4PFS,1HYQ,2OZE,1DAM


Conserved Protein Domain Family
CbiA

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pfam01656: CbiA 
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CobQ/CobB/MinD/ParA nucleotide binding domain
This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.
Statistics
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PSSM-Id: 334629
View PSSM: pfam01656
Aligned: 83 rows
Threshold Bit Score: 59.6652
Threshold Setting Gi: 494421953
Created: 19-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4PFS_A  13 LAVANQKGGVAKTTTVASIGAALTEQGRRVLLVD-LDPQGCLTF--SLGHDPDKLPV----SVHEVLLGdVEPSAALVRT 85  Mycobacterium smegmat...
P0A6E9   5 FFITGTDTSVGKTVVSRALLQALASQGKTVAGYKpVAKGSKETP---EGLRNKDALVl--qSVSTIELPyEAVNPIALSE 79  Escherichia coli K-12
P13000   5 YFVTGTDTEVGKTVASCALLQAAKAAGYRTAGYKpVASGSEKTP---EGLRNSDALAl--qRNSSLQLDyATVNPYTFAE 79  Escherichia coli K-12
O06899   5 YFVTGTDTEVGKTVASCALLQAAAQAGWQTAGYKpVASGSEMTP---EGLRNSDALAl--qHNSTLALRyEAVNPYTFAE 79  Escherichia vulneris
P36572   5 WFVTGTDTEVGKSVASSALLQAANRAGYPSAGYKpVASGSEMTA---EGLRNGDALAl--qANSGVALDyDEVNPYVFAE 79  Serratia marcescens
Q57908   5 IMVVGTSSNSGKTTITAGLCRILANKGYKVAPFK-SQNMSLNSR--VAKEDGEIAIAqytqSLACRVEPsVHFNPILLKP 81  Methanocaldococcus ja...
O33475   5 LMVQGTMSGAGKSLLVAALCRIFTNLGYDVVPFK-SQNMSLNSApsIEGGEISRAQYl--qALACRKKPsVKFNPILLKP 81  Thermococcus kodakare...
D5AV13   4 LMIQGAGSNVGKSMLVAGLCRAARRRGLTVAPFK-PQNMSNNAAvtADGGEIGRAQAl--qALACGLEPvTDMNPILLKP 80  Rhodobacter capsulatu...
P29932   5 IMLQGTGSDVGKSVLVAGLCRLAANQGLKVRPFK-PQNMSNNAAvsDDGGEIGRAQWl--qALAARVPSsVHMNPVLLKP 81  Pseudomonas denitrifi...
Q55860   4 IMVVGTTSHAGKSFLTTGLCRLLRRRGDRVTPFK-GQNMALNAFvtIDGGEMGHAQAv--qAWAAGTVPrVAMNPILLKP 80  Synechocystis sp. PCC...
4PFS_A  86 DE----GMTLLPANIDLAGaeamLLMRagr--eyaLKRAL-AKLDGdFDVVIIDCPPSLG-VLTLNGLTAAHDVIVPLQC 157 Mycobacterium smegmat...
P0A6E9  80 Ee----SSVAHSCPINYTL----------------ISNGL-ANLTEkVDHVVVEGTGGWR--SLMNDLRPLSEWVVQEQL 136 Escherichia coli K-12
P13000  80 PTsphiISAQEGRPIESLV----------------MSAGL-RALEQqADWVLVEGAGGWF--TPLSDTFTFADWVTQEQL 140 Escherichia coli K-12
O06899  80 PTsphiVSAALGQPIEAET----------------LSAGL-RMLEAqAEWVLVEGAGGWF--TPLSETLTFADWATQEQL 140 Escherichia vulneris
P36572  80 PTsphiVSADEGRPIDAAR----------------LSDGL-RRLEQrADWVLVEGAGGWF--TPLSAEYTFADWVRQEQL 140 Serratia marcescens
Q57908  82 KGnf-iSQVIVHGRPYKDMnyneYRKNkdff-lkkIKESL-EILDReYDYVIMEGAGSCCeINLLKDDIANLRIAELVNA 158 Methanocaldococcus ja...
