4P6Z


Conserved Protein Domain Family
Adaptin_N

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pfam01602: Adaptin_N 
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Adaptin N terminal region
This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Statistics
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PSSM-Id: 307641
View PSSM: pfam01602
Aligned: 30 rows
Threshold Bit Score: 359.243
Threshold Setting Gi: 74583793
Created: 16-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P6Z_B   27 K-KGEIFELKAELNSDKKE---KKKeAVKKVIASMTVGK---DVSALFPDVVNCMQ-TDNLELKKLVYLYLMNYAKSQPD 98   human
P41810   20 MeTYSSTDFQKALEKGSDE---QKIdTMKSILVTMLEGN---PMPELLMHIIRFVMpSKNKELKKLLYFYWEIVPKLAED 93   Saccharomyces cerev...
P23514   18 SePPSEISLKNDLEKGDVK---SKTeALKKVIIMILNGE---KLPGLLMTIIRFVLpLQDHTIKKLLLVFWEIVPKTTPD 91   Norway rat
O45718   11 DnRTRFADLKAMLDSNKDN---LKVdAMKRIINLIAKGK---DVSELFAAVVKNVA-AKNVELKKLVFVYLVRYAEEQQD 83   Caenorhabditis elegans
Q13367   34 SdYKRHDDLKEMLDTNKDS---LKLeAMKRIVAMIARGK---NASDLFPAVVKNVA-CKNIEVKKLVYVYLVRYAEEQQD 106  human
Q9W4K1   40 sdGRKHDDLKQMLDSNKDG---LKLeAMKRIIGMIARGR---DASDLFPAVVKNVV-SKNIEVKKLVYVYLVRYAEEQQD 112  fruit fly
O13939   30 EnELSHSDLLRLLNSNSDA---GKLeAINFILAQMMHGE---NMSLYFPDVVKLVA-SENPEIRRLVHIYLLQYAEFNPD 102  Schizosaccharomyces...
P46682   39 SqNINPQQLVTLLNSRNSR---EVRdAMKRIISIMASDDdsiDVQLYFADVVKNIT-TNDTKVKRLIHLYLLRFAENDPN 114  Saccharomyces cerev...
P36000   24 G-KGELSELRTGLVSQYPQ---TRKdAIKKTIQQMTLGK---DVSSLFPDVLKNIA-TIDVEQKKLVYLYVMNYAETHPE 95   Saccharomyces cerev...
P27351   11 KaNEIVTDLQHFGVKKFKSnitRRKnALRKIIANLVLGNy-gEMSVLFSELLKFWQiEDDLEVKRICHEYIRVIGALKPQ 89   Saccharomyces cerev...
4P6Z_B   99 -----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDP--YVRKTAAVCVAKLHDINAQL 171  human
P41810   94 gklrhEMILVCNAIQHDLQHPNEYIRGNTLRFLTKLREAELLEQMVPSVLACLEYRHA--YVRKYAILAVFSIFKVSEHL 171  Saccharomyces cerev...
P23514   92 grllhEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHS--YVRRNAVLAIYTIYRNFENL 169  Norway rat
O45718   84 -----LALLSISTFQRALKDPNQLIRGSALRVLTSIRVPMVAPIMLLAIKDAVRDMSP--YVRKVAAHAIPKLYSLEPEL 156  Caenorhabditis elegans
Q13367  107 -----LALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSP--YVRKTAAHAIPKLYSLDSDQ 179  human
Q9W4K1  113 -----LALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSP--YVRKTAAHAIPKLYSLDADQ 185  fruit fly
O13939  103 -----LALLSVNTVQKTLYDKNPLTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTAD--RVRQSAALAITKCYSLDPSY 175  Schizosaccharomyces...
P46682  115 -----LTLLSINSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILHTVKKLVTDPSA--MVRGEVALAIIKLYRAGKND 187  Saccharomyces cerev...
P36000   96 -----LCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNA--YVRKTAVICVAKLFQLNKDL 168  Saccharomyces cerev...
P27351   90 -----QAREALPFIMDDFKSRDEKLQIMALRTLVLVPVKELSDQAFDCIISLVNHKSPpeQVTRTAIYALLDLDEIDHER 164  Saccharomyces cerev...
