4K95


Conserved Protein Domain Family
IBR

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pfam01485: IBR 
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IBR domain, a half RING-finger domain
The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.
Statistics
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PSSM-Id: 307574
View PSSM: pfam01485
Aligned: 161 rows
Threshold Bit Score: 32.1131
Threshold Setting Gi: 75334031
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K95_A       318 NRYQQYGAEEcVLQ-MGGVL-CPRPGCGAGLLPEQGQRKVTCEGgnglgCGFVFCRDCKEAY----HEG 380 Norway rat
A0BCF4       173 LKYQRFLLIKqYEHvVNG-KwCPRPDCFNFVFQQGQEKILQCS------CGQQFCFDCGNPN----HPN 230 Paramecium tetraurelia
A0BMU3       314 DKYYELTLKQlV------IQrCP--KCKAPIQKKEGCNHMTCYQ-----CRFQFCWLCRARYtr-mHFD 368 Paramecium tetraurelia
Q0UKC8       154 EKFQKLATENg-------YQnCS--QCSAVVELMEACNHVTCS------CGYDFCYLCGKEWvg-lHGc 206 Parastagonospora nodorum SN15
Q1PDR2       324 RLVNDMMLKVlAND-QM-WRqCs--ECKHMIELTEGCNHITCR------CGYEFCYRCGHKWtkyhHYs 382 thale cress
Q9SJT6       329 DPLYDVKLKS-LAN-KKKWRqCV--QCSNLVELFEGCNHITCR------CGFEFCYVCGKEWn---QRg 384 thale cress
Q0WQ77       358 ERYPDDITLHrLAR-YKRWRrCQ--QCRIMIELAQGCNHMTCR------CGHEFCYSCGAEY----REG 413 thale cress
Q84RJ8       352 LKSDAAILESfVKT--QGWKkCS--QCQSIVQHGGGCQQMTCRH-----CKHEFCYTCGAPC----KKK 407 thale cress
A0BMN6       178 KENNEREFKK-LVE-NMNCKqCT--NCGAWILKEKGCNHMKCK------CFYEFCYRCGRKYr---HPD 233 Paramecium tetraurelia
XP_001537456 317 ATLEEAEYHG--------WRrCY--SCHSMVELTAGCRHITCN------CGSEFCYTCAARW----HTc 365 Ajellomyces capsulatus NAm1
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