Conserved Protein Domain Family
MAGE

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pfam01454: MAGE 
MAGE family
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Statistics
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PSSM-Id: 334545
View PSSM: pfam01454
Aligned: 106 rows
Threshold Bit Score: 78.7886
Threshold Setting Gi: 444516735
Created: 17-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75150660    25 VIRFILFKFHQ--SsgT--PIKREDLTQ----IVTKnyrqR-N-LATHVINEAKKKLSNVFGYDLKELQRARSSSTGQSR 94
gi 75142698    25 VMRHVLFKTHQ--TagC--PIKREELTQ----IVTKnyrqR-V-LPALVIKEAGDRLAATFGYEMRELQRTRAPSTRSGR 94
gi 566171822   25 VIRYVLFKNHQ--N--SgsPIKRDELTQi---VTKNyr-hR-T-LPAVVIDEAKHKLASVFGFEMRELQRARPSSTNQGR 94
gi 1091736399  48 VIRFVLFKTHQ--NsgC--PIKREELTQl---ITKNyr-qR-S-LPALVINEAREKISNIFGYEMKELQRSRPASNKQGR 117
gi 357111697   24 VMRYVLFKTHQtsG--C--PIKREELTQi---VTKDy--qK-RaLPSLVIKEAGDRLAATFGYEMRELQRTRAPSNRSVR 93
gi 255073833   28 VMRYMLFSQYRd-G--A--PVTRTKLSEhlskIAPEl--kRaK-VSSYIVAEAQVKFNEIFGIEMKELSRKAQKKTGAAR 99
gi 168048072   10 VVRFMLFKSHKqpN--V--PVKREELAQ----LITEnykqR-S-LPGTVIANAQARLKSIFGLEMVEVHLSRQTKASKNA 79
gi 260950701   49 LLRMVMTRSAR--N--Q--KIRREHFTAi---LHKHn--vK-G-NTKAIISQVDAELKEVFGLKL--------------- 100
gi 575516793   95 IIRVAFARSAS--D--K--IIRKSHLTD------GWs--gT-K-DFAGALERANSLLATSFGLRISVIDEEPGAKKTANL 158
gi 947088377   27 LIRYMLFKTHQ--NsgC--PIKREELTQ----LVTKnyhqR-N-LPTFVINEAKEKLSFVFGYEMRELQRTQPSSKARTQ 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75150660    95 LPQSQSSV-DSKSYVLVSELPL---------------------EVF---------------------------------K 119
gi 75142698    95 PSQQQVNV-DAKSYVLVSKLDP---------------------EVY---------------------------------S 119
gi 566171822   95 ASSQQSVA-DAKSYVLISQLPA---------------------DVY---------------------------------R 119
gi 1091736399 118 APQQSA-V-EAKSYIVLSQLPA---------------------DIYt--------------------------------- 141
gi 357111697   94 SSSQAPSSvDTKTYILVSKLDP---------------------EVYs--------------------------------- 119
gi 255073833  100 TN-LQASE-PTKEYVLKSLLPS---------------------KIR---------------------------------R 123
gi 168048072   80 ASQGEI-----NVYVLKSLVPE---------------------ELa---------------------------------K 100
gi 260950701  101 ------DQ-STNDIVLVSNLQKdtklllqklvengdgsefkgnPYDtfyfm-----------------------nkekrN 150
gi 575516793  159 ------------AYSLVNCMTK---------------------KERqvldklwvdvdsvhkhngrsvfddeyflarntrD 205
gi 947088377   97 SSQQSV-A-DSKSYILISQLPP---------------------NVY---------------------------------E 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75150660   120 KHVVDETTSPVTGFTFVVLAIVQLAGGKIPEETLWHHLKRMGLHENDEHNP--VFGNNKQTLETLVQQRFLQK------- 190
gi 75142698   120 KYVEHKEAAHVSGFAFVVISIVHLSGGKISEEDLWHQLRRLGLNESDENHP--VLGNNKQALELLVQQRYLLK------- 190
gi 566171822  120 KYVEDVNSAHVTGFTFVVISVVHLAGGKIPEENLWHHLKKMGLFEND--EShpALGNIKQALETLVQQRYLQK------- 190
gi 1091736399 142 KYIEDKKTSHMTGFTFVVISIVHLAGGKISEENLWHHLRRLGLNESD--ENnaVFGNTKQTLEMLVHQRYLQK------- 212
gi 357111697  120 KYVEDKERAHLSGFAFVVISIVHVAGGKISEEDLWHQLKRLGLNEND--EKhpVIGNNKQALELLVQQRYLLK------- 190
gi 255073833  124 QFIDREEDHTFRGFVMAVVALVSVSGGEIEEQVLWKHLARLGVRHDD--EAhpKLGNVRDTLNKLCLQRYLMK------- 194
gi 168048072  101 RFIETKDIAAPMGFAVVVVGVLQLAGDKVPEGTLWTQLKRMGIDEFDNSh--pVFGNIKENIQTLVKQRYIRK------- 171
gi 260950701  151 ETTVSMSDSIFGGIIMLLIGLVIVNENRIRESDLLDGLSQFGFSENLNIVVpnLNKTTQEVLTEATKKEYLQK------- 223
gi 575516793  206 KLPSDNGDLAKMGVVSVVLALVVLEDNHLQRSRLLKLLRSFGVPDDPNASNtsIDHNAVTLLAELEKQSYLKRafrtksm 285
gi 947088377  121 KYVVDVNTAHLSGFTFVIISIVYLAGGKIPEENLWSQMRRMGLGETESSHP--VLGNVKQAFELLVQQRYLQK------- 191
                         250       260
                  ....*....|....*....|....*...
gi 75150660   191 EKV-SGPEGS-TLFYDLAERALDPQVSE 216
gi 75142698   191 EKL-SGPEGH-SMMYELAERALDESISG 216
gi 566171822  191 DKI-SGPEGN-TLVYELAERALDgpvne 216
gi 1091736399 213 EKVn-GPEGN-IIMYELAERALDEsiae 238
gi 357111697  191 EKI-AGPEGH-FMVYELAERALDEsisv 216
gi 255073833  195 EKGvGSDGKD-TFRYSLAERAMDELPTE 221
gi 168048072  172 EKV-SSSEGD-VWVLDLAERALDEIFKK 197
gi 260950701  224 LVAqAHGGEPaIVSYALGKRTLREFDAH 251
gi 575516793  286 AANsASASDE-HVFYNLGSRGMVEFGPE 312
gi 947088377  192 DKV-NGPEGN-TVYYELAERALdgpmnd 217
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