4P6Z_B  172 VEDqgfLDTLKDLI--SDSNPMVVANAVAALSEIaeSHPssn-llDLNPQSINKLLTAlNECTEWGQIFILDCL-ANYMP 247  human
P41810  172 LPD---AKEIINSFivAETDPICKRNAFIGLAEL--DRE------NALHYLENNIADI-ENLDPLLQAVFVQFI-RQDAN 238  Saccharomyces cerev...
P23514  170 IPD---APELIHDFlvNEKDASCKRNAFMMLIHA--DQD------RALDYLSTCIDQV-QTFGDILQLVIVELI-YKVCH 236  Norway rat
O45718  157 -EPq-lVDCIDFLL--ADRRSLVLGSAVYAFDEIcpHRL------DLLHKHFRALCRGlADVDEWGQIVMINML-TRYAR 225  Caenorhabditis elegans
Q13367  180 --KdqlIEVIEKLL--ADKTTLVAGSVVMAFEEVcpERI------DLIHKNYRKLCNLlIDVEEWGQVVIISML-TRYAR 248  human
Q9W4K1  186 --KdelVMVIEKLL--SDRTTLVVGSAVMAFDEVcpERV------DLIHKNYRKLCNFlLDVDEWGQVIIINML-TRYAR 254  fruit fly
O13939  176 --KsqlEEHIKTLL--SDNSPIVVPAALFTFEVVcpEKL------EIIHPYYHRICTLfPQMNDWDKVVALKTL-VRYAR 244  Schizosaccharomyces...
P46682  188 Y-HeelLDILKELM--ADTDPKVISCAVLAYKECyaDHL------ELLHGHFRRYCRIiKQLDSWSQSYLIELL-IKYCK 257  Saccharomyces cerev...
P36000  169 CVElgvVEDLVNAL--DDSNPLVIANATAALIEIhnMDMdavdlsSLIQSHVSQFLLAlNECTEWARIIILGTL-SEYSA 245  Saccharomyces cerev...
P27351  165 Vlg--lSSILHDIVkaQSSSPEVIVAALHTLYSIheKNAnme-pfRIPLELAFDMLELlPELNEWNKATVLEVLtTSVVP 241  Saccharomyces cerev...
4P6Z_B  248 KDDREA-------------------------------------------------------------------------Q 254  human
P41810  239 RTPALK-------------------------------------------------------------------------A 245  Saccharomyces cerev...
P23514  237 ANPSER-------------------------------------------------------------------------A 243  Norway rat
O45718  226 HELADPdrgpp----------------------------------------------------------------dtdvV 241  Caenorhabditis elegans
Q13367  249 TQFLSPtqneslleenaekafygseedeak-------------------------gagseetaaaaapsrkpyvmdpdhR 303  human
Q9W4K1  255 TQFVDPnaddedlvndglgetpvserfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhR 334  fruit fly
O13939  245 LTLPEPstpst----------------------------------------------------------------hsdlK 260  Schizosaccharomyces...
P46682  258 QYLPKPtvvdkssegsprscplpd-------------------------------------kyneieypsyevvndpdlD 300  Saccharomyces cerev...
P36000  246 KDSLEA-------------------------------------------------------------------------Q 252  Saccharomyces cerev...
P27351  242 QHYLDT-------------------------------------------------------------------------H 248  Saccharomyces cerev...
4P6Z_B  255 SICERVTPRLS-HANSAVVLSAVKVLMKFMEMLSkdldyygtLLKKLAPPLVTLLS-AEPE-LQYVALRN-INLIVQK-- 328  human
P41810  246 QYIELLMELLStTTSDEVIFETALALTVLSANPN--------VLVPAVNKLIDLAVkVSDNnIKLIVLDR-IQDINAN-- 314  Saccharomyces cerev...
P23514  244 RFIRCIYNLLQ-SSSPAVKYEAAGTLVTLSSAPT--------AIKAAAQCYIDLIIkESDNnVKLIVLDR-LVELKEH-- 311  Norway rat
O45718  242 LLLNSARPLLQ-SRNCSVVMAVVQLFYHVAPKAQ---------LSQIARALVRLLR-GPRE-TQYVVLTN-IATICERnp 308  Caenorhabditis elegans
Q13367  304 LLLRNTKPLLQ-SRSAAVVMAVAQLYFHLAPKAE---------VGVIAKALVRLLR-SHSE-VQYVVLQN-VATMSIK-- 368  human
Q9W4K1  335 LLLRQTKPLLQ-SRNASVVMAVAQLYHHVAPKNE---------VQLIAKALIRLLR-SHKE-VQSVVLNC-IASMSTK-- 399  fruit fly
O13939  261 ELLESIKSCFF-SLLPSTIIAGARAFYYLAPSNQ---------MHLIVEPLLQLLL-EKPI-VRTTTLRY-ISQIVYK-- 325  Schizosaccharomyces...
