2PPQ,1ZYL


Conserved Protein Domain Family
APH

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pfam01636: APH 
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Phosphotransferase enzyme family
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.
Statistics
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PSSM-Id: 279908
View PSSM: pfam01636
Aligned: 156 rows
Threshold Bit Score: 50.2032
Threshold Setting Gi: 81554421
Created: 2-Aug-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PPQ_A  26 SYKGIAEG-VENSNFLLHTTK-DPLI-LTLYEKR-VEKNDLPFFLGLXQHLAAKGLscplPLPR-K------Dge--lLG 92  Agrobacterium fabrum ...
1ZYL_A  30 GLTPLNS--YENRVYQFQDEDrRRFV-VKFYRPErWTADQILEEHQFALQLVNDEVp--vAAPVaF------Ngq--tLL 96  Escherichia coli
Q8ZKU8  30 gLTPLNS--YENRVYQFQDEDrRRFV-VKFYRPErWSVDQIREEHQFALELVKDEV----PVAApL------AfngqtLL 96  Salmonella enterica s...
Q88QX5  36 DARVLALNsYENRVYQVGIEDaQPLI-AKFYRPGrWSDAAILEEHAFTAELADCEVp--vVAPMqH------Ddr--tLF 104 Pseudomonas putida KT...
Q9I632  25 DARVLALNsYENRVYQVGIEDgEPLI-AKFYRPDrWSDAAIREEHAFSAELAECEVp--vVAPLsR------Dge--sLF 93  Pseudomonas aeruginosa
Q7NZB5  31 SLLALNS--YENRVYQVGLDDaAPLV-AKFYRPArWSDAAILEEHAFSLQLAEREIpa-vP-PLaF------Ggr--tLH 97  Chromobacterium viola...
Q8Y1Z7  37 DGRMFALNsYENRVYQAGIEDgAPVV-VKFYRPGrWNDAQIVEEHAFTAELAAAEIp--vVAPLeI------Dgr--tLH 105 Ralstonia solanacearum
P73341  64 KGCRFWHR-GLSDVYLVETLA-DDYI-LRISHQHwRTESEIQFELELLNFLADRDV----PVAApL------Rhr--dGG 128 Synechocystis sp. PCC...
O34640  30 DQVRFLAD-AENYVYECMKDN-QPYI-LKITHTIrRSSDYMMGEMEWLRHLAIGGI----SVAKpLpslngkDve--aVP 100 Bacillus subtilis sub...
P29784  38 gLEFFPLG-EDSWSYRCGP----LWIsVRRDLDG-----HFPGAYEVSLLLSESGKg---YVLApL------Pgr--nGR 96  Streptomyces griseus
2PPQ_A  93 ELSGR-------PAALISFleGXWLRKpea---------khcREVGKALAAXHLA-------SEGFEIKRp----NALS- 144 Agrobacterium fabrum ...
1ZYL_A  97 NHQGF-------YFAVFPSvgGRQFEAdnidqme--avgrylGRMHQTGRK--QLf-----iHRPTIGLNe----YLIE- 155 Escherichia coli
Q8ZKU8  97 AHQGY-------HYAIFPSvgGRQFEAdni---------dqmEAVGRYLGRLHQTg-----rKRPFTFRPdiglaEYLF- 154 Salmonella enterica s...
Q88QX5 105 EHKGF-------RFTLFPRrgGHAPEpgnl---------dqlYRLGQLLGRLHAVg-----aSKPFKHREa----LAVDn 159 Pseudomonas putida KT...
Q9I632  94 AFSGF-------RFALFPRrgGRAPEpgnl---------dqlYRLGQLLGRLHAVg-----aTRPFEHREa----LAVDn 148 Pseudomonas aeruginosa
Q7NZB5  98 GHGGF-------RFALFERrgGRVPELdrd---------etlQWVGRFLGRIHALgrtegyrHRPTLDMQs----FGRE- 156 Chromobacterium viola...
Q8Y1Z7 106 AFDRW-------HFAVFPRcaGRVPAIdrd---------dtlEWMGRFLGRIHAV-------GARRPFMAr----PTLD- 157 Ralstonia solanacearum
P73341 129 YALEInapegkrYASLFPYapGGVAIGdlsk--------tqgFLLGEMLAQLHQTaq----rFKPSAHRP-------PL- 188 Synechocystis sp. PCC...
O34640 101 DGNGGs-----fLLRVYEKapGQKVDEsdwnetlfyelgrytGSMHSLTKSYKLSnp----aFKRQEWDEe----EQLK- 166 Bacillus subtilis sub...
P29784  97 VVHRIad----fPVVVFPYveSATTPPappt-------qeqiDLLIARLGEVHAFep---paSRPVDVPTe----DFRF- 157 Streptomyces griseus
2PPQ_A 145 -----VD----------------------GWKVLWDKsEERADEVEKg---LREEIRP-EIDYLAAHWPK---------- 183 Agrobacterium fabrum ...
