Conserved Protein Domain Family
Adaptin_N

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pfam01602: Adaptin_N 
Adaptin N terminal region
This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Statistics
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Aligned: 30 rows
Threshold Bit Score: 358.856
Threshold Setting Gi: 74583793
Created: 18-Mar-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P38065   38 QEKRIQSEIVKIKQHFdaakkkqgnhdrlgGYQRKK-YVAKLAYIYITSN---TTKlneilFGLEQTVELLK-SSIFSEK 112  Saccharomyces cerev...
P45437   16 LEVTNEMQLKRDLEKG--------------DTNVKIeTLKRVIKLLLNGE---RYP-----GLIMTIIRFVLpVQNHTIK 73   fruit fly
O45718   11 DNRTRFADLKAMLDSN--------------KDNLKVdAMKRIINLIAKGK---DVS-----ELFAAVVKNVA-AKNVELK 67   Caenorhabditis elegans
Q13367   34 SDYKRHDDLKEMLDTN--------------KDSLKLeAMKRIVAMIARGK---NAS-----DLFPAVVKNVA-CKNIEVK 90   human
Q9W4K1   40 sDGRKHDDLKQMLDSN--------------KDGLKLeAMKRIIGMIARGR---DAS-----DLFPAVVKNVV-SKNIEVK 96   fruit fly
O13939   30 ENELSHSDLLRLLNSN--------------SDAGKLeAINFILAQMMHGE---NMS-----LYFPDVVKLVA-SENPEIR 86   Schizosaccharomyces...
P46682   39 SQNINPQQLVTLLNSR--------------NSREVRdAMKRIISIMASDDdsiDVQ-----LYFADVVKNIT-TNDTKVK 98   Saccharomyces cerev...
P36000   24 G-KGELSELRTGLVSQ--------------YPQTRKdAIKKTIQQMTLGK---DVS-----SLFPDVLKNIA-TIDVEQK 79   Saccharomyces cerev...
O81742   13 K-KGEIPELKEELNSQ--------------YKDKRKdAVKKVIAAMTVGK---DVS-----SLFTDVVNCMQ-TENLELK 68   thale cress
Q10567   11 K-KGEIFELKAELNSD--------------KKEKKKeAVKKVIASMTVGK---DVS-----ALFPDVVNCMQ-TDNLELK 66   human
P38065  113 FIGYMTLELLYERSEV-----VAKVndeVNYQLMKDLSSSDDNFVMLALNFVGVVGelTNRLAynDDITTGVFKILRSPT 187  Saccharomyces cerev...
P45437   74 KLLLIFWEIVPKTSADgkllqEMIL---VCDAYRKDLQHPNEFLRGSTLRFLCKLK--EPELL--EPLMPAIRACLDHRH 146  fruit fly
O45718   68 KLVFVYLVRYAEEQQD-----LALL---SISTFQRALKDPNQLIRGSALRVLTSIR--VPMVA--PIMLLAIKDAVRDMS 135  Caenorhabditis elegans
Q13367   91 KLVYVYLVRYAEEQQD-----LALL---SISTFQRGLKDPNQLIRASALRVLSSIR--VPIIV--PIMMLAIKEAASDMS 158  human
Q9W4K1   97 KLVYVYLVRYAEEQQD-----LALL---SISTFQRALKDPNQLIRASALRVLSSIR--VSMIV--PIVMLAIRDSAADLS 164  fruit fly
O13939   87 RLVHIYLLQYAEFNPD-----LALL---SVNTVQKTLYDKNPLTRSTAIRVMSSIR--VPAIN--GIVLLAIQQCITDTA 154  Schizosaccharomyces...
P46682   99 RLIHLYLLRFAENDPN-----LTLL---SINSLQKSLSDSNSELRCFALSALSDMK--MSSLA--PIILHTVKKLVTDPS 166  Saccharomyces cerev...
P36000   80 KLVYLYVMNYAETHPE-----LCIL---AVNTFITDAQDPNPLIRCMAIRTMSMIR--VDKIL--EYIETPLRRTLHDDN 147  Saccharomyces cerev...
O81742   69 KLVYLYLINYAKSQPD-----LAIL---AVNTFVKDSQDPNPLIRALAVRTMGCIR--VDKIT--EYLCDPLQKCLKDDD 136  thale cress
Q10567   67 KLVYLYLMNYAKSQPD-----MAIM---AVNTFVKDCEDPNPLIRALAVRTMGCIR--VDKIT--EYLCEPLRKCLKDED 134  human
P38065  188 SsiYLKKKSALSFLALLKSnhsilTEDLQRKqlwIQRILSLL--DDTEnYRLTLATIPLIEFIakyiDPSyc---tRLLP 262  Saccharomyces cerev...