P46682  301 LFLQSLNCLIY-SSNPTVILSCCNALYQLASPLQm-------KNTKFIEALVRTVTmTENQgNKEMLLQA-IHFLSIL-- 369  Saccharomyces cerev...
P36000  253 DIIDRVTAHLQ-HVNPAVVLATIKVIVRNLPQIEyss--nslIMKRLSSAFVSLMS-TPPE-MQYVALKN-IRIILEK-- 324  Saccharomyces cerev...
P27351  249 EMIELALPYLQ-QVNTYVVLNSLKFIMYLLNYVDvik---etLAEKLSNSVIALLD-KPPE-LQFLVLRNvILLLLSR-- 320  Saccharomyces cerev...
4P6Z_B  329 --------R---PEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQ---VLAELKEYA---TEV-DVD----FV 386  human
P41810  315 --------Nv--GALEELTLDILRVLNAEDLDVRSKALDISMDLATSRNAED---VVQLLKKELqttVNNpDQDkamqYR 381  Saccharomyces cerev...
P23514  312 --------PaheRVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEE---LVIVLKKEViktNNVsEHEdtdkYR 380  Norway rat
O45718  309 veegtyaiS---KTMFDPFLKSFFVRSCDSSLVKKLKLHVLTSLVSEANVHI---ILRELQTYV---HMS---D----LA 372  Caenorhabditis elegans
Q13367  369 --------R---RGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPT---VLREFQTYI---RSM-DKD----FV 426  human
Q9W4K1  400 --------R---KAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISL---ILREFQTYI----SSsDRS----FV 457  fruit fly
O13939  326 --------T---PELFKNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQ---ILPELLYYI---NSHpNPS----VA 384  Schizosaccharomyces...
P46682  370 --------D---QTLFLPYTKKFYVFPKDPIVASIWKIQILSTLINESNVKE---IFKELKYYV---ASAhFPEn---VV 429  Saccharomyces cerev...
P36000  325 --------Y---PELLTKELRIFYVKFNDPLYVKLEKIDILVRLVDPSNLKQctlLLTELKEYA---MEY-EPE----FV 385  Saccharomyces cerev...
P27351  321 --------E---SSLLRLDISYFFIEYNDPIYIKDTKLECLYLLANKETLPR---ILEELEQYA---TDI-DIQ----MS 378  Saccharomyces cerev...
4P6Z_B  387 RKAVRAIGRCAIKV--EQSAERCVSTLLDLIQTKV--NYVVQEAIVVIKDIFRKYPNKYESVIAALCENLDSLDEPE--- 459  human
P41810  382 QLLIKTIRTVAVNF--VEMAASVVSLLLDFIGDLN--SVAASGIIAFIKEVIEKYPQLRANILENMVQTLDKVRSAK--- 454  Saccharomyces cerev...
P23514  381 QLLVRTLHSCSVRF--PDMAANVIPVLMEFLSDSN--EAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVK--- 453  Norway rat
O45718  373 SPAVEAIGRCAVRV--GAVSDQCMTGLVQLISSSD--EKVVCSAVVVIKRLLHASAPL--NLLSRLMRLMPNMIAAQ--- 443  Caenorhabditis elegans
Q13367  427 AATIQAIGRCATNI--GRVRDTCLNGLVQLLSNRD--ELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPM--- 499  human
Q9W4K1  458 AATIQAIGRCASSI--KEVTETCLSGLVHLLSNHD--EHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPA--- 530  fruit fly
O13939  385 STAVKALGDFASAN--ISMAPSCLNTLLLLLKSHN--SLIVTEAASSLRLLIHNDPKEIY--LQYLAATYETLEVPR--- 455  Schizosaccharomyces...
