2IUS


Conserved Protein Domain Family
FtsK_SpoIIIE

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pfam01580: FtsK_SpoIIIE 
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FtsK/SpoIIIE family
FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids, termed the FtsK/SpoIIIE family. This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer.
Statistics
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PSSM-Id: 279863
View PSSM: pfam01580
Aligned: 17 rows
Threshold Bit Score: 158.695
Threshold Setting Gi: 81625587
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IUS_A        131 LREVLDNAKFRDNPSPLTVVLGKDI-AGEPVVADLAKMP------HLLVAGTTGSGASVGVNAMILSMLYKAQPEDVRFI 203  Escherichia coli
P21458        424 LKEVLESKLNDRPDAKLLIGLGRNI-SGEAVLAELNKMP------HLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMM 496  Bacillus subt...
C0SP86        596 LRQMIRSSAFRTSKSPLTAALGLDI-SGNPVVIDLKKMP------HGLIAGATGSGKSVCINTILVSLLYKADPSEVKVL 668  Bacillus subt...
P9WNA7        721 LLRDAEPAQAELAVPIGIVDRPFEQ-SRVPLTIDLSGAAg-----NVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFY 794  Mycobacterium...
P9WNA9        785 aLARAGVGPRQWRWPLGEIDRPFEM-RRDPLVFDARSSAg-----NMVIHGGPKSGKSTALQTFILSAASLHSPHEVSFY 858  Mycobacterium...
Q9X8D0        140 lkrvQMPAKTDTRPMRVPVALRED---GSVHYRDYRTVP------HGLTLGATESGKSVYQRNLVAGLAP----HHVALV 206  Streptomyces ...
O24906        327 LKDLQKDEKFWTESSQFKVSVPVGWdINHKEVCFEIGNEq----nHTLICGRSGSGKSNFLHVLIQNLAFYYAPNEVQLF 402  Helicobacter ...
Q0PA12        594 LREILQSEVFKNAKSPLTIALGKDI-VGNAFVTDLKKLP------HLLIAGTTGSGKSVGINSMLLSLLYRNSPKTLRLM 666  Campylobacter...
O05560        453 LADVLTAPSTRRDHHSLVIGLGKDI-EGNFISANLAKMP------HLLVAGSTGSGKSSFVNSMLVSLLTRSTPEEVRMI 525  Mycobacterium...
WP_119607857  427 VLPSRWRMYTDNDRDRLKIPFGHEFkTGNIMYLDIKEGAefgggpHGMLIGTTGSGKSEFLRTLILSLVAMTHPNQVNLL 506  Mycobacterium...
2IUS_A        204 MIDPKML-ELSVYEGIPHLLT----EVVTDMKDAANALRWCVNEMERRY--KLMSALGVRNLAG----YNEKIAEADRMm 272  Escherichia coli
P21458        497 MIDPKMV-ELNVYNGIPHLLA----PVVTDPKKASQALKKVVNEMERRY--ELFSHTGTRNIEG----YNDYIKRANNE- 564  Bacillus subt...
C0SP86        669 LIDPKMV-ELAPYNKIPHLVS----PVITDAKAATAALKWVVEEMERRY--ELFAHSGVRDIDR----FNQLTAEHQMG- 736  Bacillus subt...
P9WNA7        795 CLDFGGG-ALAQVDELPHVGAv---AGRAQPQLASRMLAELESAVRFRE--AFFRDHGIDSVAR----YRQLRAKSAAEs 864  Mycobacterium...
P9WNA9        859 CLDYGGG-QLRALQDLAHVGSv---ASALEPERIRRTFGELEQLLLSRQqrEVFRDRGANGSTP-----DDGFGEVFLVi 929  Mycobacterium...
Q9X8D0        207 GIDCK---QGVELFPLARRFS----ALADNPDTALELLEALVSHMQDVY--QLIRAEQRISVAV----PDAEIAADIWDl 273  Streptomyces ...
