2IUS


Conserved Protein Domain Family
FtsK_SpoIIIE

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pfam01580: FtsK_SpoIIIE 
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FtsK/SpoIIIE family
FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids, termed the FtsK/SpoIIIE family. This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer.
Statistics
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PSSM-Id: 279863
View PSSM: pfam01580
Aligned: 16 rows
Threshold Bit Score: 158.695
Threshold Setting Gi: 81625587
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IUS_C  131 LREVLDNAKFRDNPSPLTVVLGKDI-AGEPVVADLAKMP--------HLLVAGTTGSGASVGVNAMILSMLYKAQPEDVR 201  Escherichia coli
P21458  424 LKEVLESKLNDRPDAKLLIGLGRNI-SGEAVLAELNKMP--------HLLVAGATGSGKSVCVNGIITSILMRAKPHEVK 494  Bacillus subtilis s...
C0SP86  596 LRQMIRSSAFRTSKSPLTAALGLDI-SGNPVVIDLKKMP--------HGLIAGATGSGKSVCINTILVSLLYKADPSEVK 666  Bacillus subtilis s...
P9WNA7  721 LLRDAEPAQAELAVPIGIVDRPFEQ-SRVPLTIDLSGAAg-------NVAVVGAPQTGKSTALRTLIMALAATHDAGRVQ 792  Mycobacterium tuber...
P9WNA9  785 aLARAGVGPRQWRWPLGEIDRPFEM-RRDPLVFDARSSAg-------NMVIHGGPKSGKSTALQTFILSAASLHSPHEVS 856  Mycobacterium tuber...
Q9X8D0  140 lkrvQMPAKTDTRPMRVPVALRED---GSVHYRDYRTVP--------HGLTLGATESGKSVYQRNLVAGLAP----HHVA 204  Streptomyces coelic...
O24906  327 LKDLQKDEKFWTESSQFKVSVPVGWdINHKEVCFEIGNEq------nHTLICGRSGSGKSNFLHVLIQNLAFYYAPNEVQ 400  Helicobacter pylori
Q0PA12  594 LREILQSEVFKNAKSPLTIALGKDI-VGNAFVTDLKKLP--------HLLIAGTTGSGKSVGINSMLLSLLYRNSPKTLR 664  Campylobacter jejun...
O05560  453 LADVLTAPSTRRDHHSLVIGLGKDI-EGNFISANLAKMP--------HLLVAGSTGSGKSSFVNSMLVSLLTRSTPEEVR 523  Mycobacterium lepra...
P9WNA5  824 LVNRFLGRPWHKEYGSACNLVFPIGiIDRPYKHDQPPWTvdtsgpgaNVLILGAGGSGKTTALQTLICSAALTHTPQQVQ 903  Mycobacterium tuber...
2IUS_C  202 FIMIDPKML-ELSVYEGIPHLLT----EVVTDMKDAANALRWCVNEMERRY--KLMSALGVRNLAG-----YNEKIAEAD 269  Escherichia coli
P21458  495 MMMIDPKMV-ELNVYNGIPHLLA----PVVTDPKKASQALKKVVNEMERRY--ELFSHTGTRNIEG-----YNDYIKRAN 562  Bacillus subtilis s...
C0SP86  667 VLLIDPKMV-ELAPYNKIPHLVS----PVITDAKAATAALKWVVEEMERRY--ELFAHSGVRDIDR-----FNQLTAEHQ 734  Bacillus subtilis s...
P9WNA7  793 FYCLDFGGG-ALAQVDELPHVGAv---AGRAQPQLASRMLAELESAVRFRE--AFFRDHGIDSVAR-----YRQLRAKSA 861  Mycobacterium tuber...
P9WNA9  857 FYCLDYGGG-QLRALQDLAHVGSv---ASALEPERIRRTFGELEQLLLSRQqrEVFRDRGANGSTP------DDGFGEVF 926  Mycobacterium tuber...
Q9X8D0  205 LVGIDCK---QGVELFPLARRFS----ALADNPDTALELLEALVSHMQDVY--QLIRAEQRISVAV-----PDAEIAADI 270  Streptomyces coelic...
