1SGV,1R3E


Conserved Protein Domain Family
TruB_N

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pfam01509: TruB_N 
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TruB family pseudouridylate synthase (N terminal domain)
Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA.
Statistics
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PSSM-Id: 334571
View PSSM: pfam01509
Aligned: 166 rows
Threshold Bit Score: 117.974
Threshold Setting Gi: 157432101
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SGV_A        27 RR---IFa------TR----RVGHAGTLDPMATGVLVIGIERATKILGLLT-AAP-KSYAATIRLGQTTSTEDAEGQV-- 89  Mycobacterium t...
Q0ZC47        15 KK---VLrkdipthFQppvlKLGHGGTLDHTATGVLAVGVGWGCKLLPIFL-HGD-KKYIATGRFGIATTTYNETGKI-- 87  two-spotted cri...
Q8C0D0        94 KRqkqTL-------------KVGHGGTLDSAAQGVLVVGIGRGTKMLTSML-SGS-KRYITIGELGKATDTLDSTGKV-- 156 house mouse
Q6BPN6        60 KR---VKs------LKv---KIGHGGTLDPMASGVLVVGVGLGTKKLQYYLsECN-KTYETKALLGISTTTGDAEGEI-- 124 Debaryomyces ha...
Q8SRW0        78 KE---ILk------CE----KTGHSGTLDPQVSGVLTICIDRATRLTKSQQ-SLG-KEYVCVIEFLSEPDEEG------- 135 Encephalitozoon...
Q3IMV7        39 RD---MAg------VE----QAAHAGTLDPKVTGCLPVLTGTATRAAQVFD-ESR-KGYVAVLELHGTAPSD-------- 95  Natronomonas ph...
Q9HIT4        28 RE---ILg------IE----KVAHIGTLDPNVTGVLTMAIGKAVRLVDVVH-ESP-KEYVGVMRFYEDITEEE------- 85  Thermoplasma ac...
XP_001704052  70 RR---ILe------VE----KTGHSGTLDPGVTGCLLVCLDRATRLVKSQQ-LMG-KEYVCVLQFKDLAALKDEDARKaf 134 Giardia lamblia...
CAK43580      60 RR------------TQrldvKIGHGGTLDPLATGILVAGVGKGTKHLNEFL-GCT-KQYETVVLFGAETDTYDRLGKV-- 123 Aspergillus niger
Q6FJU1        57 KR---KL-------RKvskvKMGHGGTLDPLASGVLVLGVGTGTKQLSQYL-SGTvKVYETEALFGISTTSGDSEGEI-- 123 [Candida] glabrata
1SGV_A        90 LQSvPAKHLTIEAIDAAMERLRGEIRQVPSSV-SAIKVGGRRAYRLARQG--RSVQLEA-RPIRIDRFELLAARRRdqli 165 Mycobacterium t...
Q0ZC47        88 TEEmKYDHITEEMFENTLQKYTGKIYQTPPKY-SALKYQGRRIGDWTREG--MDIEMKP-RPVTCYSLKSRKFHLP---- 159 two-spotted cri...
Q8C0D0       157 TEEkPYDKITREDIEGILQKFTGNIMQVPPLY-SALKKDGQRLSTLMKKG--KVVEARPaRPVTVHSISLLKFQPP---- 229 house mouse
Q6BPN6       125 ITKnQVSHITQEMIKETAPKFIGDLKQTPPIF-SALKMNGKPLYDYAREG--IPL---P-MPIKVRQVKVFDVKVHd--- 194 Debaryomyces ha...
Q8SRW0       136 -------------FHKASKRLVGSLFQRPPLM-CAVK-------------------REL-RIRNVYSIDILEFNREk--r 179 Encephalitozoon...
Q3IMV7        96 -------------LESTVAEFEGPLYQKPPRK-SAVA-------------------RRL-RTRTVHRLDVLESEAR---- 137 Natronomonas ph...
Q9HIT4        86 -------------VRYYFKKFTGRIYQLPPVR-SAVA-------------------RSL-RIKTVYSLDLLEKKDR---- 127 Thermoplasma ac...
XP_001704052 135 SAC----------LQQALATLRCAQLQLPPKEgCAVK-------------------RQL-RVREIYTLDLLEFNFKt--g 182 Giardia lamblia...
CAK43580     124 VRKaPYEHVTREMVEKALEQFRGKIMQRPPIF-SALKVNGKKLYEYAREGkePPIEIQK-RPVEVTDLRIVEWYEPgt-h 200 Aspergillus niger
Q6FJU1       124 LSRnSVKHLKLEDVKTVEEKFRGSLKQTPPIY-SALKMNGKSLHEYAREGkpLPRAIEP-RQVTIYDLEILPKTLSkdhd 201 [Candida] glabrata
1SGV_A       166 DIDVEIDCSSGTYI 179 Mycobacterium tuberculosis H37Rv
Q0ZC47       160 HFEIEVACGGGFYV 173 two-spotted cricket
Q8C0D0       230 FFTLDVECGGGFYI 243 house mouse
Q6BPN6       195 EDSLRTDHEFQTLK 208 Debaryomyces hansenii
Q8SRW0       180 LGLFKVSCEAGTYV 193 Encephalitozoon cuniculi
Q3IMV7       138 RVLLSVECESGTYI 151 Natronomonas pharaonis DSM 2160
Q9HIT4       128 LVLFHVKCESGTYI 141 Thermoplasma acidophilum DSM 1728
XP_001704052 183 QAVLRASCQAGTYM 196 Giardia lamblia ATCC 50803
CAK43580     201 EFKWPEVEAEGEEK 214 Aspergillus niger
Q6FJU1       202 YKLIETEDESNSQI 215 [Candida] glabrata
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