCC...
O28931 152 IARFARPDILIVGDIDR-GGVFASLYGTyallpddvkPLVKGFVINRLRGR--EDV-----LESGirel-erltGIRVLG 222 Archaeoglobus fulgidu...
6IUB_A 233 EyimIPKSVKLAESPSFGK-PI 253 Helicobacter pylori 26695
P0A6E9 199 E---LPY---LPRAEQRELgqy 214 Escherichia coli K-12
P13000 203 E---IPWLAENPENAATgkyin 221 Escherichia coli K-12
O06899 203 E---IPWLENV--APESDIghw 219 Pseudescherichia vulneris
P36572 204 -------KSRTCRRPERA--PL 216 Serratia marcescens
Q57908 223 I---VPYDENLVLPEEDSQ-VL 240 Methanocaldococcus jannaschii DSM 2661
P9WP95 226 T---LPWHPDLWLDSEDAL-DL 243 Mycobacterium tuberculosis H37Rv
Q9RJ20 224 V---LPFRHGLGIDEEDGL-RV 241 Streptomyces coelicolor A3(2)
Q55860 223 V---IPYGQNLFSAEDSLD--I 239 Synechocystis sp. PCC 6803 substr. Kazusa
O28931 223 V---LPYLD--YNFPSEDSlNI 239 Archaeoglobus fulgidus DSM 4304
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