P45437  147 S--YVRRNAVLAIFTIYKN-----FDWLVPD---GPELIASFldTQQD-MSCKRNAFLMLLHA----DQE------RALN 205  fruit fly
O45718  136 P--YVRKVAAHAIPKLYSL-----EPEL-EPq-lVDCIDFLL--ADRR-SLVLGSAVYAFDEIc--pHRL------DLLH 195  Caenorhabditis elegans
Q13367  159 P--YVRKTAAHAIPKLYSL-----DSDQ--KdqlIEVIEKLL--ADKT-TLVAGSVVMAFEEVc--pERI------DLIH 218  human
Q9W4K1  165 P--YVRKTAAHAIPKLYSL-----DADQ--KdelVMVIEKLL--SDRT-TLVVGSAVMAFDEVc--pERV------DLIH 224  fruit fly
O13939  155 D--RVRQSAALAITKCYSL-----DPSY--KsqlEEHIKTLL--SDNS-PIVVPAALFTFEVVc--pEKL------EIIH 214  Schizosaccharomyces...
P46682  167 A--MVRGEVALAIIKLYRA-----GKNDY-HeelLDILKELM--ADTD-PKVISCAVLAYKECy--aDHL------ELLH 227  Saccharomyces cerev...
P36000  148 A--YVRKTAVICVAKLFQL-----NKDLCVElgvVEDLVNAL--DDSN-PLVIANATAALIEIh--nMDMdavdlsSLIQ 215  Saccharomyces cerev...
O81742  137 P--YVRKTAAICVAKLFDI-----NAELVEDrgfLEALKDLI--SDNN-PMVVANAVAALAEIq---ENStsp-ifEINS 202  thale cress
Q10567  135 P--YVRKTAAVCVAKLHDI-----NAQLVEDqgfLDTLKDLI--SDSN-PMVVANAVAALSEIa--eSHPssn-llDLNP 201  human
P38065  263 QLTEILYNCvvvgtsrssdnqfpleytfaNMPNPWLITKVVSLLSILIASPTERDsgsl--------------------- 321  Saccharomyces cerev...
P45437  206 YLASCIDQV--------------------HTFGDILQLVIVELIYKVCHANPAER------------------------- 240  fruit fly
O45718  196 KHFRALCRGl-------------------ADVDEWGQIVMINMLTRYARHELADPdrgpp-------------------- 236  Caenorhabditis elegans
Q13367  219 KNYRKLCNLl-------------------IDVEEWGQVVIISMLTRYARTQFLSPtqneslleenaekafygseedeak- 278  human
Q9W4K1  225 KNYRKLCNFl-------------------LDVDEWGQVIIINMLTRYARTQFVDPnaddedlvndglgetpvserfydes 285  fruit fly
O13939  215 PYYHRICTLf-------------------PQMNDWDKVVALKTLVRYARLTLPEPstpst-------------------- 255  Schizosaccharomyces...
P46682  228 GHFRRYCRIi-------------------KQLDSWSQSYLIELLIKYCKQYLPKPtvvdkssegsprscplpd------- 281  Saccharomyces cerev...
P36000  216 SHVSQFLLAl-------------------NECTEWARIIILGTLSEYSAKDSLEA------------------------- 251  Saccharomyces cerev...
O81742  203 TILTKLLTAl-------------------NECTEWGQVFILDALSRYKASDPREA------------------------- 238  thale cress
Q10567  202 QSINKLLTAl-------------------NECTEWGQIFILDCLANYMPKDDREA------------------------- 237  human
P38065  322 ---------------------------------------------lqtNNIDNELLNKLRkcvsvaielgtrqaqdpmer 356  Saccharomyces cerev...
P45437  241 ------------------------------------------------SRFIRCIYNLLN-------------------- 252  fruit fly
O45718  237 --------------------------------------------dtdvVLLLNSARPLLQ-------------------- 252  Caenorhabditis elegans
Q13367  279 ------------------------gagseetaaaaapsrkpyvmdpdhRLLLRNTKPLLQ-------------------- 314  human
Q9W4K1  286 shssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRQTKPLLQ-------------------- 345  fruit fly
O13939  256 --------------------------------------------hsdlKELLESIKSCFF-------------------- 271  Schizosaccharomyces...
P46682  282 ------------------------------kyneieypsyevvndpdlDLFLQSLNCLIY-------------------- 311  Saccharomyces cerev...
P36000  252 ------------------------------------------------QDIIDRVTAHLQ-------------------- 263  Saccharomyces cerev...
