3K0S,1NNE,2O8B,3THW,2O8B


Conserved Protein Domain Family
MutS_I

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pfam01624: MutS_I 
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MutS domain I
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
Statistics
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Aligned: 61 rows
Threshold Bit Score: 98.4203
Threshold Setting Gi: 26396556
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K0S_A     10 TPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRG--------ASAGEP-IPMAGIPYHAVENYLA 80   Escherichia coli ...
O13396     13 HGFIRFYKSLPQLGEEAIRIFDRGDWYTAHGDDATFIARTVYKTTSVIRq------lGRSDHTgLPSVTMTVTVFRQFLR 86   Neurospora crassa...
Q9XGC9     24 QGFISFFKKLPQ-DPRAVRLFDRRDYYTAHGENATFIARTYYHTMSALRq-------lGSSSDgILSASVSKAMFETIAR 95   Zea mays
O24617     22 QGFLSFYKTLPN-DTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRq-------lGSGSNaLSSVSISRNMFETIAR 93   thale cress
P43246     17 VGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKy------mGPAGAKnLQSVVLSKMNFESFVK 90   human
O65607    105 TPLEQQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGI--------------YAHMDHnFMTASVPTFRLNFHVR 170  thale cress
P13705    188 TPLELQYLDMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNI--------------YCHLDHnFMTASIPTHRLFVHVR 253  house mouse
AAI65693   17 hGFLNFYFSMSDKPDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTNGVIKn-------LGSGNRrLESVVLSKMNFESFVR 89   zebrafish
P25336    133 TPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKltidesnpQDCNHRqFAYCSFPDVRLNVHLE 212  Saccharomyces cer...
3THW_B     14 TPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNI-----Y--------CHLDHN-FMTASIPTHRLFVHVR 79   human
3K0S_A     81 KLVN-Q-GESVAICEQIGDPATS--------K---G---PVERKVVRIVTPGTISDEA 122  Escherichia coli K-12
O13396     87 EALF-KlGKRIEIWASPSG--------------------RMNWKVVKQASPGNLQDVE 123  Neurospora crassa OR74A
Q9XGC9     96 NILLeRtDCTLELYEGS----------------------GSNWRLTKSGTPGNIGSFE 131  Zea mays
O24617     94 DLLLeRnDHTVELYEGS----------------------GSNWRLVKTGSPGNIGSFE 129  thale cress
P43246     91 DLLL-VrQYRVEVYKNRAGNKAS--------K-------ENDWYLAYKASPGNLSQFE 132  human
O65607    171 RLVN-A-GYKIGVVKQTETAAIK--------ShgaNrtgPFFRGLSALYTKATLEAAE 218  thale cress
P13705    254 RLVA-K-GYKVGVVKQTETAALK--------AigdNkssVFSRKLTALYTKSTLIGED 301  house mouse
AAI65693   90 DLLL-VrQYRVEVYKNASKSSK-----------------EHDWQIAFKASPGNLTQFE 129  zebrafish
P25336    213 RLVH-H-NLKVAVVEQAETSAIKkhdpgaskS---S---VFERKISNVFTKATFGVNS 262  Saccharomyces cerevisiae S288C
3THW_B     80 RLVA-K-GYKVGVVKQTETAALKaig--dnrS---S---LFSRKLTALYTKSTLIGED 127  human
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