1ZYL_A 156 -----PR----------------------KLFEDA---TLIPSGLKA----AFLKATDeLIAAVTAHWRE---------- 191 Escherichia coli
Q8ZKU8 155 -----EP----------------------RQVFED-A-ALIPSGQKA----AFLKATDtLLSAVTECWRT---------- 191 Salmonella enterica s...
Q88QX5 160 fghasLN----------------------TLLEGNFVpHELLPAFESv--aR--DLLKrVEDIYARTPH----------- 202 Pseudomonas putida KT...
Q9I632 149 fghasLA----------------------TLLEGNFIpRSLLPAYESv--aR--DLLKr-LDALFAEVP----------- 190 Pseudomonas aeruginosa
Q7NZB5 157 -----PV----------------------DFVLGG---GWLPPELEAvyrgVAEQALQgVARCFERAGP----------- 195 Chromobacterium viola...
Q8Y1Z7 158 -----ID----------------------TFGVQSRD-WLLEHDFIPp---DLLPAWRsVADAALDGVRRcyd----rag 202 Ralstonia solanacearum
P73341 189 -----TL----------------------SYLLDD---SLHTIAPFL-----HHRLEE-WRCLIDISMAIktqltsipth 232 Synechocystis sp. PCC...
O34640 167 -----LR----------------------KYVPED------QIKVFQ-----QADSLMnELRRLPKSQD----------- 197 Bacillus subtilis sub...
P29784 158 -----PFendldkavqaalngdaaaggpyAGLLAE---RVDRCQGFLa--eLREEATR-VAGECAARWRG---------- 216 Streptomyces griseus
2PPQ_A 184 DLPAGVIHADLFQDNVFFL--------------GDELsGLIDFYFACNDllaydvsicLn----A-WCFEKDGAYNVTKG 244 Agrobacterium fabrum ...
1ZYL_A 192 DFTVLRLHGDCHAGNILWR--------------DGPM--FVDLDDARNGpavqdlwmlL-----N-GDKAEQRMQLETII 249 Escherichia coli
Q8ZKU8 192 DFATLRLHGDCHAGNILWR--------------DGPL--FVDLDDARNGpaiqdlwmlL-----N-GDKAEQRMQLETII 249 Salmonella enterica s...
Q88QX5 203 --QLIRLHGDLHPGNLMHRd-------------EVYH--VVDLDDCRMGpavqdlwmmLa----G-NREERLGQLAELID 260 Pseudomonas putida KT...
Q9I632 191 -YQPIRLHGDCHPGNLLCRd-------------DVYH--MVDLDDCRMGpalqdlwmmL-----A-GERHERLAQIAELV 248 Pseudomonas aeruginosa
Q7NZB5 196 -VAQLRLHGDCHVGNLLWTd------------aGPH---FVDFDDSRMGpavqdlwmlL-----S-GERAEQSRQLGEVL 253 Chromobacterium viola...
Q8Y1Z7 203 EVAMLRLHGDCHASNVLWIdeadalkndplrsaGPH---FVDFDDSRTGpavqdlwmlLsgdraS--MRHQLASVLAGYE 277 Ralstonia solanacearum
P73341 233 TPYWTICWGDPHSGNVHFTa------------eDQMM--LFDFDQCGMGwrafdiakfLq----VsMQSGLGRNIRDAFL 294 Synechocystis sp. PCC...
O34640 198 --NYGLVHADLHHGNFNWD--------------HGKI-TAFDFDDIGYNwfvndisilL-----Y-NVLWYPVVPYDDKA 254 Bacillus subtilis sub...
P29784 217 -ERPALTHGDPSLANVLFT--------------KGVD--IIDWGGAMWApperdwaalQr----V-FG--TAPRSRPEFL 272 Streptomyces griseus
2PPQ_A 245 KALl----EGYQSVRPL 257 Agrobacterium fabrum str. C58
1ZYL_A 250 EAYeefseFDTAEIGLI 266 Escherichia coli
Q8ZKU8 250 EAYeevseFDTaeigli 266 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Q88QX5 261 GYNef-hdFDPRELALI 276 Pseudomonas putida KT2440
Q9I632 249 DGYnefhdFDPRQLPLL 265 Pseudomonas aeruginosa
Q7NZB5 254 AGYedfceFDLRELNLL 270 Chromobacterium violaceum
Q8Y1Z7 278 DFCaf-dtRELHLVEAL 293 Ralstonia solanacearum
P73341 295 SGYn--------SIAPL 303 Synechocystis sp. PCC 6803 substr. Kazusa
O34640 255 AFTe---eFMTHFMKGY 268 Bacillus subtilis subsp. subtilis str. 168
P29784 273 RFYel--rWHLAEIAEY 287 Streptomyces griseus
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