O81742  239 ------------------------------------------------ENIVERVTPRLQ-------------------- 250  thale cress
Q10567  238 ------------------------------------------------QSICERVTPRLS-------------------- 249  human
P38065  357 IVQNTVLFSLINFASKLDPSDE--------AISNSVTALCSLLT-SKEINIRYLTLDSLVKLCSS----------Sgkpa 417  Saccharomyces cerev...
P45437  253 SSSNAVRYESAGTLITLSLAPT--------AIKAAASCYIELVVkESDNNVKLIVLDRLVAMKEH----------Eg--m 312  fruit fly
O45718  253 SRNCSVVMAVVQLFYHVAPKAQ---------LSQIARALVRLLR-GPRE-TQYVVLTNIATICERnpveegtyaiS---- 317  Caenorhabditis elegans
Q13367  315 SRSAAVVMAVAQLYFHLAPKAE---------VGVIAKALVRLLR-SHSE-VQYVVLQNVATMSIK----------R---- 369  human
Q9W4K1  346 SRNASVVMAVAQLYHHVAPKNE---------VQLIAKALIRLLR-SHKE-VQSVVLNCIASMSTK----------R---- 400  fruit fly
O13939  272 SLLPSTIIAGARAFYYLAPSNQ---------MHLIVEPLLQLLL-EKPI-VRTTTLRYISQIVYK----------T---- 326  Schizosaccharomyces...
P46682  312 SSNPTVILSCCNALYQLASPLQm-------KNTKFIEALVRTVTmTENQGNKEMLLQAIHFLSIL----------D---- 370  Saccharomyces cerev...
P36000  264 HVNPAVVLATIKVIVRNLPQIEyss--nslIMKRLSSAFVSLMS-TPPE-MQYVALKNIRIILEK----------Y---- 325  Saccharomyces cerev...
O81742  251 HANCAVVLSAVKMILQQMELITstdv-irnLCKKMAPPLVTLLS-AEPE-IQYVALRNINLIVQK----------R---- 313  thale cress
Q10567  250 HANSAVVLSAVKVLMKFMEMLSkdldyygtLLKKLAPPLVTLLS-AEPE-LQYVALRNINLIVQK----------R---- 313  human
P38065  418 IDAVRykNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKI---IVDGLLQYIlspKNLAEPQ----IKSDIAVKIAI 490  Saccharomyces cerev...
P45437  313 EKVMQ--DLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGE---MVLVLKKEVaktHNV-EHEdtgkYRQLLVRTLHT 386  fruit fly
O45718  318 -KTMF--DPFLKSFFVRSCDSSLVKKLKLHVLTSLVSEANVHI---ILRELQTYV---HMS---D----LASPAVEAIGR 381  Caenorhabditis elegans
Q13367  370 -RGMF--EPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPT---VLREFQTYI---RSM-DKD----FVAATIQAIGR 435  human
Q9W4K1  401 -KAIF--EPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISL---ILREFQTYI----SSSDRS----FVAATIQAIGR 466  fruit fly
O13939  327 -PELF--KNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQ---ILPELLYYI---NSHPNPS----VASTAVKALGD 393  Schizosaccharomyces...
P46682  371 -QTLF--LPYTKKFYVFPKDPIVASIWKIQILSTLINESNVKE---IFKELKYYV---ASAHFPEn---VVIMAVKSLSR 438  Saccharomyces cerev...
P36000  326 -PELL--TKELRIFYVKFNDPLYVKLEKIDILVRLVDPSNLKQctlLLTELKEYA---MEY-EPE----FVSRAIQALSQ 394  Saccharomyces cerev...
O81742  314 -PTIL--AHEIKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQ---VLLEFKEYA---TEV-DVD----FVRKAVRAIGR 379  thale cress
Q10567  314 -PEIL--KHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQ---VLAELKEYA---TEV-DVD----FVRKAVRAIGR 379  human
P38065  491 LTEKY--ATDINWFVIISLQLLSLTS--NTTinDDEIWQRLCQIVVNNPSLHRITCERLVDYLCKkQASEA-------II 559  Saccharomyces cerev...
P45437  387 CSIKF--PDVAANVIPVLVEFLSDTN--ELA--AADVLIFIREAIQKFPALRALIIEHLIEAFPQ-IKSSK-------IH 452  fruit fly
O45718  382 CAVRV--GAVSDQCMTGLVQLISSSD--EKV--VCSAVVVIKRLLHASAPL--NLLSRLMRLMPN-MIAAQ-------AR 445  Caenorhabditis elegans
Q13367  436 CATNI--GRVRDTCLNGLVQLLSNRD--ELV--VAESVVVIKKLLQMQPAQHGEIIKHLAKLTDN-IQVPM-------AR 501  human
Q9W4K1  467 CASSI--KEVTETCLSGLVHLLSNHD--EHV--VAESVVVIKRLLQTKAAEHFEIITQMAKLIDY-INVPA-------AR 532  fruit fly
O13939  394 FASAN--ISMAPSCLNTLLLLLKSHN--SLI--VTEAASSLRLLIHNDPKEIY--LQYLAATYET-LEVPR-------AK 457  Schizosaccharomyces...