O24906        403 LLDYKEGvEFNAYTDPNILEHarlvSVASSVGYGMSFLNWLCKEMQERA--NLFKQFNVKDLSDy--rKHGEIPRLIVVi 478  Helicobacter ...
Q0PA12        667 MIDPKML-EFSIYNDIPHLLT----PVITDPKKAVNALSNMVAEMERRY--RLMADAKTKNIEN----YNEKMKE--LGg 733  Campylobacter...
O05560        526 LIDPKMV-ELTPYEGIPHLIT----PIITQPKKAAAALVWLVEEMEQRY--QDMQASRVRHIDVfnekVRSGEITAPLG- 597  Mycobacterium...
WP_119607857  507 LTDFKGGsTFLGMEKLPHTAAvv-tNMAEEAELVSRMGEVLTGELDRRQ--NILRQAGTLVGAAg---ALSGVAEYEKYr 580  Mycobacterium...
2IUS_A        273 rpipdpyw--------------------------kpgdsmdaQHPVLK-KEPYIVVLVDEFADLMMTVGKK--------V 317  Escherichia coli
P21458        565 ------------------------------------------EGAKQP-ELPYIVVIVDELADLMMVASSD--------V 593  Bacillus subt...
C0SP86        737 -----------------------------------------------E-KLPYLVVIIDELADLMMVAPND--------V 760  Bacillus subt...
P9WNA7        865 fadiflvidgwaslrqefaaleesivalaaqglsfgvhvalsAARWAE-IRPSLRDQIGSRIELRLADPADseldrrqaQ 943  Mycobacterium...
P9WNA9        930 dnlygfgrdntdqfntrnpl-larvtelvnvglaygihviitTPSWLE-VPLAMRDGLGLRLELRLHDARDsn----vrV 1003 Mycobacterium...
Q9X8D0        274 --------------------------------------------PEDL-RPVPVVVLVDEVAELALFASKEeekr-rdrI 307  Streptomyces ...
O24906        479 defqvlfsdnkstkavegh----lntllkkgrsygvhlilatQTMRGTdINRSIMAQIANRIALSMDAEDSns----ilG 550  Helicobacter ...
Q0PA12        734 -----------------------------------------------E-KLPFIVVIIDELADLMMTAGKD--------V 757  Campylobacter...
O05560        598 ------------------------------------------SQRVYR-PYPYILAIVDELADLMMTAPRD--------V 626  Mycobacterium...
WP_119607857  581 -----------------------------------------eRGANLA-PLPTLFVVVDEFAELLQSHPDF--------- 609  Mycobacterium...
2IUS_A        318 EELIARLAQK------AR---AAGIHLVLAT---QRPS 343  Escherichia coli
P21458        594 EDSITRLSQM------AR---AAGIHLIIAT---QRPS 619  Bacillus subtilis subsp. subtilis str. 168
C0SP86        761 EESIARIAQK------AR---ACGIHLLVAT---QRPS 786  Bacillus subtilis subsp. subtilis str. 168
P9WNA7        944 RVPVDRPGRG------LS---RDGMHMVIAL---Pdld 969  Mycobacterium tuberculosis H37Rv
P9WNA9       1004 VGALRRPADAvphdqpGRgltMAAEHFLFAA---PEld 1038 Mycobacterium tuberculosis H37Rv
Q9X8D0        308 ITALVRLAQL------GR---AAGVYLEICG---QRFG 333  Streptomyces coelicolor
O24906        551 DDAACELVRPe-----GIf-nNNGGHQKHHTkmsIPKA 582  Helicobacter pylori
Q0PA12        758 EFYIGRLAQM------AR---ASGIHLIVAT---QRPS 783  Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 70...
O05560        627 EDAIVRITQK------AR---AAGIHLVLAT---QRPS 652  Mycobacterium leprae TN
WP_119607857  610 IGLFDRICRV------GR---SLRVHLLLAT---QSLQ 635  Mycobacterium leprae
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