2PPQ,1ZYL,6CH4


Conserved Protein Domain Family
APH

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pfam01636: APH 
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Phosphotransferase enzyme family
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.
Statistics
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Aligned: 159 rows
Threshold Bit Score: 49.8143
Threshold Setting Gi: 81554421
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PPQ_A    26 SYKGIAEG-VENSNFLLHTTK-D---PLI-LTLYEKR-VEKNDLPFFLGLXQHLAAKGLs--cPLPLPRk-----DgelL 91  Agrobacterium fabru...
Q87KC4    42 GFLPLNS--YENRVYQFTDEErR---RYV-VKFYRPErWSNEQIQEEHDFTLELIDSEIpvapPV--RI------NgntL 107 Vibrio parahaemolyt...
Q88QX5    36 DARVLALNsYENRVYQVGIEDaQ---PLI-AKFYRPGrWSDAAILEEHAFTAELADCEVp--vVAPMQH------DdrtL 103 Pseudomonas putida ...
Q9I632    25 DARVLALNsYENRVYQVGIEDgE---PLI-AKFYRPDrWSDAAIREEHAFSAELAECEVp--vVAPLSR------DgesL 92  Pseudomonas aeruginosa
Q7NZB5    31 SLLALNS--YENRVYQVGLDDaA---PLV-AKFYRPArWSDAAILEEHAFSLQLAEREIpa-vP-PLAF------GgrtL 96  Chromobacterium vio...
Q8Y1Z7    37 DGRMFALNsYENRVYQAGIEDgA---PVV-VKFYRPGrWNDAQIVEEHAFTAELAAAEIp--vVAPLEI------DgrtL 104 Ralstonia solanacearum
P73341    64 KGCRFWHR-GLSDVYLVETLA-D---DYI-LRISHQHwRTESEIQFELELLNFLADRDV----PVAAPL------RhrdG 127 Synechocystis sp. P...
Q9A9Q4    41 KV-KRPVD-FGFLDYSTLELR-RwalERE-LTFNRAA---APDIYREVRRLTRATDGGI----EI-DGE------Ge-iV 101 Caulobacter vibrioides
O34640    30 DQVRFLAD-AENYVYECMKDN-Q---PYI-LKITHTIrRSSDYMMGEMEWLRHLAIGGI----SVAKPLpslngkDveaV 99  Bacillus subtilis s...
BAG22754  26 gLEFFPLG-EDSWSYRCGP-------LWIsVRRDLDG-----HFPGAYEVSLLLSESGKg---YVLAPL------PgrnG 83  Streptomyces griseu...
2PPQ_A    92 GELSGR-------PAALISFleGXWLRKpea---------khCREVGKALAAXHL-------A-------SEGFEIKRp- 140 Agrobacterium fabru...
Q87KC4   108 HHYQGY-------GFALFESvgGRQFEVdnl---------eqLEGVGRFLGRIHKv--------------GSRQAFQHrp 157 Vibrio parahaemolyt...
Q88QX5   104 FEHKGF-------RFTLFPRrgGHAPEpgn---------ldqLYRLGQLLGRLHAv-----gA-------SKPFKHREa- 154 Pseudomonas putida ...
Q9I632    93 FAFSGF-------RFALFPRrgGRAPEpgn---------ldqLYRLGQLLGRLHAv-----gA-------TRPFEHREa- 143 Pseudomonas aeruginosa
Q7NZB5    97 HGHGGF-------RFALFERrgGRVPELdrd---------etLQWVGRFLGRIHAlgrtegyR-------HRPTLDMQs- 152 Chromobacterium vio...
Q8Y1Z7   105 HAFDRW-------HFAVFPRcaGRVPAIdrd---------dtLEWMGRFLGRIHAv--------------GARRPFMAr- 153 Ralstonia solanacearum
P73341   128 GYALEInapegkrYASLFPYapGGVAIGdls--------ktqGFLLGEMLAQLHQta----qR-------FKPSAHRP-- 186 Synechocystis sp. P...
Q9A9Q4   102 EYLLEM-------RRFDQNGvlATQPWAidd---------alEDSLGRTVARFHAga---slRpqgggvsALGYTIRS-- 160 Caulobacter vibrioides
O34640   100 PDGNGGs-----fLLRVYEKapGQKVDEsdwnetlfyelgryTGSMHSLTKSYKLsn----pA-------FKRQEWDEe- 162 Bacillus subtilis s...
BAG22754  84 RVVHRIad----fPVVVFPYveSATTPPappt-------qeqIDLLIARLGEVHAfe---ppA-------SRPVDVPTe- 141 Streptomyces griseu...
2PPQ_A   141 -----NALS------VD----------------------GWKVLWDKsEERADEVEK----GLREEIRPEIDYLAAHWPK 183 Agrobacterium fabru...
Q87KC4   158 tiglqEYLY------QP----------------------REILQN---ANMIPMHLEn--sFFNDLDM-LIKAIENHWQG 203 Vibrio parahaemolyt...