P46682  430 IMAVKSLSRCGQLS--TSWESHVMKWLIDHMESHNlsASVLDAYVNVIRMLVQKNPTKHLRIIFKLADLLTVQTSLAd-- 505  Saccharomyces cerev...
P36000  386 SRAIQALSQLGIKYaqESFVSKVLDILLELLERQ---DTIKDDCCISLCDLLRHCPGN-DKMAKQVCAVFNTWSNPEvll 461  Saccharomyces cerev...
P27351  379 RKSVRAIGNLAVKLd-EDSVHDCVAVLLDLLEFGV--DYVVQEIISVFRNILRKYPNNFKANVTELVKHTEVVQEPE--- 452  Saccharomyces cerev...
4P6Z_B  460 ----ARAAMIWIVGEYAERIDn----ADELLESFLEGFHDKSTQVQLQ-LLTAIVKLF-----------LKKPt-eTQ-- 516  human
P41810  455 ----AYRGALWIMGEYAEGESeiqhcWKHIRNSVGEVPILQSEIKKLT-QNQEHTEEN-----------EVDAtakPTg- 517  Saccharomyces cerev...
P23514  454 ----IYRGALWILGEYCSTKEdiqsvMTEVRRSLGEIPIVESEIKKEAgELKPEEEITvgp------------------- 510  Norway rat
O45718  444 ----ARACVIWLVATHVEQVLh---mAPDFLRLIAKKFSTENELVKLE-ALKLAVKLW-----------LVKRddsE--- 501  Caenorhabditis elegans
Q13367  500 ----ARASILWLIGEYCEHVPr---iAPDVLRKMAKSFTAEEDIVKLQ-VINLAAKLY-----------LTNSkqtK--- 557  human
Q9W4K1  531 ----ARAAIIWLIGEYNEKVPl---iAPDVLRKMAKSFVDEQDVVKLQ-VLNLGVKLY-----------LTNPeqtS--- 588  fruit fly
O13939  456 ----AKSVTLWLISEHILIIPr---lVPDVLRIAVKTFADETLEVKYQ-ILELSVRLY-----------VLSHseeKQnd 516  Schizosaccharomyces...
P46682  506 ---nARAGIVWLFGEIASIEFk---iCPDVLRRLIQNFSNEGPETRCQ-ILVLSAKLLsydidnfkqaqVTGSeenNQnp 578  Saccharomyces cerev...
P36000  462 qsdiAKCNYVWLLGQHPNNFSd----LESKINIFIENFVQEEALTQMS-LLMTIVRLH-----------ATL----TG-- 519  Saccharomyces cerev...
P27351  453 ----SKNAMIWIITQYSDVIPn----YLELFRVFSSNMFSETLEVQFS-ILNSAIKFF-----------IRSPtkeTE-- 510  Saccharomyces cerev...
4P6Z_B  517 -----------ELVQQVLSLATqdSDNPDLRDRGY---------IYWRLLSTDP 550  human
P41810  518 -----------PVILPDGTYATesAFDVKTSQKSVtdeerdsrpPIRRFVLSGD 560  Saccharomyces cerevisiae S288c
P23514  511 ---------vqKLVTEMGTYATqsALSSSRPTKKEed-----rpPLRGFLLDGD 550  Norway rat
O45718  502 -----------KIVQYVFQLARfdL-SYDVRDRCR---------FLRNLMFNTE 534  Caenorhabditis elegans
Q13367  558 -----------LLTQYVLSLAKydQ-NYDIRDRAR---------FTRQLIVPSE 590  human
Q9W4K1  589 -----------LLCQYVFTLARydP-NYDVRDRAR---------FLRQIIFPAs 621  fruit fly
O13939  517 lesr--ddvvsLLFNYVLSLIHfdM-SYDLRDRAR---------FYKELASTPS 558  Schizosaccharomyces pombe 972h-
P46682  579 pyydfsgsrisQMYNAVLYLAKydD-EFDIRDRAR---------MISSLFDSGK 622  Saccharomyces cerevisiae S288c
P36000  520 -----------SMLQSVLELATqqTHELDVRDMAM---------MYWRCLSMPN 553  Saccharomyces cerevisiae S288c
P27351  511 -----------ELCMDLLKGCIdhENNPDLRDKTL---------MYWRLLSLTK 544  Saccharomyces cerevisiae S288c
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