O24906  401 LFLLDYKEGvEFNAYTDPNILEHarlvSVASSVGYGMSFLNWLCKEMQERA--NLFKQFNVKDLSDy---rKHGEIPRLI 475  Helicobacter pylori
Q0PA12  665 LMMIDPKML-EFSIYNDIPHLLT----PVITDPKKAVNALSNMVAEMERRY--RLMADAKTKNIEN-----YNEKMKE-- 730  Campylobacter jejun...
O05560  524 MILIDPKMV-ELTPYEGIPHLIT----PIITQPKKAAAALVWLVEEMEQRY--QDMQASRVRHIDVfn-ekVRSGEITAP 595  Mycobacterium lepra...
P9WNA5  904 FYCLAYSST-ALTTVSRIPHVGEv---AGPTDPYGVRRTVAELLALVRERK--RSFLECGIASMEMfrrrkFGGEAGPVP 977  Mycobacterium tuber...
2IUS_C  270 RMmrpipdpyw--------------------------kpgdsmdaQHPVLK-KEPYIVVLVDEFADLMMTVGKK------ 316  Escherichia coli
P21458  563 NE-------------------------------------------EGAKQP-ELPYIVVIVDELADLMMVASSD------ 592  Bacillus subtilis s...
C0SP86  735 MG------------------------------------------------E-KLPYLVVIIDELADLMMVAPND------ 759  Bacillus subtilis s...
P9WNA7  862 AEsfadiflvidgwaslrqefaaleesivalaaqglsfgvhvalsAARWAE-IRPSLRDQIGSRIELRLADPADseldrr 940  Mycobacterium tuber...
P9WNA9  927 LVidnlygfgrdntdqfntrnpl-larvtelvnvglaygihviitTPSWLE-VPLAMRDGLGLRLELRLHDARDsn---- 1000 Mycobacterium tuber...
Q9X8D0  271 WDl--------------------------------------------PEDL-RPVPVVVLVDEVAELALFASKEeekr-r 304  Streptomyces coelic...
O24906  476 VVidefqvlfsdnkstkavegh----lntllkkgrsygvhlilatQTMRGTdINRSIMAQIANRIALSMDAEDSns---- 547  Helicobacter pylori
Q0PA12  731 LGg-----------------------------------------------E-KLPFIVVIIDELADLMMTAGKD------ 756  Campylobacter jejun...
O05560  596 LG-------------------------------------------SQRVYR-PYPYILAIVDELADLMMTAPRD------ 625  Mycobacterium lepra...
P9WNA5  978 DDgfgdvylvidnyralaeenevlieqvnviinqgpsfgvhvvvtADRESE-LRPPVRSGFGSRIELRLAAVEDaklvrs 1056 Mycobacterium tuber...
2IUS_C  317 --VEELIARLAQK------AR-----AAGIHLVLAT---QRPS 343  Escherichia coli
P21458  593 --VEDSITRLSQM------AR-----AAGIHLIIAT---QRPS 619  Bacillus subtilis subsp. subtilis str. 168
C0SP86  760 --VEESIARIAQK------AR-----ACGIHLLVAT---QRPS 786  Bacillus subtilis subsp. subtilis str. 168
P9WNA7  941 qaQRVPVDRPGRG------LS-----RDGMHMVIAL---Pdld 969  Mycobacterium tuberculosis H37Rv
P9WNA9 1001 vrVVGALRRPADAvphdqpGRgl--tMAAEHFLFAA---PEld 1038 Mycobacterium tuberculosis H37Rv
Q9X8D0  305 drIITALVRLAQL------GR-----AAGVYLEICG---QRFG 333  Streptomyces coelicolor
O24906  548 ilGDDAACELVRPe-----GIf---nNNGGHQKHHTkmsIPKA 582  Helicobacter pylori
Q0PA12  757 --VEFYIGRLAQM------AR-----ASGIHLIVAT---QRPS 783  Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
O05560  626 --VEDAIVRITQK------AR-----AAGIHLVLAT---QRPS 652  Mycobacterium leprae TN
P9WNA5 1057 rfAKDVPVKPGRGmvavnyVRldsdpQAGLHTLVAR---PALG 1096 Mycobacterium tuberculosis H37Rv
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