O33475  82 EGnm-rSQVVFMGRPIGSVsardYMLSkkaelfekAIEVLkELMRE-HDLVIIEGAGSPVeINLKDYDIANMRVAKAVNA 159 Thermococcus kodakare...
D5AV13  81 ESdv-gAQVVVQGKRLTTTrarvYATLkpql-mgaVLESF-NRLKAtHDLVIVEGAGSPAeVNLRAGDIANMGFARAADV 157 Rhodobacter capsulatu...
P29932  82 QSdv-gSQIVVQGKVAGQArgreYQALkpkl-lgaVMESF-EQISAgADLVVVEGAGSPAeINLRPGDIANMGFATRANV 158 Pseudomonas denitrifi...
Q55860  81 QGdm-tSQVIMLGQAVGTTraqeYYQNyfdrgwqaIANSL-ETLAQdFDVVVCEGAGSPAeINLKHRDLTNMRVATHLQA 158 Synechocystis sp. PCC...
4PFS_A 158 ETLAHRGVGQFLRTISDVQQItn-----pdLKLLGALPTLYDSRTtHS--RDVlldv-adryELPVLApPIPRTVRFAEA 229 Mycobacterium smegmat...
P0A6E9 137 PVLMVVGIQE-GCINHALLTAqaia--ndgLPLIGWVANRINP---GLahYAEiidvlgkklPAPLIG-ELPY---LPRA 206 Escherichia coli K-12
P13000 141 PVILVVGV-KLGCINHAMLTAqviq--hagLTLAGWVANDVTPP--GKrhAEYmttl-trmiPAPLLG-EIPWLAENPEN 213 Escherichia coli K-12
O06899 141 PVILVVGV-KLGCINHAVLTAqavq--qagLRLAGWVANDVVPP--GQrhTEYlatl-krmlPAPFLG-EIPWLENV--A 211 Escherichia vulneris
P36572 141 PVILVVGI-KLGCINHAVLTAqavq--qagLTLAGWIANDVGGAP-GRrhQEYlatl-rrmlPRRCWA-----KSRTCRR 210 Serratia marcescens
Q57908 159 KAILVADIDR-GGVFASIYGTikllpenwrKLIKGIIINKFRGN--VEvlKEGieki-eeltGIPVLG-IVPYDENLVLP 233 Methanocaldococcus ja...
O33475 160 PVILVADIDR-GGSFAQIVGTmellseeerELVMGFIFNKFRGD--ASllKPGfefl-ekrcGKPVLG-VVPYIEH--RL 232 Thermococcus kodakare...
D5AV13 158 PVVLVGDIDR-GGVIAQIVGTqavldpadaEMISGFLINKFRGD--VTlfDDGyrli-gartGWRGFG-TLPWFPLAHKL 232 Rhodobacter capsulatu...
P29932 159 PVVLVGDIDR-GGVIASLVGThailpeedrRMVTGYLINKFRGD--VTlfDDGiaav-nrytGWPCFG-VVPWLKAAARL 233 Pseudomonas denitrifi...
Q55860 159 ATILIADIDR-GGVFAHVVGTlqllepeerKLIKGIVINKFRGQ--RSllDSGitwl-eeytGIPVLG-VIPYGQNLFSA 233 Synechocystis sp. PCC...
4PFS_A 230 SASGS-SV 236 Mycobacterium smegmatis str. MC2 155
P0A6E9 207 EQRELgqy 214 Escherichia coli K-12
P13000 214 AATgkyin 221 Escherichia coli K-12
O06899 212 PESDIghw 219 Escherichia vulneris
P36572 211 PERA--PL 216 Serratia marcescens
Q57908 234 EEDSQ-VL 240 Methanocaldococcus jannaschii DSM 2661
O33475 233 PEEDS-LA 239 Thermococcus kodakarensis KOD1
D5AV13 233 PAEDAlDI 240 Rhodobacter capsulatus SB 1003
P29932 234 PAEDSvVL 241 Pseudomonas denitrificans
Q55860 234 EDSLD--I 239 Synechocystis sp. PCC 6803 substr. Kazusa
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