Q88QX5   155 -----LAVDnfghasLN----------------------TLLEGNFVpHELLPAFESv--aR--DLLKRVEDIYARTPH- 202 Pseudomonas putida ...
Q9I632   144 -----LAVDnfghasLA----------------------TLLEGNFIpRSLLPAYESv--aR--DLLKR-LDALFAEVP- 190 Pseudomonas aeruginosa
Q7NZB5   153 -----FGRE------PV----------------------DFVLGG---GWLPPELEAvyrgVAEQALQGVARCFERAGP- 195 Chromobacterium vio...
Q8Y1Z7   154 -----PTLD------ID----------------------TFGVQSRD-WLLEHDFIPp---DLLPAWRSVADAALDGVRR 196 Ralstonia solanacearum
P73341   187 -------PL------TL----------------------SYLLDD---SLHTIAPFL-----HHRLEE-WRCLIDISMAI 222 Synechocystis sp. P...
Q9A9Q4   161 ------NAN------LL----------------------RGLAPRLGkQAVERLVHEt--dL-------ALERLGPLLDA 197 Caulobacter vibrioides
O34640   163 -----EQLK------LR----------------------KYVPED------QIKVFQ-----QADSLMNELRRLPKSQD- 197 Bacillus subtilis s...
BAG22754 142 -----DFRF------PFendldkavqaalngdaaaggpyAGLLAE---RVDRCQGFLa--eLREEATR-VAGECAARWRG 204 Streptomyces griseu...
2PPQ_A   184 ----------DLPAGVIHADLFQDNVFFL--------------GDELsGLIDF----YFACNDllaydvsicLn----A- 230 Agrobacterium fabru...
Q87KC4   204 ----------SFATIRLHGDCHPGNILWR--------------DGPM--FVDL----DDSRNGpavqdlwmlLn----G- 248 Vibrio parahaemolyt...
Q88QX5   203 ------------QLIRLHGDLHPGNLMHRd-------------EVYH--VVDL----DDCRMGpavqdlwmmLa----G- 246 Pseudomonas putida ...
Q9I632   191 -----------YQPIRLHGDCHPGNLLCRd-------------DVYH--MVDL----DDCRMGpalqdlwmmL-----A- 234 Pseudomonas aeruginosa
Q7NZB5   196 -----------VAQLRLHGDCHVGNLLWTd------------aGPH---FVDF----DDSRMGpavqdlwmlL-----S- 239 Chromobacterium vio...
Q8Y1Z7   197 cyd----ragEVAMLRLHGDCHASNVLWIdeadalkndplrsaGPH---FVDF----DDSRTGpavqdlwmlLsgdraS- 264 Ralstonia solanacearum
P73341   223 ktqltsipthTPYWTICWGDPHSGNVHFTa------------eDQMM--LFDF----DQCGMGwrafdiakfLq----Vs 280 Synechocystis sp. P...
Q9A9Q4   198 ra-------gEGFARHCHGDLHLGNILIEn-------------GQPI--LFDCiefnDTLSDIdiqydlaflLmd-ldFr 254 Caulobacter vibrioides
O34640   198 ------------NYGLVHADLHHGNFNWD--------------HGKI-TAFDF----DDIGYNwfvndisilL-----Y- 240 Bacillus subtilis s...
BAG22754 205 -----------ERPALTHGDPSLANVLFT--------------KGVD--IIDW----GGAMWApperdwaalQr----V- 248 Streptomyces griseu...
2PPQ_A   231 WCFEKDGAYNVTKGKALl-----eGYQSVRPL 257 Agrobacterium fabrum str. C58
Q87KC4   249 ERQDKLMQLDIILEAYQefc--dfNAAELKLI 278 Vibrio parahaemolyticus
Q88QX5   247 NREERLGQLAELIDGYNefh--dfDPRELALI 276 Pseudomonas putida KT2440
Q9I632   235 GERHERLAQIAELVDGYnef-hdfDPRQLPLL 265 Pseudomonas aeruginosa
Q7NZB5   240 GERAEQSRQLGEVLAGYedf-cefDLRELNLL 270 Chromobacterium violaceum
Q8Y1Z7   265 -MRHQLASVLAGYEDFCafd--trELHLVEAL 293 Ralstonia solanacearum
P73341   281 MQSGLGRNIRDAFLSGYn---------SIAPL 303 Synechocystis sp. PCC 6803 substr. Kazusa
Q9A9Q4   255 RRRDAAGRVLNAYLDEAartfgegLWTGLAAL 286 Caulobacter vibrioides
O34640   241 NVLWYPVVPYDDKAAFTee----fMTHFMKGY 268 Bacillus subtilis subsp. subtilis str. 168
BAG22754 249 FG--TAPRSRPEFLRFYel---rwHLAEIAEY 275 Streptomyces griseus subsp. griseus NBRC 13350
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