P46682  439 CGQLS--TSWESHVMKWLIDHMESHNlsASV--LDAYVNVIRMLVQKNPTKHLRIIFKLADLLTV-QTSLAd-----nAR 508  Saccharomyces cerev...
P36000  395 LGIKYaqESFVSKVLDILLELLERQ---DTI--KDDCCISLCDLLRHCPGN-DKMAKQVCAVFNT-WSNPEvllqsdiAK 467  Saccharomyces cerev...
O81742  380 CAIKL--ERAAERCISVLLELIKIKV--NYV--VQEAIIVIKDIFRRYPNTYESIIATLCESLDT-LDEPE-------AK 445  thale cress
Q10567  380 CAIKV--EQSAERCVSTLLDLIQTKV--NYV--VQEAIVVIKDIFRKYPNKYESVIATLCENLDS-LDEPE-------AR 445  human
P38065  560 KAAAFLLGEYSSLITDRiSSANLFTLFAEKYFSAPNVAKAM-ILTTMIKLY-----------KTSP--EIGS-------- 617  Saccharomyces cerev...
P45437  453 RAAVWILGEYVEGSQILeVIAVIQQTLGEVPMVEAEQRRLAgDQTEEQKQQ-----------QGSAggNAAGsaaegsgs 521  fruit fly
O45718  446 ACVIWLVATHVEQVLh--MAPDFLRLIAKKFSTENELVKLE-ALKLAVKLW-----------LVKRddSE---------- 501  Caenorhabditis elegans
Q13367  502 ASILWLIGEYCEHVPr--IAPDVLRKMAKSFTAEEDIVKLQ-VINLAAKLY-----------LTNSkqTK---------- 557  human
Q9W4K1  533 AAIIWLIGEYNEKVPl--IAPDVLRKMAKSFVDEQDVVKLQ-VLNLGVKLY-----------LTNPeqTS---------- 588  fruit fly
O13939  458 SVTLWLISEHILIIPr--LVPDVLRIAVKTFADETLEVKYQ-ILELSVRLY-----------VLSHseEKQNdlesr--d 521  Schizosaccharomyces...
P46682  509 AGIVWLFGEIASIEFk--ICPDVLRRLIQNFSNEGPETRCQ-ILVLSAKLLsydidnfkqaqVTGSeeNNQNppyydfsg 585  Saccharomyces cerev...
P36000  468 CNYVWLLGQHPNNFSd---LESKINIFIENFVQEEALTQMS-LLMTIVRLH-----------ATL----TG--------- 519  Saccharomyces cerev...
O81742  446 ASMIWIIGEYAERIDn---ADELLESFLENFPEEPAQVQLQ-LLTATVKLF-----------LKKPteGPQ--------- 501  thale cress
Q10567  446 AAMIWIVGEYAERIDn---ADELLESFLEGFHDESTQVQLQ-LLTAIVKLF-----------LKKPt-eTQ--------- 500  human
P38065  618 ----NVIKFFQLELN--SLDIELQTRSF---EYLNIIQLAK 649  Saccharomyces cerevisiae S288C
P45437  522 gnasNKVTSDGTYATqsAYSLAPVAKAEkrpPLRQYLMDGD 562  fruit fly
O45718  502 ----KIVQYVFQLARfdL-SYDVRDRCR---FLRNLMFNTE 534  Caenorhabditis elegans
Q13367  558 ----LLTQYVLSLAKydQ-NYDIRDRAR---FTRQLIVPSE 590  human
Q9W4K1  589 ----LLCQYVFTLARydP-NYDVRDRAR---FLRQIIFPAs 621  fruit fly
O13939  522 dvvsLLFNYVLSLIHfdM-SYDLRDRAR---FYKELASTPS 558  Schizosaccharomyces pombe 972h-
P46682  586 srisQMYNAVLYLAKydD-EFDIRDRAR---MISSLFDSGK 622  Saccharomyces cerevisiae S288C
P36000  520 ----SMLQSVLELATqqTHELDVRDMAM---MYWRCLSMPN 553  Saccharomyces cerevisiae S288C
O81742  502 ----QMIQVVLNNATveTDNPDLRDRAY---IYWRLLSTDP 535  thale cress
Q10567  501 ----ELVQQVLSLATqdSDNPDLRDRGY---IYWRLLSTDP 534  human
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