2CX1,2Q07,1Q7H,2APO,2J5T


Conserved Protein Domain Family
PUA

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pfam01472: PUA 
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PUA domain
The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes. It is predicted that the PUA domain is an RNA binding domain.
Statistics
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PSSM-Id: 279774
View PSSM: pfam01472
Aligned: 93 rows
Threshold Bit Score: 45.5604
Threshold Setting Gi: 3334438
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CX1_A  93 GVVLVDKGAAIALAKGAHLXIPGVVGVEGSF------TRGDVVAALYHEtRTPVXVGVAEVDSSALEKLYreKARGRAVR 166 Aeropyrum pernix K1
Q8TYS3  83 HVVIVDMGAVKPVASGADIMVPGIVEVRGEF------EEGDGVVVIDERnRRPLAVGIALMSAREIEESE--RGRAVRNV 154 Methanopyrus kandleri
Q9HM93  77 GVVTVDAGAVSFVSDGADVMRPGITAASPEI------TAGDLVVIQEAAhGKTLAVGRALVDGTEM-DGE--SGKVVSSL 147 Halobacterium salinarum
Q8ZWT7  82 PKAVVDAGAVKRIINGADVMRPGIKKLEGDF------NKGSIVFVADEK-GRTIAIAASLYSKGEIEQME--KGKVLLNL 152 Pyrobaculum aerophilum
P89886  91 PTVQVDRGAIKFVLSGANIMCPGLTSAGADLppapgyEKGTIVVINAENkENALAIGELMMGTEEIKSVN--KGHSIELI 168 Saccharomyces cerevis...
Q8MXH7  94 PHQQVDKGAIKFILNGSSIMCPGLTSPGAKLtp--lvPKDSVVAVMAEGkQHALAIGLMSMSSEEIQSVN--KGNGIENL 169 Caenorhabditis elegans
Q9CQ21  93 PHQQVDKGAIKFVLSGANIMCPGLTSPGAKLyt---aAVDTIVAVMAEGkEHALCVGVMKMAAADIEKIN--KGIGIENI 167 house mouse
Q8RZU5  92 KKFQVDRGAIKFVLSGANIMCPGLTSPGGSLdv--evEEETPVAIMAEGkQHALAIGYTKMSAKDIKTIN--KGIGVDNM 167 Japanese rice
Q8I3H2  91 PQIQVDKGAIKHVLRGSNIMCPGVTSPGGKLdd---vEANTVVQIRAEDkEFPCAVGITTMSSKEIIEIN--KDMCIENI 165 Plasmodium falciparum...
1Q7H_A  71 NIVTVDEGAEPHILNGSDLFAPGIVSXDDSI------RKGDXIFVKSSK-GYFIAVGXAEXDAGEVXATK--RGKAARII 141 Thermoplasma acidophi...
2CX1_A 167 RVH 169 Aeropyrum pernix K1
Q8TYS3 155 HHV 157 Methanopyrus kandleri
Q9HM93 148 HHV 150 Halobacterium salinarum
Q8ZWT7 153 HYL 155 Pyrobaculum aerophilum
P89886 169 HHL 171 Saccharomyces cerevisiae S288c
Q8MXH7 170 HYL 172 Caenorhabditis elegans
Q9CQ21 168 HYL 170 house mouse
Q8RZU5 168 HYL 170 Japanese rice
Q8I3H2 166 HYL 168 Plasmodium falciparum 3D7
1Q7H_A 142 HFP 144 Thermoplasma acidophilum DSM 1728
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